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Conserved domains on  [gi|1720361286|ref|XP_030100933|]
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pre-B lymphocyte protein 3 isoform X2 [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
27-115 5.85e-25

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04984:

Pssm-ID: 472250  Cd Length: 105  Bit Score: 90.60  E-value: 5.85e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  27 PGQDAHLSCTINSQhaTAGDIGVSWYQQQPGSAPHLLYYYaeeEHYRPADIPDRFSATVDAahNACILTISPVLPEDDAD 106
Cdd:cd04984    12 PGETVTITCTGSSG--NISGNYVNWYQQKPGSAPRYLIYE---DKHRPSGIPDRFSGSKSG--NTASLTISGAQTEDEAD 84

                  ....*....
gi 1720361286 107 YFCSIAHTF 115
Cdd:cd04984    85 YYCQVWDSN 93
 
Name Accession Description Interval E-value
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
27-115 5.85e-25

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 90.60  E-value: 5.85e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  27 PGQDAHLSCTINSQhaTAGDIGVSWYQQQPGSAPHLLYYYaeeEHYRPADIPDRFSATVDAahNACILTISPVLPEDDAD 106
Cdd:cd04984    12 PGETVTITCTGSSG--NISGNYVNWYQQKPGSAPRYLIYE---DKHRPSGIPDRFSGSKSG--NTASLTISGAQTEDEAD 84

                  ....*....
gi 1720361286 107 YFCSIAHTF 115
Cdd:cd04984    85 YYCQVWDSN 93
IGv smart00406
Immunoglobulin V-Type;
30-111 1.64e-13

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 60.86  E-value: 1.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286   30 DAHLSCTinSQHATAGDIGVSWYQQQPGSAP-HLLYYYAEEEHYRPADIPDRFSATVDAAHNACILTISPVLPEDDADYF 108
Cdd:smart00406   1 SVTLSCK--FSGSTFSSYYVSWVRQPPGKGLeWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYY 78

                   ...
gi 1720361286  109 CSI 111
Cdd:smart00406  79 CAV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
28-116 1.80e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.01  E-value: 1.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  28 GQDAHLSCTINSQHATAGDiGVSWYQQQPGSAP-HLLYYYAEEEHYRPadIPDRFSATVDAAHNACILTISPVLPEDDAD 106
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPtFLIAYYSNGSEEGV--KKGRFSGRGDPSNGDGSLTIQNLTLSDSGT 87
                          90
                  ....*....|
gi 1720361286 107 YFCSIAHTFE 116
Cdd:pfam07686  88 YTCAVIPSGE 97
 
Name Accession Description Interval E-value
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
27-115 5.85e-25

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 90.60  E-value: 5.85e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  27 PGQDAHLSCTINSQhaTAGDIGVSWYQQQPGSAPHLLYYYaeeEHYRPADIPDRFSATVDAahNACILTISPVLPEDDAD 106
Cdd:cd04984    12 PGETVTITCTGSSG--NISGNYVNWYQQKPGSAPRYLIYE---DKHRPSGIPDRFSGSKSG--NTASLTISGAQTEDEAD 84

                  ....*....
gi 1720361286 107 YFCSIAHTF 115
Cdd:cd04984    85 YYCQVWDSN 93
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
27-109 1.89e-21

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 82.00  E-value: 1.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  27 PGQDAHLSCTINSQHATAGdigVSWYQQQPGSAPHLLYYYAEEEHYRPADIPDRFSATVDAAhNACILTISPVLPEDDAD 106
Cdd:cd00099    12 EGESVTLSCEVSSSFSSTY---IYWYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFSGSRDGT-SSFSLTISNLQPEDSGT 87

                  ...
gi 1720361286 107 YFC 109
Cdd:cd00099    88 YYC 90
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
27-115 4.47e-17

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 70.50  E-value: 4.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  27 PGQDAHLSCTINSqhaTAGDIGVSWYQQQPGSAPHLLYYYAEeehYRPADIPDRFSATvdAAHNACILTISPVLPEDDAD 106
Cdd:cd04980    14 PGERVTISCKASQ---SISSNYLAWYQQKPGQAPKLLIYYAS---TLHSGVPSRFSGS--GSGTDFTLTISSVEPEDAAV 85

                  ....*....
gi 1720361286 107 YFCSIAHTF 115
Cdd:cd04980    86 YYCQQGYTF 94
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
26-110 2.18e-16

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 68.85  E-value: 2.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  26 FPGQDAHLSCTINSQHATagdigVSWYQQQPGSAPHLLYYYAEEEHYRPADIP-DRFSAT-VDAAHnaCILTISPVLPED 103
Cdd:cd05899    11 RRGQSVTLRCSQKSGHDN-----MYWYRQDPGKGLQLLFYSYGGGLNEEGDLPgDRFSASrPSLTR--SSLTIKSAEPED 83

                  ....*..
gi 1720361286 104 DADYFCS 110
Cdd:cd05899    84 SAVYLCA 90
IGv smart00406
Immunoglobulin V-Type;
30-111 1.64e-13

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 60.86  E-value: 1.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286   30 DAHLSCTinSQHATAGDIGVSWYQQQPGSAP-HLLYYYAEEEHYRPADIPDRFSATVDAAHNACILTISPVLPEDDADYF 108
Cdd:smart00406   1 SVTLSCK--FSGSTFSSYYVSWVRQPPGKGLeWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYY 78

                   ...
gi 1720361286  109 CSI 111
Cdd:smart00406  79 CAV 81
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
28-109 7.28e-13

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 59.98  E-value: 7.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  28 GQDAHLSCTinsqHATAGDIGVSWYQQQPGSAP-HLLYYYAEEEHYRPadipDRFSATVDAAHNACILTISPVLPEDDAD 106
Cdd:cd04983    13 GENVTLNCN----YSTSTFYYLFWYRQYPGQGPqFLIYISSDSGNKKK----GRFSATLDKSRKSSSLHISAAQLSDSAV 84

                  ...
gi 1720361286 107 YFC 109
Cdd:cd04983    85 YFC 87
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
28-116 1.80e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.01  E-value: 1.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  28 GQDAHLSCTINSQHATAGDiGVSWYQQQPGSAP-HLLYYYAEEEHYRPadIPDRFSATVDAAHNACILTISPVLPEDDAD 106
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPtFLIAYYSNGSEEGV--KKGRFSGRGDPSNGDGSLTIQNLTLSDSGT 87
                          90
                  ....*....|
gi 1720361286 107 YFCSIAHTFE 116
Cdd:pfam07686  88 YTCAVIPSGE 97
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
27-111 5.54e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 55.06  E-value: 5.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  27 PGQDAHLSCTINSQHATAGDIgvSWYQQQPGSAP-HLLYYYAEEEHYRPADIP-DRFSATVDAAHNACILTISPVLPEDD 104
Cdd:cd04982    12 ESKSVTISCKVSGIDFSTTYI--HWYRQKPGQALeRLLYVSSTSAVRKDSGKTkNKFEARKDVGKSTSTLTITNLEKEDS 89

                  ....*..
gi 1720361286 105 ADYFCSI 111
Cdd:cd04982    90 ATYYCAY 96
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
27-109 1.07e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.96  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286   27 PGQDAHLSCTINSqhatAGDIGVSWYQQQPgsaphllyyyaeeehyRPADIPDRFSATVDaaHNACILTISPVLPEDDAD 106
Cdd:smart00410   8 EGESVTLSCEASG----SPPPEVTWYKQGG----------------KLLAESGRFSVSRS--GSTSTLTISNVTPEDSGT 65

                   ...
gi 1720361286  107 YFC 109
Cdd:smart00410  66 YTC 68
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
27-109 1.41e-07

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 46.15  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  27 PGQDAHLSCTINSqhATAGDIGVSWYQQQPGSAPH---LLYYYAEEEHYRPaDIPDRFSATVDAAHNACILTISPVLPED 103
Cdd:cd04981    12 PGQSLKLSCKASG--FTFTSYGMGWVRQAPGKGLEwigLIYPGGGDTYYAD-SFKGRFTITRDTSKSTAYLQLNSLTSED 88

                  ....*.
gi 1720361286 104 DADYFC 109
Cdd:cd04981    89 TAVYYC 94
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
28-111 7.87e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 44.43  E-value: 7.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  28 GQDAHLSCTINSQHaTAGDIgvSWYQQQP-GSAPHLLYYYAEEEHyrpaDIPDRFSATVDAAHNACILTISPVLPEDDAD 106
Cdd:cd07706    14 GEEVTLNCRYETSW-TNYYL--FWYKQLPsGEMTFLIRQDSSEQN----AKSGRYSVNFQKAQKSISLTISALQLEDSAK 86

                  ....*
gi 1720361286 107 YFCSI 111
Cdd:cd07706    87 YFCAL 91
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
28-111 2.08e-06

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 43.19  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  28 GQDAHLSCTINSQHATAGDIGVSW-YQQQPGSAPHLLYYYAEEEHYRPADIP--DRFSATVDAAHNACILTISPVLPEDD 104
Cdd:cd05715    14 GSDVRLTCTFTSCYTVGDAFSVTWtYQPEGGNTTESMFHYSKGKPYILKVGRfkDRVSWAGNPSKKDASIVISNLQFSDN 93

                  ....*..
gi 1720361286 105 ADYFCSI 111
Cdd:cd05715    94 GTYTCDV 100
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
28-116 3.46e-05

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 39.85  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  28 GQDAHLSCTINSQhaTAGDIGVSWYQQQPGSAphLLYYYAEEEHYRPAdIPDRFSATVDAAHNACILTISPVLPEDDADY 107
Cdd:cd20988    13 GKPVTLKCSMKGE--AISNYYINWYRKTQGNT--MTFIYREGGIYGPG-FKDNFRGDIDSSNNLAVLKILEASERDEGSY 87

                  ....*....
gi 1720361286 108 FCSIAHTFE 116
Cdd:cd20988    88 YCASDTPGG 96
IgV_CD8_alpha cd05720
Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; ...
28-112 2.50e-04

Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; The members here are composed of the immunoglobulin (Ig)-like variable domain of the Cluster of Differentiation (CD) 8 alpha. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. The Ig domain of CD8 alpha binds to antibodies. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409385  Cd Length: 110  Bit Score: 37.46  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720361286  28 GQDAHLSC-TINSQhatagDIGVSWYQQQPGSA--PHLLYYYAEEEHYRPADIPD--RFSATVDAahNACILTISPVLPE 102
Cdd:cd05720    13 GQKVELVCeVLNSV-----PQGCSWLFQPRGSApqPTFLLYLSSSNKTKWAEGLDskRFSGSRSG--SSYVLTLKDFRKE 85
                          90
                  ....*....|
gi 1720361286 103 DDADYFCSIA 112
Cdd:cd05720    86 DEGYYFCSVI 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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