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Conserved domains on  [gi|1370467181|ref|XP_024305808|]
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tropomyosin alpha-1 chain isoform X16 [Homo sapiens]

Protein Classification

tropomyosin( domain architecture ID 11991670)

tropomyosin binds to actin filaments in muscle and non-muscle cells and plays a central role in regulating striated and smooth muscle contraction; forms a homodimer or a heterodimer between tropomyosin alpha and beta chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1-136 9.15e-49

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


:

Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 157.88  E-value: 9.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   1 MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKA 80
Cdd:pfam00261  80 RKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKS 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370467181  81 LMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:pfam00261 160 LEASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEA 215
 
Name Accession Description Interval E-value
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1-136 9.15e-49

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 157.88  E-value: 9.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   1 MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKA 80
Cdd:pfam00261  80 RKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKS 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370467181  81 LMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:pfam00261 160 LEASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEA 215
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-136 2.47e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 2.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:COG1196   251 LEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370467181  84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:COG1196   331 ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-134 6.37e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 6.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    2 KVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKAL 81
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESL 857

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370467181   82 MAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKI 134
Cdd:TIGR02168  858 AAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKR 910
PTZ00121 PTZ00121
MAEBL; Provisional
 10-125 1.28e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   10 KDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAElsegQVRQLEEQLRIMDQTLKAlMAAEDKYS 89
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAE----ELKKAEEENKIKAAEEAK-KAEEDKKK 1676

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370467181   90 QKEDRYEEEIKvlsDKLKEAETRAEFAERSVTKLEK 125
Cdd:PTZ00121  1677 AEEAKKAEEDE---KKAAEALKKEAEEAKKAEELKK 1709
 
Name Accession Description Interval E-value
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1-136 9.15e-49

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 157.88  E-value: 9.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   1 MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKA 80
Cdd:pfam00261  80 RKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKS 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370467181  81 LMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:pfam00261 160 LEASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEA 215
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-136 2.47e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 2.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:COG1196   251 LEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370467181  84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:COG1196   331 ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-134 6.37e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 6.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    2 KVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKAL 81
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESL 857

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370467181   82 MAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKI 134
Cdd:TIGR02168  858 AAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKR 910
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 4-134 6.87e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 6.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAE 337

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1370467181   84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKI 134
Cdd:TIGR02168  338 ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV 388
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-131 3.06e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   2 KVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKAL 81
Cdd:COG1196   256 EELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEEL 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370467181  82 MAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLE 131
Cdd:COG1196   336 EEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
40-134 1.53e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   40 ARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKAL-------------MAAEDKYSQKEDRYeEEIKVLSDKL 106
Cdd:COG4913    609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALqrlaeyswdeidvASAEREIAELEAEL-ERLDASSDDL 687

                           90       100
                   ....*....|....*....|....*...
gi 1370467181  107 KEAETRAEFAERSVTKLEKSIDDLEGKI 134
Cdd:COG4913    688 AALEEQLEELEAELEELEEELDELKGEI 715
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
7-131 2.60e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.67  E-value: 2.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    7 RAQKDEEKMEIQEIQ--LKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELS--EGQVRQLEEQLRIMDQTLKALM 82
Cdd:COG4913    609 RAKLAALEAELAELEeeLAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVAsaEREIAELEAELERLDASSDDLA 688

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1370467181   83 AAEDKYSQKE---DRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLE 131
Cdd:COG4913    689 ALEEQLEELEaelEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAE 740
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-136 2.92e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:COG1196   342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370467181  84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL 474
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2-134 3.37e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.20  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   2 KVIESRAQKDEEKMEIQEIQ--LKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQL-------- 71
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQaeLDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELgeraraly 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181  72 -----------------------------RIMDQ---TLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERS 119
Cdd:COG3883    97 rsggsvsyldvllgsesfsdfldrlsalsKIADAdadLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                         170
                  ....*....|....*
gi 1370467181 120 VTKLEKSIDDLEGKI 134
Cdd:COG3883   177 QAEQEALLAQLSAEE 191
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-131 3.78e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:COG1196   300 LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370467181  84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLE 131
Cdd:COG1196   380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE 427
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
7-129 6.53e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.51  E-value: 6.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    7 RAQKDEEKMEIQEIQLKEAKHiaEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRimdqTLKALMAAED 86
Cdd:COG4913    263 RYAAARERLAELEYLRAALRL--WFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELD----ELEAQIRGNG 336

