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Conserved domains on  [gi|1720387607|ref|XP_030105101|]
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HSPB1-associated protein 1 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cupin_8 super family cl46322
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 2-33 1.46e-10

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


The actual alignment was detected with superfamily member pfam13621:

Pssm-ID: 463936  Cd Length: 251  Bit Score: 59.69  E-value: 1.46e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1720387607   2 VTLSPGQVLFVPRHWWHYVESLDPVTVSINSW 33
Cdd:pfam13621 213 VTLNPGDVLYLPALWWHHVESLDPFNIAVNYW 244
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 2-33 1.46e-10

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 59.69  E-value: 1.46e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1720387607   2 VTLSPGQVLFVPRHWWHYVESLDPVTVSINSW 33
Cdd:pfam13621 213 VTLNPGDVLYLPALWWHHVESLDPFNIAVNYW 244
RoxA COG2850
Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal ...
 2-46 1.06e-03

Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442098  Cd Length: 274  Bit Score: 39.41  E-value: 1.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720387607   2 VTLSPGQVLFVPRHWWHYVESLDP-VTVSI----NSWIELEEDHLARVEE 46
Cdd:COG2850   169 WVLEPGDMLYLPPGFAHDGVALEEcMTYSIgfraPSWAELLSELADYLAD 218
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 3-21 4.64e-03

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 36.42  E-value: 4.64e-03
                          10
                  ....*....|....*....
gi 1720387607   3 TLSPGQVLFVPRHWWHYVE 21
Cdd:cd20306    81 TVKPGQVVFIPQGWLHWIE 99
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 2-33 1.46e-10

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 59.69  E-value: 1.46e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1720387607   2 VTLSPGQVLFVPRHWWHYVESLDPVTVSINSW 33
Cdd:pfam13621 213 VTLNPGDVLYLPALWWHHVESLDPFNIAVNYW 244
RoxA COG2850
Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal ...
 2-46 1.06e-03

Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442098  Cd Length: 274  Bit Score: 39.41  E-value: 1.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720387607   2 VTLSPGQVLFVPRHWWHYVESLDP-VTVSI----NSWIELEEDHLARVEE 46
Cdd:COG2850   169 WVLEPGDMLYLPPGFAHDGVALEEcMTYSIgfraPSWAELLSELADYLAD 218
JmjC_2 pfam08007
JmjC domain; This entry includes proteins with a JmjC domain that belong to the cupin ...
 4-30 1.59e-03

JmjC domain; This entry includes proteins with a JmjC domain that belong to the cupin superfamily, including Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Ribosomal oxygenase 1/2, and 50S ribosomal protein L16 3-hydroxylase from Escherichia coli. Proteins are bifunctional, acting as histone lysine demethylases and ribosomal histidine hydroxylases.


Pssm-ID: 462340  Cd Length: 116  Bit Score: 37.23  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....*...
gi 1720387607   4 LSPGQVLFVPRHWWHYVESLDP-VTVSI 30
Cdd:pfam08007  80 LEPGDMLYLPRGFIHQGVALDEsLHYSV 107
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 3-21 4.64e-03

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 36.42  E-value: 4.64e-03
                          10
                  ....*....|....*....
gi 1720387607   3 TLSPGQVLFVPRHWWHYVE 21
Cdd:cd20306    81 TVKPGQVVFIPQGWLHWIE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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