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Conserved domains on  [gi|1622842524|ref|XP_028684713|]
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solute carrier organic anion transporter family member 1A2 isoform X3 [Macaca mulatta]

Protein Classification

oat family protein( domain architecture ID 11489679)

oat family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
2-564 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


:

Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 857.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILR 80
Cdd:TIGR00805  76 SYEI-GNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLR 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  81 PTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVY 160
Cdd:TIGR00805 155 PTQDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIY 234
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 161 VDTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNADIIKNENEDKQREEDKKEKYGI 240
Cdd:TIGR00805 235 VDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGI 314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 241 TKDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFK 320
Cdd:TIGR00805 315 TKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFK 394
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 321 ITVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTsyEGIPQDLYMGNNVfaNCNVDCNCPSKIWDPVCGNNGLSY 400
Cdd:TIGR00805 395 LNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAY 470
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 401 LSACLAGCETSIGMGINMVFQNCSCIQTSGNSSAVLGLCDkgPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKS 480
Cdd:TIGR00805 471 LSPCHAGCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKS 548
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 481 EEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILI 560
Cdd:TIGR00805 549 EERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILI 628

                  ....
gi 1622842524 561 LLRK 564
Cdd:TIGR00805 629 LARK 632
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
2-564 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 857.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILR 80
Cdd:TIGR00805  76 SYEI-GNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLR 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  81 PTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVY 160
Cdd:TIGR00805 155 PTQDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIY 234
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 161 VDTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNADIIKNENEDKQREEDKKEKYGI 240
Cdd:TIGR00805 235 VDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGI 314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 241 TKDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFK 320
Cdd:TIGR00805 315 TKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFK 394
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 321 ITVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTsyEGIPQDLYMGNNVfaNCNVDCNCPSKIWDPVCGNNGLSY 400
Cdd:TIGR00805 395 LNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAY 470
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 401 LSACLAGCETSIGMGINMVFQNCSCIQTSGNSSAVLGLCDkgPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKS 480
Cdd:TIGR00805 471 LSPCHAGCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKS 548
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 481 EEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILI 560
Cdd:TIGR00805 549 EERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILI 628

                  ....
gi 1622842524 561 LLRK 564
Cdd:TIGR00805 629 LARK 632
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
2-477 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 847.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRP 81
Cdd:cd17458    47 SFEI-GNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNV 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 TQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYV 161
Cdd:cd17458   126 TQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYV 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 162 DTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNAD---IIKNENEDKQREEDKKEKY 238
Cdd:cd17458   206 DLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMY 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 239 GITKDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKK 318
Cdd:cd17458   286 EIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKK 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 319 FKITVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQDLYMGNNVFANCNVDCNCPSKIWDPVCGNNGL 398
Cdd:cd17458   366 FKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGL 445
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 399 SYLSACLAGCETSIGMGINMVFQNCSCIQTSGNSSAV---LGLCDKGPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLL 475
Cdd:cd17458   446 TYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLI 525

                  ..
gi 1622842524 476 RC 477
Cdd:cd17458   526 RS 527
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
7-536 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 560.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   7 GNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdps 86
Cdd:pfam03137  48 GNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGSLLFALPHFL-------------------------------------- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  87 ectkevkslmwvYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSV 166
Cdd:pfam03137  90 ------------SFFLGQLLLGIGGTPLYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 167 NtddLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNADIIKNENEDKQREEDKKEKYGIT--KDF 244
Cdd:pfam03137 158 S---LTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGTAKRRAEKKKEPESHSIKDSEKTKSLKLGKslKDF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 245 LPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVK 324
Cdd:pfam03137 235 PRALKRLLKNPVYMLLTLASVSEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 325 QAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQdlyMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSA- 403
Cdd:pfam03137 315 GLAKFNLITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQ---LSGNLTASCNSNCSCSTSFYSPVCGSDGIGYTSPc 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 404 -CLAGCETSIGMGINMVFQNCSCI----QTSGNSSAVLGLCDkgPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLRCM 478
Cdd:pfam03137 392 pCGAGCSSSSGAGKSTYNCSCCCScgssTSGGNGSATPGKCP--SDCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCV 469
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622842524 479 KSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTlKCGESGACRIYDSTTF 536
Cdd:pfam03137 470 PPEDKSFALGLQFLILRLLGFIPGPIIFGALIDSTCLLWTK-TCGGRGNCWLYDNDKL 526
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
2-564 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 857.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS-NSFLCMENGTQILR 80
Cdd:TIGR00805  76 SYEI-GNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLR 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  81 PTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVY 160
Cdd:TIGR00805 155 PTQDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIY 234
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 161 VDTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNADIIKNENEDKQREEDKKEKYGI 240
Cdd:TIGR00805 235 VDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGI 314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 241 TKDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFK 320
Cdd:TIGR00805 315 TKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFK 394
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 321 ITVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTsyEGIPQDLYMGNNVfaNCNVDCNCPSKIWDPVCGNNGLSY 400
Cdd:TIGR00805 395 LNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAY 470
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 401 LSACLAGCETSIGMGINMVFQNCSCIQTSGNSSAVLGLCDkgPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKS 480
Cdd:TIGR00805 471 LSPCHAGCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKS 548
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 481 EEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILI 560
Cdd:TIGR00805 549 EERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILI 628