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1370467181   87 kySQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDD 129
Cdd:COG4913    337 --GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPA 377
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-136 6.54e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:COG1196   293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370467181  84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:COG1196   373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE 425
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1-118 1.08e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    1 MKVIESRAQKDEEKMEIQEIQLKEAKHIAE--DADRKYEEVARKLviieSDLERAEERAELSEGQVRQLEEQLRIMDQTL 78
Cdd:COG4913    626 LAEAEERLEALEAELDALQERREALQRLAEysWDEIDVASAEREI----AELEAELERLDASSDDLAALEEQLEELEAEL 701

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370467181   79 KALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAER 118
Cdd:COG4913    702 EELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAED 741
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
4-134 1.15e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 38.69  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKME-----IQEIQLKEA--KHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQ 76
Cdd:COG2433   355 VEKKVPPDVDRDEvkarvIRGLSIEEAleELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEA 434

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370467181  77 TLKALmaaedkysqkedryEEEIKVLSDKLKEA--ETRAEF-AERSVTKLEKSIDDLEGKI 134
Cdd:COG2433   435 ELEEK--------------DERIERLERELSEArsEERREIrKDREISRLDREIERLEREL 481
PTZ00121 PTZ00121
MAEBL; Provisional
 10-125 1.28e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   10 KDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAElsegQVRQLEEQLRIMDQTLKAlMAAEDKYS 89
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAE----ELKKAEEENKIKAAEEAK-KAEEDKKK 1676

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370467181   90 QKEDRYEEEIKvlsDKLKEAETRAEFAERSVTKLEK 125
Cdd:PTZ00121  1677 AEEAKKAEEDE---KKAAEALKKEAEEAKKAEELKK 1709
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1-131 1.39e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   1 MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRkyEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKA 80
Cdd:COG1196   653 GEGGSAGGSLTGGSRRELLAALLEAEAELEELAE--RLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370467181  81 LMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEfAERSVTKLEKSIDDLE 131
Cdd:COG1196   731 EAEREELLEELLEEEELLEEEALEELPEPPDLEE-LERELERLEREIEALG 780
PRK12704 PRK12704
phosphodiesterase; Provisional
 2-114 2.02e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 37.84  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   2 KVIESRAQK--DEEKMEIQEIQlKEAKHIA-EDADRKYEEVARKLVIIESDLERAEERAELSEgqvRQLEEQLRIMDQTL 78
Cdd:PRK12704   34 KEAEEEAKRilEEAKKEAEAIK-KEALLEAkEEIHKLRNEFEKELRERRNELQKLEKRLLQKE---ENLDRKLELLEKRE 109

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1370467181  79 KALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAE 114
Cdd:PRK12704  110 EELEKKEKELEQKQQELEKKEEELEELIEEQLQELE 145
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
4-136 2.04e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.07  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKE--AKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKAL 81
Cdd:COG3206   180 LEEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPEL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181  82 MA-------------AEDKYSQKEDRY----------EEEIKVLSDKLK--------EAETRAEFAERSVTKLEKSIDDL 130
Cdd:COG3206   260 LQspviqqlraqlaeLEAELAELSARYtpnhpdvialRAQIAALRAQLQqeaqrilaSLEAELEALQAREASLQAQLAQL 339


                  ....*.
gi 1370467181 131 EGKILS 136
Cdd:COG3206   340 EARLAE 345
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
38-130 2.92e-03

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 37.81  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181  38 EVARKLVIIESDLERAEERaeLSEGQVR------QLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAET 111
Cdd:COG1193   490 EIARRLGLPEEIIERAREL--LGEESIDveklieELERERRELEEEREEAERLREELEKLREELEEKLEELEEEKEEILE 567

                          90       100
                  ....*....|....*....|
gi 1370467181 112 RAEF-AERSVTKLEKSIDDL 130
Cdd:COG1193   568 KAREeAEEILREARKEAEEL 587
PTZ00121 PTZ00121
MAEBL; Provisional
 5-120 3.51e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 37.43  E-value: 3.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    5 ESRAQKDEEKMEIQEIQLK-EAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKA--L 81
Cdd:PTZ00121  1460 EEAKKKAEEAKKADEAKKKaEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKAdeA 1539

