|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
443-678 |
1.27e-123 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 374.26 E-value: 1.27e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 443 ESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHL--PSSI 520
Cdd:cd18038 1 ELNDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALvtKREI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 521 YRLLAPSRDIRMVPEDIKTCCNWDAKKGeYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPES 600
Cdd:cd18038 81 LRLNAPSRDRASVPPELLPYCNSKAEGT-FRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720403311 601 LVAIAglmdvkETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNSLYKKGpnGYDPQFITKLLRNYR 678
Cdd:cd18038 160 LIPLS------ELASKNTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYKDG--EYNPSYITKLLKNYR 229
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
679-884 |
4.63e-67 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 222.11 E-value: 4.63e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 679 SHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLpqqGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLap 758
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPLPGP---SKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 759 sskkgKARLSPRNVGVISPYRKQVEKIRyciTKLDRELRGLDDIKdlkVGSVEEFQGQERSVILISTVRSSQSFVQLdld 838
Cdd:cd18808 76 -----KSGVKPSSIGVITPYRAQVALIR---ELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNESGGSI--- 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1720403311 839 fnlGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCK 884
Cdd:cd18808 142 ---GFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
643-867 |
6.30e-62 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 208.56 E-value: 6.30e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 643 LGYSLLERLlaynslYKKGPngydpQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCrWEGLPQQGFPII 722
Cdd:pfam13087 1 LDRSLFERL------QELGP-----SAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPD-DFHLPDPLGPLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 723 FHGVMGKDEREGNS-PSFFNPEEAATVTSYLKQLLAPSSKKgkarlsPRNVGVISPYRKQVEKIRYcitKLDRELRGLDD 801
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRK---LLKRKLGGKLE 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720403311 802 IKdlkVGSVEEFQGQERSVILISTVRSSQsfvqldlDFNLGFLKNPKRFNVAVTRAKALLIVVGNP 867
Cdd:pfam13087 140 IE---VNTVDGFQGREKDVIIFSCVRSNE-------KGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
558-886 |
1.17e-60 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 222.31 E-value: 1.17e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 558 LQQYRVLITTLITASRLVSAQFpiDHFTHIFIDEAGHCMEPESLVAIAglmdvketgnPGGQLVLAGDPRQLGPVLRSPL 637
Cdd:COG1112 532 LELAPVVGMTPASVARLLPLGE--GSFDLVIIDEASQATLAEALGALA----------RAKRVVLVGDPKQLPPVVFGEE 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 638 ALK---HGLGYSLLERLLAynslykkgpnGYDPQFITkLLRNYRSHPTILDIPNQLYYDGELQACADVVDRErfcrwegL 714
Cdd:COG1112 600 AEEvaeEGLDESLLDRLLA----------RLPERGVM-LREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARR-------L 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 715 PQQGFPIIFHGVMGKDEREGNSPSffNPEEAATVTSYLKQLLapsskkgKARLSPRNVGVISPYRKQVEKIRyciTKLDR 794
Cdd:COG1112 662 ADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL-------EDGPDGESIGVITPYRAQVALIR---ELLRE 729
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 795 ELRGLDDikDLKVGSVEEFQGQERSVILISTVRSSQSfvqlDLDFNLGFL-KNPKRFNVAVTRAKALLIVVGNPLLLGHD 873
Cdd:COG1112 730 ALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSD 803
|
330
....*....|....*.
