NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622953558|ref|XP_028706877|]
View 

ubiquitin-associated protein 1-like isoform X1 [Macaca mulatta]

Protein Classification

ubiquitin-associated protein 1-like( domain architecture ID 10198575)

ubiquitin-associated protein 1-like (UBAP1L)

Gene Ontology:  GO:0043162|GO:0043130|GO:0000813
PubMed:  19468686

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 339-375 1.70e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


:

Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.78  E-value: 1.70e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622953558 339 FLRLWEQFSDMGFQQDRIKEVLLVHGNRREQALEELV 375
Cdd:cd14316     1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
 
Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 339-375 1.70e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.78  E-value: 1.70e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622953558 339 FLRLWEQFSDMGFQQDRIKEVLLVHGNRREQALEELV 375
Cdd:cd14316     1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
 
Name Accession Description Interval E-value
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 339-375 1.70e-14

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 66.78  E-value: 1.70e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622953558 339 FLRLWEQFSDMGFQQDRIKEVLLVHGNRREQALEELV 375
Cdd:cd14316     1 FLKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH