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Conserved domains on  [gi|1622968416|ref|XP_028697477|]
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cytokine receptor common subunit gamma isoform X2 [Macaca mulatta]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
15-107 2.37e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09240:

Pssm-ID: 451288  Cd Length: 96  Bit Score: 50.87  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968416  15 EVQCFVFNVEYMNCTWNSSSEPQP-TNLTLHYWYKNsdNDKVQKCSHYLFSEEITSGCQLQ--EKEIHLYQ--TFVVQLQ 89
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSP--LGPVLQCQYYIRDDGTRIGCQFDdlEGLSSSFHqvYICVNGS 78
                          90
                  ....*....|....*...
gi 1622968416  90 DPREPRRQATQMLKLQNL 107
Cdd:pfam09240  79 SSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
110-202 3.00e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968416 110 PWAPENLTLRKLSESQLELNWNNRFLNHCLEH--LVQYRTDWDHSWTEQSVDY--RHKFSLPSVDGQKRYTFRVRSRfnp 185
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAV--- 77
                          90
                  ....*....|....*..
gi 1622968416 186 lcgSAQHWSEWSHPIHW 202
Cdd:cd00063    78 ---NGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
15-107 2.37e-08

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 50.87  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968416  15 EVQCFVFNVEYMNCTWNSSSEPQP-TNLTLHYWYKNsdNDKVQKCSHYLFSEEITSGCQLQ--EKEIHLYQ--TFVVQLQ 89
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSP--LGPVLQCQYYIRDDGTRIGCQFDdlEGLSSSFHqvYICVNGS 78
                          90
                  ....*....|....*...
gi 1622968416  90 DPREPRRQATQMLKLQNL 107
Cdd:pfam09240  79 SSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
110-202 3.00e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968416 110 PWAPENLTLRKLSESQLELNWNNRFLNHCLEH--LVQYRTDWDHSWTEQSVDY--RHKFSLPSVDGQKRYTFRVRSRfnp 185
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAV--- 77
                          90
                  ....*....|....*..
gi 1622968416 186 lcgSAQHWSEWSHPIHW 202
Cdd:cd00063    78 ---NGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
110-182 2.39e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.13  E-value: 2.39e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622968416  110 PWAPENLTLRKLSESQLELNWNNRFLNHCLEHLVQYRTDW---DHSWTEQSVDY-RHKFSLPSVDGQKRYTFRVRSR 182
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYreeGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAV 77
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
15-107 2.37e-08

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 50.87  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968416  15 EVQCFVFNVEYMNCTWNSSSEPQP-TNLTLHYWYKNsdNDKVQKCSHYLFSEEITSGCQLQ--EKEIHLYQ--TFVVQLQ 89
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSP--LGPVLQCQYYIRDDGTRIGCQFDdlEGLSSSFHqvYICVNGS 78
                          90
                  ....*....|....*...
gi 1622968416  90 DPREPRRQATQMLKLQNL 107
Cdd:pfam09240  79 SSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
110-202 3.00e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968416 110 PWAPENLTLRKLSESQLELNWNNRFLNHCLEH--LVQYRTDWDHSWTEQSVDY--RHKFSLPSVDGQKRYTFRVRSRfnp 185
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyVVEYREKGSGDWKEVEVTPgsETSYTLTGLKPGTEYEFRVRAV--- 77
                          90
                  ....*....|....*..
gi 1622968416 186 lcgSAQHWSEWSHPIHW 202
Cdd:cd00063    78 ---NGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
110-182 2.39e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.13  E-value: 2.39e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622968416  110 PWAPENLTLRKLSESQLELNWNNRFLNHCLEHLVQYRTDW---DHSWTEQSVDY-RHKFSLPSVDGQKRYTFRVRSR 182
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYreeGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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