                  ....
gi 1622842524 561 LLRK 564
Cdd:TIGR00805 629 LARK 632
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
2-477 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 847.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRP 81
Cdd:cd17458    47 SFEI-GNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNV 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 TQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYV 161
Cdd:cd17458   126 TQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYV 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 162 DTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNAD---IIKNENEDKQREEDKKEKY 238
Cdd:cd17458   206 DLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKSLPKEGEENETEpskTLTVELEENKGQETKQEMY 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 239 GITKDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKK 318
Cdd:cd17458   286 EIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKK 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 319 FKITVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQDLYMGNNVFANCNVDCNCPSKIWDPVCGNNGL 398
Cdd:cd17458   366 FKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGL 445
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 399 SYLSACLAGCETSIGMGINMVFQNCSCIQTSGNSSAV---LGLCDKGPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLL 475
Cdd:cd17458   446 TYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLI 525

                  ..
gi 1622842524 476 RC 477
Cdd:cd17458   526 RS 527
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
2-476 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 604.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrp 81
Cdd:cd17400    46 SFEI-GNLLVIIFVSYFGTKLHRPKMIGIGCVIMGLGCFLKALPHFFMNQYEY--------------------------- 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 tqdpsectkevkSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYV 161
Cdd:cd17400    98 ------------SLMWIYVFVGNILRGIGETPILPLGISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 162 DTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPktlpkeglennadiiknenedkqreedkkekygit 241
Cdd:cd17400   166 DIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVLTAIPFFFLP----------------------------------- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 242 kdflpfmkslscnPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKI 321
Cdd:cd17400   211 -------------PIYMLFILVSVIQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKI 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 322 TVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQDLYMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYL 401
Cdd:cd17400   278 TVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYL 357
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622842524 402 SACLAGCETSIGMGINMVFQNCSCIQTSGNSSAVLGLCDKG----PDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLR 476
Cdd:cd17400   358 SACLAGCETSIGTGKNIVFYNCSCIQTSGNSSANLSLCDGGcprdPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
7-536 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 560.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   7 GNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdps 86
Cdd:pfam03137  48 GNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGSLLFALPHFL-------------------------------------- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  87 ectkevkslmwvYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSV 166
Cdd:pfam03137  90 ------------SFFLGQLLLGIGGTPLYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 167 NtddLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNADIIKNENEDKQREEDKKEKYGIT--KDF 244
Cdd:pfam03137 158 S---LTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGTAKRRAEKKKEPESHSIKDSEKTKSLKLGKslKDF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 245 LPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVK 324
Cdd:pfam03137 235 PRALKRLLKNPVYMLLTLASVSEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 325 QAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQdlyMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSA- 403
Cdd:pfam03137 315 GLAKFNLITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQ---LSGNLTASCNSNCSCSTSFYSPVCGSDGIGYTSPc 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 404 -CLAGCETSIGMGINMVFQNCSCI----QTSGNSSAVLGLCDkgPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLRCM 478
Cdd:pfam03137 392 pCGAGCSSSSGAGKSTYNCSCCCScgssTSGGNGSATPGKCP--SDCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCV 469
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622842524 479 KSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTlKCGESGACRIYDSTTF 536
Cdd:pfam03137 470 PPEDKSFALGLQFLILRLLGFIPGPIIFGALIDSTCLLWTK-TCGGRGNCWLYDNDKL 526
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
2-477 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 542.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRP 81
Cdd:cd17459    46 SFEM-GNLLVIAFVSYFGAKLHRPRIIGAGCLLMAIGTFLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHS 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 -----TQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFC 156
Cdd:cd17459   125 iessdSKTGTGCEKEPGSSMWIYVFLGNLLRGIGETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLC 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 157 ANVYVDTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKeglennadiiknenedkqreedkke 236
Cdd:cd17459   205 AKLYVDIGFVNLDSITITPKDARWVGAWWLGYLIAGVITLLSAVPFWFLPKSLPK------------------------- 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 237 kygitkDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIM 316
Cdd:cd17459   260 ------DFLPSLKNLLGNPVYFLYLCTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLM 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 317 KKFKITVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQDLYMGNNVFANCNVDCNCPSKIWDPVCGNN 396
Cdd:cd17459   334 KKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGEN 413
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 397 GLSYLSACLAGCETSIGMGINMVFQNCSCI----QTSGNSSAVLGLCDKGPDCSMMLQYFLILSAMSSFIYSLAAIPGYM 472
Cdd:cd17459   414 GITYVSPCLAGCKASNGSGKNTVFHNCSCIgipsSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYI 493

                  ....*
gi 1622842524 473 VLLRC 477
Cdd:cd17459   494 LLIRC 498
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
2-476 6.11e-156

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 455.46  E-value: 6.11e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrp 81
Cdd:cd17457    46 SFEI-GNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLGSVLTALPHFFMGYYKYG-------------------------- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 tqdpseCTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYV 161
Cdd:cd17457    99 ------CLKESGSYMWVYVLMGNMLRGIGETPIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 162 DTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPktlpkeglennadiiknenedkqreedkkekygit 241
Cdd:cd17457   173 DIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSIISAIPFFFLP----------------------------------- 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 242 kDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKI 321
Cdd:cd17457   218 -GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 322 TVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQDLYMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYL 401
Cdd:cd17457   297 NTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYI 376
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622842524 402 SACLAGCETSIGMGINMVFQNCSCIQTSG----NSSAVLGLCDKGPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLR 476
Cdd:cd17457   377 SACLAGCKSSSGNGKPIVFHNCSCLEVTGsqnrNYSAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
7-476 1.89e-123

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 370.80  E-value: 1.89e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   7 GNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdps 86
Cdd:cd17336    50 GQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLLALPHFL-------------------------------------- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  87 ectkevkslmwvyvLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSV 166
Cdd:cd17336    92 --------------FVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 167 ntdDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPktlpkeglennadiiknenedkqreedkkekygitkdflp 246
Cdd:cd17336   158 ---PLGITPDDPRWIGAWWLGFLILGILLLIVSIPLFFFP---------------------------------------- 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 247 fmkslscnPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQA 326
Cdd:cd17336   195 --------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGL 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 327 AHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPqdlymgNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSACLA 406
Cdd:cd17336   267 AKFVLILSLLSVILYISLFFLGCDNPPIAGVTTPYGSSS------SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHA 340
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622842524 407 GCETSIGMGINMVFQNCSCIQT-SGNSSAVLGLCDKGPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLR 476
Cdd:cd17336   341 GCTSSDAGNGTKTYSNCSCINSgTATSSGCPPDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
7-476 1.65e-99

