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Conserved domains on  [gi|1720365776|ref|XP_030101791|]
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protein Wnt-9b isoform X1 [Mus musculus]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-217 4.07e-148

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19354:

Pssm-ID: 393294  Cd Length: 297  Bit Score: 413.91  E-value: 4.07e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:cd19354    81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKGLAPRPGDLVYMEDSPSFCRPSKYSPG 160
Cdd:cd19354   161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720365776 161 TAGRVCSRDSSCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19354   241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 1-217 4.07e-148

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 413.91  E-value: 4.07e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:cd19354    81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKGLAPRPGDLVYMEDSPSFCRPSKYSPG 160
Cdd:cd19354   161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720365776 161 TAGRVCSRDSSCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19354   241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-217 4.82e-90

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 267.11  E-value: 4.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFL-GPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVS 77
Cdd:pfam00110  90 LTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVdAREKKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVS 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  78 GSCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPggpakglaPRPGDLVYMEDSPSFCRPSKY 157
Cdd:pfam00110 170 GSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKRGRLVPRNSRFKP--------PTKNDLVYLEKSPDYCERNPK 241

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720365776 158 --SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:pfam00110 242 tgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
2-217 1.85e-65

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 204.09  E-value: 1.85e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776    2 ERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:smart00097  90 DSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSC 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVssaTNEALGRLELWAPAKPggpaKGLAPRPGDLVYMEDSPSFCR--PSKYS 158
Cdd:smart00097 170 TVKTCWLQLPDFRKVGDYLKEKYDGASEV---EVDKRGTNKAPVPKNS----TFKPPTETDLVYLESSPDFCEknPKTGS 242

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720365776  159 PGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:smart00097 243 LGTQGRQCNKTSkgldGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 1-217 4.07e-148

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 413.91  E-value: 4.07e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:cd19354    81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKGLAPRPGDLVYMEDSPSFCRPSKYSPG 160
Cdd:cd19354   161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720365776 161 TAGRVCSRDSSCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19354   241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 1-217 7.99e-109

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 314.23  E-value: 7.99e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLE-SRQAWQWGVCGDNLKYSTKFLSNFLGPKRGS-KDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSG 78
Cdd:cd19341    82 LDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  79 SCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELwAPAKPGGPAKGLAPRPGDLVYMEDSPSFCRPSKYS 158
Cdd:cd19341   162 SCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGGSQL-RKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYS 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720365776 159 PGTAGRVCSRDSSCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19341   241 PGTKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 1-217 3.49e-106

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 307.73  E-value: 3.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGpKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:cd19353    83 MERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLG-RKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSC 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKGLAPRPGDLVYMEDSPSFCRPSKYSPG 160
Cdd:cd19353   162 TVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPPKKSGAGHSDQIPRTTDLVYIDDSPSFCLMSRFSPG 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720365776 161 TAGRVCSRDSSCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19353   242 TSGRRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-217 4.82e-90

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 267.11  E-value: 4.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFL-GPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVS 77
Cdd:pfam00110  90 LTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVdAREKKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVS 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  78 GSCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPggpakglaPRPGDLVYMEDSPSFCRPSKY 157
Cdd:pfam00110 170 GSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKRGRLVPRNSRFKP--------PTKNDLVYLEKSPDYCERNPK 241

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720365776 158 --SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:pfam00110 242 tgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-216 7.94e-74

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 224.86  E-value: 7.94e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFL--GPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVS 77
Cdd:cd13113    71 LKNCGCDRTRqGPEGQGDWTWGGCSDNIKFGIKFSRKFLdaREKKKGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVS 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  78 GSCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNealgRLELWAPAKPGGPAKglaPRPGDLVYMEDSPSFCRP--S 155
Cdd:cd13113   151 GSCTTKTCWRQLPSFREIGDYLKEKYDNAVKVKLNNN----GSGLRLVPKRSRFRS---PTETDLVYLEESPDYCEPnpT 223

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720365776 156 KYSPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTC 216
Cdd:cd13113   224 LGSLGTAGRECNPTSpgpdSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 4-217 1.64e-69

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 214.82  E-value: 1.64e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   4 CTCDDS--PGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCA 81
Cdd:cd19342   100 CGCDRSrrGKRSSGNDWKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERKCKCHGMSGSCE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  82 VRTCWKQLSPFRETGQVLKLRYDTAVKVSSaTNEALGRLELWAPAKpgGPAKGlaPRPGDLVYMEDSPSFCRPSKY--SP 159
Cdd:cd19342   180 LKTCWKAAPDFREVGDILKEKYDHATLVDQ-SNLNNGARRRRLTRR--KRRRR--PPKTDLVYYERSPNFCEADPSldSP 254

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720365776 160 GTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19342   255 GTRGRVCNKTStgpdSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 4-217 2.92e-68

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 211.70  E-value: 2.92e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   4 CTCDDSPGLESRQ-AWQWGVCGDNLKYSTKFLSNFL-GPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCA 81
Cdd:cd19338    98 CGCDKSKRGKSTEgEWEWGGCSDNVRYGYRKSREFMdAKEKNRSDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCT 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  82 VRTCWKQLSPFRETGQVLKLRYDTAVKVssatnealgrlelwapaKPGGPAKGLAP------RPG--DLVYMEDSPSFCR 153
Cdd:cd19338   178 LKTCWRKMPPFREVGDRLKERFDGAIKV-----------------KGSNDGKSLIPegktikPPTkeDLVYLEESPDFCE 240

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776 154 PSKY--SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19338   241 PNKKtgSLGTRGRECNRTSmgvdGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
WNT1 smart00097
found in Wnt-1;
2-217 1.85e-65

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 204.09  E-value: 1.85e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776    2 ERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:smart00097  90 DSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSC 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVssaTNEALGRLELWAPAKPggpaKGLAPRPGDLVYMEDSPSFCR--PSKYS 158
Cdd:smart00097 170 TVKTCWLQLPDFRKVGDYLKEKYDGASEV---EVDKRGTNKAPVPKNS----TFKPPTETDLVYLESSPDFCEknPKTGS 242

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720365776  159 PGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:smart00097 243 LGTQGRQCNKTSkgldGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 4-217 3.54e-65

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 203.64  E-value: 3.54e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   4 CTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFL-GPKRGSKDLRARADA----HNTHVGIKAVKSGLRTTCKCHGVSG 78
Cdd:cd19343    88 CGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTdAPEKKKKKKKRQARAlmnlHNNRVGRKAVRDSLETQCKCHGVSG 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  79 SCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEalGRLELWAPAKPGGPAKGlaprpGDLVYMEDSPSFCRPSKY- 157
Cdd:cd19343   168 SCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVG--SRRKLVPKSLKVRPYTK-----DDLIYLTKSPDYCLPDEKl 240

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720365776 158 -SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19343   241 gSLGTRGRECNKTSvgsdSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 4-217 3.22e-64

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 201.41  E-value: 3.22e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   4 CTCDDSP---GLESRQAWQWGVCGDNLKYSTKFLSNFLGPK-RGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGS 79
Cdd:cd19334   100 CACDPTKrgkGRDSKGEFDWGGCSDNVKYGINFARKFVDAReRRVRDARALMNLHNNRAGRKAVKKNLKLQCKCHGVSGS 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  80 CAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSaTNEALGRLELWAPAKPggpakglaPRPGDLVYMEDSPSFCRPSKY-- 157
Cdd:cd19334   180 CTIRTCWRALAEFREVGDYLREKYDGAVQVTM-NQSGTNLLAANKGHKK--------PTRSDLVYFESSPDYCVPNPEtg 250

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720365776 158 SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19334   251 SLGTAGRVCNKTStgtdGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 18-217 4.24e-64

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 200.93  E-value: 4.24e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  18 WQWGVCGDNLKYSTKFLSNFL-------GPKRGSKDL-RARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQL 89
Cdd:cd19337   109 WLWGGCGDNIEYGYKFAKEFIdareretNYPRHSRELaRVLMNLHNNEAGRRAVYEKARVACKCHGVSGSCSLKTCWRQL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  90 SPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGgpakglaprPGDLVYMEDSPSFCRPSKY--SPGTAGRVCS 167
Cdd:cd19337   189 APFREVGDRLKDKYDGAVKVKLNRRGTLLRRRNSRFNKPT---------KDDLVYLDDSPDYCERNPKtgSLGTKGRECN 259

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720365776 168 RDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19337   260 KTSsgtdGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHICK 313
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 2-216 4.56e-62

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 195.65  E-value: 4.56e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   2 ERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCA 81
Cdd:cd19333    89 ESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKCHGMSGSCT 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  82 VRTCWKQLSPFRETGQVLKLRYDTAVKVS-----SATNEALGRLELWAPAKPggpaKGLAPRPGDLVYMEDSPSFCRPSK 156
Cdd:cd19333   169 VKTCWMRLPTFRTVGDRLKDRFDGASRVAygnngNNRGSRRAKKFLLEPENP----NHKPPTSKDLVYFEESPNFCEKNP 244

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720365776 157 Y--SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTC 216
Cdd:cd19333   245 KlgTLGTRGRECNATSigldGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 4-217 1.27e-61

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 194.37  E-value: 1.27e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   4 CTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFL-GPKR----GSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVS 77
Cdd:cd19344    88 CSCDSRRqGQSASEGWKWGGCSDNVDYGIWFARKFVdAPEKserkRSRDVRSLMNLHNNEVGRQAIARLMKVKCRCHGVS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  78 GSCAVRTCWKQLSPFRETGQVLKLRYDTAVKVssATNEALGRLelwapaKPGGPAKGLAPRPG-DLVYMEDSPSFCR--P 154
Cdd:cd19344   168 GSCEVKTCWKTMPSFEEVGDFLKQKYENSIQI--ATKKSKRRL------RRRERRKRKVPISKdELVYIHKSPNYCVrdP 239

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720365776 155 SKYSPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19344   240 KKGILGTSGRECNRTStgpdSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 4-217 1.91e-61

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 194.43  E-value: 1.91e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   4 CTCD--DSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCA 81
Cdd:cd19339    95 CGCDksKKGYGKSDEGWKWGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCHGVSGSCT 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  82 VRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKglaPRPGDLVYMEDSPSFCR--PSKYSP 159
Cdd:cd19339   175 TKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRRRRPTFLKLKISRKYKK---PRPRDLVYLEKSPNYCEkdPLTGSL 251

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720365776 160 GTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19339   252 GTVGRRCNRTStgtdGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 4-217 6.16e-60

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 190.29  E-value: 6.16e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   4 CTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVR 83
Cdd:cd19335    98 CGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHGLSGSCELK 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  84 TCWKQLSPFRETGQVLKLRYDTAVK-VSSATNEALGRLELWAPakpgGPAKGLAPRPGDLVYMEDSPSFCR--PSKYSPG 160
Cdd:cd19335   178 TCWWAQPDFRKIGDYLKDKYDSASEmVVERHRESRGWVETLRP----KYKLFKPPTERDLIYYEESPNFCEpnPETGSFG 253

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720365776 161 TAGRVCSRDSS----CSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19335   254 TRGRECNVTSHgidgCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 1-216 8.78e-59

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 187.11  E-value: 8.78e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDS-PGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGS 79
Cdd:cd19340    77 FEGCGCDDSkKGSKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGS 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  80 CAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATnealGRLELWAPAKPGGPAKGlapRPGDLVYMEDSPSFCRPSKY-- 157
Cdd:cd19340   157 CSTQTCWMQLAPFREIGTDLKRKYDRAVRVDYEN----GGLRETNGSRAIKLLNI---KKNDLVYLEKSPNYCRANVTlg 229

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720365776 158 SPGTAGRVCSRDS----------SCSSLCCGRGYDTQSRMVVF--SCHCQVQWCCYVECQQCAQQELVYTC 216
Cdd:cd19340   230 WPGTLGRQCSRDKkesvsrwerkSCRRLCRACGLKVRKKVVEVtsSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 1-217 3.23e-56

