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Conserved domains on  [gi|1720406793|ref|XP_030108872|]
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reduced expression 2 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 1.98e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.98e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720406793  27 LLTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFV 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
277-666 5.17e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 277 KPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCN--ECDKCFTDKGSLRVHQRIHTGEKPYKCS-ECDKCFTQPSHLSIH 353
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 354 RRIHSGEKPYKCSECDKCFTdkctlRKHQRIHTGEKPYK--CSECDKCFTEKFTLRKHQRIHtgeKPYKCNECDKCFTDK 431
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 432 GSLRVHQRIHTGEKPYKCSECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKCSECDKC 511
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 512 FTDKGSLRVHQRIHIGE-------KPYKCSECDKCFTQPSHLSIH--CRIHSGE--KPYKCSE--CDKCFTHKGSLRVHH 578
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 579 RIHAGEKPYKC--SECDKCFTEKNGLRRHQRI--HTGEKPYKCSECD-----KCFTRKSHLS--IHQRIHTGEKLYKCSE 647
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLsnsciRNFKRDSNLSlhIITHLSFRPYNCKNPP 423

                         410
                  ....*....|....*....
gi 1720406793 648 CDKCFTQQCHLSIHQKIHS 666
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 1.98e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.98e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720406793  27 LLTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFV 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
28-70 8.31e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 8.31e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720406793   28 LTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFVENH 70
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-66 7.13e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.03  E-value: 7.13e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720406793  28 LTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLF 66
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
277-666 5.17e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 277 KPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCN--ECDKCFTDKGSLRVHQRIHTGEKPYKCS-ECDKCFTQPSHLSIH 353
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 354 RRIHSGEKPYKCSECDKCFTdkctlRKHQRIHTGEKPYK--CSECDKCFTEKFTLRKHQRIHtgeKPYKCNECDKCFTDK 431
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 432 GSLRVHQRIHTGEKPYKCSECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKCSECDKC 511
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 512 FTDKGSLRVHQRIHIGE-------KPYKCSECDKCFTQPSHLSIH--CRIHSGE--KPYKCSE--CDKCFTHKGSLRVHH 578
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 579 RIHAGEKPYKC--SECDKCFTEKNGLRRHQRI--HTGEKPYKCSECD-----KCFTRKSHLS--IHQRIHTGEKLYKCSE 647
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLsnsciRNFKRDSNLSlhIITHLSFRPYNCKNPP 423

                         410
                  ....*....|....*....
gi 1720406793 648 CDKCFTQQCHLSIHQKIHS 666
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-626 3.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.57e-04
                          10        20
                  ....*....|....*....|....*
gi 1720406793 602 LRRHQRIHTGEKPYKCSECDKCFTR 626
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 1.98e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.98e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720406793  27 LLTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFV 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
28-70 8.31e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 8.31e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720406793   28 LTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFVENH 70
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-66 7.13e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.03  E-value: 7.13e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720406793  28 LTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLF 66
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
277-666 5.17e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 277 KPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCN--ECDKCFTDKGSLRVHQRIHTGEKPYKCS-ECDKCFTQPSHLSIH 353
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 354 RRIHSGEKPYKCSECDKCFTdkctlRKHQRIHTGEKPYK--CSECDKCFTEKFTLRKHQRIHtgeKPYKCNECDKCFTDK 431
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 432 GSLRVHQRIHTGEKPYKCSECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKCSECDKC 511
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 512 FTDKGSLRVHQRIHIGE-------KPYKCSECDKCFTQPSHLSIH--CRIHSGE--KPYKCSE--CDKCFTHKGSLRVHH 578
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 579 RIHAGEKPYKC--SECDKCFTEKNGLRRHQRI--HTGEKPYKCSECD-----KCFTRKSHLS--IHQRIHTGEKLYKCSE 647
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLsnsciRNFKRDSNLSlhIITHLSFRPYNCKNPP 423

