NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1390098208|ref|XP_025004424|]
View 

lysocardiolipin acyltransferase 1 isoform X1 [Gallus gallus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0016020
PubMed:  18287005|18931347|18718904

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 76-269 3.08e-90

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 270.26  E-value: 3.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  76 VALLEMVFGAKVVVTGDGFI-PGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFI 154
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 155 QRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNnl 234
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-- 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1390098208 235 DAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQ 269
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 254-328 5.16e-21

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 86.09  E-value: 5.16e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390098208 254 HLLNGnFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGkCFDETGQSIIPPCKSELRVLAV 328
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETG-TFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 76-269 3.08e-90

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 270.26  E-value: 3.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  76 VALLEMVFGAKVVVTGDGFI-PGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFI 154
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 155 QRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNnl 234
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-- 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1390098208 235 DAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQ 269
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 26-339 1.13e-63

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 208.40  E-value: 1.13e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  26 KGIYFVVALFLGSFFGSIFmLGP---FLPLMFiSPAWYRWITDRIVATWLTLPVALLEMVFGAKVVVTGDGFIPGERSVI 102
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVY-LAPvsaVLLRLF-SVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 103 IMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLL 182
Cdd:PLN02510   97 IANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 183 IFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLRegNNLDAIHDITVAYPQNIPQtekhLLNGNF-- 260
Cdd:PLN02510  177 LFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR--CSLDAVYDVTIGYKHRCPS----FLDNVFgi 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 261 -PKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCIS--LLYWT 337
Cdd:PLN02510  251 dPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFPNEGTEGELSTLKCLANFLAVIALTtvFTYLT 330


                  ..
gi 1390098208 338 VF 339
Cdd:PLN02510  331 LF 332
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 254-328 5.16e-21

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 86.09  E-value: 5.16e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390098208 254 HLLNGnFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGkCFDETGQSIIPPCKSELRVLAV 328
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETG-TFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 101-191 8.21e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.55  E-value: 8.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  101 VIIMNHRTRMDWMFLWNCLLRYsyLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHfeNMLHYFCDIHEPLQ 180
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRK--LGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARA--ALREAVELLKEGEW 77

                           90
                   ....*....|.
gi 1390098208  181 LLIFPEGTDLT 191
Cdd:smart00563  78 LLIFPEGTRSR 88
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 86-244 9.88e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.08  E-value: 9.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  86 KVVVTGDGFIP-GERSVIIMNHRTRMDWMFLWNCLlrYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSH 164
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 165 FENMLHYFcdIHEPLQLLIFPEGTdltantkarsndfaeknglRKYEYVLHPRTTGFTFVVECLRegnnldaIHDITVAY 244
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT-------------------RSREGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 52-188 6.55e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 70.42  E-value: 6.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  52 LMFISPAWYRWITDRIVATWLTLpvallemvFGAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWNCL-LRYSYLrlek 129
Cdd:COG0204     4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALpRPVRFV---- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 130 icLKSSLKSIPGFGWAMQVAAFIFIQRKwedDKSHFENMLHYFCD-IHEPLQLLIFPEGT 188
Cdd:COG0204    72 --AKKELFKIPLLGWLLRALGAIPVDRS---KRRAALRALRQAVEaLKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 84-188 1.46e-06

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 46.96  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  84 GAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLwncllRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRkwEDDK 162
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLDPLTL-----SAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1390098208 163 SHfENMLhyfcdiHEPLQLL-------IFPEGT 188
Cdd:TIGR00530  74 AI-ATAL------KAAIEVLkqgrsigVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 76-269 3.08e-90

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 270.26  E-value: 3.08e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  76 VALLEMVFGAKVVVTGDGFI-PGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFI 154
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 155 QRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNnl 234
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-- 158

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1390098208 235 DAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQ 269
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 26-339 1.13e-63

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 208.40  E-value: 1.13e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  26 KGIYFVVALFLGSFFGSIFmLGP---FLPLMFiSPAWYRWITDRIVATWLTLPVALLEMVFGAKVVVTGDGFIPGERSVI 102
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVY-LAPvsaVLLRLF-SVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 103 IMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLL 182
Cdd:PLN02510   97 IANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 183 IFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLRegNNLDAIHDITVAYPQNIPQtekhLLNGNF-- 260
Cdd:PLN02510  177 LFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR--CSLDAVYDVTIGYKHRCPS----FLDNVFgi 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 261 -PKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCIS--LLYWT 337
Cdd:PLN02510  251 dPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFPNEGTEGELSTLKCLANFLAVIALTtvFTYLT 330


                  ..
gi 1390098208 338 VF 339
Cdd:PLN02510  331 LF 332
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 35-334 1.34e-35

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 134.10  E-value: 1.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  35 FLGSFFGSIFMLGPFLPLMFISPAWYRWItDRIVAT--WLTLpVALLEMVFGAKVVVTGDG----FIPGERSVIIMNHRT 108
Cdd:PLN02380   17 LLSGLIVNLIQAVCFILVRPLSKSLYRRI-NRAVAEllWLEL-IWLVDWWAGVKVQLYADEetfeLMGKEHALVISNHRS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 109 RMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGT 188
Cdd:PLN02380   95 DIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGT 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 189 DLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREgnNLDAIHDITVAYPQNIPQ-TEKHLLNGNfPKEIHFH 267
Cdd:PLN02380  175 RFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRS--FVPAIYDVTVAVPKGQPApTMLRIFRGQ-SSVVHVH 251

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390098208 268 VQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCISLL 334
Cdd:PLN02380  252 IKRHSMKELPETDDGIAQWCKDVFVAKDALLDKHFAEDTFGDQEYQDIGRPKKSLIVVISWACLLIL 318
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 254-328 5.16e-21

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 86.09  E-value: 5.16e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390098208 254 HLLNGnFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGkCFDETGQSIIPPCKSELRVLAV 328
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETG-TFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 101-191 8.21e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.55  E-value: 8.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  101 VIIMNHRTRMDWMFLWNCLLRYsyLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHfeNMLHYFCDIHEPLQ 180
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRK--LGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARA--ALREAVELLKEGEW 77

                           90
                   ....*....|.
gi 1390098208  181 LLIFPEGTDLT 191
Cdd:smart00563  78 LLIFPEGTRSR 88
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 86-244 9.88e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.08  E-value: 9.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  86 KVVVTGDGFIP-GERSVIIMNHRTRMDWMFLWNCLlrYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSH 164
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 165 FENMLHYFcdIHEPLQLLIFPEGTdltantkarsndfaeknglRKYEYVLHPRTTGFTFVVECLRegnnldaIHDITVAY 244
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT-------------------RSREGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 86-269 2.05e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 73.99  E-value: 2.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  86 KVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWnCLLRYSYLRLEKICLK-SSLKSIPGFGWamqvAAFIFIQRKW-EDDK 162
Cdd:cd06551    13 RLEVKGPPPPPGGGPVLFVsNHSSWWDGLILF-LLLERGLRRDVYGLMDeELLERYPFFTR----LGAFSVDRDSpRSAA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 163 SHFENMLHYFCDIHEplQLLIFPEGTDLTantkarsndfAEKNGLRKYEYVLHP-RTTGFTFVVECLREGNNL-DAIHDI 240
Cdd:cd06551    88 KSLKYVARLLSKPGS--VVWIFPEGTRTR----------RDKRPLQFKPGVAHLaEKAGVPIVPVALRYTFELfEQFPEI 155

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1390098208 241 TVAYPQNIPQTEKH---LLNGNFPKEIHFHVQ 269
Cdd:cd06551   156 FVRIGPPIPYAETAlgeELAAELANRLTRLLD 187
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 52-188 6.55e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 70.42  E-value: 6.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  52 LMFISPAWYRWITDRIVATWLTLpvallemvFGAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWNCL-LRYSYLrlek 129
Cdd:COG0204     4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALpRPVRFV---- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 130 icLKSSLKSIPGFGWAMQVAAFIFIQRKwedDKSHFENMLHYFCD-IHEPLQLLIFPEGT 188
Cdd:COG0204    72 --AKKELFKIPLLGWLLRALGAIPVDRS---KRRAALRALRQAVEaLKAGESLVIFPEGT 126
PRK14014 PRK14014
putative acyltransferase; Provisional
 28-298 2.26e-11

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 64.10  E-value: 2.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  28 IYFVVALFLGSFfgsIFMLGPFLPLMFISPAWYR--WITDRIVATWLTLPVALLEMVFGAKVVVTGD-GFIPGERSVIIM 104
Cdd:PRK14014   17 LLILNTLFWSVP---IIILGLLKLLLPIPAIRRAcsRLLNFIAEAWISINNVILRLLPRTQWDVEGLeGLSKKGWYLVIS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 105 NHRTRMDWMFLwnCLLRYSYLRLEKICLKSSLKSIP--GFG-WAMQvaaFIFIQR------------KWEDDKS------ 163
Cdd:PRK14014   94 NHQSWVDILVL--QYVFNRRIPMLKFFLKQELIWVPflGLAwWALD---FPFMKRyskaylaknpelKGKDLETtrrace 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 164 HFENMlhyfcdihePLQLLIFPEGTDLTANTKARSNDfaeknglrKYEYVLHPRTTGFTFVVECLreGNNLDAIHDITVA 243
Cdd:PRK14014  169 KFKRM---------PTTIVNFVEGTRFTPEKHQQQQS--------PYQHLLKPKAGGIAFALNAM--GEQFDGLLDVTIV 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1390098208 244 YPQNIPqTEKHLLNGNfPKEIHFHVQRYPIETV--------PTSKEELQLWCQKRWEEKEERL 298
Cdd:PRK14014  230 YPDGRP-SFWDLLSGR-VKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLI 290
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 82-188 6.71e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 60.75  E-value: 6.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  82 VFGAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWNCLLRY-SYLrlekicLKSSLKSIPGFGWAMQVAAFIFIQR-KW 158
Cdd:cd07989     7 LLGVRVRVEGLENLPPKGPVIIVaNHQSYLDPLVLGAALPRPiRFV------AKKELFKIPFLGWLLRLLGAIPIDRgNG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1390098208 159 EDDKSHFENMLHYfcdIHEPLQLLIFPEGT 188
Cdd:cd07989    81 RSAREALREAIEA---LKEGESVVIFPEGT 107
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 84-188 1.46e-06

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 46.96  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208  84 GAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLwncllRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRkwEDDK 162
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLDPLTL-----SAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1390098208 163 SHfENMLhyfcdiHEPLQLL-------IFPEGT 188
Cdd:TIGR00530  74 AI-ATAL------KAAIEVLkqgrsigVFPEGT 99
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 101-188 1.37e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 42.59  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390098208 101 VIIMNHRTRMDWMFLWNCLLrYSYLRlekiclKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQ 180
Cdd:cd07991    27 IIVANHTSFIDPLILFSDLF-PSIVA------KKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKERATDPNWPP 99


                  ....*...
gi 1390098208 181 LLIFPEGT 188
Cdd:cd07991   100 ILIFPEGT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH