NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720420297|ref|XP_030097832|]
View 

latent-transforming growth factor beta-binding protein 4 isoform X4 [Mus musculus]

Protein Classification

TB and EGF_CA domain-containing protein( domain architecture ID 11256465)

protein containing domains TB, cEGF, and EGF_CA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 225-266 5.11e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.11e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720420297  225 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 266
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-764 2.35e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.35e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720420297   728 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 764
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1210-1252 2.40e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720420297 1210 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1252
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1043-1085 4.82e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720420297 1043 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1085
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 685-717 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720420297  685 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 717
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
899-940 1.40e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.40e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1720420297   899 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 940
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
770-805 8.93e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.93e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720420297   770 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 805
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 522-559 3.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720420297  522 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 559
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
164-194 3.74e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.74e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1720420297   164 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 194
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
603-644 1.68e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.68e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720420297   603 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 644
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
438-474 1.72e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.72e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720420297   438 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 474
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
480-521 3.70e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.70e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720420297   480 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 521
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1424-1458 1.32e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.32e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1720420297  1424 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1458
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 561-595 1.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720420297  561 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 595
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
811-849 2.17e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720420297   811 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 849
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1146-1175 2.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.20e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720420297 1146 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1175
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 420-441 9.49e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


:

Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 9.49e-03
                           10        20
                   ....*....|....*....|..
gi 1720420297  420 TCACDPGFRLGPQGTRCIDIDE 441
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 225-266 5.11e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.11e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720420297  225 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 266
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-764 2.35e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.35e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720420297   728 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 764
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1210-1252 2.40e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720420297 1210 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1252
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1043-1085 4.82e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720420297 1043 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1085
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 685-717 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720420297  685 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 717
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
899-940 1.40e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.40e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1720420297   899 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 940
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
685-717 2.89e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.89e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1720420297   685 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 717
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-760 3.17e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.17e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720420297  728 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 760
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 899-934 8.29e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.29e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720420297  899 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 934
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
770-805 8.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.93e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720420297   770 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 805
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 522-559 3.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720420297  522 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 559
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
164-194 3.74e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.74e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1720420297   164 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 194
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 770-801 7.78e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.78e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720420297  770 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 801
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
522-559 1.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.38e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720420297   522 DVDECtQSPGLCGRG-VCENLPGSFRCVCPAGFR-GSACE 559
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 164-198 1.40e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720420297  164 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 198
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
603-644 1.68e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.68e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720420297   603 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 644
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
438-474 1.72e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.72e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720420297   438 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 474
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
480-521 3.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.70e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720420297   480 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 521
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
770-799 9.87e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 9.87e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  770 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 799
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 909-939 1.05e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.05e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720420297  909 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 939
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 480-521 1.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720420297  480 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 521
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 603-635 1.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720420297  603 DVDECSrSPSPCAY-GRCENTEGSFKCVCPTGFQ 635
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1424-1458 1.32e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.32e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1720420297  1424 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1458
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 561-595 1.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720420297  561 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 595
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
561-595 2.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1720420297   561 DVDECAQqPPPCGPG-RCDNTAGSFHCACPAGFRSR 595
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
811-849 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720420297   811 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 849
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1146-1175 2.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.20e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720420297 1146 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1175
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1146-1175 2.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.47e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1720420297  1146 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1175