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 311.35  E-value: 1.65e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   7 GNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYEstvsvsgnlssnsflcmengtqilrptqdps 86
Cdd:cd17461    51 GNAVLIIFVSYFGSRVHRPRLIGIGGLLLALGAFLLTLPHFLSEPYQYS------------------------------- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  87 ectkevkslMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSV 166
Cdd:cd17461   100 ---------MWVLMVVAQLLAGIGTVPIQPFGISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 167 NTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKeglenNADIIKNENEDKQREEDKKEKYGIT---KD 243
Cdd:cd17461   171 NTATVELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPREMLV-----GKKPSPEGDMLRKKEDEKKEEGSLLdfiKR 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 244 FLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITV 323
Cdd:cd17461   246 FPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSL 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 324 KQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGipqdlyMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSA 403
Cdd:cd17461   326 RAIPRFSVVILSISIMLCVPLFFMGCSTQDVAGVYPKTSN------SSDGPHLSCSANCSCPESAFNPVCGENGIEYISP 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622842524 404 CLAGCeTSIGMGIN----MVFQNCSCIQT-SGNSSAVLGLCDKgpDCSMMLQYFLILSAMSSFIYSLAAIPGYMVLLR 476
Cdd:cd17461   400 CHAGC-TNSNMDSStyrqQIYSNCSCIPDlSGEKPAKTGSCPN--SCSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
2-476 2.76e-94

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 297.84  E-value: 2.76e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVEGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrp 81
Cdd:cd17460    45 SFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMALPHFISEPYEY--------------------------- 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 tqdpsectkevkslmwVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYV 161
Cdd:cd17460    98 ----------------GILFLGQLLLGIGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 162 DTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENnadiikNENEDKQREEDKKEKYGIT 241
Cdd:cd17460   162 DIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPREMPKEVVEL------QPREKKLAKTMLKKLKSLS 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 242 KD-----FLPFMKSLSC-------NPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGY 309
Cdd:cd17460   236 DIlqnlsLLQFIKKFPRillrtlrNPIYLLVVLAQVNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGI 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 310 IIGGLIMKKFKITVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPqdlymGNNVFANCNVDCNCPSKIW 389
Cdd:cd17460   316 VVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLFIGCSTQKIAGITHRTSSSP-----GLELSSQCSEACSCPPEAF 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 390 DPVCGNNGLSYLSACLAGCET---SIGMGINMVFQNCSCIQTSGN-SSAVLGLCDKGpdCSMMLQYFLILSAMSSFIYSL 465
Cdd:cd17460   391 NPVCGSDGVEYISPCHAGCKSvnvQALDNSVVNYTDCSCVSEGGPvGAASPGTCGSG--CSHLLVPFMLLVSLGGFLASL 468
                         490
                  ....*....|.
gi 1622842524 466 AAIPGYMVLLR 476
Cdd:cd17460   469 SHTPSFMLILR 479
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
2-476 2.16e-85

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 273.26  E-value: 2.16e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVEGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYestvsvsgnlssnsflcmengtqilrp 81
Cdd:cd17401    45 SFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAAGAFLLTLPHFISEPYQY--------------------------- 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 tqdpsectkevkSLMwvyvLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYV 161
Cdd:cd17401    98 ------------GIM----VVAQLLLGIGGVPIQPFGISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 162 DTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLpkeglennadiiknenedkqreedkkekygit 241
Cdd:cd17401   162 DIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPRFI-------------------------------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 242 KDFLPFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKI 321
Cdd:cd17401   210 KRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVL 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 322 TVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGIN---TSYEGIPQDlymgnnvfANCNVDCNCPSKIWDPVCGNNGL 398
Cdd:cd17401   290 SLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGVYppsSSSSIHPQS--------PACRRDCSCPDSIFNPVCGDNGV 361
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 399 SYLSACLAGCET----SIGMGINMVFQNCSCIqTSGNSSAVLGLCDKGpdCSMMLQYFLILSAMSSFIYSLAAIPGYMVL 474
Cdd:cd17401   362 EYLSPCHAGCSNinmsTSATSKQVIYTNCSCV-TGGSASAKTGSCPSP--CSHLLLPFIFLISLVSLIACLSHTPSFMMI 438

                  ..
gi 1622842524 475 LR 476
Cdd:cd17401   439 LR 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
9-476 4.46e-85

