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Conserved domains on  [gi|1720421226|ref|XP_030098072|]
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paternally-expressed gene 3 protein isoform X3 [Mus musculus]

Protein Classification

PHA03169 and zf-C2H2 domain-containing protein( domain architecture ID 13618199)

PHA03169 and zf-C2H2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03169 super family cl27451
hypothetical protein; Provisional
 862-1080 3.71e-05

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.04  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  862 RSELIEHQKIHDRERPSGSRHyERSVIRSLAPS--DPQTSYAQERFIQEQvrkfrafGQRSTTSNNLSvqkiyAQETFNA 939
Cdd:PHA03169    16 RSSCRGHCKRHGGTREQAGRR-RGTAARAAKPAppAPTTSGPQVRAVAEQ-------GHRQTESDTET-----AEESRHG 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  940 EEphDKETHGQKIHDKEPYGKEPSGkEPHGDEPQDKEPLDQEMRSEE----PHDDKPHGQEPHDDKPHGQ-EPHDDKPHG 1014
Cdd:PHA03169    83 EK--EERGQGGPSGSGSESVGSPTP-SPSGSAEELASGLSPENTSGSspesPASHSPPPSPPSHPGPHEPaPPESHNPSP 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720421226 1015 --------QEPHGDEPH-GQEPHGDEPHDKEPIDQEMRSEEPHSEESHGDEPHGEESHGQEKVEDATIQASVSEE 1080
Cdd:PHA03169   160 nqqpssflQPSHEDSPEePEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHE 234
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1147-1169 9.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 9.44e-04
                           10        20
                   ....*....|....*....|...
gi 1720421226 1147 YECPKCGESFIHSSLLFEHQRVH 1169
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 850-872 4.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|...
gi 1720421226  850 FECQECGEAFARRSELIEHQKIH 872
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 9.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 9.95e-03
                           10        20
                   ....*....|....*....|...
gi 1720421226  378 FECKECGETFSRSAALAEHRQIH 400
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PHA03169 PHA03169
hypothetical protein; Provisional
 862-1080 3.71e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.04  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  862 RSELIEHQKIHDRERPSGSRHyERSVIRSLAPS--DPQTSYAQERFIQEQvrkfrafGQRSTTSNNLSvqkiyAQETFNA 939
Cdd:PHA03169    16 RSSCRGHCKRHGGTREQAGRR-RGTAARAAKPAppAPTTSGPQVRAVAEQ-------GHRQTESDTET-----AEESRHG 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  940 EEphDKETHGQKIHDKEPYGKEPSGkEPHGDEPQDKEPLDQEMRSEE----PHDDKPHGQEPHDDKPHGQ-EPHDDKPHG 1014
Cdd:PHA03169    83 EK--EERGQGGPSGSGSESVGSPTP-SPSGSAEELASGLSPENTSGSspesPASHSPPPSPPSHPGPHEPaPPESHNPSP 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720421226 1015 --------QEPHGDEPH-GQEPHGDEPHDKEPIDQEMRSEEPHSEESHGDEPHGEESHGQEKVEDATIQASVSEE 1080
Cdd:PHA03169   160 nqqpssflQPSHEDSPEePEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHE 234
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1147-1169 9.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 9.44e-04
                           10        20
                   ....*....|....*....|...
gi 1720421226 1147 YECPKCGESFIHSSLLFEHQRVH 1169
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 850-872 4.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|...
gi 1720421226  850 FECQECGEAFARRSELIEHQKIH 872
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 9.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 9.95e-03
                           10        20
                   ....*....|....*....|...
gi 1720421226  378 FECKECGETFSRSAALAEHRQIH 400
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PHA03169 PHA03169
hypothetical protein; Provisional
 862-1080 3.71e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.04  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  862 RSELIEHQKIHDRERPSGSRHyERSVIRSLAPS--DPQTSYAQERFIQEQvrkfrafGQRSTTSNNLSvqkiyAQETFNA 939
Cdd:PHA03169    16 RSSCRGHCKRHGGTREQAGRR-RGTAARAAKPAppAPTTSGPQVRAVAEQ-------GHRQTESDTET-----AEESRHG 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  940 EEphDKETHGQKIHDKEPYGKEPSGkEPHGDEPQDKEPLDQEMRSEE----PHDDKPHGQEPHDDKPHGQ-EPHDDKPHG 1014
Cdd:PHA03169    83 EK--EERGQGGPSGSGSESVGSPTP-SPSGSAEELASGLSPENTSGSspesPASHSPPPSPPSHPGPHEPaPPESHNPSP 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720421226 1015 --------QEPHGDEPH-GQEPHGDEPHDKEPIDQEMRSEEPHSEESHGDEPHGEESHGQEKVEDATIQASVSEE 1080
Cdd:PHA03169   160 nqqpssflQPSHEDSPEePEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHE 234
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 917-1118 3.48e-04

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 45.45  E-value: 3.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  917 GQRSTTSNNLSVQKIYAQETFNAEEPHDKETHGQKIHDKEPYGKEPSGKEPHGDEPQDKEPLDQEMRSEEPHDDKPHG-- 994
Cdd:PTZ00395   398 AQSNAAQSNAGFSNAGYSNPGNSNPGYNNAPNSNTPYNNPPNSNTPYSNPPNSNPPYSNLPYSNTPYSNAPLSNAPPSsa 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  995 -----------QEPHDDKPHGQEPHDDKPHGQEPHG------DEPHGQEPHGDEPHDKEPidqeMRSEEPHSEESHGDEP 1057
Cdd:PTZ00395   478 kdhhsayhaayQHRAANQPAANLPTANQPAANNFHGaagnsvGNPFASRPFGSAPYGGNA----ATTADPNGIAKREDHP 553

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720421226 1058 HG------EESHGQEKVEDATIQASVSEEHQKDDAGDAIYECQDCGLGFTDLND----LTSHQDTHSRKAL 1118
Cdd:PTZ00395   554 EGgtnrqkYEQSDEESVESSSSENSSENENEVTDKGEEIYSLLKKTINRIDMNKiprpIINTQEKKKKKNL 624
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1147-1169 9.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 9.44e-04
                           10        20
                   ....*....|....*....|...
gi 1720421226 1147 YECPKCGESFIHSSLLFEHQRVH 1169
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 850-872 4.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|...
gi 1720421226  850 FECQECGEAFARRSELIEHQKIH 872
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK09565 PRK09565
heme-binding protein;
997-1123 9.01e-03

heme-binding protein;


Pssm-ID: 236571 [Multi-domain]  Cd Length: 533  Bit Score: 40.57  E-value: 9.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421226  997 PHDDKPHGQEPHDDKPHGQEPHGDEPHgqepHGDEPHDKEPIDQEMRSEEPHSEESHGDEPHGEESHGQEKVEDATIQAS 1076
Cdd:PRK09565   262 PTATPEDAADGGTGGTHDAEEFGEHGH----HGGHPGGEDGEHPHGHEDSGGHHGSGGDNFDHYDRHVATTVRADGGRED 337

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720421226 1077 VSEE---------------HQKDDAGDAIYECQDCGLGFTDLNDLTS---HQDTHSRKALVDSRE 1123
Cdd:PRK09565   338 SDEEirgeladagvyagqpHGEDVYALVLYSEADPDELFEEVEGLREnfdHYDTHVKTAVYEAEE 402
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 9.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 9.95e-03
                           10        20
                   ....*....|....*....|...
gi 1720421226  378 FECKECGETFSRSAALAEHRQIH 400
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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