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Conserved domains on  [gi|1720412492|ref|XP_030110067|]
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prominin-1 isoform X3 [Mus musculus]

Protein Classification

prominin family protein( domain architecture ID 12063338)

prominin family protein is a pentaspan membrane glycoprotein similar to human prominin-1 that binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in cell differentiation, proliferation, and apoptosis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
19-813 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


:

Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 1053.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492  19 SEGQPAFHNTPGAMNYELPTTKYETQD-TFNAGIVGPLYKMVHIFLNVVQPNDFPLDLIKKLIQNK--------NFDISV 89
Cdd:pfam05478   2 THEQLGQTHPPSVLYTEYPPPTYYTADlTYPAGALGPLYNFVHSFLDVVQPNPFPPGYIRKLINKKlalgpkveKNDWSV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492  90 DSKEIALYEIGVLICAILGLLFIILMPLVGCFFCMCRCCNKCGGEMHQRQKQNAPCRRKCLGLSLLVICLLMSLGIIYGF 169
Cdd:pfam05478  82 LLAEVVRYEAGILVCAVIGLLYIILMPFIGLCFCCCRCCRRCGGEMHQCQKKNDACRRKTLGVSLLLLTLLLLIGIIIAF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 170 VANQQTRTRIKGTQKLAKSNFRDFQTLLTETPKQIDYVVEQ-YTNTKNKAFSDLDGIGSVLGGRIKDQLKPKVTPVLEEI 248
Cdd:pfam05478 162 VTNQYLDRGIGESTETMRRGLRDLRTFLSDVPQHIDHVLVQnYSELQDHVSDDLDDAGKHIGLDIHDTLESNVYPALAEL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 249 KAMATAIKQTKDALQNMSSSLKSLQDAATQLNTNLSSVRNSIENSLSSSDCTSdpasKICDSIRPSLSSLG--SSLNSSQ 326
Cdd:pfam05478 242 ERILQNMPEAKDLLEQVNALLKDLRFYGTQLRDGLRGVKRDLNYALSNPLCTT----QECDKFLSSLSIEFldTSACLDQ 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 327 LPSVDRELNTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSIPiEDMLLQVSHYLN 406
Cdd:pfam05478 318 LPNVDEFLENVKGVIETNLSSIVQEGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDIH 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 407 NSNRYLNQELPKLEEYDSYWWLGGLIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFC 486
Cdd:pfam05478 397 NTERSSRTFLDVVEKYGSYRWLIGLILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLFF 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 487 WILMILVVLTFVVGANVEKLLCEPYENKKLLQVLDTPYLLkeqWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQ 566
Cdd:pfam05478 477 WFLMLVVLLYFLVGGNTYTLVCAPWENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVLR 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 567 LENVVNVSDHFNIDQISENINTELENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFAST 646
Cdd:pfam05478 554 LNNIYDISKLLNISVYTEEIQQELENLKVDLSNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLADK 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 647 LEAKANQLPEGKLKQAFLLDVQNIRAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSL 726
Cdd:pfam05478 634 LEGLANSLPNGNLKVSLQNEAQDLRAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGSS 713
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 727 IVIGETKKFGKTILGYFEHYLHWVFYAITEKMTSCKPMATAMDSAVNgILCGYVADPLNLFWFGIGKATVLLLPAVIIAI 806
Cdd:pfam05478 714 IINNESENLLDRIMGYFEQYIDWVIEEVTENVGHCKPLAYAYDSGVV-LLCDRLVDPINAFWFGLGWCTLLLLPSIIFAV 792

                  ....*..
gi 1720412492 807 KLAKYYR 813
Cdd:pfam05478 793 KLAKYYR 799
 
Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
19-813 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 1053.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492  19 SEGQPAFHNTPGAMNYELPTTKYETQD-TFNAGIVGPLYKMVHIFLNVVQPNDFPLDLIKKLIQNK--------NFDISV 89
Cdd:pfam05478   2 THEQLGQTHPPSVLYTEYPPPTYYTADlTYPAGALGPLYNFVHSFLDVVQPNPFPPGYIRKLINKKlalgpkveKNDWSV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492  90 DSKEIALYEIGVLICAILGLLFIILMPLVGCFFCMCRCCNKCGGEMHQRQKQNAPCRRKCLGLSLLVICLLMSLGIIYGF 169
Cdd:pfam05478  82 LLAEVVRYEAGILVCAVIGLLYIILMPFIGLCFCCCRCCRRCGGEMHQCQKKNDACRRKTLGVSLLLLTLLLLIGIIIAF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 170 VANQQTRTRIKGTQKLAKSNFRDFQTLLTETPKQIDYVVEQ-YTNTKNKAFSDLDGIGSVLGGRIKDQLKPKVTPVLEEI 248
Cdd:pfam05478 162 VTNQYLDRGIGESTETMRRGLRDLRTFLSDVPQHIDHVLVQnYSELQDHVSDDLDDAGKHIGLDIHDTLESNVYPALAEL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 249 KAMATAIKQTKDALQNMSSSLKSLQDAATQLNTNLSSVRNSIENSLSSSDCTSdpasKICDSIRPSLSSLG--SSLNSSQ 326
Cdd:pfam05478 242 ERILQNMPEAKDLLEQVNALLKDLRFYGTQLRDGLRGVKRDLNYALSNPLCTT----QECDKFLSSLSIEFldTSACLDQ 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 327 LPSVDRELNTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSIPiEDMLLQVSHYLN 406
Cdd:pfam05478 318 LPNVDEFLENVKGVIETNLSSIVQEGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDIH 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 407 NSNRYLNQELPKLEEYDSYWWLGGLIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFC 486
Cdd:pfam05478 397 NTERSSRTFLDVVEKYGSYRWLIGLILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLFF 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 487 WILMILVVLTFVVGANVEKLLCEPYENKKLLQVLDTPYLLkeqWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQ 566
Cdd:pfam05478 477 WFLMLVVLLYFLVGGNTYTLVCAPWENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVLR 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 567 LENVVNVSDHFNIDQISENINTELENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFAST 646
Cdd:pfam05478 554 LNNIYDISKLLNISVYTEEIQQELENLKVDLSNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLADK 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 647 LEAKANQLPEGKLKQAFLLDVQNIRAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSL 726
Cdd:pfam05478 634 LEGLANSLPNGNLKVSLQNEAQDLRAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGSS 713
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 727 IVIGETKKFGKTILGYFEHYLHWVFYAITEKMTSCKPMATAMDSAVNgILCGYVADPLNLFWFGIGKATVLLLPAVIIAI 806
Cdd:pfam05478 714 IINNESENLLDRIMGYFEQYIDWVIEEVTENVGHCKPLAYAYDSGVV-LLCDRLVDPINAFWFGLGWCTLLLLPSIIFAV 792