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 271.82  E-value: 4.46e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   9 LLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdpsec 88
Cdd:cd17403    53 VLLLLFVSYFGGRGHKPRWLGIGAFIMGIGSLVFALPHFTV--------------------------------------- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  89 tkevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSVnT 168
Cdd:cd17403    94 -----------FILAQLLHGAGATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQV-D 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 169 DDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTlpkeglennadiiknenedkqreedkkekygitkdflpfm 248
Cdd:cd17403   162 SELGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFPPT---------------------------------------- 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 249 kslscnpiYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQAAH 328
Cdd:cd17403   202 --------FMFLNLAGASEGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILK 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 329 IGCWLSLLEYLLhFLSFLVTCENSSVVGINTSYEGIPqdLYMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSACLAGC 408
Cdd:cd17403   274 FCIVCSIVAFLF-SFILLIYCPNAPFAGVTVPYGNSP--LEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGC 350
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622842524 409 ETSIGMGINMVFQNCSCIQ---TSGNSSAVLGLCDKGPDCSMMLQYFLILSAMSSFIYsLAAIPGYMVLLR 476
Cdd:cd17403   351 TTSHGDDGQKVYSNCSCIQsnsSKTSTAATGKACPCETCCQKLYLFLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
7-476 3.87e-79

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 256.51  E-value: 3.87e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   7 GNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMnqyeyestvsvsgnlssnsflcmengtqilrptqdps 86
Cdd:cd17404    50 GSLLTVVFVSYFGGRGHRPRWIAVGGVLIALGSFLFSLPHFFI------------------------------------- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  87 ectkevkslmwvyvlVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSV 166
Cdd:cd17404    93 ---------------LAQILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLST 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 167 ntdDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKtlpkeglennadiiknenedkqreedkkekygitkdflp 246
Cdd:cd17404   158 ---PPDISPGDPRWIGAWWGGFLLCGIALLLVAFPFFTFPK--------------------------------------- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 247 fmkslscnPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQA 326
Cdd:cd17404   196 --------MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGA 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 327 AHIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQ-DLYMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSACL 405
Cdd:cd17404   268 AKLALICNFLSLLLFLTLFFLGCESIKLAGITIPYTTGPSlSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCL 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 406 AGCeTSIGMGINMV--FQNCSCIQTSGNSS----AVLGLCDKGP---DCSMMLQyFLILSAMSSFIYSLAAIPGYMVLLR 476
Cdd:cd17404   348 AGC-TSVGNTSTGIrnYTNCACLQSRSSISpptvGQGSQLQAGPcsrTCNTLIP-FLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
2-476 1.25e-75

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 247.92  E-value: 1.25e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   2 SFQVeGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEyestvsvsgnlssnsflcmengtqilrp 81
Cdd:cd17402    46 SFEI-GNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYK---------------------------- 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  82 tqdpsectkevKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYV 161
Cdd:cd17402    97 -----------TNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 162 DTGSVNTDDLTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLpkeglennadiiknenedkqreedkKEKYGIT 241
Cdd:cd17402   166 DAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSL-------------------------QQLRVIP 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 242 KdflpFMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKI 321
Cdd:cd17402   221 K----VTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 322 TVKQAAHIGCWLSLLEYLLHFLSFLVTCENSSVVGI-----NTSYEGIPQDLYmgnnvfANCNVDCNCPSKIWDPVCGNN 396
Cdd:cd17402   297 SALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVtvpygNDTAPGSSLDPY------APCNSNCECQTDSFSPVCGAD 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 397 GLSYLSACLAGCETsigmginMVFQNCSCIQT--SGNSSAVLGLCDKgPDCSMMLQYFLILSAMSSFIYSLAAIPGYMVL 474
Cdd:cd17402   371 GITYLSACFAGCSS-------TNLSGCACLSSvpAENATVVPGKCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIIL 442

                  ..
gi 1622842524 475 LR 476
Cdd:cd17402   443 IR 444
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
10-476 1.66e-59

