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Conserved domains on  [gi|1370468505|ref|XP_024306059|]
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zinc finger homeobox protein 3 isoform X4 [Homo sapiens]

Protein Classification

COG5576 and homeodomain domain-containing protein( domain architecture ID 13909615)

protein containing domains COG5576, homeodomain, and Herpes_BLLF1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
1758-1814 2.73e-20

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.40  E-value: 2.73e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 1758 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERK 1814
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
1359-1415 5.34e-20

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 85.63  E-value: 5.34e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 1359 RSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARK 1415
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2063-2119 4.96e-18

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 4.96e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 2063 KRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKK 2119
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1261-1317 2.10e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 69.59  E-value: 2.10e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505  1261 NKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKER 1317
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
1710-1854 1.33e-10

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1710 PQIPASSATSPSTPTS-TMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTitPEQLEILYQKYLLDSNPTRKMLD 1788
Cdd:COG5576      5 PMQPLSALESQRMPQIrTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRTT--DEQLMVLEREFEINPYPSSITRI 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 1789 HIAHEVGLKKRVVQVWFQNTRARERK---GQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEA 1854
Cdd:COG5576     83 KLSLLLNMPPKSVQIWFQNKRAKEKKkrsGKVEQRPGEEEADLAKIGSLSTGQISIIETLEFSRTSYEE 151
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 2220-2307 3.24e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 2220 TPLQALNLPTAyPALQGIPPVLLPGLN--SPSLpGFTPSNTALTSPKPNLMG-LPSTTVPSPG--LPTSGlPNKPSSAsL 2294
Cdd:pfam05109  508 SPTSAVTTPTP-NATSPTPAVTTPTPNatSPTL-GKTSPTSAVTTPTPNATSpTPAVTTPTPNatIPTLG-KTSPTSA-V 583

                           90
                   ....*....|...
gi 1370468505 2295 SSPTPAQATMAMG 2307
Cdd:pfam05109  584 TTPTPNATSPTVG 596
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
1758-1814 2.73e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.40  E-value: 2.73e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 1758 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERK 1814
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
1359-1415 5.34e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 85.63  E-value: 5.34e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 1359 RSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARK 1415
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2063-2119 4.96e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 4.96e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 2063 KRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKK 2119
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1358-1414 6.73e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 79.60  E-value: 6.73e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505  1358 KRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKAR 1414
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1359-1416 5.21e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 77.28  E-value: 5.21e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370468505 1359 RSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKN 1416
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1758-1816 8.74e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 76.51  E-value: 8.74e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 1758 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQ 1816
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1758-1813 1.37e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 75.75  E-value: 1.37e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370468505  1758 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARER 1813
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1261-1317 2.10e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 69.59  E-value: 2.10e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505  1261 NKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKER 1317
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2062-2118 4.54e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 68.82  E-value: 4.54e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505  2062 QKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEK 2118
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2063-2121 5.31e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 68.42  E-value: 5.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 2063 KRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSK 2121
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1262-1320 7.40e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 68.04  E-value: 7.40e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 1262 KRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRN 1320
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
1262-1321 2.16e-13

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 66.75  E-value: 2.16e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1262 KRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTlfkeRQRNK 1321
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR----RAKWK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1348-1430 6.25e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 69.00  E-value: 6.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1348 EPPKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKnyENQGEGKDGE 1427
Cdd:COG5576     41 LERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK--KRSGKVEQRP 118


                   ...
gi 1370468505 1428 RRE 1430
Cdd:COG5576    119 GEE 121
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1710-1854 1.33e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1710 PQIPASSATSPSTPTS-TMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTitPEQLEILYQKYLLDSNPTRKMLD 1788
Cdd:COG5576      5 PMQPLSALESQRMPQIrTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRTT--DEQLMVLEREFEINPYPSSITRI 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 1789 HIAHEVGLKKRVVQVWFQNTRARERK---GQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEA 1854
Cdd:COG5576     83 KLSLLLNMPPKSVQIWFQNKRAKEKKkrsGKVEQRPGEEEADLAKIGSLSTGQISIIETLEFSRTSYEE 151
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2051-2130 3.65e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 3.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 2051 GKSGDSGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKK-SKLSMAKHFG 2129
Cdd:COG5576     40 KLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkRSGKVEQRPG 119


                   .
gi 1370468505 2130 I 2130
Cdd:COG5576    120 E 120
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1262-1372 8.42e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.06  E-value: 8.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1262 KRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNtlfkERQRNKDSpYNFSN---PPITSLEEL 1338
Cdd:COG5576     52 KSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQN----KRAKEKKK-RSGKVeqrPGEEEADLA 126

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1370468505 1339 KIdsrpPSPEPPKQEYWGSKRSSRTRFTDYQLRV 1372
Cdd:COG5576    127 KI----GSLSTGQISIIETLEFSRTSYEEGGLQY 156
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 2220-2307 3.24e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 2220 TPLQALNLPTAyPALQGIPPVLLPGLN--SPSLpGFTPSNTALTSPKPNLMG-LPSTTVPSPG--LPTSGlPNKPSSAsL 2294
Cdd:pfam05109  508 SPTSAVTTPTP-NATSPTPAVTTPTPNatSPTL-GKTSPTSAVTTPTPNATSpTPAVTTPTPNatIPTLG-KTSPTSA-V 583

                           90
                   ....*....|...
gi 1370468505 2295 SSPTPAQATMAMG 2307
Cdd:pfam05109  584 TTPTPNATSPTVG 596
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
1758-1814 2.73e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.40  E-value: 2.73e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 1758 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERK 1814
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
1359-1415 5.34e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 85.63  E-value: 5.34e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 1359 RSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARK 1415
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2063-2119 4.96e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 4.96e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505 2063 KRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKK 2119
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1358-1414 6.73e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 79.60  E-value: 6.73e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505  1358 KRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKAR 1414
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1359-1416 5.21e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 77.28  E-value: 5.21e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370468505 1359 RSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKN 1416
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1758-1816 8.74e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 76.51  E-value: 8.74e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 1758 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQ 1816
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1758-1813 1.37e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 75.75  E-value: 1.37e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370468505  1758 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARER 1813
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1261-1317 2.10e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 69.59  E-value: 2.10e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505  1261 NKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKER 1317
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2062-2118 4.54e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 68.82  E-value: 4.54e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468505  2062 QKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEK 2118
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2063-2121 5.31e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 68.42  E-value: 5.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 2063 KRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSK 2121
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1262-1320 7.40e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 68.04  E-value: 7.40e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 1262 KRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRN 1320
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
1262-1321 2.16e-13

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 66.75  E-value: 2.16e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1262 KRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTlfkeRQRNK 1321
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR----RAKWK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1348-1430 6.25e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 69.00  E-value: 6.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1348 EPPKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKnyENQGEGKDGE 1427
Cdd:COG5576     41 LERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK--KRSGKVEQRP 118


                   ...
gi 1370468505 1428 RRE 1430
Cdd:COG5576    119 GEE 121
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1710-1854 1.33e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1710 PQIPASSATSPSTPTS-TMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTitPEQLEILYQKYLLDSNPTRKMLD 1788
Cdd:COG5576      5 PMQPLSALESQRMPQIrTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRTT--DEQLMVLEREFEINPYPSSITRI 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370468505 1789 HIAHEVGLKKRVVQVWFQNTRARERK---GQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEA 1854
Cdd:COG5576     83 KLSLLLNMPPKSVQIWFQNKRAKEKKkrsGKVEQRPGEEEADLAKIGSLSTGQISIIETLEFSRTSYEE 151
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2051-2130 3.65e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 3.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 2051 GKSGDSGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKK-SKLSMAKHFG 2129
Cdd:COG5576     40 KLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkRSGKVEQRPG 119


                   .
gi 1370468505 2130 I 2130
Cdd:COG5576    120 E 120
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1262-1372 8.42e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.06  E-value: 8.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 1262 KRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNtlfkERQRNKDSpYNFSN---PPITSLEEL 1338
Cdd:COG5576     52 KSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQN----KRAKEKKK-RSGKVeqrPGEEEADLA 126

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1370468505 1339 KIdsrpPSPEPPKQEYWGSKRSSRTRFTDYQLRV 1372
Cdd:COG5576    127 KI----GSLSTGQISIIETLEFSRTSYEEGGLQY 156
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 2220-2307 3.24e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468505 2220 TPLQALNLPTAyPALQGIPPVLLPGLN--SPSLpGFTPSNTALTSPKPNLMG-LPSTTVPSPG--LPTSGlPNKPSSAsL 2294
Cdd:pfam05109  508 SPTSAVTTPTP-NATSPTPAVTTPTPNatSPTL-GKTSPTSAVTTPTPNATSpTPAVTTPTPNatIPTLG-KTSPTSA-V 583

                           90
                   ....*....|...
gi 1370468505 2295 SSPTPAQATMAMG 2307
Cdd:pfam05109  584 TTPTPNATSPTVG 596
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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