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Conserved domains on  [gi|1720431762|ref|XP_030100259|]
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protocadherin Fat 3 isoform X6 [Mus musculus]

Protein Classification

Cadherin_repeat and LamG domain-containing protein( domain architecture ID 10877250)

protein containing domains Cadherin_repeat, LamG, and EGF_CA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2107-2203 1.28e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.28e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2107 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPA 2186
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1720431762 2187 LSTAATVSIDLTDVNDN 2203
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-93 6.91e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 6.91e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762    1 MENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQST 80
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGGPPLSST 85

                           90
                   ....*....|...
gi 1720431762   81 IWVVVQVLDENDN 93
Cdd:cd11304     86 ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2211-2308 2.51e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.51e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2211 VYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIP 2290
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1720431762 2291 AMSSTTTVNIDISDVNDN 2308
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2001-2098 7.18e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2001 HYTACVYENTATKALLTRVQAMDPDVGINRKVVYSL-EDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpG 2079
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1720431762 2080 QSLSSLASVTITVLDINDN 2098
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1157-1256 1.50e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.50e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1157 TYNTTLSESSLIGTPVLQLVSTDADSGNNKLVRYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNG 1236
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1720431762 1237 FPSLSSEVLVQIYISDVNDN 1256
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1684-1786 2.77e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 2.77e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1684 TYETIIMEGMPVGTKLAQVRAIDMDWGANGQVTYSLHSDSHLEKvieaFNIDSNTGWISTLKDLDHETDPAFSFFVVASD 1763
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1720431762 1764 LGEaFSLSSMALVSVKVTDINDN 1786
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 639-745 1.49e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.49e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  639 QYSGSLSEAAPINSIVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVH 718
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1720431762  719 VRDSGNPQLTaeSPVEVNIEVTDVNDN 745
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1900-1993 3.67e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 3.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1900 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNNEFF-LDPESGELKTLAVLDRERVPVYNLIARATDGGG-- 1976
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1720431762 1977 RFCSSSVLLLLEDVNDN 1993
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2731-2859 1.28e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 1.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2731 LRTLQSNGIIMYTRA--NPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLALDDSYVERRR 2808
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720431762 2809 APLYFQTLSTDSAIFFGALVqadnvrSLTDTRVTQVLGGFQGCLDSVVLNH 2859
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLP------PLLLLPALPVRAGFVGCIRDVRVNG 125
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 437-527 6.14e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 6.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  437 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPP 516
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1720431762  517 MSATAIVRISI 527
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 330-428 4.54e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 4.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  330 HYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTIHSSidaVSMRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 407
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762  408 EFPYRRNLARVIVNVEDANDH 428
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1366-1462 1.19e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1366 TYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENPLEgdISIYLRALDGG 1444
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1720431762 1445 G--RTTFCTVRVIVVDENDN 1462
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 542-631 2.97e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  542 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG-- 614
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1720431762  615 MASNATISVQIVDENDN 631
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1794-1891 3.03e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 3.03e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1794 VYRGNVKESDPPGEVVAVLSTLDKDtSNINRQVSYHITGGNPRGQFALGmvQSEWKVYVKRPLDREEQDIYFLNITASDG 1873
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762 1874 ---LFVTQAMVEVTVSDVNDN 1891
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1057-1149 2.62e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 2.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1057 YTASINEDITMNTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGA 1133
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1720431762 1134 R-AEVTVDLLVDDINDN 1149
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 954-1045 4.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 4.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  954 PYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILREAFNSDLSNIdYGVTILAKDGGN 1031
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1720431762 1032 PSLSTFVELPITIV 1045
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 101-191 8.78e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 8.78e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  101 VYQIKLPERDrkKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 177
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1720431762  178 GRPQKSSTARLHIE 191
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1470-1565 8.55e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 8.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1470 EYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDG 1549
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1720431762 1550 GIPVRHSLIPVYIHVL 1565
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2317-2408 2.75e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2317 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 2395
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1720431762 2396 QQVSHTYIRVRVI 2408
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1264-1356 2.91e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.91e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1264 IYESYVSELAPRGHFVTCVQASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDG--- 1340
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1720431762 1341 LFTSTAQVHIRVLGAN 1356
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 853-946 1.52e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  853 YSTSISENSTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDH 928
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT---DG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762  929 LRVARVVVRV---NIEDVNDN 946
Cdd:cd11304     78 GGPPLSSTATvtiTVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1578-1676 3.62e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 3.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1578 QYSFTITEDTSIGSTVDTLR-----ILPNQSVRFSMVNGerpenNKEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 1652
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1720431762 1653 iplDKVDIVF--TVDVDVKVLDLNDN 1676
Cdd:cd11304     76 ---DGGGPPLssTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 764-843 7.31e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 7.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  764 IGVEVLKVSATDPDSEVPPELTYSLMEGSVDN-FLMDPNTGVLTIKN--NNLSKDHYMLIVRVSDG---KFYSTAMVTVM 837
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1720431762  838 VKEAMD 843
Cdd:cd11304     92 VLDVND 97
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2964-2999 1.66e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 63.81  E-value: 1.66e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720431762 2964 DVDECEREE-CENGGSCVNLFGSFFCNCTPGYVGQYC 2999
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 210-322 3.68e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 3.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  210 YNFTVMESDKVTEIVGVVSVQ----PANTPLWFDIVGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 285
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720431762  286 PLDAEQRSVYNMSVEVTDGTNI---AVTQVFIKVLDNNDN 322
Cdd:cd11304     59 PLDREEQSSYTLTVTATDGGGPplsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2427-2504 1.05e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2427 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 2497
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1720431762 2498 DVVVHVE 2504
Cdd:cd11304     87 TVTITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2923-2962 2.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 2.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720431762 2923 CESeitacfPNPCRNGGSCDPIGNTFVCSCKAGLTGVTCE 2962
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2889-2924 2.03e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 2.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720431762 2889 DACQ-RSPCLHGGSCSSLPsGGYQCSCLSQFTGTNCE 2924
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2107-2203 1.28e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.28e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2107 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPA 2186
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1720431762 2187 LSTAATVSIDLTDVNDN 2203
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-93 6.91e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 6.91e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762    1 MENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQST 80
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGGPPLSST 85

                           90
                   ....*....|...
gi 1720431762   81 IWVVVQVLDENDN 93
Cdd:cd11304     86 ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2211-2308 2.51e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.51e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2211 VYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIP 2290
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1720431762 2291 AMSSTTTVNIDISDVNDN 2308
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2001-2098 7.18e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2001 HYTACVYENTATKALLTRVQAMDPDVGINRKVVYSL-EDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpG 2079
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1720431762 2080 QSLSSLASVTITVLDINDN 2098
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1157-1256 1.50e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.50e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1157 TYNTTLSESSLIGTPVLQLVSTDADSGNNKLVRYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNG 1236
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1720431762 1237 FPSLSSEVLVQIYISDVNDN 1256
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1684-1786 2.77e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 2.77e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1684 TYETIIMEGMPVGTKLAQVRAIDMDWGANGQVTYSLHSDSHLEKvieaFNIDSNTGWISTLKDLDHETDPAFSFFVVASD 1763
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1720431762 1764 LGEaFSLSSMALVSVKVTDINDN 1786
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 639-745 1.49e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.49e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  639 QYSGSLSEAAPINSIVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVH 718
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1720431762  719 VRDSGNPQLTaeSPVEVNIEVTDVNDN 745
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1900-1993 3.67e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 3.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1900 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNNEFF-LDPESGELKTLAVLDRERVPVYNLIARATDGGG-- 1976
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1720431762 1977 RFCSSSVLLLLEDVNDN 1993
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2731-2859 1.28e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 1.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2731 LRTLQSNGIIMYTRA--NPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLALDDSYVERRR 2808
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720431762 2809 APLYFQTLSTDSAIFFGALVqadnvrSLTDTRVTQVLGGFQGCLDSVVLNH 2859
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLP------PLLLLPALPVRAGFVGCIRDVRVNG 125
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 437-527 6.14e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 6.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  437 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPP 516
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1720431762  517 MSATAIVRISI 527
Cdd:cd11304     82 LSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2126-2205 2.93e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.66  E-value: 2.93e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2126 ATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPALSTAATVSIDLTDVNDNPP 2205
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 330-428 4.54e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 4.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  330 HYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTIHSSidaVSMRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 407
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762  408 EFPYRRNLARVIVNVEDANDH 428
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2020-2100 6.25e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.89  E-value: 6.25e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2020 QAMDPDVGINRKVVYSLED-SASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQSLSSLASVTITVLDINDN 2098
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1720431762  2099 PP 2100
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 14-95 7.90e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.50  E-value: 7.90e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762    14 QAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDN 93
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1720431762    94 RP 95
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1366-1462 1.19e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1366 TYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENPLEgdISIYLRALDGG 1444
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1720431762 1445 G--RTTFCTVRVIVVDENDN 1462
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2231-2310 2.64e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 2.64e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2231 AEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPAMSSTTTVNIDISDVNDNSP 2310
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 542-631 2.97e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  542 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG-- 614
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1720431762  615 MASNATISVQIVDENDN 631
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2107-2198 4.74e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.53  E-value: 4.74e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2107 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPA 2186
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1720431762 2187 LSTAATVSIDLT 2198
Cdd:pfam00028   81 LSSTATVTITVL 92
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2703-2858 6.06e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.57  E-value: 6.06e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2703 SLSFAGNSYIKYRLSENSKEEdFKLALRLRTLQSNGIIMYT---RANPCMILKIVEGKLWFQLDCGSGPGILGiSSRAVN 2779
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762 2780 DGSWHSVFLELNRNFTSLALDDSYVERRRAPLYFQTLSTDSAIFFGALVQADNVRSLTDTRvtqvlgGFQGCLDSVVLN 2858
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP------GFVGCIRDLKVN 151
Cadherin pfam00028
Cadherin domain;
2212-2302 3.99e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 3.99e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2212 YSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPA 2291
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1720431762 2292 MSSTTTVNIDI 2302
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1178-1258 9.01e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 9.01e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1178 TDADSGNNKLVRYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGFPSLSSEVLVQIYISDVNDNP 1257
Cdd:smart00112    3 TDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1720431762  1258 P 1258
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 665-747 2.90e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 2.90e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762   665 RATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVHVRDSGNPQLTaeSPVEVNIEVTDVND 744
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1720431762   745 NPP 747
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1794-1891 3.03e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 3.03e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1794 VYRGNVKESDPPGEVVAVLSTLDKDtSNINRQVSYHITGGNPRGQFALGmvQSEWKVYVKRPLDREEQDIYFLNITASDG 1873
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762 1874 ---LFVTQAMVEVTVSDVNDN 1891
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1-88 7.90e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.36  E-value: 7.90e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762    1 MENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGSSPKQST 80
Cdd:pfam00028    6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 1720431762   81 IWVVVQVL 88
Cdd:pfam00028   85 ATVTITVL 92
LamG smart00282
Laminin G domain;
2726-2859 1.74e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.79  E-value: 1.74e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2726 KLALRLRTLQSNGIIMYTRANP---CMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLALDDS 2802
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggdYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720431762  2803 YVERRRAPLYFQTLSTDSAIFFGALVQADNVRSLTDTRvtqvlgGFQGCLDSVVLNH 2859
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP------GFRGCIRNLKVNG 131
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1057-1149 2.62e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 2.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1057 YTASINEDITMNTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGA 1133
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1720431762 1134 R-AEVTVDLLVDDINDN 1149
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2002-2093 5.01e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 5.01e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2002 YTACVYENTATKALLTRVQAMDPDVGINRKVVYS-LEDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQ 2080
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 1720431762 2081 SLSSLASVTITVL 2093
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1703-1788 1.31e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.31e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1703 RAIDMDWGANGQVTYSLHSDSHLEKvieaFNIDSNTGWISTLKDLDHETDPAFSFFVVASDLGEAfSLSSMALVSVKVTD 1782
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ....*.
gi 1720431762  1783 INDNAP 1788
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1918-1995 2.47e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 2.47e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1918 SAKDADIGSNGDIRYSL-YGSGNNEFFLDPESGELKTLAVLDRERVPVYNLIARATDGGG--RFCSSSVLLLLEDVNDNP 1994
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 1720431762  1995 P 1995
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 954-1045 4.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 4.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  954 PYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILREAFNSDLSNIdYGVTILAKDGGN 1031
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1720431762 1032 PSLSTFVELPITIV 1045
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 101-191 8.78e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 8.78e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  101 VYQIKLPERDrkKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 177
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1720431762  178 GRPQKSSTARLHIE 191
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
437-527 1.65e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 1.65e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  437 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPP 516
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1720431762  517 MSATAIVRISI 527
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1470-1565 8.55e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 8.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1470 EYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDG 1549
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1720431762 1550 GIPVRHSLIPVYIHVL 1565
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2317-2408 2.75e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2317 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 2395
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1720431762 2396 QQVSHTYIRVRVI 2408
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1264-1356 2.91e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.91e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1264 IYESYVSELAPRGHFVTCVQASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDG--- 1340
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1720431762 1341 LFTSTAQVHIRVLGAN 1356
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
1367-1456 3.60e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 3.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1367 YVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLID-SNGQIITTERLDRENPleGDISIYLRALDGGG 1445
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|.
gi 1720431762 1446 RTTFCTVRVIV 1456
Cdd:pfam00028   79 PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 565-633 4.53e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 4.53e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720431762   565 STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG--MASNATISVQIVDENDNPP 633
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
640-738 5.53e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 5.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  640 YSGSLSEAAPINSIVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVHV 719
Cdd:pfam00028    1 YSASVPENAPVGTEV-------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 1720431762  720 RDSGNPQLTAESPVEVNIE 738
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1900-1977 6.58e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 6.58e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762 1900 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYS-LYGSGNNEFFLDPESGELKTLAVLDRERVPVYNLIARATDGGGR 1977
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
1158-1250 4.02e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 4.02e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1158 YNTTLSESSLIGTPVLQLVSTDADSGNNKLVRYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGF 1237
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1720431762 1238 PSLSSEVLVQIYI 1250
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1078-1151 7.55e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 7.55e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431762  1078 SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGAR-AEVTVDLLVDDINDNPP 1151
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
542-625 7.73e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 7.73e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  542 YQAEVNENVDIGTSVILISAIS-----QSTLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMA--G 614
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|.
gi 1720431762  615 MASNATISVQI 625
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1385-1464 1.08e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 1.08e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1385 RATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENplEGDISIYLRALDGGG--RTTFCTVRVIVVDEND 1461
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREE--QPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1720431762  1462 NAP 1464
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1057-1142 1.48e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1057 YTASINEDITMNTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGA 1133
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1720431762 1134 R---AEVTVDLL 1142
Cdd:pfam00028   81 LsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
102-191 1.41e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 1.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  102 YQIKLPERDRkkRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 178
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1720431762  179 RPQKSSTARLHIE 191
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-430 1.49e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 1.49e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762   350 ATDRDE--KHKLSYTIHSSIDAvsmRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 427
Cdd:smart00112    2 ATDADSgeNGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1720431762   428 HSP 430
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1816-1893 1.83e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 1.83e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1816 DKDtSNINRQVSYHITGGNPRGQFALGMVQSEwkVYVKRPLDREEQDIYFLNITASDG---LFVTQAMVEVTVSDVNDNS 1892
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1720431762  1893 P 1893
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
331-423 1.85e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 1.85e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  331 YDVTISEDVLPDTEILQIEATDRDEK--HKLSYTIHSSIdavSMRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 408
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGG---PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1720431762  409 FPYRRNLARVIVNVE 423
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 123-191 3.80e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 3.80e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720431762   123 AFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 191
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 455-533 4.84e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 4.84e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762   455 TALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPPMSATAIVRISIS-MSDNS 533
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVNDNA 80
Cadherin pfam00028
Cadherin domain;
1685-1781 9.96e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 9.96e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1685 YETIIMEGMPVGTKLAQVRAIDMDWGANGQVTYSLHSDSHLEKvieaFNIDSNTGWISTLKDLDHETDPAFSFFVVASDL 1764
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*..
gi 1720431762 1765 GEAfSLSSMALVSVKVT 1781
Cdd:pfam00028   77 GGP-PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 853-946 1.52e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  853 YSTSISENSTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDH 928
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT---DG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762  929 LRVARVVVRV---NIEDVNDN 946
Cdd:cd11304     78 GGPPLSSTATvtiTVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1578-1676 3.62e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 3.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1578 QYSFTITEDTSIGSTVDTLR-----ILPNQSVRFSMVNGerpenNKEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 1652
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1720431762 1653 iplDKVDIVF--TVDVDVKVLDLNDN 1676
Cdd:cd11304     76 ---DGGGPPLssTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 764-843 7.31e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 7.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  764 IGVEVLKVSATDPDSEVPPELTYSLMEGSVDN-FLMDPNTGVLTIKN--NNLSKDHYMLIVRVSDG---KFYSTAMVTVM 837
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1720431762  838 VKEAMD 843
Cdd:cd11304     92 VLDVND 97
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2964-2999 1.66e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 63.81  E-value: 1.66e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720431762 2964 DVDECEREE-CENGGSCVNLFGSFFCNCTPGYVGQYC 2999
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin pfam00028
Cadherin domain;
955-1044 3.44e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 3.44e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  955 YYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILREAFNSDLSNIdYGVTILAKDGGNP 1032
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1720431762 1033 SLSTFVELPITI 1044
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1471-1565 1.75e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 1.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1471 YRASVRADVGRGHLVTQVQALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGG 1550
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1720431762 1551 IPVRHSLIPVYIHVL 1565
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 210-322 3.68e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 3.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  210 YNFTVMESDKVTEIVGVVSVQ----PANTPLWFDIVGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 285
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720431762  286 PLDAEQRSVYNMSVEVTDGTNI---AVTQVFIKVLDNNDN 322
Cdd:cd11304     59 PLDREEQSSYTLTVTATDGGGPplsSTATVTITVLDVNDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
2964-2999 1.22e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 58.80  E-value: 1.22e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720431762  2964 DVDECERE-ECENGGSCVNLFGSFFCNCTPGYV-GQYC 2999
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
Cadherin pfam00028
Cadherin domain;
1265-1353 2.00e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 2.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1265 YESYVSELAPRGHFVTCVQASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDGLF 1342
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1720431762 1343 ---TSTAQVHIRVL 1353
Cdd:pfam00028   79 pplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2335-2415 3.12e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 3.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2335 VVTDRDSFHNGPpFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKPQQVSHTYIRVRVIEESTH 2413
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1720431762  2414 KP 2415
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1795-1885 4.82e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 4.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1795 YRGNVKESDPPGEVVAVLSTLDKDTSNiNRQVSYHITGGNPRGQFAL----GMVqsewkvYVKRPLDREEQDIYFLNITA 1870
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIdpdtGDI------STTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*...
gi 1720431762 1871 SDGLF---VTQAMVEVTV 1885
Cdd:pfam00028   74 TDSGGpplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 973-1045 5.08e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 5.08e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431762   973 TAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILREAFNSDLSNIdYGVTILAKDGGNPSLSTFVELPITIV 1045
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
2317-2408 5.86e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 5.86e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2317 YTAVIQENKPVGTSILQLVVTDRDSFHNGPPFsFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 2395
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1720431762 2396 QQVSHTYIRVRVI 2408
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
853-923 1.16e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.16e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720431762  853 YSTSISENSTNITKVAIVNAV----GnrLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEAS 923
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1489-1565 2.35e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 2.35e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720431762  1489 QALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGGIPVRHSLIPVYIHVL 1565
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-324 3.18e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 3.18e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720431762   265 GGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDGTNI---AVTQVFIKVLDNNDNGP 324
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 878-948 3.83e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 3.83e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720431762   878 NEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDHLRVARVVVRV---NIEDVNDNSP 948
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEAT---DGGGPPLSSTATvtiTVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1600-1678 4.94e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.43  E-value: 4.94e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1600 PNQSVRFSMVNGerpenNKEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAATiplDKVDIVF--TVDVDVKVLDLNDNK 1677
Cdd:smart00112    9 ENGKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGGPPLssTATVTITVLDVNDNA 80


                    .
gi 1720431762  1678 P 1678
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1283-1356 7.82e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 7.82e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762  1283 QASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDG---LFTSTAQVHIRVLGAN 1356
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVN 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2427-2504 1.05e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2427 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 2497
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1720431762 2498 DVVVHVE 2504
Cdd:cd11304     87 TVTITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2923-2962 2.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 2.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720431762 2923 CESeitacfPNPCRNGGSCDPIGNTFVCSCKAGLTGVTCE 2962
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2889-2924 2.03e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 2.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720431762 2889 DACQ-RSPCLHGGSCSSLPsGGYQCSCLSQFTGTNCE 2924
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
1579-1652 3.81e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 3.81e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762 1579 YSFTITEDTSIGSTVDTLRIL-----PNQSVRFSMVNGERpennkEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 1652
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlgPNGRIFYSILGGGP-----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 772-843 8.95e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 8.95e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762   772 SATDPDSEVPPELTYSLMEGSVDN-FLMDPNTGVLTIkNNNL---SKDHYMLIVRVSDG---KFYSTAMVTVMVKEAMD 843
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITT-TKPLdreEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2930-2958 9.53e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.38  E-value: 9.53e-07
                           10        20
                   ....*....|....*....|....*....
gi 1720431762 2930 CFPNPCRNGGSCDPIGNTFVCSCKAGLTG 2958
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2968-2998 2.19e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.19e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720431762 2968 CEREECENGGSCVNLFGSFFCNCTPGYVGQY 2998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
764-838 3.35e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 3.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  764 IGVEVLKVSATDPDSEVPPELTYSLMEGSVDN-FLMDPNTGVLTIKnNNL---SKDHYMLIVRVSDGKFY---STAMVTV 836
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT-KPLdreSIGEYELTVEATDSGGPplsSTATVTI 89


