NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720423838|ref|XP_030098770|]
View 

tetratricopeptide repeat protein 23 isoform X4 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-299 6.64e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.31  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA------ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457    79 ---------LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYE 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 211 KALEYteitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIIL 290
Cdd:COG0457   135 RALEL--------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206


                  ....*....
gi 1720423838 291 SKDPSPEEA 299
Cdd:COG0457   207 LRKKLAILT 215
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-299 6.64e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.31  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA------ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457    79 ---------LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYE 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 211 KALEYteitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIIL 290
Cdd:COG0457   135 RALEL--------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206


                  ....*....
gi 1720423838 291 SKDPSPEEA 299
Cdd:COG0457   207 LRKKLAILT 215
TPR_12 pfam13424
Tetratricopeptide repeat;
187-253 3.28e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 3.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720423838 187 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-299 6.64e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.31  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA------ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457    79 ---------LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYE 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 211 KALEYteitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIIL 290
Cdd:COG0457   135 RALEL--------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206


                  ....*....
gi 1720423838 291 SKDPSPEEA 299
Cdd:COG0457   207 LRKKLAILT 215
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 52-257 1.78e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  52 AKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKglslqakqHAEKAKEILANSIESPCHNktd 131
Cdd:COG2956    49 GNLYRRRGEYDRAIRIHQKLLERDP--------DRAEALLELAQDYLKAG--------LLDRAEELLEKLLELDPDD--- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 132 ifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQK 211
Cdd:COG2956   110 -----AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE---------------NAHAYCELAELYLEQGDYDEAIEALEK 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1720423838 212 ALEYTEitkdekslECVQVLRELAGVEQALGLYAAAISHFSRKPRQ 257
Cdd:COG2956   170 ALKLDP--------DCARALLLLAELYLEQGDYEEAIAALERALEQ 207
TPR_12 pfam13424
Tetratricopeptide repeat;
187-253 3.28e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 3.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720423838 187 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 52-248 1.65e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.56  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  52 AKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktd 131
Cdd:COG2956   117 AEIYEQEGDWEKAIEVLERLLKLGP--------ENAHAYCELAELYLEQGDYD-EAIEALEKALKLDPDCARA------- 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 132 ifkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQK 211
Cdd:COG2956   181 --------LLLLAELYLEQGDYEEAIAALERALEQDPDYLP---------------ALPRLAELYEKLGDPEEALELLRK 237

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1720423838 212 ALEytEITKDEKSLECVQVLRELAGVEQALGLYAAAI 248
Cdd:COG2956   238 ALE--LDPSDDLLLALADLLERKEGLEAALALLERQL 272
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-253 1.79e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  85 KLAEAYVNLAQGYLQLkGLSLQAKQHAEKAKEILANSIESpchnktdifkcslelFYTLGRALLSLQKFKDASENLIKAE 164
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDAEA---------------LYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 165 RLSKEMLQCgnivkeeWIEIqsriklsfAQLYQGQKRSKEAFPFYQKALEYteitkdekSLECVQVLRELAGVEQALGLY 244
Cdd:COG0457    70 ELDPDDAEA-------LNNL--------GLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126


                  ....*....
gi 1720423838 245 AAAISHFSR 253
Cdd:COG0457   127 DEAIEAYER 135
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 136-281 1.73e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.45  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 136 SLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEy 215
Cdd:COG4235    16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALA- 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720423838 216 teitKDEKSlecVQVLRELAGVEQALGLYAAAISHFSRkprqvcagLHSLLPTASGWKLWTAHITR 281
Cdd:COG4235    80 ----LDPDN---PEALYLLGLAAFQQGDYAEAIAAWQK--------LLALLPADAPARLLEASIAE 130
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 140-416 2.44e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 140 FYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQKALEyteit 219
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVE---------------AHLALGNLYRRRGEYDRAIRIHQKLLE----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 220 KDEKSLecvQVLRELAGVEQALGLYAAAISHFSRkprqvcagLHSLLPTASGWKLWTAHI---TRMTQAHLIILSKdpSP 296
Cdd:COG2956    71 RDPDRA---EALLELAQDYLKAGLLDRAEELLEK--------LLELDPDDAEALRLLAEIyeqEGDWEKAIEVLER--LL 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 297 EEAADSAHFIARAAAASGMHDHRDVAEKYFQESmtsIKDSEGAERAKFLSIQdefcsFLQTTGQKERAAMILRESLEAkv 376
Cdd:COG2956   138 KLGPENAHAYCELAELYLEQGDYDEAIEALEKA---LKLDPDCARALLLLAE-----LYLEQGDYEEAIAALERALEQ-- 207

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1720423838 377 gafgdfSPEVAETYRALGRADLAQGNNSGAYAKLKKCVQI 416
Cdd:COG2956   208 ------DPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 87-214 3.21e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  87 AEAYVNLAQGYLQLkGLSLQAKQHAEKAKEIlansieSPCHnktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERL 166
Cdd:COG3914   112 AEALFNLGNLLLAL-GRLEEALAALRRALAL------NPDF---------AEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1720423838 167 SKEMlqcgnivkeewIEIQSRIklsfAQLYQGQKRSKEAFPFYQKALE 214
Cdd:COG3914   176 DPDN-----------AEALNNL----GNALQDLGRLEEAIAAYRRALE 208
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 50-214 7.23e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.09  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838  50 ERAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSiespchnk 129
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDP--------DNPEAFALLGEILLQLGDLD-EAIVLLHEALELDPDE-------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423838 130 tdifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEMlqcgnivkeewIEIQSRIklsfAQLYQGQKRSKEAFPFY 209
Cdd:COG4783    72 -------PEARLNLGLALLKAGDYDEALALLEKALKLDPEH-----------PEAYLRL----ARAYRALGRPDEAIAAL 129


                  ....*
gi 1720423838 210 QKALE 214
Cdd:COG4783   130 EKALE 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH