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Conserved domains on  [gi|1370484349|ref|XP_024309339|]
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inositol hexakisphosphate kinase 2 isoform X5 [Homo sapiens]

Protein Classification

inositol polyphosphate kinase family protein( domain architecture ID 10510177)

inositol polyphosphate kinase family protein similar to inositol hexakisphosphate kinase, which converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) and 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

CATH:  1.10.510.50
EC:  2.7.-.-
Gene Ontology:  GO:0032958|GO:0016301|GO:0005524
SCOP:  4002804

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
203-418 7.65e-84

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


:

Pssm-ID: 397715  Cd Length: 190  Bit Score: 254.79  E-value: 7.65e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 203 FILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSV 282
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTYGDDASEEKRRRQQKKCRETTSASLGFRICGMKVWNVDTDGYIFRDKYYGRSLSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 283 QGFKEALFQFFHNGRYLRR--ELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpevvlDSDAEDLEDLSEesa 360
Cdd:pfam03770  81 EEFKEALKRFFSNGKSLRRkkKIIPRFLERLQELRNVLESQESYRFYSSSLLFVYDG--------DPESAEEDPPPK--- 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370484349 361 desagayaykpigassVDVRMIDFAHTTCRLYGeDTVVHEGQDAGYIFGLQSLIDIVT 418
Cdd:pfam03770 150 ----------------VKVKLIDFAHTVPLPDG-PPWPGGGPDEGYLFGLRSLIKILE 190
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
203-418 7.65e-84

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 254.79  E-value: 7.65e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 203 FILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSV 282
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTYGDDASEEKRRRQQKKCRETTSASLGFRICGMKVWNVDTDGYIFRDKYYGRSLSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 283 QGFKEALFQFFHNGRYLRR--ELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpevvlDSDAEDLEDLSEesa 360
Cdd:pfam03770  81 EEFKEALKRFFSNGKSLRRkkKIIPRFLERLQELRNVLESQESYRFYSSSLLFVYDG--------DPESAEEDPPPK--- 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370484349 361 desagayaykpigassVDVRMIDFAHTTCRLYGeDTVVHEGQDAGYIFGLQSLIDIVT 418
Cdd:pfam03770 150 ----------------VKVKLIDFAHTVPLPDG-PPWPGGGPDEGYLFGLRSLIKILE 190
PLN02667 PLN02667
inositol polyphosphate multikinase
202-426 3.07e-34

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 129.07  E-value: 3.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 202 KFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLS 281
Cdd:PLN02667   79 GLLVLEDLLAGYTKPCVMDVKMGSRTWYPEASEEYIQKCLKKDRETTTVSLGFRVSGFKVYDHKESEFWKAERKLVKGLD 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 282 VQGFKEALFQFFHNG--------RYLRRELLG---PVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpEVVLDSDAE 350
Cdd:PLN02667  159 ADGVRLALRKFVSSNspadpnpdCAFASAVYGgshGILAQLLELKSWFEEQTLYHFFSASILIVYEG----EAILKGNPE 234
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370484349 351 DledlseesadesagayaykpigaSSVDVRMIDFAHTTcrlYGEDTVvhegqDAGYIFGLQSLIDIVTEISEESGE 426
Cdd:PLN02667  235 D-----------------------SRVEVKLVDFAHVL---DGNGVI-----DHNFLGGLCSLIKFISEILTSPDE 279
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
203-418 7.65e-84

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 254.79  E-value: 7.65e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 203 FILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSV 282
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTYGDDASEEKRRRQQKKCRETTSASLGFRICGMKVWNVDTDGYIFRDKYYGRSLSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 283 QGFKEALFQFFHNGRYLRR--ELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpevvlDSDAEDLEDLSEesa 360
Cdd:pfam03770  81 EEFKEALKRFFSNGKSLRRkkKIIPRFLERLQELRNVLESQESYRFYSSSLLFVYDG--------DPESAEEDPPPK--- 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370484349 361 desagayaykpigassVDVRMIDFAHTTCRLYGeDTVVHEGQDAGYIFGLQSLIDIVT 418
Cdd:pfam03770 150 ----------------VKVKLIDFAHTVPLPDG-PPWPGGGPDEGYLFGLRSLIKILE 190
PLN02667 PLN02667
inositol polyphosphate multikinase
202-426 3.07e-34

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 129.07  E-value: 3.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 202 KFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLS 281
Cdd:PLN02667   79 GLLVLEDLLAGYTKPCVMDVKMGSRTWYPEASEEYIQKCLKKDRETTTVSLGFRVSGFKVYDHKESEFWKAERKLVKGLD 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484349 282 VQGFKEALFQFFHNG--------RYLRRELLG---PVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpEVVLDSDAE 350
Cdd:PLN02667  159 ADGVRLALRKFVSSNspadpnpdCAFASAVYGgshGILAQLLELKSWFEEQTLYHFFSASILIVYEG----EAILKGNPE 234
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370484349 351 DledlseesadesagayaykpigaSSVDVRMIDFAHTTcrlYGEDTVvhegqDAGYIFGLQSLIDIVTEISEESGE 426
Cdd:PLN02667  235 D-----------------------SRVEVKLVDFAHVL---DGNGVI-----DHNFLGGLCSLIKFISEILTSPDE 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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