gi 1720403311 874 P---DWKTFLEFCKEN 886
Cdd:COG1112 804 PstpALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
430-889 |
3.31e-55 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 203.12 E-value: 3.31e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 430 PSDVKFKLYDRSLesNPEQLQAMKHIVrgtTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKahILACAPSNSGADLLC 509
Cdd:TIGR00376 146 SEIHDFQFFDPNL--NESQKEAVLFAL---SSKDLFLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 510 QRL--------RVHLPSSIY------------------------------------RLLAPSRDIRMVPEDIKTCCNwDA 545
Cdd:TIGR00376 219 ERLalcdqkivRLGHPARLLksnkqhsldylienhpkyqivadirekidelieernKKTKPSPQKRRGLSDIKILRK-AL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 546 KKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPID--------------------------HFTHIFIDEAGHCMEPE 599
Cdd:TIGR00376 298 KKREARGIESLKIASMAEWIETNKSIDRLLKLLPESEerimneilaesdatnsmagseilngqYFDVAVIDEASQAMEPS 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 600 SLVAIaglmdvketgNPGGQLVLAGDPRQLGPVLRSPLAlkHGLGYSLLERLLaynSLYkkgpngydPQFITKLLRNYRS 679
Cdd:TIGR00376 378 CLIPL----------LKARKLILAGDHKQLPPTILSHDA--EELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 680 HPTILDIPNQLYYDGELQACADVVDR-------ERFCRWEGLPQQGFPIIFHGVMGKD---EREGNSPSFFNPEEAATVT 749
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHESVANIllrdlpkVEATESEDDLETGIPLLFIDTSGCElfeLKEADSTSKYNPGEAELVS 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 750 SYLKQLLapsskkgKARLSPRNVGVISPYRKQVEKIRYCItkldrELRGLddikDLKVGSVEEFQGQERSVILISTVRSS 829
Cdd:TIGR00376 515 EIIQALV-------KMGVPANDIGVITPYDAQVDLLRQLL-----EHRHI----DIEVSSVDGFQGREKEVIIISFVRSN 578
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 830 QSfvqldldFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGY 889
Cdd:TIGR00376 579 RK-------GEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
448-636 |
1.34e-16 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 80.47 E-value: 1.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 448 QLQAMKHIVRgttRPAPYIIFGPPGTGKTVTLVEAIKQVVKHL-----PKAHILACAPSNSGADLLCQRL---------- 512
Cdd:pfam13086 2 QREAIRSALS---SSHFTLIQGPPGTGKTTTIVELIRQLLSYPatsaaAGPRILVCAPSNAAVDNILERLlrkgqkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 513 --RVHLPSSI-------------------YRLLAPSRDIRMVPEDIKTCCNWDAK------KGEYVYPAKKHLQQYR--- 562
Cdd:pfam13086 79 ivRIGHPAAIseavlpvsldylvesklnnEEDAQIVKDISKELEKLAKALRAFEKeiivekLLKSRNKDKSKLEQERrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 563 ---------------------------VLITTLITASRLV---SAQFPIdhfthIFIDEAGHCMEPESLVAIagLMDVKe 612
Cdd:pfam13086 159 rserkelrkelrrreqslereildeaqIVCSTLSGAGSRLlssLANFDV-----VIIDEAAQALEPSTLIPL--LRGPK- 230
|
250 260
....*....|....*....|....
gi 1720403311 613 tgnpggQLVLAGDPRQLGPVLRSP 636
Cdd:pfam13086 231 ------KVVLVGDPKQLPPTVISK 248
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
441-632 |
4.95e-11 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 66.15 E-value: 4.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 441 SLESNPEQLQAMKHIVrgTTRPApYIIFGPPGTGKTvTLVEAIKQVVKHLpKAHILACAPSNSGAdllcQRLR--VHLPS 518
Cdd:COG0507 122 GITLSDEQREAVALAL--TTRRV-SVLTGGAGTGKT-TTLRALLAALEAL-GLRVALAAPTGKAA----KRLSesTGIEA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 519 S-IYRLLApsrdirmvpediktccnWDAKKGEYVYPAKKHLQQYRVLIttlitasrlvsaqfpidhfthifIDEAghcme 597
Cdd:COG0507 193 RtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDEA----- 227
|
170 180 190
....*....|....*....|....*....|....*..
gi 1720403311 598 peSLVAIAgLMD--VKETGNPGGQLVLAGDPRQLGPV 632
Cdd:COG0507 228 --SMVDTR-LMAalLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
445-600 |
3.36e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 48.64 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVRGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLL 524
Cdd:smart00487 10 RPYQKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVV 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403311 525 A--PSRDIRMVPEDIKTCCnwdakkgeyvypakkhlqqYRVLITTLITASRLVSAQ-FPIDHFTHIFIDEAgHCMEPES 600
Cdd:smart00487 87 GlyGGDSKREQLRKLESGK-------------------TDILVTTPGRLLDLLENDkLSLSNVDLVILDEA-HRLLDGG 145
|
|
| cdc6 |
PRK00411 |
ORC1-type DNA replication protein; |
447-479 |
5.07e-03 |
|
ORC1-type DNA replication protein;
Pssm-ID: 234751 [Multi-domain] Cd Length: 394 Bit Score: 40.22 E-value: 5.07e-03
10 20 30
....*....|....*....|....*....|....*.
gi 1720403311 447 EQLQAMKHIVRGTTR---PAPYIIFGPPGTGKTVTL 479
Cdd:PRK00411 37 EQIEELAFALRPALRgsrPLNVLIYGPPGTGKTTTV 72
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
443-678 |
1.27e-123 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 374.26 E-value: 1.27e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 443 ESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHL--PSSI 520
Cdd:cd18038 1 ELNDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALvtKREI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 521 YRLLAPSRDIRMVPEDIKTCCNWDAKKGeYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPES 600
Cdd:cd18038 81 LRLNAPSRDRASVPPELLPYCNSKAEGT-FRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720403311 601 LVAIAglmdvkETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNSLYKKGpnGYDPQFITKLLRNYR 678
Cdd:cd18038 160 LIPLS------ELASKNTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYKDG--EYNPSYITKLLKNYR 229
|
|
| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
445-678 |
2.28e-79 |
|
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 257.30 E-value: 2.28e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRL---RVHLPSSIY 521
Cdd:cd18078 3 NELQKEAVKRILGGECRPLPYILFGPPGTGKTVTIIEAILQVVYNLPRSRILVCAPSNSAADLVTSRLhesKVLKPGDMV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 522 RLLAPSRDIRMVPEDIKTCCnwdaKKGEYVYPAKKHlqqyRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESL 601
Cdd:cd18078 83 RLNAVNRFESTVIDARKLYC----RLGEDLSKASRH----RIVISTCSTAGLLYQMGLPVGHFTHVFVDEAGQATEPESL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 602 VAIaGLMDVKetgnpGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNsLYKKGPN------GYDPQFITKLLR 675
Cdd:cd18078 155 IPL-GLISSR-----DGQIILAGDPMQLGPVIKSRLASAYGLGVSFLERLMNRP-LYLRDPNrfgesgGYNPLLVTKLVD 227
|
...
gi 1720403311 676 NYR 678
Cdd:cd18078 228 NYR 230
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
679-884 |
4.63e-67 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 222.11 E-value: 4.63e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 679 SHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLpqqGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLap 758
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPLPGP---SKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 759 sskkgKARLSPRNVGVISPYRKQVEKIRyciTKLDRELRGLDDIKdlkVGSVEEFQGQERSVILISTVRSSQSFVQLdld 838
Cdd:cd18808 76 -----KSGVKPSSIGVITPYRAQVALIR---ELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNESGGSI--- 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1720403311 839 fnlGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCK 884
Cdd:cd18808 142 ---GFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
643-867 |
6.30e-62 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 208.56 E-value: 6.30e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 643 LGYSLLERLlaynslYKKGPngydpQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCrWEGLPQQGFPII 722
Cdd:pfam13087 1 LDRSLFERL------QELGP-----SAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPD-DFHLPDPLGPLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 723 FHGVMGKDEREGNS-PSFFNPEEAATVTSYLKQLLAPSSKKgkarlsPRNVGVISPYRKQVEKIRYcitKLDRELRGLDD 801
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRK---LLKRKLGGKLE 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720403311 802 IKdlkVGSVEEFQGQERSVILISTVRSSQsfvqldlDFNLGFLKNPKRFNVAVTRAKALLIVVGNP 867
Cdd:pfam13087 140 IE---VNTVDGFQGREKDVIIFSCVRSNE-------KGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
558-886 |
1.17e-60 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 222.31 E-value: 1.17e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 558 LQQYRVLITTLITASRLVSAQFpiDHFTHIFIDEAGHCMEPESLVAIAglmdvketgnPGGQLVLAGDPRQLGPVLRSPL 637
Cdd:COG1112 532 LELAPVVGMTPASVARLLPLGE--GSFDLVIIDEASQATLAEALGALA----------RAKRVVLVGDPKQLPPVVFGEE 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 638 ALK---HGLGYSLLERLLAynslykkgpnGYDPQFITkLLRNYRSHPTILDIPNQLYYDGELQACADVVDRErfcrwegL 714
Cdd:COG1112 600 AEEvaeEGLDESLLDRLLA----------RLPERGVM-LREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARR-------L 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 715 PQQGFPIIFHGVMGKDEREGNSPSffNPEEAATVTSYLKQLLapsskkgKARLSPRNVGVISPYRKQVEKIRyciTKLDR 794
Cdd:COG1112 662 ADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL-------EDGPDGESIGVITPYRAQVALIR---ELLRE 729
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 795 ELRGLDDikDLKVGSVEEFQGQERSVILISTVRSSQSfvqlDLDFNLGFL-KNPKRFNVAVTRAKALLIVVGNPLLLGHD 873
Cdd:COG1112 730 ALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSD 803
|
330
....*....|....*.
gi 1720403311 874 P---DWKTFLEFCKEN 886
Cdd:COG1112 804 PstpALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
430-889 |
3.31e-55 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 203.12 E-value: 3.31e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 430 PSDVKFKLYDRSLesNPEQLQAMKHIVrgtTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKahILACAPSNSGADLLC 509
Cdd:TIGR00376 146 SEIHDFQFFDPNL--NESQKEAVLFAL---SSKDLFLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 510 QRL--------RVHLPSSIY------------------------------------RLLAPSRDIRMVPEDIKTCCNwDA 545
Cdd:TIGR00376 219 ERLalcdqkivRLGHPARLLksnkqhsldylienhpkyqivadirekidelieernKKTKPSPQKRRGLSDIKILRK-AL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 546 KKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPID--------------------------HFTHIFIDEAGHCMEPE 599
Cdd:TIGR00376 298 KKREARGIESLKIASMAEWIETNKSIDRLLKLLPESEerimneilaesdatnsmagseilngqYFDVAVIDEASQAMEPS 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 600 SLVAIaglmdvketgNPGGQLVLAGDPRQLGPVLRSPLAlkHGLGYSLLERLLaynSLYkkgpngydPQFITKLLRNYRS 679
Cdd:TIGR00376 378 CLIPL----------LKARKLILAGDHKQLPPTILSHDA--EELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 680 HPTILDIPNQLYYDGELQACADVVDR-------ERFCRWEGLPQQGFPIIFHGVMGKD---EREGNSPSFFNPEEAATVT 749
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHESVANIllrdlpkVEATESEDDLETGIPLLFIDTSGCElfeLKEADSTSKYNPGEAELVS 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 750 SYLKQLLapsskkgKARLSPRNVGVISPYRKQVEKIRYCItkldrELRGLddikDLKVGSVEEFQGQERSVILISTVRSS 829
Cdd:TIGR00376 515 EIIQALV-------KMGVPANDIGVITPYDAQVDLLRQLL-----EHRHI----DIEVSSVDGFQGREKEVIIISFVRSN 578
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 830 QSfvqldldFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGY 889
Cdd:TIGR00376 579 RK-------GEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
445-678 |
3.61e-32 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 124.90 E-value: 3.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVRGTTRPAPYI-IFGPPGTGKTVTLVEAIKQVVKHlPKAHILACAPSNSGADLLCQR------LRVHLP 517
Cdd:cd18077 3 NAKQKEAVLAITTPLSIQLPPVlLIGPFGTGKTFTLAQAVKHILQQ-PETRILICTHSNSAADLYIKEylhpyvETGNPR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 518 SSIYRLLAPSRDIRMVPEDIKTCCNWDAKkGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCME 597
Cdd:cd18077 82 ARPLRVYYRNRWVKTVHPVVQKYCLIDEH-GTFRMPTREDVMRHRVVVVTLSTSQYLCQLDLEPGFFTHILLDEAAQAME 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 598 PESLVAIAglMDVKETgnpggQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYnslykkgpngYDPQF--ITKLLR 675
Cdd:cd18077 161 CEAIMPLA--LATKST-----RIVLAGDHMQLSPEVYSEFARERNLHISLLERLYEH----------YPSEHpcRILLCE 223
|
...
gi 1720403311 676 NYR 678
Cdd:cd18077 224 NYR 226
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
466-678 |
2.36e-31 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 121.56 E-value: 2.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 466 IIFGPPGTGKTVTLVEAIKQVVKhlPKAHILACAPSNSGADLLCQRLrVHLPSSIYRLLAPSRdirmVPEDIKTCCnWDA 545
Cdd:cd18044 21 LIHGPPGTGKTTTVVEIILQAVK--RGEKVLACAPSNIAVDNLVERL-VALKVKVVRIGHPAR----LLESVLDHS-LDA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 546 kkgeyvypakkhLQQYRVLITTLITASrlvSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAglmdvketgnPGGQLVLAG 624
Cdd:cd18044 93 ------------LVAAQVVLATNTGAG---SRQLlPNELFDVVVIDEAAQALEASCWIPLL----------KARRCILAG 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1720403311 625 DPRQLGPVLRSPLALKHGLGYSLLERLLaynslykkgpNGYDPQFITKLLRNYR 678
Cdd:cd18044 148 DHKQLPPTILSDKAARGGLGVTLFERLV----------NLYGESVVRMLTVQYR 191
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
445-653 |
1.82e-29 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 117.35 E-value: 1.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVrgtTRPAPYIIfGPPGTGKTVTlveaIKQVVKHLPKAH---ILACAPSNSGADLLCQRL--------- 512
Cdd:cd18039 3 NHSQVDAVKTAL---QRPLSLIQ-GPPGTGKTVT----SATIVYHLVKQGngpVLVCAPSNVAVDQLTEKIhqtglkvvr 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 513 -----RVHLPSSIYrLLAPSRDIRMVPEDIKT------------CCNWDAKKGEYVYPAKKH--LQQYRVLITTLITA-- 571
Cdd:cd18039 75 lcaksREAVESPVS-FLALHNQVRNLDSAEKLellkllkletgeLSSADEKRYRKLKRKAERelLRNADVICCTCVGAgd 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 572 SRLVSAQFPidhftHIFIDEAGHCMEPESLVAIagLMDVKetgnpggQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERL 651
Cdd:cd18039 154 PRLSKMKFR-----TVLIDEATQATEPECLIPL--VHGAK-------QVILVGDHCQLGPVVMCKKAAKAGLSQSLFERL 219
|
..
