NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720389227|ref|XP_030105415|]
View 

neurogenic locus notch homolog protein 3 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1277-1368 6.14e-50

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411987  Cd Length: 90  Bit Score: 171.86  E-value: 6.14e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1277 ERLDFPYPLRDVRGEPLEAPEQSVPLLPLLVAGAVFLLIIFILGVMVARRKREHSTLWFPEGFALHKDIAagHKGRREPV 1356
Cdd:cd21704      1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                           90
                   ....*....|..
gi 1720389227 1357 GQDALGMKNMAK 1368
Cdd:cd21704     79 GQDALGMKHIAK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1489-1697 1.32e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.80  E-value: 1.32e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1489 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1568
Cdd:COG0666     33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1569 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1648
Cdd:COG0666    112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1720389227 1649 LAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRLLDQ 1697
Cdd:COG0666    192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1164-1219 6.90e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 90.65  E-value: 6.90e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720389227 1164 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHR 1219
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1236-1296 1.74e-21

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 89.25  E-value: 1.74e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720389227 1236 VIGSVVMLEIDNRLCLQSAenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEAP 1296
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1698-1985 2.11e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 2.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1698 PSGPRSPSGPHGLGPLLC------PPGAFLPGLKAVQSGTKksrrppgkTGLGPQGTRGRGKKLTLAcPGPLADSSVTLS 1771
Cdd:PHA03247  2680 PQRPRRRAARPTVGSLTSladpppPPPTPEPAPHALVSATP--------LPPGPAAARQASPALPAA-PAPPAVPAGPAT 2750

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1772 PVDSLDSPRP--FSGPPAS-PGGFPLEGPyATTATAVSLAQLGASR-AGPLGRQPPGgcvlsfgllNPVAVPLDWARLPP 1847
Cdd:PHA03247  2751 PGGPARPARPptTAGPPAPaPPAAPAAGP-PRRLTRPAVASLSESReSLPSPWDPAD---------PPAAVLAPAAALPP 2820

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1848 PAPPGpsfllPLAPGPQLLNPGAPVSPQERPPPYLA-----APG-----HGEEYPAAGTRSSPTKARFLRVPSehPYLTP 1917
Cdd:PHA03247  2821 AASPA-----GPLPPPTSAQPTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVSR 2893

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720389227 1918 SPESpehWASPSPPslsdwSDSTPSPATATNATASGALPAQPHPISVPSLP-QSQTQLGPQPEVTPKRQ 1985
Cdd:PHA03247  2894 STES---FALPPDQ-----PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPpRPQPPLAPTTDPAGAGE 2954
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1080-1117 2.72e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 54.25  E-value: 2.72e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227  1080 VDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1117
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-505 3.59e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 3.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  469 DVDECAGASPCGPHGTCTNLPGNFRCICHRGYTGPFC 505
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1039-1076 5.09e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 53.48  E-value: 5.09e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227  1039 EVPEEPRCPRAACQAKRGDQNCDRECNTPGCGWDGGDC 1076
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1133-1159 5.88e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 53.30  E-value: 5.88e-09
                           10        20
                   ....*....|....*....|....*..
gi 1720389227 1133 YCADHFADGRCDQGCNTEECGWDGLDC 1159
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 50-88 4.62e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720389227   50 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 88
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 128-164 5.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 5.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  128 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSMCQ 164
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 166-202 1.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  166 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCE 202
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 90-126 2.17e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.17e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227   90 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTYCE 126
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 508-543 3.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.06e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  508 DIDDCD-PNPCLHGGSCQDGVGSFSCSCLDGFAGPRC 543
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 830-862 3.37e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.37e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720389227  830 DSGVQCLHNGTCVDLVGGFRCNCPPGYTGLHCE 862
Cdd:cd00054      6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 781-817 1.86e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.86e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  781 NIDECASQ-PCQNGGSCIDLVARYLCSCPPGTLGVLCE 817
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 588-619 2.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.64e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720389227  588 SPSSCFNGGTCVDGVSSFSCLCRPGYTGTHCQ 619
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 546-581 6.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  546 DVDECLS-SPCGP-GTCTDHVASFTCACPPGYGGFHCE 581
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 744-779 7.47e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  744 VDPC-TAQPCQHGGTCRGYMGGYVCECPAGYAGDSCE 779
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 242-277 2.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 2.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  242 VDECRSQ-PCRYGGKCLDLVDKYLCRCPPGTTGVNCE 277
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 204-239 2.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  204 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGIRCE 239
Cdd:cd00054      1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 317-345 3.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.19e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  317 INECAS-SPCGEGGSCVDGENGFHCLCPPG 345
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 623-657 4.76e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720389227  623 DPCFSR-PCLHGGICNPTHPGFECTCREGFTGSQCQ 657
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 395-429 1.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720389227  395 DACESQ-PCQAGGTCTSDGIGFRCTCAPGFQGHQCE 429
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 279-313 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  279 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 313
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-388 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720389227  355 NHPCAHkpcsHGVCHDAPGGFRCVCEPGWSGPRC 388
Cdd:cd00054      8 GNPCQN----GGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 664-692 7.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 7.96e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  664 SQAPCQNGGRCVQT--GAYCICPPGWSGRLC 692
Cdd:cd00054      7 SGNPCQNGGTCVNTvgSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1277-1368 6.14e-50

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 171.86  E-value: 6.14e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1277 ERLDFPYPLRDVRGEPLEAPEQSVPLLPLLVAGAVFLLIIFILGVMVARRKREHSTLWFPEGFALHKDIAagHKGRREPV 1356
Cdd:cd21704      1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                           90
                   ....*....|..
gi 1720389227 1357 GQDALGMKNMAK 1368
Cdd:cd21704     79 GQDALGMKHIAK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1489-1697 1.32e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.80  E-value: 1.32e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1489 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1568
Cdd:COG0666     33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1569 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1648
Cdd:COG0666    112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1720389227 1649 LAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRLLDQ 1697
Cdd:COG0666    192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1164-1219 6.90e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 90.65  E-value: 6.90e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720389227 1164 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHR 1219
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1236-1296 1.74e-21

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 89.25  E-value: 1.74e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720389227 1236 VIGSVVMLEIDNRLCLQSAenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEAP 1296
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1581-1673 6.22e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 6.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1581 LILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNgANKDMQDSKeETPLFLAAREGSYEAAK 1660
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1720389227 1661 LLLDHLANREITD 1673
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1438-1663 1.30e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 1.30e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1438 GVDVNVRGpdpyacdtllvpADGFTPL--MLASFCggalepmpaeedeaddTSASIISDLICQGAQLGARtDRTGETALH 1515
Cdd:PHA03095   107 GADVNAKD------------KVGRTPLhvYLSGFN----------------INPKVIRLLLRKGADVNAL-DLYGMTPLA 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1516 --LAARYARADAAKRLLDAGADTNAQDHSGRTPLHT-AVTADA-QGVFQILIRnRSTDLDARMADGSTALILAARLAV-- 1589
Cdd:PHA03095   158 vlLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSck 236

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720389227 1590 EGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1663
Cdd:PHA03095   237 RSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1698-1985 2.11e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 2.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1698 PSGPRSPSGPHGLGPLLC------PPGAFLPGLKAVQSGTKksrrppgkTGLGPQGTRGRGKKLTLAcPGPLADSSVTLS 1771
Cdd:PHA03247  2680 PQRPRRRAARPTVGSLTSladpppPPPTPEPAPHALVSATP--------LPPGPAAARQASPALPAA-PAPPAVPAGPAT 2750

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1772 PVDSLDSPRP--FSGPPAS-PGGFPLEGPyATTATAVSLAQLGASR-AGPLGRQPPGgcvlsfgllNPVAVPLDWARLPP 1847
Cdd:PHA03247  2751 PGGPARPARPptTAGPPAPaPPAAPAAGP-PRRLTRPAVASLSESReSLPSPWDPAD---------PPAAVLAPAAALPP 2820

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1848 PAPPGpsfllPLAPGPQLLNPGAPVSPQERPPPYLA-----APG-----HGEEYPAAGTRSSPTKARFLRVPSehPYLTP 1917
Cdd:PHA03247  2821 AASPA-----GPLPPPTSAQPTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVSR 2893

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720389227 1918 SPESpehWASPSPPslsdwSDSTPSPATATNATASGALPAQPHPISVPSLP-QSQTQLGPQPEVTPKRQ 1985
Cdd:PHA03247  2894 STES---FALPPDQ-----PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPpRPQPPLAPTTDPAGAGE 2954
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1080-1117 2.72e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 54.25  E-value: 2.72e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227  1080 VDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1117
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-505 3.59e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 3.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  469 DVDECAGASPCGPHGTCTNLPGNFRCICHRGYTGPFC 505
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1084-1117 4.84e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 53.30  E-value: 4.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720389227 1084 WRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1117
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1039-1076 5.09e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 53.48  E-value: 5.09e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227  1039 EVPEEPRCPRAACQAKRGDQNCDRECNTPGCGWDGGDC 1076
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1133-1159 5.88e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 53.30  E-value: 5.88e-09
                           10        20
                   ....*....|....*....|....*..
gi 1720389227 1133 YCADHFADGRCDQGCNTEECGWDGLDC 1159
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1043-1077 7.02e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.92  E-value: 7.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720389227 1043 EPRCPRAACQAKRGDQNCDRECNTPGCGWDGGDCS 1077
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 50-88 4.62e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720389227   50 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 88
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 128-164 5.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 5.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  128 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSMCQ 164
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
469-506 9.49e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 9.49e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   469 DVDECAGASPCGPHGTCTNLPGNFRCICHRGYT-GPFCD 506
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1132-1159 1.35e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.25  E-value: 1.35e-07
                            10        20
                    ....*....|....*....|....*...
gi 1720389227  1132 KYCADHFADGRCDQGCNTEECGWDGLDC 1159
Cdd:smart00004   11 AQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 166-202 1.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  166 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCE 202
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 90-126 2.17e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.17e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227   90 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTYCE 126
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
50-88 2.53e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.53e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720389227    50 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYT-GPRCE 88
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 508-543 3.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.06e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  508 DIDDCD-PNPCLHGGSCQDGVGSFSCSCLDGFAGPRC 543
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 830-862 3.37e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.37e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720389227  830 DSGVQCLHNGTCVDLVGGFRCNCPPGYTGLHCE 862
Cdd:cd00054      6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
128-164 7.65e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 7.65e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   128 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFS-GSMCQ 164
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
90-126 1.22e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.22e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227    90 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFT-GTYCE 126
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
166-202 1.66e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.66e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   166 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFE-GTLCE 202
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 781-817 1.86e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.86e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  781 NIDECASQ-PCQNGGSCIDLVARYLCSCPPGTLGVLCE 817
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1751-1982 2.07e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.23  E-value: 2.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1751 RGKKLTLACP-GPLADSSVTLSPVDSLDSPRPFSGPPA-----SPGGFPLEGPYATTATAVSLAQLGASRAGPL--GRQP 1822
Cdd:pfam03154  168 QTQPPVLQAQsGAASPPSPPPPGTTQAATAGPTPSAPSvppqgSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRlpSPHP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1823 PggcvlsfglLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGA-----PVSPQE------------RPPPYLAAP 1885
Cdd:pfam03154  248 P---------LQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPshmqhPVPPQPfpltpqssqsqvPPGPSPAAP 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1886 GHGEE-------YPAAGTRSSPTKARFLRVPSEHPYLTPSPES-------------PEHWASPSPPSLSdwSDSTPSPAT 1945
Cdd:pfam03154  319 GQSQQrihtppsQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTpipqlpnpqshkhPPHLSGPSPFQMN--SNLPPPPAL 396

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1720389227 1946 ATNATASGALPAQPHPISVPSLPQSQtQLGPQPEVTP 1982
Cdd:pfam03154  397 KPLSSLSTHHPPSAHPPPLQLMPQSQ-QLPPPPAQPP 432
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 588-619 2.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.64e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720389227  588 SPSSCFNGGTCVDGVSSFSCLCRPGYTGTHCQ 619
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
508-543 3.89e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.89e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227   508 DIDDC-DPNPCLHGGSCQDGVGSFSCSCLDGF-AGPRC 543
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
781-817 6.42e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.42e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   781 NIDECAS-QPCQNGGSCIDLVARYLCSCPPG-TLGVLCE 817
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 546-581 6.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  546 DVDECLS-SPCGP-GTCTDHVASFTCACPPGYGGFHCE 581
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 744-779 7.47e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  744 VDPC-TAQPCQHGGTCRGYMGGYVCECPAGYAGDSCE 779
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
830-862 1.63e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.63e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1720389227   830 DSGVQCLHNGTCVDLVGGFRCNCPPGYT-GLHCE 862
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 242-277 2.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 2.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  242 VDECRSQ-PCRYGGKCLDLVDKYLCRCPPGTTGVNCE 277
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 204-239 2.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  204 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGIRCE 239
Cdd:cd00054      1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1543-1679 2.60e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 2.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1543 GRTPLHTAVTADAQGVFQILIRNRSTDLDARMA----DGSTALILAARLAVEGMVEELIASHADVNA-----------VD 1607
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgPK 130

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720389227 1608 EL---GKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHLANREITDH---LDRLP 1679
Cdd:cd22192    131 NLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 317-345 3.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.19e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  317 INECAS-SPCGEGGSCVDGENGFHCLCPPG 345
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
316-345 4.31e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.31e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1720389227   316 EINECAS-SPCGEGGSCVDGENGFHCLCPPG 345
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
588-619 8.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 8.41e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1720389227   588 SPSSCFNGGTCVDGVSSFSCLCRPGYT-GTHCQ 619
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
546-581 9.19e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 9.19e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   546 DVDECLS-SPCGPG-TCTDHVASFTCACPPGY-GGFHCE 581
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYtDGRNCE 39
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 1863-1986 9.36e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 47.46  E-value: 9.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1863 PQLLNPGAPVSPQ-ERP----PPYLAAPGHG----EEYPAAGTRSSPTKARFLRVP---SEHPYLTPSPESPEHWASPSP 1930
Cdd:NF033839   323 PQLEKPKPEVKPQpEKPkpevKPQLETPKPEvkpqPEKPKPEVKPQPEKPKPEVKPqpeTPKPEVKPQPEKPKPEVKPQP 402

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720389227 1931 PSLSdwSDSTPSPATATNATASGalPAQPHPISVPSLPQSQTQLGPQPEvTPKRQV 1986
Cdd:NF033839   403 EKPK--PEVKPQPEKPKPEVKPQ--PEKPKPEVKPQPEKPKPEVKPQPE-KPKPEV 453
EGF_CA smart00179
Calcium-binding EGF-like domain;
743-779 1.66e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.66e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   743 EVDPC-TAQPCQHGGTCRGYMGGYVCECPAGY-AGDSCE 779
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
50-81 2.08e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.08e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720389227   50 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 81
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 512-542 2.33e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.33e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  512 CDPNPCLHGGSCQDGVGSFSCSCLDGFAGPR 542
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
242-277 3.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227   242 VDECRS-QPCRYGGKCLDLVDKYLCRCPPG-TTGVNCE 277
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 747-776 4.33e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.33e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  747 CTAQPCQHGGTCRGYMGGYVCECPAGYAGD 776
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
204-239 4.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 4.61e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   204 NVDDC-SPDPCHHG-RCVDGIASFSCACAPGYT-GIRCE 239
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 623-657 4.76e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720389227  623 DPCFSR-PCLHGGICNPTHPGFECTCREGFTGSQCQ 657
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 395-429 1.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720389227  395 DACESQ-PCQAGGTCTSDGIGFRCTCAPGFQGHQCE 429
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 170-198 1.11e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.11e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720389227  170 CASTPCRNGAKCVDQPDGYECRCAEGFEG 198
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 279-313 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  279 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 313
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 835-860 1.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.31e-03
                           10        20
                   ....*....|....*....|....*.
gi 1720389227  835 CLHNGTCVDLVGGFRCNCPPGYTGLH 860
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-388 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720389227  355 NHPCAHkpcsHGVCHDAPGGFRCVCEPGWSGPRC 388
Cdd:cd00054      8 GNPCQN----GGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 208-237 3.22e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.22e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  208 CSPDPCHH-GRCVDGIASFSCACAPGYTGIR 237
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 475-502 5.93e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.04  E-value: 5.93e-03
                           10        20
                   ....*....|....*....|....*...
gi 1720389227  475 GASPCGPHGTCTNLPGNFRCICHRGYTG 502
Cdd:pfam12947    4 NNGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 785-810 6.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.93e-03
                           10        20
                   ....*....|....*....|....*.
gi 1720389227  785 CASQPCQNGGSCIDLVARYLCSCPPG 810
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEG 26
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 587-615 7.00e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 7.00e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720389227  587 CSPSSCFNGGTCVDGVSSFSCLCRPGYTG 615
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1537-1675 7.90e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.22  E-value: 7.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1537 NAQDHSGRTPLhtavtadaqgvFQILIRNRSTDL---------DARMADgstALILAARLAVEGMVEELI----ASHAD- 1602
Cdd:TIGR00870   46 NCPDRLGRSAL-----------FVAAIENENLELtelllnlscRGAVGD---TLLHAISLEYVDAVEAILlhllAAFRKs 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1603 -----VNA--VDEL--GKSALHWAAAVNNVEATLALLKNGAN------------KDMQDS--KEETPLFLAAREGSYEAA 1659
Cdd:TIGR00870  112 gplelANDqyTSEFtpGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQGVDSfyHGESPLNAAACLGSPSIV 191

                          170
                   ....*....|....*.
gi 1720389227 1660 KLLLDHLANREITDHL 1675
Cdd:TIGR00870  192 ALLSEDPADILTADSL 207
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 664-692 7.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 7.96e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  664 SQAPCQNGGRCVQT--GAYCICPPGWSGRLC 692
Cdd:cd00054      7 SGNPCQNGGTCVNTvgSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 625-655 8.11e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.11e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  625 CFSRPCLHGGICNPTHPGFECTCREGFTGSQ 655
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 663-690 9.04e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.04e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  663 CSQAPCQNGGRCVQT--GAYCICPPGWSGR 690
Cdd:pfam00008    1 CAPNPCSNGGTCVDTpgGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1277-1368 6.14e-50

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 171.86  E-value: 6.14e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1277 ERLDFPYPLRDVRGEPLEAPEQSVPLLPLLVAGAVFLLIIFILGVMVARRKREHSTLWFPEGFALHKDIAagHKGRREPV 1356
Cdd:cd21704      1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                           90
                   ....*....|..
gi 1720389227 1357 GQDALGMKNMAK 1368
Cdd:cd21704     79 GQDALGMKHIAK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1489-1697 1.32e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.80  E-value: 1.32e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1489 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1568
Cdd:COG0666     33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1569 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1648
Cdd:COG0666    112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1720389227 1649 LAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRLLDQ 1697
Cdd:COG0666    192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1484-1695 7.34e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.71  E-value: 7.34e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1484 ADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILI 1563
Cdd:COG0666     61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1564 RNRStDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKE 1643
Cdd:COG0666    141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720389227 1644 ETPLFLAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRLL 1695
Cdd:COG0666    220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1491-1695 6.21e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.38  E-value: 6.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1491 IISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIrNRSTDL 1570
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL-AAGADI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1571 DARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLA 1650
Cdd:COG0666     81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1720389227 1651 AREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRLL 1695
Cdd:COG0666    161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1414-1678 3.11e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 3.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1414 LVAADIRVAPATALTPPQGDADADGVDVNVRGPDPYACDTLLVPADGFTPLMLASFCGgalepmpaeedeaddtSASIIS 1493
Cdd:COG0666     41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG----------------DLEIVK 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1494 DLICQGAQLGARtDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIrNRSTDLDAR 1573
Cdd:COG0666    105 LLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNAR 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1574 MADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAARE 1653
Cdd:COG0666    183 DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262

                          250       260
                   ....*....|....*....|....*
gi 1720389227 1654 GSYEAAKLLLDHLANREITDHLDRL 1678
Cdd:COG0666    263 GAALIVKLLLLALLLLAAALLDLLT 287
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1282-1366 3.23e-31

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 118.25  E-value: 3.23e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1282 PYPLRDVRGEPLEAP--EQSVPLLPLLVAGAVFLLIIFILGVMVARRKREHSTLWFPEGFALHKdiAAGHKGRREPVGQD 1359
Cdd:cd21701      1 PYPIYSVRSEPGPATktTPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRRHGTLWFPEGFPRTR--ASRRSRRRDPVGQD 78


                   ....*..
gi 1720389227 1360 ALGMKNM 1366
Cdd:cd21701     79 SVGLKNL 85
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1282-1366 2.41e-28

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 109.85  E-value: 2.41e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1282 PYPLRDVRGEPLEAPEQSvpLLPLLVAGAVFLLIIFILGVMVARRKREHSTLWFPEGFALHKDiAAGHKgRREPVGQDAL 1361
Cdd:cd21703      2 PYPLVSVTSEPLKETKFN--LLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKE-NSNRK-RREPVGQDAV 77


                   ....*
gi 1720389227 1362 GMKNM 1366
Cdd:cd21703     78 GMKNL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1436-1647 2.42e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.64  E-value: 2.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1436 ADGVDVNVRGpdpyacdtllvpADGFTPLMLASFCGgalepmpaeedeaddtSASIISDLICQGAQLGARtDRTGETALH 1515
Cdd:COG0666    108 EAGADVNARD------------KDGETPLHLAAYNG----------------NLEIVKLLLEAGADVNAQ-DNDGNTPLH 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1516 LAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRStDLDARMADGSTALILAARLAVEGMVEE 1595
Cdd:COG0666    159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKL 237

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720389227 1596 LIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPL 1647
Cdd:COG0666    238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1164-1219 6.90e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 90.65  E-value: 6.90e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720389227 1164 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHR 1219
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1236-1296 1.74e-21

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 89.25  E-value: 1.74e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720389227 1236 VIGSVVMLEIDNRLCLQSAenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEAP 1296
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1288-1364 4.46e-17

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 77.53  E-value: 4.46e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720389227 1288 VRGEPLEAPEQSvPLLPLLVAGAVFLLIIFI-LGVMVAR-RKREHSTLWFPEGFalhKDIAAGHKGRREPVGQDALGMK 1364
Cdd:cd21702      2 VKSETVEPPPPS-QLYPMYVVLAALVLLAFVgVGVLVSRkRRREHGQLWFPEGF---KVSEPSKKKRREPVGEDSVGLK 76
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1581-1673 6.22e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 6.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1581 LILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNgANKDMQDSKeETPLFLAAREGSYEAAK 1660
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1720389227 1661 LLLDHLANREITD 1673
Cdd:pfam12796   79 LLLEKGADINVKD 91
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1281-1364 7.32e-16

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 74.74  E-value: 7.32e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1281 FPYPLRDVRGEPLEAPEQSV------PLLPLLVAGAVFLLIIFILGVMVAR-RKREHSTLWFPEGFALHKDiAAGHKgRR 1353
Cdd:cd21705      1 LPFPLLAVTVEEAEKDPQLVaaqlpwPLVCSSVAGVLALVLGALLGVQLIRrRQREHGALWLPPGFARHRD-PNPHR-RR 78

                           90
                   ....*....|.
gi 1720389227 1354 EPVGQDALGMK 1364
Cdd:cd21705     79 EPVGEDAIGLK 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1438-1663 1.30e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 1.30e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1438 GVDVNVRGpdpyacdtllvpADGFTPL--MLASFCggalepmpaeedeaddTSASIISDLICQGAQLGARtDRTGETALH 1515
Cdd:PHA03095   107 GADVNAKD------------KVGRTPLhvYLSGFN----------------INPKVIRLLLRKGADVNAL-DLYGMTPLA 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1516 --LAARYARADAAKRLLDAGADTNAQDHSGRTPLHT-AVTADA-QGVFQILIRnRSTDLDARMADGSTALILAARLAV-- 1589
Cdd:PHA03095   158 vlLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSck 236

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720389227 1590 EGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1663
Cdd:PHA03095   237 RSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1614-1695 8.14e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 8.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1614 LHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHlANREITDHlDRLPRDVAQERLHQDIVR 1693
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78


                   ..
gi 1720389227 1694 LL 1695
Cdd:pfam12796   79 LL 80
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
 1282-1369 1.82e-12

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 64.97  E-value: 1.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1282 PYPLRDVRGE--PLEAPEQSVPLLPLLVAGAVFLLIIFIL-GVMV-ARRKREHSTLWFPEGFALHK-DIAAGHKGRREPV 1356
Cdd:cd21706      1 DFPIYQVRGEdpPDPPPEPPPSNLTYVVIGVVVVLLIGLLlGVLVtTQRKRARGITWFPEGFFTTSsSQRRRRSRRRGPD 80

                           90
                   ....*....|...
gi 1720389227 1357 GQDalgMKNMAKG 1369
Cdd:cd21706     81 GQE---MRNLKKQ 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1480-1670 2.83e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.45  E-value: 2.83e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1480 EEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVF 1559
Cdd:PHA02878   138 KKSKDDIIEAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIV 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1560 QILIRNRSTdLDARMADGSTAL-ILAARLAVEGMVEELIASHADVNAVDE-LGKSALHwaAAVNNVEATLALLKNGANKD 1637
Cdd:PHA02878   218 HILLENGAS-TDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADIN 294

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1720389227 1638 MQDSKEETPLFLAAREGS-YEAAKLLLDHLANRE 1670
Cdd:PHA02878   295 SLNSYKLTPLSSAVKQYLcINIGRILISNICLLK 328
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1698-1985 2.11e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 2.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1698 PSGPRSPSGPHGLGPLLC------PPGAFLPGLKAVQSGTKksrrppgkTGLGPQGTRGRGKKLTLAcPGPLADSSVTLS 1771
Cdd:PHA03247  2680 PQRPRRRAARPTVGSLTSladpppPPPTPEPAPHALVSATP--------LPPGPAAARQASPALPAA-PAPPAVPAGPAT 2750

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1772 PVDSLDSPRP--FSGPPAS-PGGFPLEGPyATTATAVSLAQLGASR-AGPLGRQPPGgcvlsfgllNPVAVPLDWARLPP 1847
Cdd:PHA03247  2751 PGGPARPARPptTAGPPAPaPPAAPAAGP-PRRLTRPAVASLSESReSLPSPWDPAD---------PPAAVLAPAAALPP 2820

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1848 PAPPGpsfllPLAPGPQLLNPGAPVSPQERPPPYLA-----APG-----HGEEYPAAGTRSSPTKARFLRVPSehPYLTP 1917
Cdd:PHA03247  2821 AASPA-----GPLPPPTSAQPTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVSR 2893

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720389227 1918 SPESpehWASPSPPslsdwSDSTPSPATATNATASGALPAQPHPISVPSLP-QSQTQLGPQPEVTPKRQ 1985
Cdd:PHA03247  2894 STES---FALPPDQ-----PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPpRPQPPLAPTTDPAGAGE 2954
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1529-1670 4.14e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.17  E-value: 4.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGM-VEELIASHADVNAVD 1607
Cdd:PHA02876   259 LYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVNAAD 338

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720389227 1608 ELGKSALHWAAAVN-NVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHLANRE 1670
Cdd:PHA02876   339 RLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIE 402
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1529-1640 5.42e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 5.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAvtadaqgvfqilIRNRSTDldarmadgstalilaarlavegMVEELIaSHADVNAVDE 1608
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLA------------AKNGHLE----------------------IVKLLL-EHADVNLKDN 60

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1720389227 1609 lGKSALHWAAAVNNVEATLALLKNGANKDMQD 1640
Cdd:pfam12796   61 -GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1529-1668 4.13e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.28  E-value: 4.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAV---TADAQGVFQILIRNrSTDLDARMADGSTALILAARLA-VEGMVEELIASHADVN 1604
Cdd:PHA03095    33 LLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGADVN 111

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720389227 1605 AVDELGKSALHWAAAVNNVEATL--ALLKNGANKDMQDSKEETPL--FLAAREGSYEAAKLLLDHLAN 1668
Cdd:PHA03095   112 AKDKVGRTPLHVYLSGFNINPKVirLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGAD 179
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1698-1982 5.76e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 5.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1698 PSGPRSPSGPHGLGPLLCPPgafLPGLKAVQSgtkKSRRPpgktGLGPQGTRGR------GKKLTLACPGPLADSSVTLS 1771
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAP---RPSEPAVTS---RARRP----DAPPQSARPRapvddrGDPRGPAPPSPLPPDTHAPD 2625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1772 PVDSLDSPRPFSGPPASPGGFPlEGPYATTATAVSLAQLgASRAGPLGRQPPGGCVL----------SFGLLNPVAVPLD 1841
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVP-PPERPRDDPAPGRVSR-PRRARRLGRAAQASSPPqrprrraarpTVGSLTSLADPPP 2703

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1842 WARLPPPAPPGPSFLLPLAPGPQLLN---PGAPVSPQERPPPYLAA-PGHGEEYPAAGTRSSPTKARFLRVPSEHP--YL 1915
Cdd:PHA03247  2704 PPPTPEPAPHALVSATPLPPGPAAARqasPALPAAPAPPAVPAGPAtPGGPARPARPPTTAGPPAPAPPAAPAAGPprRL 2783

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1916 TP---SPESPEHWASPSPPSLSDWSDSTPSPATATNATASGALPAQPHPISVPSLPQSQTqlGPQPEVTP 1982
Cdd:PHA03247  2784 TRpavASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP--GPPPPSLP 2851
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1529-1695 7.45e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.47  E-value: 7.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAVT-ADAQGVFQILIRNRSTDlDARMADGSTALILAARLAVEGMVEELIASHADVNAVD 1607
Cdd:PHA02875    54 LMKHGAIPDVKYPDIESELHDAVEeGDVKAVEELLDLGKFAD-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPN 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1608 ELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHLANreiTDHLDRLPrDV----- 1682
Cdd:PHA02875   133 TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN---IDYFGKNG-CVaalcy 208

                          170
                   ....*....|...
gi 1720389227 1683 AQERLHQDIVRLL 1695
Cdd:PHA02875   209 AIENNKIDIVRLF 221
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1080-1117 2.72e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 54.25  E-value: 2.72e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227  1080 VDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1117
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-505 3.59e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 3.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  469 DVDECAGASPCGPHGTCTNLPGNFRCICHRGYTGPFC 505
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1084-1117 4.84e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 53.30  E-value: 4.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720389227 1084 WRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1117
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1039-1076 5.09e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 53.48  E-value: 5.09e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227  1039 EVPEEPRCPRAACQAKRGDQNCDRECNTPGCGWDGGDC 1076
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1133-1159 5.88e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 53.30  E-value: 5.88e-09
                           10        20
                   ....*....|....*....|....*..
gi 1720389227 1133 YCADHFADGRCDQGCNTEECGWDGLDC 1159
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1043-1077 7.02e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.92  E-value: 7.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720389227 1043 EPRCPRAACQAKRGDQNCDRECNTPGCGWDGGDCS 1077
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
Ank_4 pfam13637
Ankyrin repeats (many copies);
1612-1663 1.60e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 1.60e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720389227 1612 SALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1663
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 50-88 4.62e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1720389227   50 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 88
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 128-164 5.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 5.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  128 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSMCQ 164
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
469-506 9.49e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 9.49e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   469 DVDECAGASPCGPHGTCTNLPGNFRCICHRGYT-GPFCD 506
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1768-1986 1.22e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 57.40  E-value: 1.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1768 VTLSPVDSLdsprpFSGPPASPG----------GFPLEGPYATTATAVSLAQLGASRAGPLGRQPPggcvlSFGLLNPVA 1837
Cdd:PRK10263   285 VAADPDDVL-----FSGNRATQPeydeydpllnGAPITEPVAVAAAATTATQSWAAPVEPVTQTPP-----VASVDVPPA 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1838 VP-LDWARlpppappgpsfllplAPGPQLLNPGAPVSPQERPP-PYLAAPG--HGEEYPAAGTRSSPTKARFLRVPSEHP 1913
Cdd:PRK10263   355 QPtVAWQP---------------VPGPQTGEPVIAPAPEGYPQqSQYAQPAvqYNEPLQQPVQPQQPYYAPAAEQPAQQP 419

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720389227 1914 YLTPSPESPEHWASPSPPSLSDWSDST--PSPATATNATASGALPAQPHPISVPSLPQSQTQ--LGPQPEVTPKRQV 1986
Cdd:PRK10263   420 YYAPAPEQPAQQPYYAPAPEQPVAGNAwqAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPqpVEQQPVVEPEPVV 496
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1529-1668 1.34e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.13  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRN----------------------RSTDLDARMADGSTALILAAR 1586
Cdd:PHA02874    54 FIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNgvdtsilpipciekdmiktildCGIDVNIKDAELKTFLHYAIK 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1587 LAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHL 1666
Cdd:PHA02874   134 KGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213


                   ..
gi 1720389227 1667 AN 1668
Cdd:PHA02874   214 NH 215
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1132-1159 1.35e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.25  E-value: 1.35e-07
                            10        20
                    ....*....|....*....|....*...
gi 1720389227  1132 KYCADHFADGRCDQGCNTEECGWDGLDC 1159
Cdd:smart00004   11 AQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 166-202 1.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  166 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCE 202
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 90-126 2.17e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.17e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227   90 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTYCE 126
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
50-88 2.53e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.53e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720389227    50 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYT-GPRCE 88
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 508-543 3.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.06e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  508 DIDDCD-PNPCLHGGSCQDGVGSFSCSCLDGFAGPRC 543
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 830-862 3.37e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.37e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720389227  830 DSGVQCLHNGTCVDLVGGFRCNCPPGYTGLHCE 862
Cdd:cd00054      6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1506-1644 3.45e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 3.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1506 TDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNrstdldARMADGSTA---LI 1582
Cdd:PLN03192   554 GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHF------ASISDPHAAgdlLC 627