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1370467181   82 MAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSV 120
Cdd:PTZ00121  1540 KKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNM 1578
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-136 4.12e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.22  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370467181  84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILS 136
Cdd:COG1196   324 ELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
5-117 4.19e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.20  E-value: 4.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    5 ESRAQKDEEKMEIQEI----QLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQL------RIM 74
Cdd:COG4913    262 ERYAAARERLAELEYLraalRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIrgnggdRLE 341

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1370467181   75 D--QTLKALMAAEDKYSQKEDRYEEEIKVLsdKLKEAETRAEFAE 117
Cdd:COG4913    342 QleREIERLERELEERERRRARLEALLAAL--GLPLPASAEEFAA 384
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
7-134 4.63e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 37.05  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   7 RAQKDEEKMEiQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAElsegQVRQLEEQLRIMDQTLKALMAAED 86
Cdd:COG4717   106 ELEAELEELR-EELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLE----ELRELEEELEELEAELAELQEELE 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370467181  87 KYSQKED-RYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKI 134
Cdd:COG4717   181 ELLEQLSlATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEEL 229
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 4-134 5.34e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 36.67  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:COG4942    32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLR 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370467181  84 AEDKYSQKEdryEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKI 134
Cdd:COG4942   112 ALYRLGRQP---PLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL 159
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 4-131 5.58e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 36.97  E-value: 5.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    4 IESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMA 83
Cdd:TIGR02169  817 IEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA 896

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1370467181   84 AEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLE 131
Cdd:TIGR02169  897 QLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE 944
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
49-137 6.70e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 36.43  E-value: 6.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   49 DLERAEERAELSEGQVRQLE---------EQLRIMDQTLKALMAAEDKY--SQKEDRYEEEIKVLSDKLKEAETRAEFAE 117
Cdd:COG4913    236 DLERAHEALEDAREQIELLEpirelaeryAAARERLAELEYLRAALRLWfaQRRLELLEAELEELRAELARLEAELERLE 315

                           90       100
                   ....*....|....*....|
gi 1370467181  118 RSVTKLEKSIDDLEGKILSS 137
Cdd:COG4913    316 ARLDALREELDELEAQIRGN 335
PTZ00121 PTZ00121
MAEBL; Provisional
 7-126 7.06e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 7.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    7 RAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKlviiESDLERAEERAELSEgQVRQLEEQLRIMDQTLKalmAAED 86
Cdd:PTZ00121  1358 EAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKA----DEAKKKAEEDKKKAD-ELKKAAAAKKKADEAKK---KAEE 1429

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370467181   87 KYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKS 126
Cdd:PTZ00121  1430 KKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEA 1469
PTZ00121 PTZ00121
MAEBL; Provisional
 8-125 7.67e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 7.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181    8 AQKDEEKMEIQEIQLKEAKHIAEDAdRKYEEVARKlviieSDLERAEERAELSEgqVRQLEEQLRIMDQTLKALMAAEDK 87
Cdd:PTZ00121  1515 AKKAEEAKKADEAKKAEEAKKADEA-KKAEEKKKA-----DELKKAEELKKAEE--KKKAEEAKKAEEDKNMALRKAEEA 1586

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1370467181   88 YSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEK 125
Cdd:PTZ00121  1587 KKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE 1624
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 5-131 7.72e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 36.45  E-value: 7.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   5 ESRAQKDEEKMEIQEIQLKEAKHIAEDAD---------RKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMD 75
Cdd:COG1196   271 ELRLELEELELELEEAQAEEYELLAELARleqdiarleERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370467181  76 QTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLE 131
Cdd:COG1196   351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
21-114 9.87e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 36.05  E-value: 9.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370467181   21 QLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRI-----MDQTLKALmAAEDKYSQKEDRY 95
Cdd:COG4913    693 QLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLelralLEERFAAA-LGDAVERELRENL 771

                           90
                   ....*....|....*....
gi 1370467181   96 EEEIKVLSDKLKEAETRAE 114
Cdd:COG4913    772 EERIDALRARLNRAEEELE 790
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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