                   ..
gi 1720431762  837 MV 838
Cdd:pfam00028   90 TV 91
EGF_CA smart00179
Calcium-binding EGF-like domain;
2923-2962 3.45e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 3.45e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1720431762  2923 CESeitacfPNPCRNGGSCDPIGNTFVCSCKAGLT-GVTCE 2962
Cdd:smart00179    5 CAS------GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
210-317 4.77e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 4.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  210 YNFTVMESDKVTEIVGVVSVQPANTPLwfdivggkHAREMFYILqtacgqncsteGGNFDSSFDAEKGVGTIVIAKPLDA 289
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--------NGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDR 61

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1720431762  290 EQRSVYNMSVEVTD-GTNI--AVTQVFIKVL 317
Cdd:pfam00028   62 ESIGEYELTVEATDsGGPPlsSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
2889-2924 5.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 5.26e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720431762  2889 DACQ-RSPCLHGGSCSSLPsGGYQCSCLSQFT-GTNCE 2924
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2891-2920 2.31e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 2.31e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720431762 2891 CQRSPCLHGGSCSSLPsGGYQCSCLSQFTG 2920
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2107-2203 1.28e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.28e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2107 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPA 2186
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1720431762 2187 LSTAATVSIDLTDVNDN 2203
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-93 6.91e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 6.91e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762    1 MENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQST 80
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGGPPLSST 85

                           90
                   ....*....|...
gi 1720431762   81 IWVVVQVLDENDN 93
Cdd:cd11304     86 ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2211-2308 2.51e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.51e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2211 VYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIP 2290
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1720431762 2291 AMSSTTTVNIDISDVNDN 2308
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2001-2098 7.18e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2001 HYTACVYENTATKALLTRVQAMDPDVGINRKVVYSL-EDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpG 2079
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1720431762 2080 QSLSSLASVTITVLDINDN 2098
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1157-1256 1.50e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.50e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1157 TYNTTLSESSLIGTPVLQLVSTDADSGNNKLVRYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNG 1236
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1720431762 1237 FPSLSSEVLVQIYISDVNDN 1256
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1684-1786 2.77e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 2.77e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1684 TYETIIMEGMPVGTKLAQVRAIDMDWGANGQVTYSLHSDSHLEKvieaFNIDSNTGWISTLKDLDHETDPAFSFFVVASD 1763
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1720431762 1764 LGEaFSLSSMALVSVKVTDINDN 1786
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 639-745 1.49e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 1.49e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  639 QYSGSLSEAAPINSIVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVH 718
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1720431762  719 VRDSGNPQLTaeSPVEVNIEVTDVNDN 745
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1900-1993 3.67e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 3.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1900 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNNEFF-LDPESGELKTLAVLDRERVPVYNLIARATDGGG-- 1976
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1720431762 1977 RFCSSSVLLLLEDVNDN 1993
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2731-2859 1.28e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 1.28e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2731 LRTLQSNGIIMYTRA--NPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLALDDSYVERRR 2808
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720431762 2809 APLYFQTLSTDSAIFFGALVqadnvrSLTDTRVTQVLGGFQGCLDSVVLNH 2859
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLP------PLLLLPALPVRAGFVGCIRDVRVNG 125
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 437-527 6.14e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 6.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  437 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPP 516
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1720431762  517 MSATAIVRISI 527
Cdd:cd11304     82 LSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2126-2205 2.93e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.66  E-value: 2.93e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2126 ATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPALSTAATVSIDLTDVNDNPP 2205
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 330-428 4.54e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 4.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  330 HYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTIHSSidaVSMRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 407
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762  408 EFPYRRNLARVIVNVEDANDH 428
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2020-2100 6.25e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.89  E-value: 6.25e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2020 QAMDPDVGINRKVVYSLED-SASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQSLSSLASVTITVLDINDN 2098
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1720431762  2099 PP 2100
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 14-95 7.90e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.50  E-value: 7.90e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762    14 QAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDN 93
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1720431762    94 RP 95
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1366-1462 1.19e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.19e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1366 TYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENPLEgdISIYLRALDGG 1444
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1720431762 1445 G--RTTFCTVRVIVVDENDN 1462
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2231-2310 2.64e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 2.64e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2231 AEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPAMSSTTTVNIDISDVNDNSP 2310
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 542-631 2.97e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  542 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG-- 614
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1720431762  615 MASNATISVQIVDENDN 631
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2107-2198 4.74e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.53  E-value: 4.74e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2107 YLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPA 2186
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1720431762 2187 LSTAATVSIDLT 2198
Cdd:pfam00028   81 LSSTATVTITVL 92
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2703-2858 6.06e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.57  E-value: 6.06e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2703 SLSFAGNSYIKYRLSENSKEEdFKLALRLRTLQSNGIIMYT---RANPCMILKIVEGKLWFQLDCGSGPGILGiSSRAVN 2779
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762 2780 DGSWHSVFLELNRNFTSLALDDSYVERRRAPLYFQTLSTDSAIFFGALVQADNVRSLTDTRvtqvlgGFQGCLDSVVLN 2858
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP------GFVGCIRDLKVN 151
Cadherin pfam00028
Cadherin domain;
2212-2302 3.99e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 3.99e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2212 YSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPA 2291
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1720431762 2292 MSSTTTVNIDI 2302
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1178-1258 9.01e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 9.01e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1178 TDADSGNNKLVRYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGFPSLSSEVLVQIYISDVNDNP 1257
Cdd:smart00112    3 TDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1720431762  1258 P 1258
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 665-747 2.90e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 2.90e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762   665 RATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVHVRDSGNPQLTaeSPVEVNIEVTDVND 744
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1720431762   745 NPP 747
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1794-1891 3.03e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 3.03e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1794 VYRGNVKESDPPGEVVAVLSTLDKDtSNINRQVSYHITGGNPRGQFALGmvQSEWKVYVKRPLDREEQDIYFLNITASDG 1873
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762 1874 ---LFVTQAMVEVTVSDVNDN 1891
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1-88 7.90e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.36  E-value: 7.90e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762    1 MENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGSSPKQST 80
Cdd:pfam00028    6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 1720431762   81 IWVVVQVL 88
Cdd:pfam00028   85 ATVTITVL 92
LamG smart00282
Laminin G domain;
2726-2859 1.74e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.79  E-value: 1.74e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2726 KLALRLRTLQSNGIIMYTRANP---CMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLALDDS 2802
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggdYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720431762  2803 YVERRRAPLYFQTLSTDSAIFFGALVQADNVRSLTDTRvtqvlgGFQGCLDSVVLNH 2859
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP------GFRGCIRNLKVNG 131
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1057-1149 2.62e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 2.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1057 YTASINEDITMNTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGA 1133
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1720431762 1134 R-AEVTVDLLVDDINDN 1149
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2002-2093 5.01e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 5.01e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2002 YTACVYENTATKALLTRVQAMDPDVGINRKVVYS-LEDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSpGQ 2080
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 1720431762 2081 SLSSLASVTITVL 2093
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1703-1788 1.31e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.31e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1703 RAIDMDWGANGQVTYSLHSDSHLEKvieaFNIDSNTGWISTLKDLDHETDPAFSFFVVASDLGEAfSLSSMALVSVKVTD 1782
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ....*.
gi 1720431762  1783 INDNAP 1788
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1918-1995 2.47e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 2.47e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1918 SAKDADIGSNGDIRYSL-YGSGNNEFFLDPESGELKTLAVLDRERVPVYNLIARATDGGG--RFCSSSVLLLLEDVNDNP 1994
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 1720431762  1995 P 1995
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 954-1045 4.85e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 4.85e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  954 PYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILREAFNSDLSNIdYGVTILAKDGGN 1031
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1720431762 1032 PSLSTFVELPITIV 1045
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 101-191 8.78e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 8.78e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  101 VYQIKLPERDrkKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 177
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1720431762  178 GRPQKSSTARLHIE 191
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
437-527 1.65e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 1.65e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  437 YEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPP 516
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1720431762  517 MSATAIVRISI 527
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1470-1565 8.55e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 8.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1470 EYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDG 1549
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1720431762 1550 GIPVRHSLIPVYIHVL 1565
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2317-2408 2.75e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2317 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 2395
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1720431762 2396 QQVSHTYIRVRVI 2408
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1264-1356 2.91e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.91e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1264 IYESYVSELAPRGHFVTCVQASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDG--- 1340
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1720431762 1341 LFTSTAQVHIRVLGAN 1356
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
1367-1456 3.60e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 3.60e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1367 YVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLID-SNGQIITTERLDRENPleGDISIYLRALDGGG 1445
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|.
gi 1720431762 1446 RTTFCTVRVIV 1456
Cdd:pfam00028   79 PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 565-633 4.53e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 4.53e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720431762   565 STLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAG--MASNATISVQIVDENDNPP 633
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
640-738 5.53e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 5.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  640 YSGSLSEAAPINSIVrsldnspLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVHV 719
Cdd:pfam00028    1 YSASVPENAPVGTEV-------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 1720431762  720 RDSGNPQLTAESPVEVNIE 738
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1900-1977 6.58e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 6.58e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762 1900 YSASLPEDIPSNKIILKVSAKDADIGSNGDIRYS-LYGSGNNEFFLDPESGELKTLAVLDRERVPVYNLIARATDGGGR 1977
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
1158-1250 4.02e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 4.02e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1158 YNTTLSESSLIGTPVLQLVSTDADSGNNKLVRYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGF 1237
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1720431762 1238 PSLSSEVLVQIYI 1250
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1078-1151 7.55e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 7.55e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431762  1078 SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGAR-AEVTVDLLVDDINDNPP 1151
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
542-625 7.73e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 7.73e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  542 YQAEVNENVDIGTSVILISAIS-----QSTLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMA--G 614
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|.
gi 1720431762  615 MASNATISVQI 625
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1385-1464 1.08e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 1.08e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1385 RATDGDPGTYGQVSYSIINDFAKDRFLIDSN-GQIITTERLDRENplEGDISIYLRALDGGG--RTTFCTVRVIVVDEND 1461
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREE--QPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1720431762  1462 NAP 1464
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1057-1142 1.48e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1057 YTASINEDITMNTPILSINAT---SPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGA 1133
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1720431762 1134 R---AEVTVDLL 1142
Cdd:pfam00028   81 LsstATVTITVL 92
Laminin_G_1 pfam00054
Laminin G domain;
2732-2859 1.34e-15

