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Conserved domains on  [gi|1720395833|ref|XP_030106939|]
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MMS19 nucleotide excision repair protein homolog isoform X5 [Mus musculus]

Protein Classification

MMS19_C domain-containing protein( domain architecture ID 12116530)

MMS19_C domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MMS19_C pfam12460
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision ...
191-618 2.68e-126

RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.


:

Pssm-ID: 463594  Cd Length: 426  Bit Score: 380.45  E-value: 2.68e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 191 CLQALSAVSTHPSIVKETLPLLLQHLCQANKGNMVteSSEVVAVCQSLQQVAE-KCQQDPESYWYFHKTAVPCLFALAVQ 269
Cdd:pfam12460   1 ILEALADLSTEPQLFETLVIRLLNKLDLVCKAESS--SAYAFALLSTLLYLLEnKKLIKQFDVNSYYDRIVPRLLNLFID 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 270 ASMPEKESSVLRkvllEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDGNTsfLPENSFPDQFQPFQDGSS-GQR 348
Cdd:pfam12460  79 AALISSDDSVLT----DERLLELLGRIINLIVRSLSVEKQQEILNDVYTLFLTGDV--LQSIPAPSNFLPLQPSASsLQR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 349 RLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSC-PFSSTAATKCFAGLLNKQPPGQQLEEFLQLAVGTVEAGLAS 427
Cdd:pfam12460 153 RLVILFTAILAALDKEVKLPDLSELLDKLVRLLASSATsPFQRLAYLRLLALLVNKFLDDDRLEELLDFLDDLLDSNLTS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 428 ESSRdQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLSDPELGCAAADGFSLLMSDCTDVLTRAGHADVRIMFRQRFFTD 507
Cdd:pfam12460 233 KIST-QALEILIWITKALVLRNHPLATELLDKLLELLSDEELGQLAAKGFGILVSDDDDVLSKENHANIRLLYKQRFFNT 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 508 NVPALVQGFHAA-PQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQIMSL 586
Cdd:pfam12460 312 VLPKLVEGFKSAdDSSIKPNYLTALSLILKNVPKSLLLPELPTLLPLLLQALDLPDAEVRLSTLETLLSLLEEAPQLVSE 391
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1720395833 587 HVDTLVTKFLNLS---SSYSMAVRIAALQCMHALT 618
Cdd:pfam12460 392 HLSSLVPRLLKLStpsSMNSAKVRIAALQCLGLLP 426
 
Name Accession Description Interval E-value
MMS19_C pfam12460
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision ...
191-618 2.68e-126

RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.


Pssm-ID: 463594  Cd Length: 426  Bit Score: 380.45  E-value: 2.68e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 191 CLQALSAVSTHPSIVKETLPLLLQHLCQANKGNMVteSSEVVAVCQSLQQVAE-KCQQDPESYWYFHKTAVPCLFALAVQ 269
Cdd:pfam12460   1 ILEALADLSTEPQLFETLVIRLLNKLDLVCKAESS--SAYAFALLSTLLYLLEnKKLIKQFDVNSYYDRIVPRLLNLFID 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 270 ASMPEKESSVLRkvllEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDGNTsfLPENSFPDQFQPFQDGSS-GQR 348
Cdd:pfam12460  79 AALISSDDSVLT----DERLLELLGRIINLIVRSLSVEKQQEILNDVYTLFLTGDV--LQSIPAPSNFLPLQPSASsLQR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 349 RLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSC-PFSSTAATKCFAGLLNKQPPGQQLEEFLQLAVGTVEAGLAS 427
Cdd:pfam12460 153 RLVILFTAILAALDKEVKLPDLSELLDKLVRLLASSATsPFQRLAYLRLLALLVNKFLDDDRLEELLDFLDDLLDSNLTS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 428 ESSRdQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLSDPELGCAAADGFSLLMSDCTDVLTRAGHADVRIMFRQRFFTD 507
Cdd:pfam12460 233 KIST-QALEILIWITKALVLRNHPLATELLDKLLELLSDEELGQLAAKGFGILVSDDDDVLSKENHANIRLLYKQRFFNT 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 508 NVPALVQGFHAA-PQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQIMSL 586
Cdd:pfam12460 312 VLPKLVEGFKSAdDSSIKPNYLTALSLILKNVPKSLLLPELPTLLPLLLQALDLPDAEVRLSTLETLLSLLEEAPQLVSE 391
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1720395833 587 HVDTLVTKFLNLS---SSYSMAVRIAALQCMHALT 618
Cdd:pfam12460 392 HLSSLVPRLLKLStpsSMNSAKVRIAALQCLGLLP 426
 
Name Accession Description Interval E-value
MMS19_C pfam12460
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision ...
191-618 2.68e-126

RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.