                  ....*..
gi 1720412492 807 KLAKYYR 813
Cdd:pfam05478 793 KLAKYYR 799
 
Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
19-813 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 1053.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492  19 SEGQPAFHNTPGAMNYELPTTKYETQD-TFNAGIVGPLYKMVHIFLNVVQPNDFPLDLIKKLIQNK--------NFDISV 89
Cdd:pfam05478   2 THEQLGQTHPPSVLYTEYPPPTYYTADlTYPAGALGPLYNFVHSFLDVVQPNPFPPGYIRKLINKKlalgpkveKNDWSV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492  90 DSKEIALYEIGVLICAILGLLFIILMPLVGCFFCMCRCCNKCGGEMHQRQKQNAPCRRKCLGLSLLVICLLMSLGIIYGF 169
Cdd:pfam05478  82 LLAEVVRYEAGILVCAVIGLLYIILMPFIGLCFCCCRCCRRCGGEMHQCQKKNDACRRKTLGVSLLLLTLLLLIGIIIAF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 170 VANQQTRTRIKGTQKLAKSNFRDFQTLLTETPKQIDYVVEQ-YTNTKNKAFSDLDGIGSVLGGRIKDQLKPKVTPVLEEI 248
Cdd:pfam05478 162 VTNQYLDRGIGESTETMRRGLRDLRTFLSDVPQHIDHVLVQnYSELQDHVSDDLDDAGKHIGLDIHDTLESNVYPALAEL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 249 KAMATAIKQTKDALQNMSSSLKSLQDAATQLNTNLSSVRNSIENSLSSSDCTSdpasKICDSIRPSLSSLG--SSLNSSQ 326
Cdd:pfam05478 242 ERILQNMPEAKDLLEQVNALLKDLRFYGTQLRDGLRGVKRDLNYALSNPLCTT----QECDKFLSSLSIEFldTSACLDQ 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 327 LPSVDRELNTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSIPiEDMLLQVSHYLN 406
Cdd:pfam05478 318 LPNVDEFLENVKGVIETNLSSIVQEGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDIH 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 407 NSNRYLNQELPKLEEYDSYWWLGGLIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFC 486
Cdd:pfam05478 397 NTERSSRTFLDVVEKYGSYRWLIGLILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLFF 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 487 WILMILVVLTFVVGANVEKLLCEPYENKKLLQVLDTPYLLkeqWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQ 566
Cdd:pfam05478 477 WFLMLVVLLYFLVGGNTYTLVCAPWENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVLR 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 567 LENVVNVSDHFNIDQISENINTELENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFAST 646
Cdd:pfam05478 554 LNNIYDISKLLNISVYTEEIQQELENLKVDLSNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLADK 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 647 LEAKANQLPEGKLKQAFLLDVQNIRAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSL 726
Cdd:pfam05478 634 LEGLANSLPNGNLKVSLQNEAQDLRAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGSS 713
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412492 727 IVIGETKKFGKTILGYFEHYLHWVFYAITEKMTSCKPMATAMDSAVNgILCGYVADPLNLFWFGIGKATVLLLPAVIIAI 806
Cdd:pfam05478 714 IINNESENLLDRIMGYFEQYIDWVIEEVTENVGHCKPLAYAYDSGVV-LLCDRLVDPINAFWFGLGWCTLLLLPSIIFAV 792

                  ....*..
gi 1720412492 807 KLAKYYR 813
Cdd:pfam05478 793 KLAKYYR 799
FliD_N pfam02465
Flagellar hook-associated protein 2 N-terminus; The flagellar hook-associated protein 2 (HAP2 ...
248-298 5.58e-03

Flagellar hook-associated protein 2 N-terminus; The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria. This alignment covers the N-terminal region of this family of proteins.


Pssm-ID: 460566 [Multi-domain]  Cd Length: 97  Bit Score: 37.16  E-value: 5.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720412492 248 IKAMATAIKQTKDALQNMSSSLKSLQDAATQLNTNLSSVRNSIENSLSSSD 298
Cdd:pfam02465   9 VDQLMAAERAPLDRLEQQKTTLEWKQSAYGELNSKLSSLQSALKALSSSST 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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