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 204.59  E-value: 1.66e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  10 LLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLmnqyeyestvsvsgnlssnsflcmengtqilrptqdpsect 89
Cdd:cd17463    54 LLSLFVSFYGERGHKPRWLAFSAFMIGLGSLVFSLPHFF----------------------------------------- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  90 kevkslmwVYVLvGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSVNTD 169
Cdd:cd17463    93 --------VFIL-GQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 170 DLTitPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPkeglennadiiknenedkqreedkkekyGITKdflpfmk 249
Cdd:cd17463   164 DLT--EEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPKHLP----------------------------GLLK------- 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 250 slscNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQAAHI 329
Cdd:cd17463   207 ----NPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKF 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 330 GCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPqdlyMGNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCE 409
Cdd:cd17463   283 AIITTTVSLLLLSVFIFAKCGNDPFAGVSETYNGTG----KIGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCT 358
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622842524 410 TSIGMGINMVFQNCSCIQ-TSGNSSAVLGLCDKGPDCSMM---LQYFLILSAMSSFIYSLAAIPGYMVLLR 476
Cdd:cd17463   359 NENLHDKKKVYYNCSCIGnFTEEFSANTTKCEEGKKCETTcknLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
10-476 2.11e-59

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 204.30  E-value: 2.11e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  10 LLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFlmnqyeyesTVsvsgnlssnsflcmengtqilrptqdpsect 89
Cdd:cd17462    54 LCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHF---------TV------------------------------- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  90 kevkslmwvyVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSvNTD 169
Cdd:cd17462    94 ----------FMLGQFLHGIGATPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGR-QTE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 170 dltITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPkeglennadiiknenedkqreedkkekyGITKdflpfmk 249
Cdd:cd17462   163 ---LTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQLP----------------------------GLLK------- 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 250 slscNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQAAHI 329
Cdd:cd17462   205 ----NPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKF 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 330 gCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEG--IPQDLymgNNVFANCNVDCNCPSKIWDPVCGNNGLSYLSACLAG 407
Cdd:cd17462   281 -CLICTVVSLLAIFIFSLHCPNVPMAGVTASYRGsvLPEGS---LNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAG 356
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622842524 408 CETSIGMGIN--MVFQNCSCIqtSGNSSAVLGLCDKGPDCSM-----MLQYFLILSAMSSFiysLAAIPGYMVLLR 476
Cdd:cd17462   357 CSEAYSDIRNgqKVYQDCSCV--AGNLSVGFGEASAGKCTSNcnhmpLLLAFVFLVILFTF---LCSIPALTATLR 427
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
8-476 5.61e-34

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 134.20  E-value: 5.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   8 NLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFlmnqyeyestvsvsgnlssnsflcmengtqilrptqdpse 87
Cdd:cd17405    51 SFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFF---------------------------------------- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  88 ctkevkslmwVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYVDTGSVN 167
Cdd:cd17405    91 ----------TFHIAGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGYLLGYVGGLPNFQPPPNEKSVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 168 TddlTITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPkeglennadiiknenedkqreedkkekyGITKdflpf 247
Cdd:cd17405   161 I---EVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLP----------------------------GLLK----- 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 248 mkslscNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQAA 327
Cdd:cd17405   205 ------NPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKM 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 328 HIGCWLSLLEYLLHFLSFLVTCENSSVVGINTSYEGIPQdlyMGNnVFANCNVDCNCPSKIWDPVCGNNGLSYLSACLAG 407
Cdd:cd17405   279 RFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQ---LGN-LTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAG 354
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622842524 408 CETSIGMGINMVFQNCSCIQTSGNSS--------AVLGLCDKgpDCSMMLQYFLILsaMSSFIYS-LAAIPGYMVLLR 476
Cdd:cd17405   355 CKASKVSNTEKTYYNCSCIKEGLAAAddegdfidAIAGKCDS--KCYKLPLFFAFY--FSATVFSnMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
375-427 4.74e-22

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 89.29  E-value: 4.74e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622842524 375 FANCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGMGINMVFQNCSCIQ 427
Cdd:cd01330     2 TSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
7-347 8.90e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.56  E-value: 8.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524   7 GNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHflmnqyeyestvsvsgnlssnsflcmengtqilrptqdps 86
Cdd:cd06174    43 GYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP---------------------------------------- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  87 ectkevkslMWVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCAnvyvdtgsv 166
Cdd:cd06174    83 ---------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA--------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 167 ntddltitptdTRWVGAWWFGFLICAGVNVLTAIPFFFLPKTLPKEGLENNadiiknenedkqreedkkeKYGITKDFLP 246
Cdd:cd06174   145 -----------SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKN-------------------EEASSKSVLK 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 247 FMKSLSCNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQA 326
Cdd:cd06174   195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
                         330       340
                  ....*....|....*....|.
gi 1622842524 327 AHIGCWLSLLEYLLHFLSFLV 347
Cdd:cd06174   275 IGLLLMALGLALLLLAPSLLL 295
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
379-425 9.25e-13

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 62.90  E-value: 9.25e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622842524 379 NVDCNCPSKIWDPVCGNNGLSYLSAC---LAGCETSIGMGINMVFQNCSC 425
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS_1 pfam07690
Major Facilitator Superfamily;
97-340 7.45e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.81  E-value: 7.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  97 WVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYvdtgsvntddltitpt 176
Cdd:pfam07690  85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---------------- 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 177 DTRWVgawwfgFLICAGVNVLTAIPFFFLpktlpkeglennadiiknenEDKQREEDKKEKYGITKDFLPFMKSLSCNPI 256
Cdd:pfam07690 149 GWRAA------FLILAILSLLAAVLLLLP--------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPV 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 257 YMLFILIsVIQFNAFVNMISFMPKYIEqQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLL 336
Cdd:pfam07690 203 LWLLLAL-LLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                  ....
gi 1622842524 337 EYLL 340
Cdd:pfam07690 281 GLLL 284
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
384-425 3.05e-07

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 46.88  E-value: 3.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622842524 384 CPsKIWDPVCGNNGLSYLSACLAGCETSIGMGINMVFQNCSC 425
Cdd:cd00104     1 CP-KEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
97-317 2.66e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.88  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  97 WVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIET----GAIIGPLIGLLLASFcanvyvdtgsvntddlt 172
Cdd:cd17325    84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSaiglGFLIGPLLGGLLADA----------------- 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 173 itptdtrwvGAWWFGFLICAGVNVLTAIPFFFLPKTLPKeglennadiikneNEDKQREEDKKekygitkdFLPFMKSLS 252
Cdd:cd17325   147 ---------LGYRAPFLVCAALALLALVLALLLLPEPRP-------------PPNKRAVSAAR--------LRSGLRLLL 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622842524 253 CNPIYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMK 317
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
141-319 1.41e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 41.46  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 141 GAIIGPLIGLLLASFcanvyvdtgsvntddltitpTDTRWVGAWWFGFLICAGVNVLTaipFFFLPKTLPKEGLeNNADI 220
Cdd:cd17345   144 GGLVGPLAGLGLAIF--------------------GDGWWRGAFIFPAIIAIIVAVIV---LFLGKDTPESEGL-PPIEE 199
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 221 IKNENEDKQREEDKKEKYGItkdFLPFMKSLSCNPIYMLFILIsviqfNAFVNMI-----SFMPKYIEQQYGKSSSDAIF 295
Cdd:cd17345   200 YKGDYPEEADGEEEEQELSA---WEIFVKYVLKNKLLWYIAIA-----NVFVYLVrygilDWAPTYLSEVKGFSKAQAMW 271
                         170       180
                  ....*....|....*....|....
gi 1622842524 296 LIGIYNLPPIcIGYIIGGLIMKKF 319
Cdd:cd17345   272 AFSLFEWAAI-PGTLLAGWLSDKL 294
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
97-348 5.22e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.45  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524  97 WVYVLVGNIVRGMGETPILPLGISYIEDFAKSENSPLYIGLIETGAIIGPLIGLLLASFCANVYvdtgsvntddltitpt 176
Cdd:cd17324    87 FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL---------------- 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 177 DTRWVgawwfgFLICAGVNVLTAIPF-FFLPKTLPKEGlennadiiknenedkqreedkkekygITKDFLPFMKSLSCNP 255
Cdd:cd17324   151 GWRAA------FLAIAVLALLAALLLwRLLPSLPPKKP--------------------------GSLGLLSSLLLLLRNP 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842524 256 IYMLFILISVIQFNAFVNMISFMPKYIEQQYGKSSSDAIFLIGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSL 335
Cdd:cd17324   199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL 278
                         250
                  ....*....|...
gi 1622842524 336 LEYLLHFLSFLVT 348
Cdd:cd17324   279 LLTLLGPSPLLLL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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