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Conserved domains on  [gi|1622829469|ref|XP_028682913|]
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immunoglobulin superfamily member 8 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 18-127 4.70e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  18 VTGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSyaIFKSRVvagEVQVQRLQGDAVvLKIARLQA 97
Cdd:pfam07686   9 ALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRF---SGRGDPSNGDGS-LTIQNLTL 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622829469  98 QDAGIYECHTPSTDTRYLGSysgKVELRVL 127
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 429-523 2.32e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 43.86  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 429 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPEDGElssvpaQLVGGVGQDGVAELGVRPGGgpVSVELVGPRSHRLR 508
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKPGQGP------EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                          90
                  ....*....|....*
gi 1622829469 509 LHSLGPEDEGVYHCA 523
Cdd:cd00099    77 ISNLQPEDSGTYYCA 91
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 296-397 1.19e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 296 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGvGSLGPGYEGRHIAmEKVASRTYRLRLEAA 374
Cdd:cd00099    12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                          90       100
                  ....*....|....*....|....*....
gi 1622829469 375 RPGDAGTYRCLAKA------YVRGSGTRL 397
Cdd:cd00099    81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
PksD super family cl43841
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 136-578 1.88e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


The actual alignment was detected with superfamily member COG3321:

Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 41.40  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  136 APPGPRGRQAPTSPPrlmvhEGQELALGCLARTSTQQHTHLAVSFGRSVPEAPVGRATLQEVVGIRSDLAVEAGAPYAER 215
Cdd:COG3321    854 PGRGRRRVPLPTYPF-----QREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAA 928

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  216 LAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIG 295
Cdd:COG3321    929 LLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAA 1008

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  296 PGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHiamekVASRTYRLRLEAAR 375
Cdd:COG3321   1009 ALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALL-----LLAALAELALAAAA 1083

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  376 PGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAA 455
Cdd:COG3321   1084 LALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAAL 1163

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  456 SWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSW 535
Cdd:COG3321   1164 AAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAA 1243

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1622829469  536 YQAGSARSGPVTVYPYMHALDTLLVPLLVGTGVALVTGATVLG 578
Cdd:COG3321   1244 AVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALA 1286
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 18-127 4.70e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  18 VTGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSyaIFKSRVvagEVQVQRLQGDAVvLKIARLQA 97
Cdd:pfam07686   9 ALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRF---SGRGDPSNGDGS-LTIQNLTL 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622829469  98 QDAGIYECHTPSTDTRYLGSysgKVELRVL 127
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 429-523 2.32e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.86  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 429 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPEDGElssvpaQLVGGVGQDGVAELGVRPGGgpVSVELVGPRSHRLR 508
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKPGQGP------EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                          90
                  ....*....|....*
gi 1622829469 509 LHSLGPEDEGVYHCA 523
Cdd:cd00099    77 ISNLQPEDSGTYYCA 91
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 296-397 1.19e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 296 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGvGSLGPGYEGRHIAmEKVASRTYRLRLEAA 374
Cdd:cd00099    12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                          90       100
                  ....*....|....*....|....*....
gi 1622829469 375 RPGDAGTYRCLAKA------YVRGSGTRL 397
Cdd:cd00099    81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 13-126 2.77e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469   13 GPLYRVTGTAVSISCNVTGYEGPaqqNFEWFLYRPEAPdtalgivstkdtqfsyaIFKSRVvagevQVQRlQGDAVVLKI 92
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP---EVTWYKQGGKLL-----------------AESGRF-----SVSR-SGSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1622829469   93 ARLQAQDAGIYECHTpstdTRYLGSYSGKVELRV 126
Cdd:smart00410  56 SNVTPEDSGTYTCAA----TNSSGSASSGTTLTV 85
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 136-578 1.88e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 41.40  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  136 APPGPRGRQAPTSPPrlmvhEGQELALGCLARTSTQQHTHLAVSFGRSVPEAPVGRATLQEVVGIRSDLAVEAGAPYAER 215
Cdd:COG3321    854 PGRGRRRVPLPTYPF-----QREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAA 928

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  216 LAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIG 295
Cdd:COG3321    929 LLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAA 1008

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  296 PGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHiamekVASRTYRLRLEAAR 375
Cdd:COG3321   1009 ALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALL-----LLAALAELALAAAA 1083

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  376 PGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAA 455
Cdd:COG3321   1084 LALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAAL 1163

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  456 SWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSW 535
Cdd:COG3321   1164 AAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAA 1243