                         410
                  ....*....|....*....
gi 1720406793 648 CDKCFTQQCHLSIHQKIHS 666
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-638 4.12e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 220 KKSYKYSESDKCFTQTSHLSIHHTIHSGEKPYKCSEcdkcftdkctlrkhqrihtgekpykcSECDKCFTDKCTLRKHQR 299
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSY--------------------------SGCDKSFSRPLELSRHLR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 300 IHTGEKPYKCNecDKCFTDKGSLRVHQRIHTGEKPykcSECDKCFTQPSHLSIHRRIHSgeKPYKCSECDKCFTDKCTLR 379
Cdd:COG5048    85 THHNNPSDLNS--KSLPLSNSKASSSSLSSSSSNS---NDNNLLSSHSLPPSSRDPQLP--DLLSISNLRNNPLPGNNSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 380 KHQRIHTGEKPYKCS--ECDKCFTEKFTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFT 457
Cdd:COG5048   158 SVNTPQSNSLHPPLPanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 458 KPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGE-------KPYKCSECDKCFTDKGSLRVHQR--IHIGE 528
Cdd:COG5048   238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 529 --KPYKCSE--CDKCFTQPSHLSIHCRIHSGEKPYKCSECDKCFTHKGSL-------RVHHRIHAGEKPYKC--SECDKC 595
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRN 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1720406793 596 FTEKNGLRRHQRIHTGEKP--YKCSECDKCFTRKSHLSIHQRIHT 638
Cdd:COG5048   398 FKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-534 4.74e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793  96 NRKKSSKCNELRNVIHESSESTPYNTNHRDATLqSSNLKRHK---TGTTKGVCTYKDCVNclKGSSIISLNQGTHIEKKE 172
Cdd:COG5048    13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSR-LEHLTRHIrshTGEKPSQCSYSGCDK--SFSRPLELSRHLRTHHNN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 173 HNRNKNLDEVLVSRQNNSEMNTYTCGEFDKCFTQSDNLQSQQRIYPGKKSYKY-SESDKCFTQTSHLSIHHTIHSGEKPY 251
Cdd:COG5048    90 PSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSiSNLRNNPLPGNNSSSVNTPQSNSLHP 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 252 KCSecdkcftdkctlrkhqRIHTGEKPYKCSecdkcftdkcTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTG 331
Cdd:COG5048   170 PLP----------------ANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 332 EKPYKCSECDKCFTQPSHLSIHRRIHSGEKPYKCSECDKCFTDK--CTLRKHQRIHTGE-----KPYKCSECDKCFTEKF 404
Cdd:COG5048   224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTasSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSS 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 405 TLRKHQR--IHTGE--KPYKCNE--CDKCFTDKGSLRVHQRIHTGEKPYKCSEC------DKCFTKPSHLSIH-RRIHSG 471
Cdd:COG5048   304 PLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQqYKDLKN 383

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720406793 472 EKPYKCSECDKCFTQPS----PLSIHRRIHSGEKPYKCSECDKCFTDKGSLRVHQRIHIGEKPYKCS 534
Cdd:COG5048   384 DKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-626 3.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.57e-04
                          10        20
                  ....*....|....*....|....*
gi 1720406793 602 LRRHQRIHTGEKPYKCSECDKCFTR 626
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 526-605 4.40e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 526 IGEKPYKCS--ECDKCFTQPSHLSIHcRIHSgekpykcsECDKCFTHKGSLRVHHRIHAGEKPYKCSECDKCFTEKNGLR 603
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 1720406793 604 RH 605
Cdd:COG5189   416 YH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 387-470 7.80e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 387 GEKPYKCS--ECDKCFTEKFTLRKHqRIHtgekpykcNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTKPSHLSI 464
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720406793 465 HRRiHS 470
Cdd:COG5189   417 HRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 359-437 1.15e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 359 GEKPYKCS--ECDKCFTDKCTLRKHqRIHtgekpykcSECDKCFTEKFTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRV 436
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720406793 437 H 437
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406793 321 SLRVHQRIHTGEKPYKCSECDKCFTQ 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-317 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....
gi 1720406793 294 LRKHQRIHTGEKPYKCNECDKCFT 317
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-429 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....
gi 1720406793 406 LRKHQRIHTGEKPYKCNECDKCFT 429
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-401 1.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.67e-03
                          10        20
                  ....*....|....*....|....
gi 1720406793 378 LRKHQRIHTGEKPYKCSECDKCFT 401
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-289 1.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.67e-03
                          10        20
                  ....*....|....*....|....
gi 1720406793 266 LRKHQRIHTGEKPYKCSECDKCFT 289
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 555-633 1.85e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 555 GEKPYKCS--ECDKCFTHKGSLRvHHRIHAgekpykcsECDKCFTEKNGLRRHQRIHTGEKPYKCSECDKCFTRKSHLSI 632
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLK-YHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720406793 633 H 633
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
433-458 2.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406793 433 SLRVHQRIHTGEKPYKCSECDKCFTK 458
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 247-325 2.67e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 247 GEKPYKCS--ECDKCFTDKCTLRKHqRIHtgekpykcSECDKCFTDKCTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRV 324
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720406793 325 H 325
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 443-521 3.46e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 443 GEKPYKCS--ECDKCFTKPSHLSIHRrIHSGEKPykcsecdKCFTQPSPLSiHRRIHSGEKPYKCSECDKCFTDKGSLRV 520
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720406793 521 H 521
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-542 3.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406793 517 SLRVHQRIHIGEKPYKCSECDKCFTQ 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 275-358 4.49e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 275 GEKPYKCS--ECDKCFTDKCTLRKHqRIHtgekpykcNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQPSHLSI 352
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720406793 353 HRRiHS 358
Cdd:COG5189   417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
545-570 6.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720406793 545 HLSIHCRIHSGEKPYKCSECDKCFTH 570
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 471-554 8.29e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720406793 471 GEKPYKCS--ECDKCFTQPSPLSIHRrihsgekpyKCSECDKCFTDKGSLRVHQRIHIGEKPYKCSECDKCFTQPSHLSI 548
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1720406793 549 HcRIHS 554
Cdd:COG5189   417 H-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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