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 75.82  E-value: 1.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2732 RTLQSNGIIMYTRANP---CMILKIVEGKLWFQLDCGSGPGILGISSRaVNDGSWHSVFLELNRNFTSLALDDSYVERRR 2808
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTerdFLALELRDGRLEVSYDLGSGAAVVRSGDK-LNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720431762 2809 APL-YFQTLSTDSAIFFGALVQADNVRSLTDTRVtqvlgGFQGCLDSVVLNH 2859
Cdd:pfam00054   81 SPLgATTDLDVDGPLYVGGLPSLGVKKRRLAISP-----SFDGCIRDVIVNG 127
Cadherin pfam00028
Cadherin domain;
102-191 1.41e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 1.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  102 YQIKLPERDRkkRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 178
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1720431762  179 RPQKSSTARLHIE 191
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-430 1.49e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 1.49e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762   350 ATDRDE--KHKLSYTIHSSIDAvsmRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 427
Cdd:smart00112    2 ATDADSgeNGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1720431762   428 HSP 430
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1816-1893 1.83e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 1.83e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1816 DKDtSNINRQVSYHITGGNPRGQFALGMVQSEwkVYVKRPLDREEQDIYFLNITASDG---LFVTQAMVEVTVSDVNDNS 1892
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1720431762  1893 P 1893
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
331-423 1.85e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 1.85e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  331 YDVTISEDVLPDTEILQIEATDRDEK--HKLSYTIHSSIdavSMRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 408
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGG---PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1720431762  409 FPYRRNLARVIVNVE 423
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 123-191 3.80e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 3.80e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720431762   123 AFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 191
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 455-533 4.84e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 4.84e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762   455 TALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPPMSATAIVRISIS-MSDNS 533
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVNDNA 80
Cadherin pfam00028
Cadherin domain;
1685-1781 9.96e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 9.96e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1685 YETIIMEGMPVGTKLAQVRAIDMDWGANGQVTYSLHSDSHLEKvieaFNIDSNTGWISTLKDLDHETDPAFSFFVVASDL 1764
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*..
gi 1720431762 1765 GEAfSLSSMALVSVKVT 1781
Cdd:pfam00028   77 GGP-PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 853-946 1.52e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  853 YSTSISENSTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDH 928
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT---DG 77