gi 1720403311 652 LA 653
Cdd:cd18039 220 VQ 221
|
|
| DEXXQc_HELZ2-N |
cd18076 |
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
445-654 |
1.03e-24 |
|
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB, and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350834 [Multi-domain] Cd Length: 230 Bit Score: 103.82 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIV---RGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHlPKAHILACAPSNSGADLLcqrLRVHLPSSI- 520
Cdd:cd18076 3 NNKQQLAFNFIAgkpSEARFVPPLLIYGPFGTGKTFTLAMAALEVIRE-PGTKVLICTHTNSAADIY---IREYFHPYVd 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 521 --------YRLLAPSRDIRMV-PEDIKTCCNWDAKKGeYVYPAKKHLQQYRVLITTLITASRLVSaqfPIDHFTHIFIDE 591
Cdd:cd18076 79 kghpearpLRIKATDRPNAITdPDTITYCCLTKDRQC-FRLPTRDELDFHNIVITTTAMAFNLHV---LSGFFTHIFIDE 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720403311 592 AGHCMEPESLVAIAglmdvkeTGNPGGQLVLAGDPRQLGPVLRSpLALKHGLGYSLLERLLAY 654
Cdd:cd18076 155 AAQMLECEALIPLS-------YAGPKTRVVLAGDHMQMTPKLFS-VADYNRANHTLLNRLFHY 209
|
|
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
445-655 |
4.20e-19 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 86.88 E-value: 4.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVRGTTRPApyIIFGPPGTGKTVTLVEAI-----------------------KQVVKHLPKAHILACAPS 501
Cdd:cd18042 2 NESQLEAIASALQNSPGIT--LIQGPPGTGKTKTIVGILsvllagkyrkyyekvkkklrklqRNLNNKKKKNRILVCAPS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 502 NSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKtccnwdakkgeyvypaKKHLQQYRVLITTLITA-SRLVSAqfP 580
Cdd:cd18042 80 NAAVDEIVLRLLSEGFLDGDGRSYKPNVVRVGRQELR----------------ASILNEADIVCTTLSSSgSDLLES--L 141
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720403311 581 IDHFTHIFIDEAGHCMEPESLVAIAglMDVKetgnpggQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYN 655
Cdd:cd18042 142 PRGFDTVIIDEAAQAVELSTLIPLR--LGCK-------RLILVGDPKQLPATVFSKVAQKLGYDRSLFERLQLAG 207
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
448-636 |
1.34e-16 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 80.47 E-value: 1.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 448 QLQAMKHIVRgttRPAPYIIFGPPGTGKTVTLVEAIKQVVKHL-----PKAHILACAPSNSGADLLCQRL---------- 512
Cdd:pfam13086 2 QREAIRSALS---SSHFTLIQGPPGTGKTTTIVELIRQLLSYPatsaaAGPRILVCAPSNAAVDNILERLlrkgqkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 513 --RVHLPSSI-------------------YRLLAPSRDIRMVPEDIKTCCNWDAK------KGEYVYPAKKHLQQYR--- 562
Cdd:pfam13086 79 ivRIGHPAAIseavlpvsldylvesklnnEEDAQIVKDISKELEKLAKALRAFEKeiivekLLKSRNKDKSKLEQERrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 563 ---------------------------VLITTLITASRLV---SAQFPIdhfthIFIDEAGHCMEPESLVAIagLMDVKe 612
Cdd:pfam13086 159 rserkelrkelrrreqslereildeaqIVCSTLSGAGSRLlssLANFDV-----VIIDEAAQALEPSTLIPL--LRGPK- 230
|
250 260
....*....|....*....|....