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1622829469  536 YQAGSARSGPVTVYPYMHALDTLLVPLLVGTGVALVTGATVLG 578
Cdd:COG3321   1244 AVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALA 1286
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 287-398 8.12e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 36.28  E-value: 8.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 287 VGPGERRIGPGEPLELLCnvsgALPPAGRHAAYSVGWEMAPAGApGPGRLVA-QLDTEGVGSLGPGYEGRHIAMEKVASr 365
Cdd:pfam07686   1 QTPREVTVALGGSVTLPC----TYSSSMSEASTSVYWYRQPPGK-GPTFLIAyYSNGSEEGVKKGRFSGRGDPSNGDGS- 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1622829469 366 tyrLRLEAARPGDAGTYRCLA---KAYVRGSGTRLR 398
Cdd:pfam07686  75 ---LTIQNLTLSDSGTYTCAVipsGEGVFGKGTRLT 107
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 18-127 4.70e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 4.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  18 VTGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSyaIFKSRVvagEVQVQRLQGDAVvLKIARLQA 97
Cdd:pfam07686   9 ALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRF---SGRGDPSNGDGS-LTIQNLTL 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622829469  98 QDAGIYECHTPSTDTRYLGSysgKVELRVL 127
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 429-523 2.32e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.86  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 429 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPEDGElssvpaQLVGGVGQDGVAELGVRPGGgpVSVELVGPRSHRLR 508
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKPGQGP------EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                          90
                  ....*....|....*
gi 1622829469 509 LHSLGPEDEGVYHCA 523
Cdd:cd00099    77 ISNLQPEDSGTYYCA 91
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 296-397 1.19e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 296 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGvGSLGPGYEGRHIAmEKVASRTYRLRLEAA 374
Cdd:cd00099    12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                          90       100
                  ....*....|....*....|....*....
gi 1622829469 375 RPGDAGTYRCLAKA------YVRGSGTRL 397
Cdd:cd00099    81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 13-126 2.77e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469   13 GPLYRVTGTAVSISCNVTGYEGPaqqNFEWFLYRPEAPdtalgivstkdtqfsyaIFKSRVvagevQVQRlQGDAVVLKI 92
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP---EVTWYKQGGKLL-----------------AESGRF-----SVSR-SGSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1622829469   93 ARLQAQDAGIYECHTpstdTRYLGSYSGKVELRV 126
Cdd:smart00410  56 SNVTPEDSGTYTCAA----TNSSGSASSGTTLTV 85
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 136-578 1.88e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 41.40  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  136 APPGPRGRQAPTSPPrlmvhEGQELALGCLARTSTQQHTHLAVSFGRSVPEAPVGRATLQEVVGIRSDLAVEAGAPYAER 215
Cdd:COG3321    854 PGRGRRRVPLPTYPF-----QREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAA 928

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  216 LAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIG 295
Cdd:COG3321    929 LLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAA 1008

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  296 PGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHiamekVASRTYRLRLEAAR 375
Cdd:COG3321   1009 ALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALL-----LLAALAELALAAAA 1083

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  376 PGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAA 455
Cdd:COG3321   1084 LALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAAL 1163

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469  456 SWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSW 535
Cdd:COG3321   1164 AAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAA 1243

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1622829469  536 YQAGSARSGPVTVYPYMHALDTLLVPLLVGTGVALVTGATVLG 578
Cdd:COG3321   1244 AVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALA 1286
IGv smart00406
Immunoglobulin V-Type;
23-105 5.34e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.21  E-value: 5.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469   23 VSISCNVTGYEGPAQQNFeWFLYRPEAPDTALGIVSTKDTQFSYAIFKSRVvagEVQVQRLQGDaVVLKIARLQAQDAGI 102
Cdd:smart00406   2 VTLSCKFSGSTFSSYYVS-WVRQPPGKGLEWLGYIGSNGSSYYQESYKGRF---TISKDTSKND-VSLTISNLRVEDTGT 76


                   ...
gi 1622829469  103 YEC 105
Cdd:smart00406  77 YYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 287-398 8.12e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 36.28  E-value: 8.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622829469 287 VGPGERRIGPGEPLELLCnvsgALPPAGRHAAYSVGWEMAPAGApGPGRLVA-QLDTEGVGSLGPGYEGRHIAMEKVASr 365
Cdd:pfam07686   1 QTPREVTVALGGSVTLPC----TYSSSMSEASTSVYWYRQPPGK-GPTFLIAyYSNGSEEGVKKGRFSGRGDPSNGDGS- 74

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1622829469 366 tyrLRLEAARPGDAGTYRCLA---KAYVRGSGTRLR 398
Cdd:pfam07686  75 ---LTIQNLTLSDSGTYTCAVipsGEGVFGKGTRLT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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