                           90       100
                   ....*....|....*....|.
gi 1720431762  929 LRVARVVVRV---NIEDVNDN 946
Cdd:cd11304     78 GGPPLSSTATvtiTVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1578-1676 3.62e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 3.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1578 QYSFTITEDTSIGSTVDTLR-----ILPNQSVRFSMVNGerpenNKEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 1652
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1720431762 1653 iplDKVDIVF--TVDVDVKVLDLNDN 1676
Cdd:cd11304     76 ---DGGGPPLssTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 764-843 7.31e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 7.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  764 IGVEVLKVSATDPDSEVPPELTYSLMEGSVDN-FLMDPNTGVLTIKN--NNLSKDHYMLIVRVSDG---KFYSTAMVTVM 837
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1720431762  838 VKEAMD 843
Cdd:cd11304     92 VLDVND 97
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2964-2999 1.66e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 63.81  E-value: 1.66e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720431762 2964 DVDECEREE-CENGGSCVNLFGSFFCNCTPGYVGQYC 2999
Cdd:cd00054      1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin pfam00028
Cadherin domain;
955-1044 3.44e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 3.44e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  955 YYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILREAFNSDLSNIdYGVTILAKDGGNP 1032
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGE-YELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1720431762 1033 SLSTFVELPITI 1044
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1471-1565 1.75e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 1.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1471 YRASVRADVGRGHLVTQVQALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGG 1550
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1720431762 1551 IPVRHSLIPVYIHVL 1565
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 210-322 3.68e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 3.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  210 YNFTVMESDKVTEIVGVVSVQ----PANTPLWFDIVGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 285
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1720431762  286 PLDAEQRSVYNMSVEVTDGTNI---AVTQVFIKVLDNNDN 322
Cdd:cd11304     59 PLDREEQSSYTLTVTATDGGGPplsSTATVTITVLDVNDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
2964-2999 1.22e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 58.80  E-value: 1.22e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720431762  2964 DVDECERE-ECENGGSCVNLFGSFFCNCTPGYV-GQYC 2999
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
Cadherin pfam00028
Cadherin domain;
1265-1353 2.00e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 2.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1265 YESYVSELAPRGHFVTCVQASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDGLF 1342
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1720431762 1343 ---TSTAQVHIRVL 1353
Cdd:pfam00028   79 pplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2335-2415 3.12e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 3.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  2335 VVTDRDSFHNGPpFSFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKPQQVSHTYIRVRVIEESTH 2413
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1720431762  2414 KP 2415
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
1795-1885 4.82e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 4.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 1795 YRGNVKESDPPGEVVAVLSTLDKDTSNiNRQVSYHITGGNPRGQFAL----GMVqsewkvYVKRPLDREEQDIYFLNITA 1870
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIdpdtGDI------STTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*...
gi 1720431762 1871 SDGLF---VTQAMVEVTV 1885
Cdd:pfam00028   74 TDSGGpplSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 973-1045 5.08e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 5.08e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431762   973 TAIDKDKGANGEVTYVL--QDDYGHFEINPNSGNVILREAFNSDLSNIdYGVTILAKDGGNPSLSTFVELPITIV 1045
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
2317-2408 5.86e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 5.86e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2317 YTAVIQENKPVGTSILQLVVTDRDSFHNGPPFsFSILSGNEDEEFMLDSH-GILRSAVVFRHMESPEYLLCIQAKDSGKP 2395
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1720431762 2396 QQVSHTYIRVRVI 2408
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
853-923 1.16e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 1.16e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720431762  853 YSTSISENSTNITKVAIVNAV----GnrLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEAS 923
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1489-1565 2.35e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 2.35e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720431762  1489 QALDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGGIPVRHSLIPVYIHVL 1565
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-324 3.18e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 3.18e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720431762   265 GGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDGTNI---AVTQVFIKVLDNNDNGP 324
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 878-948 3.83e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 3.83e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720431762   878 NEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASrelDHLRVARVVVRV---NIEDVNDNSP 948
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEAT---DGGGPPLSSTATvtiTVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1600-1678 4.94e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.43  E-value: 4.94e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  1600 PNQSVRFSMVNGerpenNKEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAATiplDKVDIVF--TVDVDVKVLDLNDNK 1677
Cdd:smart00112    9 ENGKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGGPPLssTATVTITVLDVNDNA 80


