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Conserved domains on  [gi|1720412638|ref|XP_030110118|]
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ataxin-2 isoform X27 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 88-161 5.90e-21

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 87.99  E-value: 5.90e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638   88 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESVLFKCSDFVVVQFK 161
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 228-289 8.28e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.28e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638  228 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 289
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 483-1062 1.70e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  483 HNPPSEAAAPPVARTSPAGGtwssvvSGVPRLSPKTHRPRSPRQSSIGNSPSG-PV-------------LASPQAGiipa 548
Cdd:PHA03247  2480 YRRPAEARFPFAAGAAPDPG------GGGPPDPDAPPAPSRLAPAILPDEPVGePVhprmltwirgleeLASDDAG---- 2549

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  549 eavsMPVPAASPTPASPASNRALTPSieakdsrlqdqrQNSPAGSKENVKASETSPSFSKADNKGMSPVvsehrkqiDDl 628
Cdd:PHA03247  2550 ----DPPPPLPPAAPPAAPDRSVPPP------------RPAPRPSEPAVTSRARRPDAPPQSARPRAPV--------DD- 2604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  629 kkfKNDFRLQPSSTSESMDQllsknregeksrdlikDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHK 708
Cdd:PHA03247  2605 ---RGDPRGPAPPSPLPPDT----------------HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  709 RGPEvTSQGVQTSSPAckqEKDDREEKKDTTEQVrKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQA--QPSPSMVGHQQ 786
Cdd:PHA03247  2666 RARR-LGRAAQASSPP---QRPRRRAARPTVGSL-TSLADPPPPPPTPEPAPHALVSATPLPPGPAAarQASPALPAAPA 2740

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  787 PAPVYTQPVcfapnmmypVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPA--SAAGPPIVA 864
Cdd:PHA03247  2741 PPAVPAGPA---------TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSpwDPADPPAAV 2811

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  865 TPPAYSTQYVAYSPQQFPNQPLVQHV-PHYQSQHPHVYSP----VIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAM 939
Cdd:PHA03247  2812 LAPAAALPPAASPAGPLPPPTSAQPTaPPPPPGPPPPSLPlggsVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAV 2891

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  940 YVSTGSLAQQyahPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTP 1019
Cdd:PHA03247  2892 SRSTESFALP---PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 1720412638 1020 PSMTPASNTQSPQSSfpaaqqtvftihPSHVQPAYTTPPHMAH 1062
Cdd:PHA03247  2969 PGRVAVPRFRVPQPA------------PSREAPASSTPPLTGH 2999
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 88-161 5.90e-21

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 87.99  E-value: 5.90e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638   88 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESVLFKCSDFVVVQFK 161
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 228-289 8.28e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.28e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638  228 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 289
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 483-1062 1.70e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  483 HNPPSEAAAPPVARTSPAGGtwssvvSGVPRLSPKTHRPRSPRQSSIGNSPSG-PV-------------LASPQAGiipa 548
Cdd:PHA03247  2480 YRRPAEARFPFAAGAAPDPG------GGGPPDPDAPPAPSRLAPAILPDEPVGePVhprmltwirgleeLASDDAG---- 2549

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  549 eavsMPVPAASPTPASPASNRALTPSieakdsrlqdqrQNSPAGSKENVKASETSPSFSKADNKGMSPVvsehrkqiDDl 628
Cdd:PHA03247  2550 ----DPPPPLPPAAPPAAPDRSVPPP------------RPAPRPSEPAVTSRARRPDAPPQSARPRAPV--------DD- 2604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  629 kkfKNDFRLQPSSTSESMDQllsknregeksrdlikDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHK 708
Cdd:PHA03247  2605 ---RGDPRGPAPPSPLPPDT----------------HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  709 RGPEvTSQGVQTSSPAckqEKDDREEKKDTTEQVrKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQA--QPSPSMVGHQQ 786
Cdd:PHA03247  2666 RARR-LGRAAQASSPP---QRPRRRAARPTVGSL-TSLADPPPPPPTPEPAPHALVSATPLPPGPAAarQASPALPAAPA 2740

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  787 PAPVYTQPVcfapnmmypVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPA--SAAGPPIVA 864
Cdd:PHA03247  2741 PPAVPAGPA---------TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSpwDPADPPAAV 2811

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  865 TPPAYSTQYVAYSPQQFPNQPLVQHV-PHYQSQHPHVYSP----VIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAM 939
Cdd:PHA03247  2812 LAPAAALPPAASPAGPLPPPTSAQPTaPPPPPGPPPPSLPlggsVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAV 2891

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  940 YVSTGSLAQQyahPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTP 1019
Cdd:PHA03247  2892 SRSTESFALP---PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 1720412638 1020 PSMTPASNTQSPQSSfpaaqqtvftihPSHVQPAYTTPPHMAH 1062
Cdd:PHA03247  2969 PGRVAVPRFRVPQPA------------PSREAPASSTPPLTGH 2999
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 740-988 2.42e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 51.96  E-value: 2.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  740 EQVRKSTLNPNAKEFNP--RSFSQPKPSTTPTSPRPQAQPSPSMVG---HQQPAPVytqpvcfaPNM-----MYPVPVSP 809
Cdd:pfam09770   98 EQVRFNRQQPAARAAQSsaQPPASSLPQYQYASQQSQQPSKPVRTGyekYKEPEPI--------PDLqvdasLWGVAPKK 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  810 GVQPLYPIPMTPMPVNQAKTYRagKV--------------PNMPQQRQDQHHQstmmhpasaagpPIVATPPAYSTQYVA 875
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSR--KMmsleeveaamraqaKKPAQQPAPAPAQ------------PPAAPPAQQAQQQQQ 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  876 YSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQgnARMMAPPahAQPGLVSSSAAQFGAHEQTHAMYVSTGSLAQQYAHPNA 955
Cdd:pfam09770  236 FPPQIQQQQQPQQQPQQPQQHPGQGHPVTIL--QRPQSPQ--PDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSA 311

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1720412638  956 ALHPHTPHPQPSATPT-GQQQSQHGGSHPAPSPV 988
Cdd:pfam09770  312 ARVGYPQNPQPGVQPApAHQAHRQQGSFGRQAPI 345
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 734-901 3.32e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 3.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  734 EKKDTteqvRKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQP 813
Cdd:TIGR01628  362 QRKEQ----RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPL 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  814 LypiPMTPMPVNQaktyrAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHY 893
Cdd:TIGR01628  433 R---PNGLAPMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQM 504

                          170
                   ....*....|....
gi 1720412638  894 QSQ------HPHVY 901
Cdd:TIGR01628  505 QKQvlgerlFPLVE 518
Sm_like cd00600
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
 92-159 3.78e-03

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


Pssm-ID: 212462 [Multi-domain]  Cd Length: 63  Bit Score: 36.84  E-value: 3.78e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638   92 LTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTEsssgpKREEIMESVLFKCSDFVVVQ 159
Cdd:cd00600      1 LKDFIGKTVSVELKDGRVLTGTLVAFDKYMNLVLDDVVETGRD-----GKVRVLGLVLIRGSNIVSIR 63
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 88-161 5.90e-21

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 87.99  E-value: 5.90e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638   88 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSTESSSG--PKREEIMESVLFKCSDFVVVQFK 161
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 228-289 8.28e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.28e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638  228 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 289
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 483-1062 1.70e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  483 HNPPSEAAAPPVARTSPAGGtwssvvSGVPRLSPKTHRPRSPRQSSIGNSPSG-PV-------------LASPQAGiipa 548
Cdd:PHA03247  2480 YRRPAEARFPFAAGAAPDPG------GGGPPDPDAPPAPSRLAPAILPDEPVGePVhprmltwirgleeLASDDAG---- 2549

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  549 eavsMPVPAASPTPASPASNRALTPSieakdsrlqdqrQNSPAGSKENVKASETSPSFSKADNKGMSPVvsehrkqiDDl 628
Cdd:PHA03247  2550 ----DPPPPLPPAAPPAAPDRSVPPP------------RPAPRPSEPAVTSRARRPDAPPQSARPRAPV--------DD- 2604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  629 kkfKNDFRLQPSSTSESMDQllsknregeksrdlikDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHK 708
Cdd:PHA03247  2605 ---RGDPRGPAPPSPLPPDT----------------HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  709 RGPEvTSQGVQTSSPAckqEKDDREEKKDTTEQVrKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQA--QPSPSMVGHQQ 786
Cdd:PHA03247  2666 RARR-LGRAAQASSPP---QRPRRRAARPTVGSL-TSLADPPPPPPTPEPAPHALVSATPLPPGPAAarQASPALPAAPA 2740