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720389227 1583 LAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEE 1644
Cdd:PLN03192   628 TAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
EGF_CA smart00179
Calcium-binding EGF-like domain;
128-164 7.65e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 7.65e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   128 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFS-GSMCQ 164
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Ank_5 pfam13857
Ankyrin repeats (many copies);
1529-1584 1.07e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 1.07e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720389227 1529 LLDAG-ADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRStDLDARMADGSTALILA 1584
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
90-126 1.22e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.22e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227    90 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFT-GTYCE 126
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1698-1942 1.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1698 PSGPRSPSGPHGlgPLLCPPGAFLPGLKAVQSGTKKSRRPPGKTGLGPQGTRGRGKKL-TLACPGPLADSSVTLSPVDSL 1776
Cdd:PHA03247  2763 TAGPPAPAPPAA--PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPP 2840

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1777 DSPRPFSGPPASPGGFPLEGPYATTATAVSLAQLGASRAGP----LGRQPPGGCVLSFGLLNPVAVPLDWARLPPPAPPG 1852
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPpvrrLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1853 PSFLLPLAPGPQLLNPGAPVSPqerPPPYLAAPGHGEEYPAAgtrssPTKARFLRVPSEHP---YLTPSPESPEHWASPS 1929
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPRPQPP---LAPTTDPAGAGEPSGAV-----PQPWLGALVPGRVAvprFRVPQPAPSREAPASS 2992

                          250
                   ....*....|...
gi 1720389227 1930 PPSLSDWSDSTPS 1942
Cdd:PHA03247  2993 TPPLTGHSLSRVS 3005
EGF_CA smart00179
Calcium-binding EGF-like domain;
166-202 1.66e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.66e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   166 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFE-GTLCE 202
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1529-1673 1.80e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQI-LIRNRSTDLDARMADGSTALilaaRLAVEG------MVEELIASHA 1601
Cdd:PHA03100    92 LLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeYLLDNGANVNIKNSDGENLL----HLYLESnkidlkILKLLIDKGV 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1602 DVNA----------------VDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1665
Cdd:PHA03100   168 DINAknrvnyllsygvpiniKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247


                   ....*...
gi 1720389227 1666 LANREITD 1673
Cdd:PHA03100   248 GPSIKTII 255
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 781-817 1.86e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.86e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  781 NIDECASQ-PCQNGGSCIDLVARYLCSCPPGTLGVLCE 817
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1751-1982 2.07e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.23  E-value: 2.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1751 RGKKLTLACP-GPLADSSVTLSPVDSLDSPRPFSGPPA-----SPGGFPLEGPYATTATAVSLAQLGASRAGPL--GRQP 1822
Cdd:pfam03154  168 QTQPPVLQAQsGAASPPSPPPPGTTQAATAGPTPSAPSvppqgSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRlpSPHP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1823 PggcvlsfglLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGA-----PVSPQE------------RPPPYLAAP 1885
Cdd:pfam03154  248 P---------LQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPshmqhPVPPQPfpltpqssqsqvPPGPSPAAP 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1886 GHGEE-------YPAAGTRSSPTKARFLRVPSEHPYLTPSPES-------------PEHWASPSPPSLSdwSDSTPSPAT 1945
Cdd:pfam03154  319 GQSQQrihtppsQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTpipqlpnpqshkhPPHLSGPSPFQMN--SNLPPPPAL 396

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1720389227 1946 ATNATASGALPAQPHPISVPSLPQSQtQLGPQPEVTP 1982
Cdd:pfam03154  397 KPLSSLSTHHPPSAHPPPLQLMPQSQ-QLPPPPAQPP 432
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 588-619 2.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.64e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720389227  588 SPSSCFNGGTCVDGVSSFSCLCRPGYTGTHCQ 619
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1529-1668 2.65e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 2.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTN--AQDHSGRTPLHTAVTADAQGVFQI--LIRNRSTDLDARMADGSTALILAARLAVEG--MVEELIASHAD 1602
Cdd:PHA03100    54 LLDNGADINssTKNNSTPLHYLSNIKYNLTDVKEIvkLLLEYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGAN 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1603 VNAVDELGKSALHWAAAVNNVEATLA------------------LLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLD 1664
Cdd:PHA03100   134 VNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLD 213


                   ....
gi 1720389227 1665 HLAN 1668
Cdd:PHA03100   214 LGAN 217
EGF_CA smart00179
Calcium-binding EGF-like domain;
508-543 3.89e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.89e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227   508 DIDDC-DPNPCLHGGSCQDGVGSFSCSCLDGF-AGPRC 543
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1436-1692 4.02e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.50  E-value: 4.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1436 ADGVDVNVRGPDPYACdTLLVPADGFTPLMLASFCGGALEPMPAEEDEaddtsasIISDLICQGAQLGARtDRTGETALH 1515
Cdd:PHA02874    59 ADINHINTKIPHPLLT-AIKIGAHDIIKLLIDNGVDTSILPIPCIEKD-------MIKTILDCGIDVNIK-DAELKTFLH 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1516 LAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTdLDARMADGSTALILAARLAVEGMVEE 1595
Cdd:PHA02874   130 YAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKL 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1596 LIASHADVNAVDELGKSALHWAAAVNnvEATLALLKNGANKDMQDSKEETPLFLAAR-EGSYEAAKLLLDHLANREITDH 1674
Cdd:PHA02874   209 LIDHGNHIMNKCKNGFTPLHNAIIHN--RSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDN 286

                          250
                   ....*....|....*...
gi 1720389227 1675 LDRLPRDVAQERLHQDIV 1692
Cdd:PHA02874   287 KGENPIDTAFKYINKDPV 304
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1698-1982 4.83e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.69  E-value: 4.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1698 PSGPRSPSGPHGL---GPLLCPPGaflpgLKAVQSGTKKSRRPPGKTGLGPQGTrgrgKKLTLACPGPLADSSVTLSP-- 1772
Cdd:pfam03154  218 PNQTQSTAAPHTLiqqTPTLHPQR-----LPSPHPPLQPMTQPPPPSQVSPQPL----PQPSLHGQMPPMPHSLQTGPsh 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1773 VDSLDSPRPFSGPP-ASPGGFPLEGPYATTATAVSLAQLGASRAGPLGRQPPGGCVLsfgllnPVAvPLDWARLPPPapp 1851
Cdd:pfam03154  289 MQHPVPPQPFPLTPqSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPL------PPA-PLSMPHIKPP--- 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1852 gpsfllPLAPGPQLLNPGAPVSPQ--ERPPPYlAAPGHGEEYPAAGTRSS-PTKarflRVPSEHPY-LTPSPESPEHWAS 1927
Cdd:pfam03154  359 ------PTTPIPQLPNPQSHKHPPhlSGPSPF-QMNSNLPPPPALKPLSSlSTH----HPPSAHPPpLQLMPQSQQLPPP 427

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1928 PS-PPSLSDWSDSTPSPATATNATASGALPAQP----HPISVPSLPQSQTQLGPQPEVTP 1982
Cdd:pfam03154  428 PAqPPVLTQSQSLPPPAASHPPTSGLHQVPSQSpfpqHPFVPGGPPPITPPSGPPTSTSS 487
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1529-1663 5.38e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.79  E-value: 5.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNrSTDLDARMADGSTAL---ILAARLAVEGMVEELiASHADVNA 1605
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKH-ACNVHIRDANGNTALwnaISAKHHKIFRILYHF-ASISDPHA 621

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720389227 1606 VDELgksaLHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1663
Cdd:PLN03192   622 AGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
EGF_CA smart00179
Calcium-binding EGF-like domain;
781-817 6.42e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 6.42e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   781 NIDECAS-QPCQNGGSCIDLVARYLCSCPPG-TLGVLCE 817
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 546-581 6.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  546 DVDECLS-SPCGP-GTCTDHVASFTCACPPGYGGFHCE 581
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 744-779 7.47e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  744 VDPC-TAQPCQHGGTCRGYMGGYVCECPAGYAGDSCE 779
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1486-1631 1.32e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1486 DTSASIISDLICQGAQLGARTDRtGETALH--LAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQG---VFQ 1560
Cdd:PHA03095   164 NANVELLRLLIDAGADVYAVDDR-FRSLLHhhLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrslVLP 242

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720389227 1561 ILIRNrsTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLK 1631
Cdd:PHA03095   243 LLIAG--ISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
Ank_5 pfam13857
Ankyrin repeats (many copies);
1600-1650 1.32e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 1.32e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720389227 1600 HADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLA 1650
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1561-1695 1.37e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 1.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1561 ILIRNRSTDLDARMAdgsTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQD 1640
Cdd:PLN03192   512 LLGDNGGEHDDPNMA---SNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRD 588

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1641 SKEETPLF-------------------------------LAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQ 1689
Cdd:PLN03192   589 ANGNTALWnaisakhhkifrilyhfasisdphaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHV 668


                   ....*.
gi 1720389227 1690 DIVRLL 1695
Cdd:PLN03192   669 DMVRLL 674
EGF_CA smart00179
Calcium-binding EGF-like domain;
830-862 1.63e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.63e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1720389227   830 DSGVQCLHNGTCVDLVGGFRCNCPPGYT-GLHCE 862
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 242-277 2.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 2.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  242 VDECRSQ-PCRYGGKCLDLVDKYLCRCPPGTTGVNCE 277
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 204-239 2.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720389227  204 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGIRCE 239
Cdd:cd00054      1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1543-1679 2.60e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 2.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1543 GRTPLHTAVTADAQGVFQILIRNRSTDLDARMA----DGSTALILAARLAVEGMVEELIASHADVNA-----------VD 1607
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgPK 130

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720389227 1608 EL---GKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHLANREITDH---LDRLP 1679
Cdd:cd22192    131 NLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 317-345 3.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.19e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  317 INECAS-SPCGEGGSCVDGENGFHCLCPPG 345
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
Ank_4 pfam13637
Ankyrin repeats (many copies);
1577-1630 4.24e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 4.24e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720389227 1577 GSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALL 1630
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA smart00179
Calcium-binding EGF-like domain;
316-345 4.31e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.31e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1720389227   316 EINECAS-SPCGEGGSCVDGENGFHCLCPPG 345
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1545-1665 4.61e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 4.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1545 TPLHTAVTADAqgVFQILIRNRSTDLDARMADGSTaliLAARLavegmveeLIASHADVNAVDELGKSALHWAAAVNNVE 1624
Cdd:PTZ00322    63 TPDHNLTTEEV--IDPVVAHMLTVELCQLAASGDA---VGARI--------LLTGGADPNCRDYDGRTPLHIACANGHVQ 129

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1720389227 1625 ATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1665
Cdd:PTZ00322   130 VVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1529-1695 5.55e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 5.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1529 LLDAGADTNAQDHSGRTPLHTAVTA-DAQGVFQILIRNRSTDLDARMADGSTA----------LILAARL---------- 1587
Cdd:PHA02878    56 LLTRGHNVNQPDHRDLTPLHIICKEpNKLGMKEMIRSINKCSVFYTLVAIKDAfnnrnveifkIILTNRYkniqtidlvy 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1588 --------AVEGMVEELIASH-ADVNAVDE-LGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYE 1657
Cdd:PHA02878   136 idkkskddIIEAEITKLLLSYgADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKP 215

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1720389227 1658 AAKLLLDHLANREITDHLDRLPRDVAQERLHQ-DIVRLL 1695
Cdd:PHA02878   216 IVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLL 254
EGF_CA smart00179
Calcium-binding EGF-like domain;
588-619 8.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 8.41e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1720389227   588 SPSSCFNGGTCVDGVSSFSCLCRPGYT-GTHCQ 619
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
546-581 9.19e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 9.19e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   546 DVDECLS-SPCGPG-TCTDHVASFTCACPPGY-GGFHCE 581
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYtDGRNCE 39
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 1863-1986 9.36e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 47.46  E-value: 9.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1863 PQLLNPGAPVSPQ-ERP----PPYLAAPGHG----EEYPAAGTRSSPTKARFLRVP---SEHPYLTPSPESPEHWASPSP 1930
Cdd:NF033839   323 PQLEKPKPEVKPQpEKPkpevKPQLETPKPEvkpqPEKPKPEVKPQPEKPKPEVKPqpeTPKPEVKPQPEKPKPEVKPQP 402

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720389227 1931 PSLSdwSDSTPSPATATNATASGalPAQPHPISVPSLPQSQTQLGPQPEvTPKRQV 1986
Cdd:NF033839   403 EKPK--PEVKPQPEKPKPEVKPQ--PEKPKPEVKPQPEKPKPEVKPQPE-KPKPEV 453
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1615-1695 1.35e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 1.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1615 HWAAAVNNVEATLaLLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRL 1694
Cdd:PTZ00322    88 QLAASGDAVGARI-LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                   .
gi 1720389227 1695 L 1695
Cdd:PTZ00322   167 L 167
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1697-1981 1.50e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1697 QPSGPRSPSGPHGLGPLLCPP--GAFLPGLKAVQSGTKKSRRP--PGKTGLGPQGTRGRGKKL-TLACPGPLADSSVTLS 1771
Cdd:pfam03154  250 QPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQTGPSHMQHPvpPQPFPLTPQSSQSQVPPGpSPAAPGQSQQRIHTPP 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1772 PVDSLDSPRPFSGPPASPGgfPLEGPYATTATAVSLAQLGASRAG--PLGRQPPGGCVLSFGLLNPVAV-PLdwarlppp 1848
Cdd:pfam03154  330 SQSQLQSQQPPREQPLPPA--PLSMPHIKPPPTTPIPQLPNPQSHkhPPHLSGPSPFQMNSNLPPPPALkPL-------- 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1849 aPPGPSFLLPLAPGP--QLLNPGAPVSPQERPPPYLAapgHGEEYPAAGTrSSPTKARFLRVPSEHPY------------ 1914
Cdd:pfam03154  400 -SSLSTHHPPSAHPPplQLMPQSQQLPPPPAQPPVLT---QSQSLPPPAA-SHPPTSGLHQVPSQSPFpqhpfvpggppp 474

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720389227 1915 ----LTPSPESPEHWASPSPPSLSDWSDSTPSPATATNATASGALPAQP-----HPISVPSLPQSqtqlgPQPEVT 1981
Cdd:pfam03154  475 itppSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEAldeaeEPESPPPPPRS-----PSPEPT 545
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1473-1696 1.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 1.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1473 ALEPMPAEEDEADDTSASIISDLICQGAQLGARtDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVT 1552
Cdd:PHA02876   142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAK-DIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVD 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1553 ADAQGVFQILIRNRS----TDLDARMADGSTALILAARLAVEGMveeliashaDVNAVDELGKSALHWAAAVNNVEATL- 1627
Cdd:PHA02876   221 SKNIDTIKAIIDNRSninkNDLSLLKAIRNEDLETSLLLYDAGF---------SVNSIDDCKNTPLHHASQAPSLSRLVp 291

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720389227 1628 ALLKNGANKDMQDSKEETPLFLAAREG-SYEAAKLLLDHLANREITDHLDRLPRDVAQ--ERLHQDIVRLLD 1696
Cdd:PHA02876   292 KLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLE 363
EGF_CA smart00179
Calcium-binding EGF-like domain;
743-779 1.66e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.66e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   743 EVDPC-TAQPCQHGGTCRGYMGGYVCECPAGY-AGDSCE 779
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 472-504 1.94e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.54  E-value: 1.94e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720389227  472 ECAGASPCGPHGTCTNLPGNFRCICHRGYTGPF 504
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA pfam07645
Calcium-binding EGF domain;
50-81 2.08e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.08e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720389227   50 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 81
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 512-542 2.33e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.33e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  512 CDPNPCLHGGSCQDGVGSFSCSCLDGFAGPR 542
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
242-277 3.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.05e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720389227   242 VDECRS-QPCRYGGKCLDLVDKYLCRCPPG-TTGVNCE 277
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PHA03378 PHA03378
EBNA-3B; Provisional
 1742-1983 3.06e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.83  E-value: 3.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1742 GLGP----QGTRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFSGPPASPGgfPLEGPYATTATAVSLAQLGASRAGP 1817
Cdd:PHA03378   568 GLGPlqiqPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSA--PRQWPMPLRPIPMRPLRMQPITFNV 645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1818 LGR----QPPGgcvlsfglLNPVAVPLDWARLPPP----APPGPSFLLPLAPGPQLLNPgAPVSPQERPPPYlAAPGHGE 1889
Cdd:PHA03378   646 LVFptphQPPQ--------VEITPYKPTWTQIGHIpyqpSPTGANTMLPIQWAPGTMQP-PPRAPTPMRPPA-APPGRAQ 715

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1890 EYPAAGTRSSPTKARFLRvpSEHPYLTPSPESPEHWAspspPSLSDWSDSTPSPATATNATASGALPAQPHpiSVPSLPQ 1969
Cdd:PHA03378   716 RPAAATGRARPPAAAPGR--ARPPAAAPGRARPPAAA----PGRARPPAAAPGRARPPAAAPGAPTPQPPP--QAPPAPQ 787

                          250
                   ....*....|....
gi 1720389227 1970 SQTQLGPQPEVTPK 1983
Cdd:PHA03378   788 QRPRGAPTPQPPPQ 801
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1789-1985 3.89e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 3.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1789 PGGFPLEGPYATTATAVSLAQLGASRAGPLGRQPPGGCVLSFGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNP 1868
Cdd:PRK12323   365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1869 GAPVSPQERPPPylaAPGHGEEYPAAGTRSSPTKARFLRVPSEhPYLTPSP---------ESPEHWASPSP----PSLSD 1935
Cdd:PRK12323   445 GGAPAPAPAPAA---APAAAARPAAAGPRPVAAAAAAAPARAA-PAAAPAPadddpppweELPPEFASPAPaqpdAAPAG 520

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720389227 1936 W-SDSTPSPATatnATASGALPAQPHPISVPSLPQSQTQLGPQPEVTPKRQ 1985
Cdd:PRK12323   521 WvAESIPDPAT---ADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRA 568
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1587-1715 4.29e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 4.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1587 LAVEGMVEELIASHADVNAvdelgKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHL 1666
Cdd:PLN03192   507 LNVGDLLGDNGGEHDDPNM-----ASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1720389227 1667 ANREITDHLDRLPRDVAQERLHQDIVRLLDQPSgprSPSGPHGLGPLLC 1715
Cdd:PLN03192   582 CNVHIRDANGNTALWNAISAKHHKIFRILYHFA---SISDPHAAGDLLC 627
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 747-776 4.33e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.33e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  747 CTAQPCQHGGTCRGYMGGYVCECPAGYAGD 776
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
204-239 4.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 4.61e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720389227   204 NVDDC-SPDPCHHG-RCVDGIASFSCACAPGYT-GIRCE 239
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 623-657 4.76e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720389227  623 DPCFSR-PCLHGGICNPTHPGFECTCREGFTGSQCQ 657
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1858-1987 5.39e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 5.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1858 PLAPGPQLLNPGAPVSPQERPPPYLAA-PGHGE----EYPAAGTRSSPTKARFLRVPSEHPYLTPSPESPEHWASPSPPS 1932
Cdd:pfam03154  179 GAASPPSPPPPGTTQAATAGPTPSAPSvPPQGSpatsQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPP 258

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720389227 1933 LSDWSDSTPSPATATNATASG------------ALPAQPHPISvPSLPQSQTQLGPQPEVTPKRQVM 1987
Cdd:pfam03154  259 SQVSPQPLPQPSLHGQMPPMPhslqtgpshmqhPVPPQPFPLT-PQSSQSQVPPGPSPAAPGQSQQR 324
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1696-1977 7.52e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 7.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1696 DQPSGPRSPSGPHGLGPLLCPPGAFLPGLKAVQSGTKKSRRPPGKTGLGP-QGTRGRGKKLTLACPGPLADSSVTlSPVD 1774
Cdd:PHA03307   110 GPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPaAVASDAASSRQAALPLSSPEETAR-APSS 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1775 SLDSPRPFSGPPASPGGFPLEGPYATTATAVSLAQLGASRAGPLGR-----QPPGGCVLSFGLLNpvAVPLDWARLPPPA 1849
Cdd:PHA03307   189 PPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGAsssdsSSSESSGCGWGPEN--ECPLPRPAPITLP 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1850 PPGPSFLLPLAPGPQLLNPGAPVSPQERPPPylAAPGHgEEYPAAGTRSSPTKARFLRVPSEHPYLTPSPESPEHWASPS 1929
Cdd:PHA03307   267 TRIWEASGWNGPSSRPGPASSSSSPRERSPS--PSPSS-PGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP 343

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720389227 1930 ------PPSLSDWSDSTPSPATATNATASGALPAQPHPISVPSLPQSQTQLGPQ 1977
Cdd:PHA03307   344 gpspsrSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGR 397
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 1860-1982 8.74e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 44.49  E-value: 8.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1860 APGPQLLNPGAPVSPQERPPP-----------YLAAPGHGEEYPAAGTRSSPtkARFL-------RVPSEHPYLTPSPES 1921
Cdd:pfam15324  988 VPTPQPTPPCSPPSPLKEPSPvktpdsspcvsEHDFFPVKEIPPEKGADTGP--AVSLvitptvtPIATPPPAATPTPPL 1065

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1922 PE----HWASPSPPSLSDWSDS-------TPSPATATN-------------ATASGALPAQPhPISVPSLPQSQTQLGPQ 1977
Cdd:pfam15324 1066 SEnsidKLKSPSPELPKPWEDSdlpleeeNPNSEQEELhpravvmsvardeEPESVVLPASP-PEPKPLAPPPLGAAPPS 1144


                   ....*
gi 1720389227 1978 PEVTP 1982
Cdd:pfam15324 1145 PPQSP 1149
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1479-1572 9.26e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 9.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1479 AEEDEADDTSASIISDLICQ----GAQLGART-----------DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSG 1543
Cdd:PTZ00322    69 TTEEVIDPVVAHMLTVELCQlaasGDAVGARIlltggadpncrDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDG 148

                           90       100
                   ....*....|....*....|....*....
gi 1720389227 1544 RTPLHTAVTADAQGVFQILIRNRSTDLDA 1572
Cdd:PTZ00322   149 KTPLELAEENGFREVVQLLSRHSQCHFEL 177
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1560-1695 9.46e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 9.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1560 QILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGA----- 1634
Cdd:PHA02874    18 EKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVdtsil 97

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720389227 1635 -----NKDM-------------QDSKEETPLFLAAREGSYEAAKLLLDHLANREITDHLDRLPRDVAQERLHQDIVRLL 1695
Cdd:PHA02874    98 pipciEKDMiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 835-862 1.07e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 1.07e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720389227  835 CLHNGTCVDLVGGFRCNCPPGYTG-LHCE 862
Cdd:cd00053      8 CSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 395-429 1.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720389227  395 DACESQ-PCQAGGTCTSDGIGFRCTCAPGFQGHQCE 429
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 170-198 1.11e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.11e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720389227  170 CASTPCRNGAKCVDQPDGYECRCAEGFEG 198
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 279-313 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720389227  279 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 313
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 835-860 1.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.31e-03
                           10        20
                   ....*....|....*....|....*.
gi 1720389227  835 CLHNGTCVDLVGGFRCNCPPGYTGLH 860
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 355-388 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720389227  355 NHPCAHkpcsHGVCHDAPGGFRCVCEPGWSGPRC 388
Cdd:cd00054      8 GNPCQN----GGTCVNTVGSYRCSCPPGYTGRNC 37
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1508-1638 1.66e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1508 RTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTdLDARMADGSTALILAARL 1587
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAMAK 178

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720389227 1588 AVEGMVEELIASHADVNAVDELGKSALHWAAAVNN-VEATLALLKNGANKDM 1638
Cdd:PHA02875   179 GDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNkIDIVRLFIKRGADCNI 230
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1510-1670 1.66e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.46  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1510 GETALHLAARYARADAAKRLLDAGAD-----TNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMAD-------- 1576
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpgpk 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1577 -----GSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNveATLA------LLKNGANKD------MQ 1639
Cdd:cd22192    131 nliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPN--KTFAcqmydlILSYDKEDDlqpldlVP 208

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1720389227 1640 DSKEETPLFLAAREGSYEaaklLLDHLANRE 1670
Cdd:cd22192    209 NNQGLTPFKLAAKEGNIV----MFQHLVQKR 235
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1748-1968 1.93e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1748 TRGRGKkLTLAcPGPLADSSVTL------SPVDSLDSPRPFSGPPASPGGFPLEGPYATTATAVSLAQLGASRAGPLGRQ 1821
Cdd:PRK07003   332 TVGRGE-LGLA-PDEYAGFTMTLlrmlafEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAA 409

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1822 PPGGCVLSFGLLNPVAVPLDWARLPPPAPPGPSfllPLAPGPQLLNPGAPVSPQERPPPYLAAPGHGEEYPAAGTRSSPT 1901
Cdd:PRK07003   410 LAPKAAAAAAATRAEAPPAAPAPPATADRGDDA---ADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPP 486

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720389227 1902 KARFlrvpsehpyltpspeSPEHWASPSPPSLSDWSDSTPSPATATNATASgALPAQPHPISVPSLP 1968
Cdd:PRK07003   487 DAAF---------------EPAPRAAAPSAATPAAVPDARAPAAASREDAP-AAAAPPAPEARPPTP 537
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1858-1984 1.96e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1858 PLAPGPQLLNPGAP----------------VSPQERPPPYLAAPGHGEEYPAAGTRSSPTKARFLRVPSEHPYLTPSPES 1921
Cdd:PTZ00449   511 PEGPEASGLPPKAPgdkegeegehedskesDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKD 590