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
164-193 2.66e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  164 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 193
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1424-1462 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720420297 1424 DVNECDEAeatSPLCVNARCVNTDGSFRCICRPGFAPTH 1462
Cdd:cd00054      1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 689-717 3.83e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.42  E-value: 3.83e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720420297  689 CSSGT-PCGLHGQCTNTKGSFHCSCSTGYR 717
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYT 30
EGF_CA pfam07645
Calcium-binding EGF domain;
522-552 4.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  522 DVDECTQSPGLCGR-GVCENLPGSFRCVCPAG 552
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1424-1457 4.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720420297 1424 DVNECDEAEATSPlcVNARCVNTDGSFRCICRPG 1457
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
480-510 5.68e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 5.68e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  480 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 510
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 438-470 5.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720420297  438 DIDECRRvPTPCAP-GRCENTPGSFRCVCGTGFQ 470
Cdd:cd00054      1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
603-633 9.12e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.12e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  603 DVDECSRSPSPCAY-GRCENTEGSFKCVCPTG 633
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 420-441 9.49e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 9.49e-03
                           10        20
                   ....*....|....*....|..
gi 1720420297  420 TCACDPGFRLGPQGTRCIDIDE 441
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 225-266 5.11e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.11e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720420297  225 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 266
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-764 2.35e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.35e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720420297   728 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 764
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1210-1252 2.40e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720420297 1210 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1252
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1043-1085 4.82e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720420297 1043 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1085
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 685-717 1.12e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720420297  685 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 717
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
899-940 1.40e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.40e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1720420297   899 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 940
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
685-717 2.89e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.89e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1720420297   685 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 717
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-760 3.17e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.17e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720420297  728 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 760
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 899-934 8.29e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.29e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720420297  899 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 934
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
770-805 8.93e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.93e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720420297   770 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 805
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 522-559 3.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720420297  522 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 559
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
164-194 3.74e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.74e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1720420297   164 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 194
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 770-801 7.78e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.78e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720420297  770 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 801
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
522-559 1.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.38e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720420297   522 DVDECtQSPGLCGRG-VCENLPGSFRCVCPAGFR-GSACE 559
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 164-198 1.40e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720420297  164 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 198
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
603-644 1.68e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.68e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720420297   603 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 644
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
438-474 1.72e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.72e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720420297   438 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 474
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
480-521 3.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.70e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720420297   480 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 521
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
770-799 9.87e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 9.87e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  770 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 799
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 909-939 1.05e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.05e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720420297  909 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 939
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 480-521 1.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720420297  480 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 521
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 603-635 1.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720420297  603 DVDECSrSPSPCAY-GRCENTEGSFKCVCPTGFQ 635
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1424-1458 1.32e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.32e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1720420297  1424 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1458
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 561-595 1.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720420297  561 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 595
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
167-199 1.74e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.74e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1720420297   167 ECATGGRCQHGECANTRGGYTCVCPDGFLLDSS 199
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
561-595 2.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1720420297   561 DVDECAQqPPPCGPG-RCDNTAGSFHCACPAGFRSR 595
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
811-849 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720420297   811 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 849
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1146-1175 2.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.20e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720420297 1146 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1175
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1146-1175 2.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.47e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1720420297  1146 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1175
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
164-193 2.66e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  164 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 193
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1424-1462 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720420297 1424 DVNECDEAeatSPLCVNARCVNTDGSFRCICRPGFAPTH 1462
Cdd:cd00054      1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 689-717 3.83e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.42  E-value: 3.83e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720420297  689 CSSGT-PCGLHGQCTNTKGSFHCSCSTGYR 717
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYT 30
EGF_CA pfam07645
Calcium-binding EGF domain;
522-552 4.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  522 DVDECTQSPGLCGR-GVCENLPGSFRCVCPAG 552
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1424-1457 4.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720420297 1424 DVNECDEAEATSPlcVNARCVNTDGSFRCICRPG 1457
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
480-510 5.68e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 5.68e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  480 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 510
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 438-470 5.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720420297  438 DIDECRRvPTPCAP-GRCENTPGSFRCVCGTGFQ 470
Cdd:cd00054      1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
603-633 9.12e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.12e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720420297  603 DVDECSRSPSPCAY-GRCENTEGSFKCVCPTG 633
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 420-441 9.49e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 9.49e-03
                           10        20
                   ....*....|....*....|..
gi 1720420297  420 TCACDPGFRLGPQGTRCIDIDE 441
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH