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Conserved domains on  [gi|1720423116|ref|XP_030098562|]
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zinc finger protein 780B isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 5.14e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 5.14e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720423116   14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAvVGRCISKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-605 3.42e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 197 KPYECEECGKAFRLPQQLTRHQKSHSGEKPFECN--ECGKAFHLPDLLKYHKTIHTGEKPFECR-ECGKSFNRVSNLVAH 273
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 274 RIIHADVKPYKCSECGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQ----------------------LTRHQN 331
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 332 IHTGEKSFECHECGKAFRLPQQLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLV 411
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 412 EHRLIHADV-------KPHKCNECGKAFKRSKSLMQHQ--KIHSGE--RPFQC--QECGKAFIVLTHLTRHQTIHTGEKS 478
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 479 FEC--NECGKKFRTATHLVMHQTIHtgekpfecnvcgkafrlQVYLSEHQKIHIEEKPFKCKLCGSAFRRKYQLNEHYTI 556
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF 414

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1720423116 557 HTDEKPyqCKECGKCFRQRSNFTEHQSIHTGNKPFECKECGKFFRLNTL 605
Cdd:COG5048   415 RPYNCK--NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 5.14e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 5.14e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720423116   14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAvVGRCISKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.72e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 4.72e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720423116  13 SVTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAV 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-51 6.53e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 6.53e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720423116  14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLV 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-605 3.42e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 197 KPYECEECGKAFRLPQQLTRHQKSHSGEKPFECN--ECGKAFHLPDLLKYHKTIHTGEKPFECR-ECGKSFNRVSNLVAH 273
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 274 RIIHADVKPYKCSECGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQ----------------------LTRHQN 331
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 332 IHTGEKSFECHECGKAFRLPQQLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLV 411
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 412 EHRLIHADV-------KPHKCNECGKAFKRSKSLMQHQ--KIHSGE--RPFQC--QECGKAFIVLTHLTRHQTIHTGEKS 478
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 479 FEC--NECGKKFRTATHLVMHQTIHtgekpfecnvcgkafrlQVYLSEHQKIHIEEKPFKCKLCGSAFRRKYQLNEHYTI 556
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF 414

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1720423116 557 HTDEKPyqCKECGKCFRQRSNFTEHQSIHTGNKPFECKECGKFFRLNTL 605
Cdd:COG5048   415 RPYNCK--NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-266 8.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.92e-04
                          10        20
                  ....*....|....*....|....*
gi 1720423116 242 LKYHKTIHTGEKPFECRECGKSFNR 266
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 423-501 6.99e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 6.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 423 HKCNECGKAFKRSKSLMQHQKihsgerpfqcqecgkafivlthltrhqtihtgEKSFECNECGKKFRTATHLVMH-QTIH 501
Cdd:cd20908     2 PWCYYCDREFDDEKILIQHQK--------------------------------AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 5.14e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 5.14e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720423116   14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAvVGRCISKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.72e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 4.72e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720423116  13 SVTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAV 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-51 6.53e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 6.53e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720423116  14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLV 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-605 3.42e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 197 KPYECEECGKAFRLPQQLTRHQKSHSGEKPFECN--ECGKAFHLPDLLKYHKTIHTGEKPFECR-ECGKSFNRVSNLVAH 273
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 274 RIIHADVKPYKCSECGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQ----------------------LTRHQN 331
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 332 IHTGEKSFECHECGKAFRLPQQLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLV 411
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 412 EHRLIHADV-------KPHKCNECGKAFKRSKSLMQHQ--KIHSGE--RPFQC--QECGKAFIVLTHLTRHQTIHTGEKS 478
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 479 FEC--NECGKKFRTATHLVMHQTIHtgekpfecnvcgkafrlQVYLSEHQKIHIEEKPFKCKLCGSAFRRKYQLNEHYTI 556
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF 414