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720389227 1922 PEHWASPSPPSLSDWSDSTPSPATATnataSGALPAQPHPISVPSLPQSQTQlgPQPEVTPKR 1984
Cdd:PTZ00449   591 PEEPKKPKRPRSAQRPTRPKSPKLPE----LLDIPKSPKRPESPKSPKRPPP--PQRPSSPER 647
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 59-86 2.69e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.69e-03
                           10        20
                   ....*....|....*....|....*...
gi 1720389227   59 NPCEHLGRCVNTQGSFLCQCGRGYTGPR 86
Cdd:pfam00008    4 NPCSNGGTCVDTPGGYTCICPEGYTGKR 31
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 42-83 2.86e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.22  E-value: 2.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1720389227   42 FTGGACdQDVDECSIGANPCEHLgrCVNTQGSFLCQCGRGYT 83
Cdd:cd01475    179 FQGKIC-VVPDLCATLSHVCQQV--CISTPGSYLCACTEGYA 217
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 835-856 3.11e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 3.11e-03
                           10        20
                   ....*....|....*....|..
gi 1720389227  835 CLHNGTCVDLVGGFRCNCPPGY 856
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 208-237 3.22e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.22e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  208 CSPDPCHH-GRCVDGIASFSCACAPGYTGIR 237
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1578-1663 3.95e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 3.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1578 STALILAARlavEGMVEE----LIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNG---ANKDMQDS--KEETPLF 1648
Cdd:cd22192     18 ESPLLLAAK---ENDVQAikklLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQGETALH 94

                           90
                   ....*....|....*
gi 1720389227 1649 LAAREGSYEAAKLLL 1663
Cdd:cd22192     95 IAVVNQNLNLVRELI 109
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 131-162 4.10e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 4.10e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720389227  131 ECQ-SSPCVNGGVCKDRVNGFSCTCPSGFSGSM 162
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1509-1684 4.92e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.79  E-value: 4.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1509 TGETALH---LAARYARADAAKRLLDAGADTNAQD-----------HSGRTPLHTAVTADAQGVFQILIRNRStDLDARM 1574
Cdd:cd21882     25 TGKTCLHkaaLNLNDGVNEAIMLLLEAAPDSGNPKelvnapctdefYQGQTALHIAIENRNLNLVRLLVENGA-DVSARA 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1575 AD-------------GSTALILAARLAVEGMVEELI---ASHADVNAVDELGKSALHWAAAV--NNVEATL-------AL 1629
Cdd:cd21882    104 TGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVLHALVLQadNTPENSAfvcqmynLL 183

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720389227 1630 LKNGANKDMQDSKEE-------TPLFLAAREGSYEaaklLLDHLANREITDHLDRLPRDVAQ 1684
Cdd:cd21882    184 LSYGAHLDPTQQLEEipnhqglTPLKLAAVEGKIV----MFQHILQREFSGPYQPLSRKFTE 241
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 588-619 5.29e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 5.29e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720389227  588 SPSSCFNGGTCVDGVSSFSCLCRPGYTG-THCQ 619
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 475-502 5.93e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.04  E-value: 5.93e-03
                           10        20
                   ....*....|....*....|....*...
gi 1720389227  475 GASPCGPHGTCTNLPGNFRCICHRGYTG 502
Cdd:pfam12947    4 NNGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 785-810 6.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.93e-03
                           10        20
                   ....*....|....*....|....*.
gi 1720389227  785 CASQPCQNGGSCIDLVARYLCSCPPG 810
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEG 26
PHA03377 PHA03377
EBNA-3C; Provisional
 1666-1984 6.93e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 41.58  E-value: 6.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1666 LANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPS-GPHGLGPLLCPPGAFLPglkAVQSGTKKSRRPPGKTGLG 1744
Cdd:PHA03377   634 LRERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPAtQSTPPRPSWLPSVFVLP---SVDAGRAQPSEESHLSSMS 710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1745 PQGTRGRGKKLTLACPGPLADssVTLSP-VDSLDSPR-PFSG---PPAS-----------PGGFPLEGPYATTATAVSLA 1808
Cdd:PHA03377   711 PTQPISHEEQPRYEDPDDPLD--LSLHPdQAPPPSHQaPYSGheePQAQqapypgyweprPPQAPYLGYQEPQAQGVQVS 788

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1809 QLgASRAGPLGRQPPGGCvlsfgllnpvavpldwarlpppappgpsFLLPLAPGPQLLNPGAPVSPQERPPPYLA----- 1883
Cdd:PHA03377   789 SY-PGYAGPWGLRAQHPR----------------------------YRHSWAYWSQYPGHGHPQGPWAPRPPHLPpqwdg 839

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1884 APGHGE----EYPAAGTRSSPTKARFLRVPSEHPYLTPSPESPEHWASPSPPS-LSDWSDSTPSPAT------ATNATAS 1952
Cdd:PHA03377   840 SAGHGQdqvsQFPHLQSETGPPRLQLSQVPQLPYSQTLVSSSAPSWSSPQPRApIRPIPTRFPPPPMplqdsmAVGCDSS 919

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1720389227 1953 GAlpAQPHPISVPSLPQSQ-TQLGPQPEvTPKR 1984
Cdd:PHA03377   920 GT--ACPSMPFASDYSQGAfTPLDINAQ-TPKR 949
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 587-615 7.00e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 7.00e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720389227  587 CSPSSCFNGGTCVDGVSSFSCLCRPGYTG 615
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
PHA02946 PHA02946
ankyin-like protein; Provisional
 1506-1649 7.09e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.19  E-value: 7.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1506 TDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQI-LIRNRSTDLDARMADGSTALILA 1584
Cdd:PHA02946    68 TDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERInLLVQYGAKINNSVDEEGCGPLLA 147

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720389227 1585 ARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLA--LLKNGANKDMQDSKEETPLFL 1649
Cdd:PHA02946   148 CTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKASTIswMMKLGISPSKPDHDGNTPLHI 214
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 513-542 7.19e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 7.19e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  513 DPNPCLHGGSCQDGVGSFSCSCLDGFAGPR 542
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1537-1675 7.90e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.22  E-value: 7.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1537 NAQDHSGRTPLhtavtadaqgvFQILIRNRSTDL---------DARMADgstALILAARLAVEGMVEELI----ASHAD- 1602
Cdd:TIGR00870   46 NCPDRLGRSAL-----------FVAAIENENLELtelllnlscRGAVGD---TLLHAISLEYVDAVEAILlhllAAFRKs 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1603 -----VNA--VDEL--GKSALHWAAAVNNVEATLALLKNGAN------------KDMQDS--KEETPLFLAAREGSYEAA 1659
Cdd:TIGR00870  112 gplelANDqyTSEFtpGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQGVDSfyHGESPLNAAACLGSPSIV 191

                          170
                   ....*....|....*.
gi 1720389227 1660 KLLLDHLANREITDHL 1675
Cdd:TIGR00870  192 ALLSEDPADILTADSL 207
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 664-692 7.96e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 7.96e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  664 SQAPCQNGGRCVQT--GAYCICPPGWSGRLC 692
Cdd:cd00054      7 SGNPCQNGGTCVNTvgSYRCSCPPGYTGRNC 37
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1510-1677 7.96e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 7.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1510 GETALHLAARYARADAAKRLLDAGADTNAQdhsgrtplhtavtadAQGVFqilirNRSTDLDARMADGSTALILAARLAV 1589
Cdd:cd22194    141 GQTALNIAIERRQGDIVKLLIAKGADVNAH---------------AKGVF-----FNPKYKHEGFYFGETPLALAACTNQ 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389227 1590 EGMVEELIA-SHADVNAVDELGKSALHWAAAV-NNVEATLA--------LLKNGANKD---MQDSKEETPLFLAAREGSY 1656
Cdd:cd22194    201 PEIVQLLMEkESTDITSQDSRGNTVLHALVTVaEDSKTQNDfvkrmydmILLKSENKNletIRNNEGLTPLQLAAKMGKA 280

                          170       180
                   ....*....|....*....|....*
gi 1720389227 1657 EaaklLLDHLANREITD----HLDR 1677
Cdd:cd22194    281 E----ILKYILSREIKEkpnrSLSR 301
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 625-655 8.11e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.11e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  625 CFSRPCLHGGICNPTHPGFECTCREGFTGSQ 655
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 169-198 8.25e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 8.25e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  169 ECA-STPCRNGAKCVDQPDGYECRCAEGFEG 198
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 750-779 8.75e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 8.75e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720389227  750 QPCQHGGTCRGYMGGYVCECPAGYAGD-SCE 779
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 663-690 9.04e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.04e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720389227  663 CSQAPCQNGGRCVQT--GAYCICPPGWSGR 690
Cdd:pfam00008    1 CAPNPCSNGGTCVDTpgGYTCICPEGYTGK 30
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 53-86 9.56e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 9.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720389227   53 ECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPR 86
Cdd:cd00053      1 ECAAS-NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH