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Conserved domains on  [gi|1720395717|ref|XP_030106916|]
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tectonic-3 isoform X1 [Mus musculus]

Protein Classification

tectonic family protein( domain architecture ID 10405)

tectonic family protein, formerly called DUF1619 domain, similar to Homo sapiens tectonic proteins which are components of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes, and is required for hedgehog signaling transduction

Gene Ontology:  GO:0008589|GO:1904491
PubMed:  16357211|22179047

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCTN_DUF1619 super family cl06690
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 4-96 1.52e-21

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


The actual alignment was detected with superfamily member pfam07773:

Pssm-ID: 462260  Cd Length: 315  Bit Score: 92.61  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395717   4 QVPVTLASQASPPLLAGNTCQNIVSQVVYEIETNGTFGIQKVSVSFRQTNLTVKPgVSLQQDFIVHFRAFQQRKaaaPAA 83
Cdd:pfam07773 227 TLTSTSLRGSPSPLLNNGTCRNVVLEVKYVITYNGTGGITEATVSLVLANVSASQ-LPLQQRFQVSFLSANSES---ASE 302

                          90
                  ....*....|...
gi 1720395717  84 PRSGNPGYLTGKP 96
Cdd:pfam07773 303 SRSGNPGYVVGKP 315
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 4-96 1.52e-21

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 92.61  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395717   4 QVPVTLASQASPPLLAGNTCQNIVSQVVYEIETNGTFGIQKVSVSFRQTNLTVKPgVSLQQDFIVHFRAFQQRKaaaPAA 83
Cdd:pfam07773 227 TLTSTSLRGSPSPLLNNGTCRNVVLEVKYVITYNGTGGITEATVSLVLANVSASQ-LPLQQRFQVSFLSANSES---ASE 302

                          90
                  ....*....|...
gi 1720395717  84 PRSGNPGYLTGKP 96
Cdd:pfam07773 303 SRSGNPGYVVGKP 315
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 4-96 1.52e-21

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 92.61  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395717   4 QVPVTLASQASPPLLAGNTCQNIVSQVVYEIETNGTFGIQKVSVSFRQTNLTVKPgVSLQQDFIVHFRAFQQRKaaaPAA 83
Cdd:pfam07773 227 TLTSTSLRGSPSPLLNNGTCRNVVLEVKYVITYNGTGGITEATVSLVLANVSASQ-LPLQQRFQVSFLSANSES---ASE 302

                          90
                  ....*....|...
gi 1720395717  84 PRSGNPGYLTGKP 96
Cdd:pfam07773 303 SRSGNPGYVVGKP 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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