gi 1720403311 613 tgnpggQLVLAGDPRQLGPVLRSP 636
Cdd:pfam13086 231 ------KVVLVGDPKQLPPTVISK 248
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
445-651 |
1.72e-16 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 80.65 E-value: 1.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKhivRGTTRPApYIIFGPPGTGKTVTLV-----------EAIKQVVKHLPKAHILACAPSNSGAD----LLC 509
Cdd:cd18040 3 NPSQNHAVR---TALTKPF-TLIQGPPGTGKTVTGVhiaywfakqnrEIQSVSGEGDGGPCVLYCGPSNKSVDvvaeLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 510 QR-----LRVH----------LPSSIYRLLAPSRD----------------IRMVP----EDIKTCCNWDAKKGEYVypA 554
Cdd:cd18040 79 KVpglkiLRVYseqietteypIPNEPRHPNKKSEReskpnselssitlhhrIRQPSnphsQQIKAFEARFERTQEKI--T 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 555 KKHLQQYRVLITT------------LITASRLVSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKetgnpggQLV 621
Cdd:cd18040 157 EEDIKTYKILIWEarfeeletvdviLCTCSEAASQKMrTHANVKQCIVDECGMCTEPESLIPIVSAPRAE-------QVV 229
|
250 260 270
....*....|....*....|....*....|
gi 1720403311 622 LAGDPRQLGPVLRSPLALKHGLGYSLLERL 651
Cdd:cd18040 230 LIGDHKQLRPVVQNKEAQKLGLGRSLFERY 259
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
466-678 |
1.18e-15 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 74.19 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 466 IIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSgadllcqrlrvhlpssiyrllapsrdirmvpediktccnwda 545
Cdd:cd17934 3 LIQGPPGTGKTTTIAAIVLQLLKGLRGKRVLVTAQSNV------------------------------------------ 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 546 kkgeyvypakkhlqqyrvlittlitasrlvsaqfPIDHFTHIFIDEAGHCMEPESLVAIAGlmdvketgnpGGQLVLAGD 625
Cdd:cd17934 41 ----------------------------------AVDNVDVVIIDEASQITEPELLIALIR----------AKKVVLVGD 76
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720403311 626 PRQLGPVL----RSPLALKHGLGYSLLERLLAYNSLYkkgpngydpqfiTKLLRNYR 678
Cdd:cd17934 77 PKQLPPVVqedhAALLGLSFILSLLLLFRLLLPGSPK------------VMLDTQYR 121
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
445-678 |
2.97e-14 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 72.65 E-value: 2.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVRGTTrpapY-IIFGPPGTGKTVTLVEAIKqvVKHLPKAHILACAPSNSGADLLCQRLRVHlPSSIYRL 523
Cdd:cd18041 3 NKDQRQAIKKVLNAKD----YaLILGMPGTGKTTTIAALVR--ILVALGKSVLLTSYTHSAVDNILLKLKKF-GVNFLRL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 524 lapSRDIRMVPEDIKTCCNWDAKKGEYVYPAKKHLQQYRVLITTLITasrlvsaqfpIDHftHIF---------IDEAGH 594
Cdd:cd18041 76 ---GRLKKIHPDVQEFTLEAILKSCKSVEELESKYESVSVVATTCLG----------INH--PIFrrrtfdyciVDEASQ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 595 CMEPESLVAIAGlmdvketgnpGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNslykkgpngydPQFITKLL 674
Cdd:cd18041 141 ITLPICLGPLRL----------AKKFVLVGDHYQLPPLVKSREARELGMDESLFKRLSEAH-----------PDAVVQLT 199
|
....
gi 1720403311 675 RNYR 678
Cdd:cd18041 200 IQYR 203
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
441-632 |
4.95e-11 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 66.15 E-value: 4.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 441 SLESNPEQLQAMKHIVrgTTRPApYIIFGPPGTGKTvTLVEAIKQVVKHLpKAHILACAPSNSGAdllcQRLR--VHLPS 518
Cdd:COG0507 122 GITLSDEQREAVALAL--TTRRV-SVLTGGAGTGKT-TTLRALLAALEAL-GLRVALAAPTGKAA----KRLSesTGIEA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 519 S-IYRLLApsrdirmvpediktccnWDAKKGEYVYPAKKHLQQYRVLIttlitasrlvsaqfpidhfthifIDEAghcme 597
Cdd:COG0507 193 RtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDEA----- 227
|
170 180 190
....*....|....*....|....*....|....*..
gi 1720403311 598 peSLVAIAgLMD--VKETGNPGGQLVLAGDPRQLGPV 632
Cdd:COG0507 228 --SMVDTR-LMAalLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
447-632 |
3.40e-09 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 56.41 E-value: 3.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 447 EQLQAMKHIVRGttrpaPYIIF-GPPGTGKTVTLveaiKQVVKHL--PKAHILACAPSNSGAdllcQRLR--VHLPSS-I 520
Cdd:cd17933 1 EQKAAVRLVLRN-----RVSVLtGGAGTGKTTTL----KALLAALeaEGKRVVLAAPTGKAA----KRLSesTGIEAStI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 521 YRLLapsrdirmvpediktccnWDAKKGEYVYPAKKHLQQYRVLIttlitasrlvsaqfpidhfthifIDEAghcmepeS 600
Cdd:cd17933 68 HRLL------------------GINPGGGGFYYNEENPLDADLLI-----------------------VDEA-------S 99
|
170 180 190
....*....|....*....|....*....|...
gi 1720403311 601 LVAIAgLMD-VKETGNPGGQLVLAGDPRQLGPV 632
Cdd:cd17933 100 MVDTR-LMAaLLSAIPAGARLILVGDPDQLPSV 131
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
380-865 |
5.10e-08 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 56.76 E-value: 5.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 380 SRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLW---------PMLFPVASRGVSLLPSDVKF-KLYDRSLESNP-EQ 448
Cdd:COG3972 77 SGAEQVVLDGVRALFEVLLQVDRESVRNLTEDHLRSlrllaasrrDFLFALLLPEIPPAPFVQALrLLNLVSLEDFFlPL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 449 LQAM----KHIVRgTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILA-CApSNSgadlLCQRLRVHLPSSIYRL 523
Cdd:COG3972 157 IAVLdlqqERIAR-SIPDGPQRIRGVAGSGKTVLLAAKAAYLALKHPGWRILVtCF-NRS----LADHLRDLIPRFLRRF 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 524 LAPSrdirmVPEDIKTCCN--WDAK-KGEYVYPAKKHLQQ---YRVLITTLITASRLVSAQFPIDHfthIFIDEAgHCME 597
Cdd:COG3972 231 SNGE-----PEDNVKLIVFhaWGGKlLKQYGIPPLTFSQPneaFDEACKALLEAIQGEIIPPIYDA---ILIDEA-QDFE 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 598 PESLVAIAGLMDvketgNPGGQLVLAGDPRQlgpvlrsplalkhglgysllerllaynSLYKK---GPNGYDPQF--ITK 672
Cdd:COG3972 302 PEFLRLLYQLLK-----PPKKRLIWAYDEAQ---------------------------NIYGRkipSAGGIPAGIgrDTI 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 673 LLRNYRSHPTILDIPNQLY-----YDGELQACADVVDRERFcrweglpqqGFPIIFHGVMGKDEREGNSPSFF----NPE 743
Cdd:COG3972 350 LKKNYRNTRPILTFAHAFGmgllrPPGLLQGDAEDYEVERP---------GDKVTLIRPPEPAGRKGPLPEFKkyddRAE 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 744 EAATVTSYLKQLLApsskkgKARLSPRNVGVI----SPYRKQVEKIRYCITKLDRELRGLDDIKD---------LKVGSV 810
Cdd:COG3972 421 ELEAIAEEIKKNLR------DEGLRPSDIAVIylgnNEAKELGDRLAAALERQGIDSYIAGARSDpnffwkdggVTISTI 494
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1720403311 811 EEFQGQERSVILISTVRSSQSFVQLDLDFNLGFlknpkrfnVAVTRAKALLIVVG 865
Cdd:COG3972 495 HRAKGLEAPVVIIVGLDQLAKGESLERLRNLLY--------VAMTRARGWLVVSG 541
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
445-651 |
2.75e-07 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 51.39 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVrgTTRPApyIIFGPPGTGKT---VTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIY 521
Cdd:cd17936 3 DPSQLEALKHAL--TSELA--LIQGPPGTGKTflgVKLVRALLQNQDLSITGPILVVCYTNHALDQFLEGLLDFGPTKIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 522 RLLApsrdirmvpeDIKTCCNWDAKKgeyvypakkhlqqYRVLITTLitasrlvsaQFPIdhfthIFIDEAGHCMEPESL 601
Cdd:cd17936 79 RLGA----------RVIGMTTTGAAK-------------YRELLQAL---------GPKV-----VIVEEAAEVLEAHIL 121
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1720403311 602 VAIaglmdvketGNPGGQLVLAGDPRQLGPVLRSPL--ALKHGLGYSLLERL 651
Cdd:cd17936 122 AAL---------TPSTEHLILIGDHKQLRPKVNVYEltAKKYNLDVSLFERL 164
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
445-632 |
3.13e-07 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 51.80 E-value: 3.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVRGTTRPApyIIFGPPGTGKTvTLVEAIKQVVKHLPKaHILACAPSNSGADLLCQRLRVHlPSSIYRLL 524
Cdd:pfam13604 3 NAEQAAAVRALLTSGDRVA--VLVGPAGTGKT-TALKALREAWEAAGY-RVIGLAPTGRAAKVLGEELGIP-ADTIAKLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 525 APSRDIRmvpediktccNWDAKkgeyvypakkhlqqyRVLIttlitasrlvsaqfpidhfthifIDEAGhcmepesLVAI 604
Cdd:pfam13604 78 HRLGGRA----------GLDPG---------------TLLI-----------------------VDEAG-------MVGT 102
|
170 180
....*....|....*....|....*....