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 180.59  E-value: 3.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFL-GPKRGSKDL---RARADAHNTHVGIKAVKSGLRTTCKCHGV 76
Cdd:cd19336    91 LEKCGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFVdARERRKGRAsssRALMNLHNNEAGRKAIEKNMRVECKCHGV 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  77 SGSCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNealgrlelwapakpgGPAKGLAPR--------PGDLVYMEDS 148
Cdd:cd19336   171 SGSCELKTCWRAMPTFREVGNILKEKFDGATEVQQKRI---------------GSRPVLVPKnpqfkphtDADLVYLDSS 235

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720365776 149 PSFCR--PSKYSPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19336   236 PDFCEpdPKTGSLGTHGRVCNKTSkaidGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTCR 310
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 1-217 2.08e-49

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 163.68  E-value: 2.08e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSP--GLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSG 78
Cdd:cd19349    97 LSDCGCDKEKqgQYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  79 SCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKglaPRPGDLVYMEDSPSFCR--PSK 156
Cdd:cd19349   177 SCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRK---PMDTDLVYIEKSPNYCEedPVT 253

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720365776 157 YSPGTAGRVCSR----DSSCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19349   254 GSVGTQGRMCNKtaqqNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 1-217 1.75e-48

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 160.87  E-value: 1.75e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLESRQA---WQWGVCGDNLKYSTKFLSNFLGPK-RGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGV 76
Cdd:cd19345    97 LKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDAKeRKGKDARALMNLHNNRAGRKAVKRFMTLECKCHGV 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  77 SGSCAVRTCWKQLSPFRETGQVLKLRYDTAVKV---SSATNEALGRLELWAPAKpggpakglaprpGDLVYMEDSPSFCR 153
Cdd:cd19345   177 SGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVvmnQDGTGFTVANKHFKKPTK------------NDLVYFENSPDYCV 244

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776 154 PSKY--SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19345   245 RDRDagSLGTAGRVCNRTSrgmdGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 1-217 2.27e-47

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 158.16  E-value: 2.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPGLES---RQAWQWGVCGDNLKYSTKFLSNFLGPK-RGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGV 76
Cdd:cd19346    97 LKSCSCDPHKRGRShdeRGEFDWGGCSDNINYGIKFAKAFVDAKeKKEKDARALMNLHNNRCGRMAVKRFMKLECKCHGV 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  77 SGSCAVRTCWKQLSPFRETGQVLKLRYDTAVKVS---SATNEALGRLELWAPAKpggpakglaprpGDLVYMEDSPSFCR 153
Cdd:cd19346   177 SGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTmnqDGTGFTVANKNFRKATK------------TDLVYFENSPDYCV 244

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776 154 PSKY--SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19346   245 MDKSagSLGTAGRVCNKSSrgtdGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 1-217 2.50e-45

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 152.44  E-value: 2.50e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDdspglesrqaWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:cd19355    97 LKACGCD----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKCHGTSGSC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVsSATNEALGRLElwapakPGGPAKGLAPRPGDLVYMEDSPSFCR--PSKYS 158
Cdd:cd19355   167 QLKTCWQVTPEFRTVGSLLKDRFYVATLI-KPHNRNTGQLE------PGHAPHRRRASINDLVYFEKSPDFCErePRLDS 239

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720365776 159 PGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19355   240 AGTQGRICNKTSpgmdNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 17-217 3.35e-45

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 151.96  E-value: 3.35e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  17 AWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETG 96
Cdd:cd19356   103 EWEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKCHGTSGSCQFKTCWHVTPEFRLVG 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  97 QVLKLRYDTAVKVSSATNEAlgrlelwapakpGGPAKGLAPR--PGDLVYMEDSPSFCR--PSKYSPGTAGRVCSRDS-- 170
Cdd:cd19356   183 ALLREKFQRAIFINSHNKNS------------GVFLPRLRPRrlARELVYFEKSPDFCErdPAVDSPGTQGRICNKTSpg 250

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1720365776 171 --SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19356   251 mdGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 1-217 4.32e-45

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 152.47  E-value: 4.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDSPG--LESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSG 78
Cdd:cd19350    97 LSNCGCDREKQgyYNQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCHGVSG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  79 SCAVRTCWKQLSPFRETGQVLKLRYDTAVKVSSATNEALGRLELWAPAKPGGPAKglaPRPGDLVYMEDSPSFCRPSKY- 157
Cdd:cd19350   177 SCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRASRLRQPTFLKIKKRRSYQK---PMETDLVYIERSPNYCEEDAAt 253

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720365776 158 -SPGTAGRVCSRDS----SCSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19350   254 gSVGTQGRLCNRTSphtdGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 1-216 2.01e-42

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 145.04  E-value: 2.01e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   1 MERCTCDDS-PGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGS 79
Cdd:cd19351    79 FENCGCDDSrNGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGS 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  80 CAVRTCWKQLSPFRETGQVLKLRYDTAVKVS------SATNEALGRlelWAPAKPGGPAKglaprPGDLVYMEDSPSFC- 152
Cdd:cd19351   159 CSIQTCWLQLADFREIGNYLKVKHDQALKLEmdkrrmRAGNSADNR---GAIAEAFGSVA-----ETELIYLEDSPDYCt 230

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720365776 153 -RPSKYSPGTAGRVCSRDS---------SCSSLC--CGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTC 216
Cdd:cd19351   231 kNASLGLQGTEGRECLQSGknlsqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 18-217 1.17e-41

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 143.28  E-value: 1.17e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  18 WQWGVCGDNLKYSTKFLSNFLGPK-------RGSKD-LRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQL 89
Cdd:cd19347   109 WLWGGCGDNLEYGYRFAKEFVDARerekiyqKGSYEsARTLMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  90 SPFRETGQVLKLRYDTAVKVSSATNEALGRLElwapakpggpAKGLAPRPGDLVYMEDSPSFC--RPSKYSPGTAGRVCS 167
Cdd:cd19347   189 ADFRKVGDALKEKYDSAAAMKLNSRGKLVQVN----------SRFNPPTTLDLVYIDPSPDYCvrNESTGSLGTQGRLCN 258

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720365776 168 RDSS----CSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19347   259 KTSEgmdgCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 18-217 5.07e-41

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 141.66  E-value: 5.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  18 WQWGVCGDNLKYSTKFLSNFLG--------PKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQL 89
Cdd:cd19348   109 WLWGGCGDNVEYGYRFAKEFVDarereknyPKGSEEHARTLMNLQNNEAGRRAVYNLADVACKCHGVSGSCSLKTCWLQL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  90 SPFRETGQVLKLRYDTAVKVSSATNealGRLELWApakpggpAKGLAPRPGDLVYMEDSPSFC--RPSKYSPGTAGRVCS 167
Cdd:cd19348   189 ADFRKVGDLLKEKYDSAAAMRINRK---GKLELVN-------SRFNPPTAEDLVYIDPSPDYClrNETTGSLGTQGRLCN 258

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720365776 168 RDSS----CSSLCCGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTCK 217
Cdd:cd19348   259 KTSEgmdgCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 2-216 7.94e-41

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 140.93  E-value: 7.94e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776   2 ERCTCDDS-PGLESRQAWQWGVCGDNLKYSTKFLSNFLGPKRGSKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 80
Cdd:cd19352    81 DNCGCDDSrNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720365776  81 AVRTCWKQLSPFRETGQVLKLRYDTAVKVS---SATNEALGRlelwapakpGGPAKGLAP-RPGDLVYMEDSPSFCRPSK 156
Cdd:cd19352   161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDllqGAGNSAASR---------GAIAETFRSiSKKELVHLEDSPDYCLENK 231

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720365776 157 Y--SPGTAGRVCSRDS---------SCSSLC--CGRGYDTQSRMVVFSCHCQVQWCCYVECQQCAQQELVYTC 216
Cdd:cd19352   232 TlgLLGTEGRECLKRGkalskwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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