                    .
gi 1720431762  1678 P 1678
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1283-1356 7.82e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 7.82e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762  1283 QASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSH--RKQRmePLYSLNVSVSDG---LFTSTAQVHIRVLGAN 1356
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVN 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2427-2504 1.05e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2427 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 2497
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1720431762 2498 DVVVHVE 2504
Cdd:cd11304     87 TVTITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2923-2962 2.01e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 2.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720431762 2923 CESeitacfPNPCRNGGSCDPIGNTFVCSCKAGLTGVTCE 2962
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2889-2924 2.03e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 2.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720431762 2889 DACQ-RSPCLHGGSCSSLPsGGYQCSCLSQFTGTNCE 2924
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
1579-1652 3.81e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 3.81e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762 1579 YSFTITEDTSIGSTVDTLRIL-----PNQSVRFSMVNGERpennkEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAAT 1652
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlgPNGRIFYSILGGGP-----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2967-2999 7.61e-07

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 47.86  E-value: 7.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720431762 2967 ECERE-ECENGGSCVNLFGSFFCNCTPGYVGQ-YC 2999
Cdd:cd00053      1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGDrSC 35
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 772-843 8.95e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 8.95e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720431762   772 SATDPDSEVPPELTYSLMEGSVDN-FLMDPNTGVLTIkNNNL---SKDHYMLIVRVSDG---KFYSTAMVTVMVKEAMD 843
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITT-TKPLdreEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2930-2958 9.53e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.38  E-value: 9.53e-07
                           10        20
                   ....*....|....*....|....*....
gi 1720431762 2930 CFPNPCRNGGSCDPIGNTFVCSCKAGLTG 2958
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2968-2998 2.19e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.19e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720431762 2968 CEREECENGGSCVNLFGSFFCNCTPGYVGQY 2998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
764-838 3.35e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 3.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  764 IGVEVLKVSATDPDSEVPPELTYSLMEGSVDN-FLMDPNTGVLTIKnNNL---SKDHYMLIVRVSDGKFY---STAMVTV 836
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT-KPLdreSIGEYELTVEATDSGGPplsSTATVTI 89


                   ..
gi 1720431762  837 MV 838
Cdd:pfam00028   90 TV 91
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2973-2994 7.09e-06

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 45.02  E-value: 7.09e-06
                           10        20
                   ....*....|....*....|..
gi 1720431762 2973 CENGGSCVNLFGSFFCNCTPGY 2994
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2932-2962 1.88e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.00  E-value: 1.88e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720431762 2932 PNPCRNGGSCDPIGNTFVCSCKAGLTGV-TCE 2962
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
2923-2962 3.45e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 3.45e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1720431762  2923 CESeitacfPNPCRNGGSCDPIGNTFVCSCKAGLT-GVTCE 2962
Cdd:smart00179    5 CAS------GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2110-2203 3.52e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.03  E-value: 3.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762 2110 TVPEDTSLGTQVLSVfatSKDIGTNAEITYLIRS-GNEQ--GKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPA 2186
Cdd:cd00031      5 SAVEGRSRGSFRVSI---PTDLIASSGEIIKISAaGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                           90
                   ....*....|....*..
gi 1720431762 2187 LSTAATVSIDLTDVNDN 2203
Cdd:cd00031     82 PQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
210-317 4.77e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 4.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  210 YNFTVMESDKVTEIVGVVSVQPANTPLwfdivggkHAREMFYILqtacgqncsteGGNFDSSFDAEKGVGTIVIAKPLDA 289
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--------NGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDR 61

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1720431762  290 EQRSVYNMSVEVTD-GTNI--AVTQVFIKVL 317
Cdd:pfam00028   62 ESIGEYELTVEATDsGGPPlsSTATVTITVL 92
EGF_CA pfam07645
Calcium-binding EGF domain;
2964-2993 4.96e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 4.96e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720431762 2964 DVDEC--EREECENGGSCVNLFGSFFCNCTPG 2993
Cdd:pfam07645    1 DVDECatGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2889-2924 5.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 5.26e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720431762  2889 DACQ-RSPCLHGGSCSSLPsGGYQCSCLSQFT-GTNCE 2924
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2891-2924 5.42e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 42.85  E-value: 5.42e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720431762 2891 CQRS-PCLHGGSCSSLPsGGYQCSCLSQFTG-TNCE 2924
Cdd:cd00053      2 CAASnPCSNGGTCVNTP-GSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2891-2920 2.31e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 2.31e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720431762 2891 CQRSPCLHGGSCSSLPsGGYQCSCLSQFTG 2920
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
EGF smart00181
Epidermal growth factor-like domain;
2967-2999 2.54e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.58  E-value: 2.54e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1720431762  2967 ECEREE-CENGgSCVNLFGSFFCNCTPGYVGQ-YC 2999
Cdd:smart00181    1 ECASGGpCSNG-TCINTPGSYTCSCPPGYTGDkRC 34
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2935-2955 7.80e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.24  E-value: 7.80e-04
                           10        20
                   ....*....|....*....|.
gi 1720431762 2935 CRNGGSCDPIGNTFVCSCKAG 2955
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPG 21
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 679-745 8.96e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.18  E-value: 8.96e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  679 YQIVESTAKK---FFTVDSSTGAIRTIANLDHEAIAHFHFHVHVRDSGNPqlTAESPVEVNIEVTDVNDN 745
Cdd:cd00031     31 IKISAAGKEAlpsWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN--VPQTSSVFSIEVYDENDN 98
Cadherin_3 pfam16184
Cadherin-like;
732-826 2.99e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.89  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431762  732 PVEVNIEVTDVNDNPPVftqAVFETVLLLP----TYIGVEVLkvSATDPDSevPPE-LTYSLMEG--------------S 792
Cdd:pfam16184    4 PFTFNITIIPVNDEAPV---LTTNTGLRLWegssRPITPDLL--QAEDPDT--PPEdLTYTVVQGpshghlalkgapglP 76

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1720431762  793 VDNF-LMDPNTGVLTIKNNNLSKDHYMLIVRVSDG 826
Cdd:pfam16184   77 VTNFtQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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