gi 1720403311 605 AGLMDV-KETGNPGGQLVLAGDPRQLGPV 632
Cdd:pfam13604 103 RQMARLlKLAEDAGARVILVGDPRQLPSV 131
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
445-600 |
3.36e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 48.64 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIVRGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLL 524
Cdd:smart00487 10 RPYQKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVV 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720403311 525 A--PSRDIRMVPEDIKTCCnwdakkgeyvypakkhlqqYRVLITTLITASRLVSAQ-FPIDHFTHIFIDEAgHCMEPES 600
Cdd:smart00487 87 GlyGGDSKREQLRKLESGK-------------------TDILVTTPGRLLDLLENDkLSLSNVDLVILDEA-HRLLDGG 145
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
440-691 |
5.66e-06 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 48.19 E-value: 5.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 440 RSLESNPEQLQAmkhIVRGTtRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQ---RLRV-- 514
Cdd:cd17935 2 NTVKFTPTQIEA---IRSGM-QPGLTMVVGPPGTGKTDVAVQIISNLYHNFPNQRTLIVTHSNQALNQLFEkimALDIde 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 515 -HLpssiYRLLAPSRDIRMvpedikTCCNWDAKKGEyvypakkhlqqyrvlittlitasrLVSAQFpidHFTHIFIDEAG 593
Cdd:cd17935 78 rHL----LRLGHGAKIIAM------TCTHAALKRGE------------------------LVELGF---KYDNILMEEAA 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 594 HCMEPESLVAIagLMDVKETG-NPGGQLVLAGDPRQLGPVLRSPLALKHG-LGYSLLERLLAYNSlykkgpngydpqFIT 671
Cdd:cd17935 121 QILEIETFIPL--LLQNPEDGpNRLKRLIMIGDHHQLPPVIKNMAFQKYSnMEQSLFTRLVRLGV------------PTV 186
|
250 260
....*....|....*....|
gi 1720403311 672 KLLRNYRSHPTILDIPNQLY 691
Cdd:cd17935 187 DLDAQGRARASISSLYNWRY 206
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
772-865 |
6.45e-06 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 45.12 E-value: 6.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 772 VGVISPYRKQVEKIRYCITKLDRELrglDDIKDLKVGSVEEFQGQERSVILISTVRSsqsfvqldldfnlgFLKNPKRFN 851
Cdd:cd18786 13 GVVLTPYHRDRAYLNQYLQGLSLDE---FDLQLVGAITIDSSQGLTFDVVTLYLPTA--------------NSLTPRRLY 75
|
90
....*....|....
gi 1720403311 852 VAVTRAKALLIVVG 865
Cdd:cd18786 76 VALTRARKRLVIYD 89
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
466-506 |
1.90e-05 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 44.78 E-value: 1.90e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1720403311 466 IIFGPPGTGKTVTLVEAIKQVV--KHLPKAHILACAPSNSGAD 506
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMqnKNGEPGRILLVTPTNKAAA 45
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
466-622 |
1.29e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 40.08 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 466 IIFGPPGTGKTVTLVEAIKQV-VKHLPKAHILacAPSNSGADLLCQRLRvhlpssiyRLLAPSRDIRMvpediktcCNWD 544
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLlLKKGKKVLVL--VPTKALALQTAERLR--------ELFGPGIRVAV--------LVGG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 545 AKKGEyvyPAKKHLQQYRVLITTLITASRLVSA--QFPIDHFTHIFIDEAgHCMEPESLVAIAGLMDVKETGNPGGQLVL 622
Cdd:cd00046 67 SSAEE---REKNKLGDADIIIATPDMLLNLLLRedRLFLKDLKLIIVDEA-HALLIDSRGALILDLAVRKAGLKNAQVIL 142
|
|
| cdc6 |
PRK00411 |
ORC1-type DNA replication protein; |
447-479 |
5.07e-03 |
|
ORC1-type DNA replication protein;
Pssm-ID: 234751 [Multi-domain] Cd Length: 394 Bit Score: 40.22 E-value: 5.07e-03
10 20 30
....*....|....*....|....*....|....*.
gi 1720403311 447 EQLQAMKHIVRGTTR---PAPYIIFGPPGTGKTVTL 479
Cdd:PRK00411 37 EQIEELAFALRPALRgsrPLNVLIYGPPGTGKTTTV 72
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
455-524 |
6.58e-03 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 37.97 E-value: 6.58e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720403311 455 IVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVK-HLPKAHILACAPSNSGADLLCQRLrvHLPSS-IYRLL 524
Cdd:pfam13245 4 AVRTALPSKVVLLTGGPGTGKTTTIRHIVALLVAlGGVSFPILLAAPTGRAAKRLSERT--GLPAStIHRLL 73
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
445-525 |
7.75e-03 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 39.92 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720403311 445 NPEQLQAMKHIvrgttrPAPYIIFGPPGTGKTVTLVEAIKQVV--KHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYR 522
Cdd:COG0210 8 NPEQRAAVEHP------EGPLLVLAGAGSGKTRVLTHRIAYLIaeGGVDPEQILAVTFTNKAAREMRERIEALLGRLARG 81
|
...
gi 1720403311 523 LLA 525
Cdd:COG0210 82 LWV 84
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
461-515 |
8.36e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 37.74 E-value: 8.36e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1720403311 461 RPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVH 515
Cdd:smart00382 1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVG 55
|
|
| |