Pssm-ID: 463594  Cd Length: 426  Bit Score: 380.45  E-value: 2.68e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 191 CLQALSAVSTHPSIVKETLPLLLQHLCQANKGNMVteSSEVVAVCQSLQQVAE-KCQQDPESYWYFHKTAVPCLFALAVQ 269
Cdd:pfam12460   1 ILEALADLSTEPQLFETLVIRLLNKLDLVCKAESS--SAYAFALLSTLLYLLEnKKLIKQFDVNSYYDRIVPRLLNLFID 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 270 ASMPEKESSVLRkvllEDEVLAALASVIGTATTHLSPELAAQSVTCIVPLFLDGNTsfLPENSFPDQFQPFQDGSS-GQR 348
Cdd:pfam12460  79 AALISSDDSVLT----DERLLELLGRIINLIVRSLSVEKQQEILNDVYTLFLTGDV--LQSIPAPSNFLPLQPSASsLQR 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 349 RLVALLTAFVCSLPRNVEIPQLNRLMRELLKQSCGHSC-PFSSTAATKCFAGLLNKQPPGQQLEEFLQLAVGTVEAGLAS 427
Cdd:pfam12460 153 RLVILFTAILAALDKEVKLPDLSELLDKLVRLLASSATsPFQRLAYLRLLALLVNKFLDDDRLEELLDFLDDLLDSNLTS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 428 ESSRdQAFTLLLWVTKALVLRYHPLSACLTTRLMGLLSDPELGCAAADGFSLLMSDCTDVLTRAGHADVRIMFRQRFFTD 507
Cdd:pfam12460 233 KIST-QALEILIWITKALVLRNHPLATELLDKLLELLSDEELGQLAAKGFGILVSDDDDVLSKENHANIRLLYKQRFFNT 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 508 NVPALVQGFHAA-PQDVKPNYLKGLSHVLNRLPKPVLLPELPTLLSLLLEALSCPDSVVQLSTLSCLQPLLLEAPQIMSL 586
Cdd:pfam12460 312 VLPKLVEGFKSAdDSSIKPNYLTALSLILKNVPKSLLLPELPTLLPLLLQALDLPDAEVRLSTLETLLSLLEEAPQLVSE 391
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1720395833 587 HVDTLVTKFLNLS---SSYSMAVRIAALQCMHALT 618
Cdd:pfam12460 392 HLSSLVPRLLKLStpsSMNSAKVRIAALQCLGLLP 426
Pdase_M17_N2 pfam18295
M17 aminopeptidase N-terminal domain 2; This domain is found in the N-terminal region of M17 ...
147-234 8.45e-03

M17 aminopeptidase N-terminal domain 2; This domain is found in the N-terminal region of M17 aminopeptidase (pfam00883) present in Homo sapiens and Mus musculus. M17 aminopeptidases are Zn-dependent exopeptidases that catalyze the removal of unsubstituted amino acid residues from the N-terminus of peptides.


Pssm-ID: 408104  Cd Length: 121  Bit Score: 36.99  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720395833 147 GTLATLYPGAFS--RHLLPKLAEE---LHKGESDVARADG------------PTKCSRH---FRClQALSA-VSTHPSIV 205
Cdd:pfam18295   7 GTLETLNELTLQdvAHLEPRVAELidrVASAHTYLPVADGcslvlsvtvaqlPTKASRHntpARP-HAISKlVKANVSGV 85
                          90       100
                  ....*....|....*....|....*....
gi 1720395833 206 KETLPLLLqhlcqankgnmVTESSEVVAV 234
Cdd:pfam18295  86 KEVVVDVL-----------VCESENVLAS 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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