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  787 PAPVYTQPVcfapnmmypVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPA--SAAGPPIVA 864
Cdd:PHA03247  2741 PPAVPAGPA---------TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSpwDPADPPAAV 2811

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  865 TPPAYSTQYVAYSPQQFPNQPLVQHV-PHYQSQHPHVYSP----VIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAM 939
Cdd:PHA03247  2812 LAPAAALPPAASPAGPLPPPTSAQPTaPPPPPGPPPPSLPlggsVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAV 2891

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  940 YVSTGSLAQQyahPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTP 1019
Cdd:PHA03247  2892 SRSTESFALP---PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 1720412638 1020 PSMTPASNTQSPQSSfpaaqqtvftihPSHVQPAYTTPPHMAH 1062
Cdd:PHA03247  2969 PGRVAVPRFRVPQPA------------PSREAPASSTPPLTGH 2999
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 740-988 2.42e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 51.96  E-value: 2.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  740 EQVRKSTLNPNAKEFNP--RSFSQPKPSTTPTSPRPQAQPSPSMVG---HQQPAPVytqpvcfaPNM-----MYPVPVSP 809
Cdd:pfam09770   98 EQVRFNRQQPAARAAQSsaQPPASSLPQYQYASQQSQQPSKPVRTGyekYKEPEPI--------PDLqvdasLWGVAPKK 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  810 GVQPLYPIPMTPMPVNQAKTYRagKV--------------PNMPQQRQDQHHQstmmhpasaagpPIVATPPAYSTQYVA 875
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSR--KMmsleeveaamraqaKKPAQQPAPAPAQ------------PPAAPPAQQAQQQQQ 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  876 YSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQgnARMMAPPahAQPGLVSSSAAQFGAHEQTHAMYVSTGSLAQQYAHPNA 955
Cdd:pfam09770  236 FPPQIQQQQQPQQQPQQPQQHPGQGHPVTIL--QRPQSPQ--PDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSA 311

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1720412638  956 ALHPHTPHPQPSATPT-GQQQSQHGGSHPAPSPV 988
Cdd:pfam09770  312 ARVGYPQNPQPGVQPApAHQAHRQQGSFGRQAPI 345
PHA03247 PHA03247
large tegument protein UL36; Provisional
 485-942 2.13e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  485 PPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSP---SGPVLASPQAGIIPAEAVSMPVPAASPT 561
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPvddRGDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  562 PAS---PASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQ 638
Cdd:PHA03247  2633 PAAnepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  639 PSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSiSPSMLSNAEHKRGPEVTSQGV 718
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA-PPAAPAAGPPRRLTRPAVASL 2791

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  719 QTSSPACKQEKDDREEKKDTTEqvRKSTLNPNAKefnPRSFSQPKPSTTPTSPRPQAQPSPSMVG--------------- 783
Cdd:PHA03247  2792 SESRESLPSPWDPADPPAAVLA--PAAALPPAAS---PAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsvapggdvrrrp 2866

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  784 -HQQPAPVYTQPVCFAPNMMY--PVPVSPGVQPLYPIPMTPMPVNQAKTyRAGKVPNMPQQRQDQHHQSTMMHPASAAgP 860
Cdd:PHA03247  2867 pSRSPAAKPAAPARPPVRRLArpAVSRSTESFALPPDQPERPPQPQAPP-PPQPQPQPPPPPQPQPPPPPPPRPQPPL-A 2944

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  861 PIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvySPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMY 940
Cdd:PHA03247  2945 PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP---APSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021


                   ..
gi 1720412638  941 VS 942
Cdd:PHA03247  3022 VS 3023
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 734-901 3.32e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 3.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  734 EKKDTteqvRKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQP 813
Cdd:TIGR01628  362 QRKEQ----RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPL 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  814 LypiPMTPMPVNQaktyrAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHY 893
Cdd:TIGR01628  433 R---PNGLAPMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQM 504

                          170
                   ....*....|....
gi 1720412638  894 QSQ------HPHVY 901
Cdd:TIGR01628  505 QKQvlgerlFPLVE 518
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
399-606 5.64e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 5.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  399 QSGPNSLPPRAAT----PTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSM 474
Cdd:PRK12323   367 QSGGGAGPATAAAapvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  475 SSGlefvshnPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSP--------SGPVLASPQAGII 546
Cdd:PRK12323   447 APA-------PAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweelppefASPAPAQPDAAPA 519

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  547 PAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQnsPAGSKENVKASETSPSF 606
Cdd:PRK12323   520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPV--VAPRPPRASASGLPDMF 577
PHA03247 PHA03247
large tegument protein UL36; Provisional
 747-1072 7.81e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  747 LNPNAKEFNPRSFSQPKPSTTPTSPRPQAQ--PSPSMVG---------------------------------------HQ 785
Cdd:PHA03247  2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSrprrarrlgraaqassppqrprrraarptvgsltsladpPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  786 QPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPAS-AAGPPIVA 864
Cdd:PHA03247  2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAApAAGPPRRL 2783

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  865 TPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYVSTG 944
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  945 SLAQQYAHPNAALHPHTPH-------PQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAP 1017
Cdd:PHA03247  2861 DVRRRPPSRSPAAKPAAPArppvrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720412638 1018 TPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPPHMAHVPQYKPTTNS 1072
Cdd:PHA03247  2941 PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 843-1065 8.15e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.95  E-value: 8.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  843 QDQHHQSTMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNA--RMMAPP 915
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVApkKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  916 AHAQPGLVSSSAAQFG----------------AHEQTHAMYVSTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHG 979
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  980 GSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQ----SSFPAAQQTVFTIHPSHVQPAYT 1055
Cdd:pfam09770  255 QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNrlsaARVGYPQNPQPGVQPAPAHQAHR 334

                          250
                   ....*....|
gi 1720412638 1056 TPPHMAHVPQ 1065
Cdd:pfam09770  335 QQGSFGRQAP 344
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 756-1065 1.57e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  756 PRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPvytqpvcfAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKV 835
Cdd:PRK07764   400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAP--------APAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPA 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  836 PNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAySTQYVAYSPQQFPNqpLVQHVPHYQ-------SQHPHVYSpvIQGN 908
Cdd:PRK07764   472 AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA-GADDAATLRERWPE--ILAAVPKRSrktwailLPEATVLG--VRGD 546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  909 -----------ARMMAPPAHAQpGLVSSSAAQFGAHEQTHAmYVSTGSLAQQYAHPNAAL----HPHTPHPQPSATPTGQ 973
Cdd:PRK07764   547 tlvlgfstgglARRFASPGNAE-VLVTALAEELGGDWQVEA-VVGPAPGAAGGEGPPAPAssgpPEEAARPAAPAAPAAP 624

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  974 QQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPA 1053
Cdd:PRK07764   625 AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPA 704

                          330
                   ....*....|..
gi 1720412638 1054 YTTPPHMAHVPQ 1065
Cdd:PRK07764   705 PAATPPAGQADD 716
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 746-1058 2.51e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  746 TLNPNAKEFNPRSFSQPKPsttPTSPRPQAQPSPSMVGHQQPAPVYTQPVcfaPNMMYPVPVSPgvqPLYPIPMTPMPVN 825
Cdd:pfam03154  229 TLIQQTPTLHPQRLPSPHP---PLQPMTQPPPPSQVSPQPLPQPSLHGQM---PPMPHSLQTGP---SHMQHPVPPQPFP 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  826 QAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPivatppaystqyvaysPQQFPNQplvQHVPHYQSQHPHVYSPVI 905
Cdd:pfam03154  300 LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQ----------------SQQPPRE---QPLPPAPLSMPHIKPPPT 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  906 QGNARMMAPPAHAQPGLVSS-SAAQFGAHEQTHAMYVSTGSLAQQY---AHPNA-ALHPHT-PHPQPSATPTGQQQSQhg 979
Cdd:pfam03154  361 TPIPQLPNPQSHKHPPHLSGpSPFQMNSNLPPPPALKPLSSLSTHHppsAHPPPlQLMPQSqQLPPPPAQPPVLTQSQ-- 438

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720412638  980 gSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPP 1058
Cdd:pfam03154  439 -SLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516
PHA03247 PHA03247
large tegument protein UL36; Provisional
 398-1034 2.84e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  398 YQSGPNSLPPRAATPtrpPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSpkaqrhprnhrvsagrgSMSSG 477
Cdd:PHA03247  2480 YRRPAEARFPFAAGA---APDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRML-----------------TWIRG 2539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  478 LEFVSHN------PPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSPSGPvlaspqAGIIPAEAV 551
Cdd:PHA03247  2540 LEELASDdagdppPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDD------RGDPRGPAP 2613

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  552 SMPVPAASPTPASPASNRaltpsieakdsrlqdqrqnSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKf 631
Cdd:PHA03247  2614 PSPLPPDTHAPDPPPPSP-------------------SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA- 2673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  632 kndfrLQPSSTSESMDQLLSKNREG---EKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEhk 708
Cdd:PHA03247  2674 -----AQASSPPQRPRRRAARPTVGsltSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA-- 2746

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  709 rGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPA 788
Cdd:PHA03247  2747 -GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  789 PvytqpvcfapnmmyPVPVSPGVQPLYPiPMTPMPVNQAKTYRAGKVPNMPQQRQdqhhqstmmhPASAAGPPIVATPPA 868
Cdd:PHA03247  2826 G--------------PLPPPTSAQPTAP-PPPPGPPPPSLPLGGSVAPGGDVRRR----------PPSRSPAAKPAAPAR 2880

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  869 YSTQYVAYSPQQFPNQPLVQHVPHYQSQHPhvyspviqgnarmmaPPAHAQPglvsssaaqfgaheqthamyvSTGSLAQ 948
Cdd:PHA03247  2881 PPVRRLARPAVSRSTESFALPPDQPERPPQ---------------PQAPPPP---------------------QPQPQPP 2924

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  949 QYAHPNAALHPHtPHPQPSATPTGQQQSQHGGSHPAPSPvqhhqhqaaqALHLASPQQQSAIYHAGLAPTPPSMTPASNT 1028
Cdd:PHA03247  2925 PPPQPQPPPPPP-PRPQPPLAPTTDPAGAGEPSGAVPQP----------WLGALVPGRVAVPRFRVPQPAPSREAPASST 2993


                   ....*.
gi 1720412638 1029 QSPQSS 1034
Cdd:PHA03247  2994 PPLTGH 2999
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 779-1005 6.87e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 6.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  779 PSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPgVQPLYPIPMTPMPVNQaktyragkvPNMPQQRQdqhhqstmmhPASAA 858
Cdd:PRK10263   309 PLLNGAPITEPVAVAAAATTATQSWAAPVEP-VTQTPPVASVDVPPAQ---------PTVAWQPV----------PGPQT 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  859 GPPIVATPPAystqyvAYSPQQFPNQPLVQHVPHYQSQHPHvyspviqgnarmmAPPAHAQPGLVSSSAAQFGAHEQTHA 938
Cdd:PRK10263   369 GEPVIAPAPE------GYPQQSQYAQPAVQYNEPLQQPVQP-------------QQPYYAPAAEQPAQQPYYAPAPEQPA 429

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720412638  939 MYvstGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQ 1005
Cdd:PRK10263   430 QQ---PYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPE 493
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 760-1032 7.16e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 7.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  760 SQPKPSTTPTSPRPQAQPSPsmvGHQQPAPVYT-QPVCFAPNMMYPVPVSPGVQPLypipmtPMPVNQAKTYRAGKVPNM 838
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPL------QQPVQPQQPYYAPAAEQP 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  839 PQQRQDQHHQSTmmhPASAAGPPIVATPPAYSTQYVAYspqqfPNQPLVQHVPHYQSQHPHVySPVIQgNARMMAPPAHA 918
Cdd:PRK10263   416 AQQPYYAPAPEQ---PAQQPYYAPAPEQPVAGNAWQAE-----EQQSTFAPQSTYQTEQTYQ-QPAAQ-EPLYQQPQPVE 485

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  919 QPGLVSSSAAQFGAHEQTHAMYVSTgSLAQQYAHPNAALHP-HTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQ 997
Cdd:PRK10263   486 QQPVVEPEPVVEETKPARPPLYYFE-EVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPL 564

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1720412638  998 ALHLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 1032
Cdd:PRK10263   565 ASGV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 901-1068 2.26e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 2.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  901 YSPVIQGNArMMAPPAHAQPGLVSSS--AAQFGAHEQTHAMYVSTGSLAQQYAHPNAALHPHTPHP----QPSATPTGQQ 974
Cdd:PRK10263   307 YDPLLNGAP-ITEPVAVAAAATTATQswAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPviapAPEGYPQQSQ 385

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  975 QSQHGGSHPAP--------SPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIH 1046
Cdd:PRK10263   386 YAQPAVQYNEPlqqpvqpqQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTE 465

                          170       180
                   ....*....|....*....|..
gi 1720412638 1047 PSHVQPAYTTPPHMAhvPQYKP 1068
Cdd:PRK10263   466 QTYQQPAAQEPLYQQ--PQPVE 485
DUF3498 pfam12004
Domain of unknown function (DUF3498); This presumed domain is functionally uncharacterized. ...
 468-617 3.65e-03

Domain of unknown function (DUF3498); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 433 to 538 amino acids in length. This domain is found associated with pfam00616, pfam00168. This domain has two conserved sequence motifs: DLQ and PLSFQNP.


Pssm-ID: 463427 [Multi-domain]  Cd Length: 511  Bit Score: 41.28  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  468 SAGRGSMSSGLE-FVSHNPPSEAAAPPVARTSPAGGTWSSVVS--GVPR----------LSPKTHRPRSPRQSSIGnsPS 534
Cdd:pfam12004  196 PRGLGSPDSSSEtHSSFSSHSNSEDLSSAAANKKSGPSNSSYSedFARRsteftrrqlsLTELQHQPAVPRQNSAG--PQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  535 GPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGM 614
Cdd:pfam12004  274 RRIDQQGLGGPPLTRGRTPPSLLNSASYPRPSSGSLMSSSPDWPPARLRQQSSSSKGDSPETKQRTQHQQVPSPVNPSTL 353


                   ...
gi 1720412638  615 SPV 617
Cdd:pfam12004  354 SPV 356
Sm_like cd00600
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
 92-159 3.78e-03

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


Pssm-ID: 212462 [Multi-domain]  Cd Length: 63  Bit Score: 36.84  E-value: 3.78e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720412638   92 LTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTEsssgpKREEIMESVLFKCSDFVVVQ 159
Cdd:cd00600      1 LKDFIGKTVSVELKDGRVLTGTLVAFDKYMNLVLDDVVETGRD-----GKVRVLGLVLIRGSNIVSIR 63
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 693-823 4.92e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 4.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  693 NSPSISPSMLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQP-KPSTTPTSP 771
Cdd:PRK10263   741 HEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPvAPQPQYQQP 820

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720412638  772 RPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIP----MTPMP 823
Cdd:PRK10263   821 QQPVAPQPQYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLHKPTTPLPsldlLTPPP 876
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 743-758 5.59e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 5.59e-03
                           10
                   ....*....|....*.
gi 1720412638  743 RKSTLNPNAKEFNPRS 758
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 443-780 8.07e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 8.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  443 PKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSMSSGlefvshnPPSEAAAPPVARTSPAGGTWSSVVSGVP--RLSPKTHR 520
Cdd:PHA03307    73 PGPGTEAPANESRSTPTWSLSTLAPASPAREGSPT-------PPGPSSPDPPPPTPPPASPPPSPAPDLSemLRPVGSPG 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  521 PRSPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSrlqDQRQNSPAGSKenvkas 600
Cdd:PHA03307   146 PPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPR---PPRRSSPISAS------ 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  601 etspsfskadnkGMSPVVSEHRKQIDDLkkfkndfRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSS 680
Cdd:PHA03307   217 ------------ASSPAPAPGRSAADDA-------GASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNG 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720412638  681 SSSNCTSGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQTSSPackQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFS 760
Cdd:PHA03307   278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSS---SRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS 354

                          330       340
                   ....*....|....*....|
gi 1720412638  761 QPKPSTTPTSPRPQAQPSPS 780
Cdd:PHA03307   355 RPPPPADPSSPRKRPRPSRA 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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