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1720423116 557 HTDEKPyqCKECGKCFRQRSNFTEHQSIHTGNKPFECKECGKFFRLNTL 605
Cdd:COG5048   415 RPYNCK--NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
306-749 1.80e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 306 SDERPFQCKDCGKGFIVLAQLTRHQNIHTGEKSFECH--ECGKAFRLPQQLTRHQKSHSGEKPFKCN-ECGKAFHLPDLL 382
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 383 KYHKTIHTSTKPFECRECGKSFHRISNLVEHRLIH---ADVKPHKCNECGKAFK-RSKSLMQHQKIHSGERPFQCQecgk 458
Cdd:COG5048   109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNL---- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 459 afivltHLTRHQTIHTGEKSFECNECGKKFRTATHLVMHQTIHTGEKPFECNVCGKAFRLQVYLSEHQKIHIEEKPFKCK 538
Cdd:COG5048   185 ------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 539 LCGSAF---RRKYQLNEHYTIHTDEK----PYQCKECGKCFRQRSNFTEHQ--SIHTG--NKPFECKE--CGKFFRLNTL 605
Cdd:COG5048   259 ESPRSSlptASSQSSSPNESDSSSEKgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 606 LIRHQKSHSSERPYKCK--ECGKAFHLPSELNNHQIVHTS-----NRPFECKV--CGKSFKRESTLIQHSVIHGGVKSYE 676
Cdd:COG5048   339 LKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720423116 677 CnecgkafihrsslfhhrkihsdekpfKCQECGKAFVVLAYLTRHQSIHTGEKSFECQQCGSaFRYKSQLSKH 749
Cdd:COG5048   419 C--------------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-793 1.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 365 KPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECR--ECGKSFHRISNLVEHRLIHADVKPHKCN--ECGKAFKRSKSLMQ 440
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 441 HqKIHSGERPFQCQECGKAFIV---LTHLTRHQTIHTGEKSFECNECGKKFRTATHLVM-HQTIHTGEKPFECNVcgkaf 516
Cdd:COG5048   112 S-SSSNSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS----- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 517 rlqvyLSEHQKIHIEEKPFKCKLCGSAFRRKYQLNEHYTIHTDEKPYQCKECGKCFRQRSNFTEHQSIHTGNKPFECKEC 596
Cdd:COG5048   186 -----LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 597 GKFFRLNTLLIRHQKSHSSER-------PYKCKECGKAFHLPSELNNHQ--IVHTS--NRPFECKV--CGKSFKRESTLI 663
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 664 QHSVIHGGVKSYECNecgkaFIHRSSLFHHRKIHSDEKPFkcqecgkafvvlayltRHQSIHTGEKSFEC--QQCGSAFR 741
Cdd:COG5048   341 RHILLHTSISPAKEK-----LLNSSSKFSPLLNNEPPQSL----------------QQYKDLKNDKKSETlsNSCIRNFK 399

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720423116 742 YKSQLSKHQRSHTDVKLFQCMEGGND--FVHGTNLSIHQGIHTSENPFQCNEYG 793
Cdd:COG5048   400 RDSNLSLHIITHLSFRPYNCKNPPCSksFNRHYNLIPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-386 4.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 165 HNTEKPYECKECGKCFGCRSTLTQHQSIHTGEKPYECEECGKAFRLPQQLTRHQKSHSGE-------KPFECNECGKAFH 237
Cdd:COG5048   221 ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 238 LPDLLKYHK--TIHTGE--KPFECRE--CGKSFNRVSNLVAHRIIHADVKPYKC--SECGKAFKRRSN-----LVQHQKT 304
Cdd:COG5048   301 RSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKD 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 305 HSDERPFQC-KDCGKGFIV---LAQLTRHQNIHTGEKSFECHECGKAFRLPQQLTRHQKSHSGEKPFKCNECGKAFHLPD 380
Cdd:COG5048   381 LKNDKKSETlSNSCIRNFKrdsNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460


                  ....*.
gi 1720423116 381 LLKYHK 386
Cdd:COG5048   461 LSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-266 8.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.92e-04
                          10        20
                  ....*....|....*....|....*
gi 1720423116 242 LKYHKTIHTGEKPFECRECGKSFNR 266
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 223-306 1.49e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 223 GEKPFECN--ECGKAFHLPDLLKYHKtIHTgekpfecrECGKSFNRVSNLVAHRIIHADVKPYKCSECGKAFKRRSNLVQ 300
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720423116 301 HqKTHS 306
Cdd:COG5189   417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 363-446 1.78e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 363 GEKPFKCN--ECGKAFHLPDLLKYHKtIHTstkpfecrECGKSFHRISNLVEHRLIHADVKPHKCNECGKAFKRSKSLMQ 440
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720423116 441 HQKiHS 446
Cdd:COG5189   417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-376 2.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.12e-03
                          10        20
                  ....*....|....*....|...
gi 1720423116 354 LTRHQKSHSGEKPFKCNECGKAF 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-460 2.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|....
gi 1720423116 437 SLMQHQKIHSGERPFQCQECGKAF 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-236 3.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.23e-03
                          10        20
                  ....*....|....*....|...
gi 1720423116 214 LTRHQKSHSGEKPFECNECGKAF 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 283-305 3.48e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.48e-03
                          10        20
                  ....*....|....*....|...
gi 1720423116 283 YKCSECGKAFKRRSNLVQHQKTH 305
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
465-490 5.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.94e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720423116 465 HLTRHQTIHTGEKSFECNECGKKFRT 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-516 6.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.55e-03
                          10        20
                  ....*....|....*....|....
gi 1720423116 493 HLVMHQTIHTGEKPFECNVCGKAF 516
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 423-501 6.99e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 6.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423116 423 HKCNECGKAFKRSKSLMQHQKihsgerpfqcqecgkafivlthltrhqtihtgEKSFECNECGKKFRTATHLVMH-QTIH 501
Cdd:cd20908     2 PWCYYCDREFDDEKILIQHQK--------------------------------AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-208 9.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.81e-03
                          10        20
                  ....*....|....*....|...
gi 1720423116 186 LTQHQSIHTGEKPYECEECGKAF 208
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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