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Conserved domains on  [gi|1720428033|ref|XP_030099548|]
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thrombospondin type-1 domain-containing protein 1 isoform X2 [Mus musculus]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641280)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

CATH:  2.20.100.10
SCOP:  4003415

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 342-391 8.03e-14

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 66.46  E-value: 8.03e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720428033  342 WGPWQPWSPCSTTCGDAVRERRRLCVTSFPSRP--SCSGMSSETSPCSLEEC 391
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGggPCTGEDVETRACNEQPC 52
PTZ00441 super family cl25523
sporozoite surface protein 2 (SSP2); Provisional
 289-406 1.43e-09

sporozoite surface protein 2 (SSP2); Provisional


The actual alignment was detected with superfamily member PTZ00441:

Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 61.52  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428033 289 VAENRLPLGERRTVFNCTLFDVGKnkycFNFGIVKKGHFSAKECMLIQRnIETWGPWQPWSPCSTTCGDAVRERrrlcvt 368
Cdd:PTZ00441  192 HQFNRLLAGCRPREGKCKFYSDAD----WEEAKNLIKPFIAKVCTEVER-TASCGPWDEWTPCSVTCGKGTHSR------ 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720428033 369 sfpSRPSC-SGMSSE-TSPCSLEECAVFRP----PGPSPVSPQD 406
Cdd:PTZ00441  261 ---SRPILhEGCTTHmVEECEEEECPVEPEplpvPAPVPPTPED 301
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 342-391 8.03e-14

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 66.46  E-value: 8.03e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720428033  342 WGPWQPWSPCSTTCGDAVRERRRLCVTSFPSRP--SCSGMSSETSPCSLEEC 391
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGggPCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
343-391 3.94e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 3.94e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720428033 343 GPWQPWSPCSTTCGDAVRERRRLCVTSFPSRPSCSGMSSETSPCSLEEC 391
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 289-406 1.43e-09

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 61.52  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428033 289 VAENRLPLGERRTVFNCTLFDVGKnkycFNFGIVKKGHFSAKECMLIQRnIETWGPWQPWSPCSTTCGDAVRERrrlcvt 368
Cdd:PTZ00441  192 HQFNRLLAGCRPREGKCKFYSDAD----WEEAKNLIKPFIAKVCTEVER-TASCGPWDEWTPCSVTCGKGTHSR------ 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720428033 369 sfpSRPSC-SGMSSE-TSPCSLEECAVFRP----PGPSPVSPQD 406
Cdd:PTZ00441  261 ---SRPILhEGCTTHmVEECEEEECPVEPEplpvPAPVPPTPED 301
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 342-391 8.03e-14

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 66.46  E-value: 8.03e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720428033  342 WGPWQPWSPCSTTCGDAVRERRRLCVTSFPSRP--SCSGMSSETSPCSLEEC 391
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGggPCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
343-391 3.94e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 3.94e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720428033 343 GPWQPWSPCSTTCGDAVRERRRLCVTSFPSRPSCSGMSSETSPCSLEEC 391
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 289-406 1.43e-09

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 61.52  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428033 289 VAENRLPLGERRTVFNCTLFDVGKnkycFNFGIVKKGHFSAKECMLIQRnIETWGPWQPWSPCSTTCGDAVRERrrlcvt 368
Cdd:PTZ00441  192 HQFNRLLAGCRPREGKCKFYSDAD----WEEAKNLIKPFIAKVCTEVER-TASCGPWDEWTPCSVTCGKGTHSR------ 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720428033 369 sfpSRPSC-SGMSSE-TSPCSLEECAVFRP----PGPSPVSPQD 406
Cdd:PTZ00441  261 ---SRPILhEGCTTHmVEECEEEECPVEPEplpvPAPVPPTPED 301
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 343-391 1.92e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 1.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720428033 343 GPWQPWSPCSTTCGDAVRERRRLcVTSFPSR-----PScsgmSSETSPCSLEEC 391
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRT-VIVEPQNggrpcPE----LLERRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 346-391 8.81e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 8.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720428033 346 QPWSPCSTTCGDAVRERRRLCVTSFP----SRPSCSG--MSSETSPCSLEEC 391
Cdd:pfam19030   4 GPWGECSVTCGGGVQTRLVQCVQKGGgsivPDSECSAqkKPPETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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