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Conserved domains on  [gi|1720384504|ref|XP_030104472|]
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gasdermin-C2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
4-232 8.47e-94

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


:

Pssm-ID: 398339  Cd Length: 240  Bit Score: 283.86  E-value: 8.47e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504   4 SFDRASKDVVKKLQ-GRDLRPVECLSDATKFRLFHILQETPRS--GWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFI 80
Cdd:pfam04598   1 MFEKATRNLVKELDsGGDLIPVDSLNDSTKFQPFCLVTKKKRSswFWQPRYVPVDFTLLDVLEPDSPVPEPVESGFFKFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504  81 HVQSTDLEANLNVA-----DIARGGVGYVGYGGyNIEVQSTSIPNPKLEILQNRKLLDNLPTFMKFCRMERKNLYVVTEA 155
Cdd:pfam04598  81 DKMDGKVQGDVEVAaggelKIGGGAAVSQSSFG-SLEVQELSVQPLTLESLQERKLLDPEPSFLQQCRERGENLYVVTEV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 156 YEVSKDTMLTGLSSVNLSVKGFFKQLFKVRGKAG--RSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSA-TKKKMTFP 232
Cdd:pfam04598 160 IETTQEVVLTEHSQVEGSGKGMLPGTKTVQGSGQghKDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLLdDDKQGTFE 239
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
270-441 1.70e-71

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


:

Pssm-ID: 407590  Cd Length: 174  Bit Score: 224.16  E-value: 1.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 270 HLDFMCLQNEVYKQTEQLAELSKGVQEVVLSSILSMLyeGDRKVLYDLMNMLELN----QLGHMDGPGGKILDELRKDSS 345
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALL--RDEEALQALEDMLEDLcgggELGPLDGPDGAILLELVGDSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 346 NPCVDLKDLILYLLQALMVLSDSQLNLLAQSVEMGILPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYE 425
Cdd:pfam17708  79 LLSQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQR 158
                         170
                  ....*....|....*.
gi 1720384504 426 LLEECGLKMELNNPRS 441
Cdd:pfam17708 159 LLESCGLELELDSPKA 174
 
Name Accession Description Interval E-value
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
4-232 8.47e-94

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 283.86  E-value: 8.47e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504   4 SFDRASKDVVKKLQ-GRDLRPVECLSDATKFRLFHILQETPRS--GWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFI 80
Cdd:pfam04598   1 MFEKATRNLVKELDsGGDLIPVDSLNDSTKFQPFCLVTKKKRSswFWQPRYVPVDFTLLDVLEPDSPVPEPVESGFFKFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504  81 HVQSTDLEANLNVA-----DIARGGVGYVGYGGyNIEVQSTSIPNPKLEILQNRKLLDNLPTFMKFCRMERKNLYVVTEA 155
Cdd:pfam04598  81 DKMDGKVQGDVEVAaggelKIGGGAAVSQSSFG-SLEVQELSVQPLTLESLQERKLLDPEPSFLQQCRERGENLYVVTEV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 156 YEVSKDTMLTGLSSVNLSVKGFFKQLFKVRGKAG--RSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSA-TKKKMTFP 232
Cdd:pfam04598 160 IETTQEVVLTEHSQVEGSGKGMLPGTKTVQGSGQghKDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLLdDDKQGTFE 239
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
270-441 1.70e-71

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 224.16  E-value: 1.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 270 HLDFMCLQNEVYKQTEQLAELSKGVQEVVLSSILSMLyeGDRKVLYDLMNMLELN----QLGHMDGPGGKILDELRKDSS 345
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALL--RDEEALQALEDMLEDLcgggELGPLDGPDGAILLELVGDSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 346 NPCVDLKDLILYLLQALMVLSDSQLNLLAQSVEMGILPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYE 425
Cdd:pfam17708  79 LLSQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQR 158
                         170
                  ....*....|....*.
gi 1720384504 426 LLEECGLKMELNNPRS 441
Cdd:pfam17708 159 LLESCGLELELDSPKA 174
 
Name Accession Description Interval E-value
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
4-232 8.47e-94

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 283.86  E-value: 8.47e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504   4 SFDRASKDVVKKLQ-GRDLRPVECLSDATKFRLFHILQETPRS--GWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFI 80
Cdd:pfam04598   1 MFEKATRNLVKELDsGGDLIPVDSLNDSTKFQPFCLVTKKKRSswFWQPRYVPVDFTLLDVLEPDSPVPEPVESGFFKFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504  81 HVQSTDLEANLNVA-----DIARGGVGYVGYGGyNIEVQSTSIPNPKLEILQNRKLLDNLPTFMKFCRMERKNLYVVTEA 155
Cdd:pfam04598  81 DKMDGKVQGDVEVAaggelKIGGGAAVSQSSFG-SLEVQELSVQPLTLESLQERKLLDPEPSFLQQCRERGENLYVVTEV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 156 YEVSKDTMLTGLSSVNLSVKGFFKQLFKVRGKAG--RSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSA-TKKKMTFP 232
Cdd:pfam04598 160 IETTQEVVLTEHSQVEGSGKGMLPGTKTVQGSGQghKDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLLdDDKQGTFE 239
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
270-441 1.70e-71

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 224.16  E-value: 1.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 270 HLDFMCLQNEVYKQTEQLAELSKGVQEVVLSSILSMLyeGDRKVLYDLMNMLELN----QLGHMDGPGGKILDELRKDSS 345
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALL--RDEEALQALEDMLEDLcgggELGPLDGPDGAILLELVGDSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720384504 346 NPCVDLKDLILYLLQALMVLSDSQLNLLAQSVEMGILPHQVELVKSILQPNFKYPWNIPFTLQPQLLAPLQGEGLAITYE 425
Cdd:pfam17708  79 LLSQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQR 158
                         170
                  ....*....|....*.
gi 1720384504 426 LLEECGLKMELNNPRS 441
Cdd:pfam17708 159 LLESCGLELELDSPKA 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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