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Conserved domains on  [gi|1720413731|ref|XP_030110406|]
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transducin beta-like protein 2 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-209 1.50e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  12 GKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGH 90
Cdd:COG2319   216 GKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLR--TLTGH 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  91 SASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALATGTN-IHLFN 169
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1720413731 170 TRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 209
Cdd:COG2319   359 LATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-209 1.50e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  12 GKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGH 90
Cdd:COG2319   216 GKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLR--TLTGH 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  91 SASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALATGTN-IHLFN 169
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1720413731 170 TRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 209
Cdd:COG2319   359 LATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-210 8.43e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 8.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731   2 PPWYASALTAGKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgKKGEFQe 80
Cdd:cd00200    53 PVRDVAASADGTYLASGSSDKTIRLWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCL- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  81 vlraFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDtdveykkqqdpylLRTGRFE---EASTMPCR-LALSPDTHV 156
Cdd:cd00200   129 ----TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD-------------LRTGKCVatlTGHTGEVNsVAFSPDGEK 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720413731 157 LALATGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLF 210
Cdd:cd00200   192 LLSSSSDGtIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSeDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-119 2.85e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 2.85e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720413731   85 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 119
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
86-119 7.34e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 7.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720413731  86 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 119
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-209 1.50e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  12 GKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGH 90
Cdd:COG2319   216 GKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL------ATGELLR--TLTGH 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  91 SASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALATGTN-IHLFN 169
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1720413731 170 TRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 209
Cdd:COG2319   359 LATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
2-215 3.61e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 3.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731   2 PPWYASALTAGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAV-ISPCSRFVGSCGFTPDVKVWEVCFGKkgefqe 80
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRLWDLATGK------ 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  81 vlRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALA 160
Cdd:COG2319   154 --LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRSVAFSPDGKLLASG 222

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720413731 161 TGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLFHNTPG 215
Cdd:COG2319   223 SADGtVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSaDGTVRLWDLATG 278
WD40 COG2319
WD40 repeat [General function prediction only];
6-220 9.15e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 9.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731   6 ASALTAGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgefQEVLRAF 85
Cdd:COG2319    43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL--------ATGLLLR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  86 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCRLALSPDTHVLALATGTN- 164
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-------TGKLLRT--LTGHSGAVTSVAFSPDGKLLASGSDDGt 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720413731 165 IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLF--------HNTPGHRAVV 220
Cdd:COG2319   186 VRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSaDGTVRLWdlatgkllRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
12-121 1.41e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  12 GKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGH 90
Cdd:COG2319   300 GKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL------ATGELLR--TLTGH 371

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720413731  91 SASVHSFAFSNDSRRMASVSKDGTWKLWDTD 121
Cdd:COG2319   372 TGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-210 8.43e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 8.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731   2 PPWYASALTAGKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgKKGEFQe 80
Cdd:cd00200    53 PVRDVAASADGTYLASGSSDKTIRLWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCL- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  81 vlraFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDtdveykkqqdpylLRTGRFE---EASTMPCR-LALSPDTHV 156
Cdd:cd00200   129 ----TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD-------------LRTGKCVatlTGHTGEVNsVAFSPDGEK 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720413731 157 LALATGTN-IHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLF 210
Cdd:cd00200   192 LLSSSSDGtIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSeDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-210 9.22e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 9.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  12 GKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVI-SPCSRFVGSCGFTPDVKVWEVcfgkkgEFQEVLRafELKGH 90
Cdd:cd00200    21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTYLASGSSDKTIRLWDL------ETGECVR--TLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  91 SASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTGRFEEASTMpcRLALSPDTHVLALATG-TNIHLFN 169
Cdd:cd00200    93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTDWVN--SVAFSPDGTFVASSSQdGTIKLWD 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1720413731 170 TRRGEKEEYFEcVHGECIADLTFDITG-RFLASCGDRAVRLF 210
Cdd:cd00200   164 LRTGKCVATLT-GHTGEVNSVAFSPDGeKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-210 1.43e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  12 GKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVcfgKKGEFQEVLrafelKGH 90
Cdd:cd00200   105 GRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL---RTGKCVATL-----TGH 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  91 SASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKQQdpylLRTGRFEEAStmPCRLALSPDTHVLALATGTN-IHLFN 169
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC----LGTLRGHENG--VNSVAFSPDGYLLASGSEDGtIRVWD 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1720413731 170 TRRGEKEEYFECVHGECIAdLTFDITGRFLASCG-DRAVRLF 210
Cdd:cd00200   248 LRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-119 1.17e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  12 GKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVCFGKkgefqevlRAFELKGH 90
Cdd:cd00200   189 GEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE--------CVQTLSGH 260

                          90       100
                  ....*....|....*....|....*....
gi 1720413731  91 SASVHSFAFSNDSRRMASVSKDGTWKLWD 119
Cdd:cd00200   261 TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-215 1.65e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720413731  85 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkQQDPYLLRTGRFEEASTmpcrLALSPDTHVLALATGTN 164
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----TGELLRTLKGHTGPVRD----VAASADGTYLASGSSDK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720413731 165 -IHLFNTRRGEKEEYFECvHGECIADLTFDITGRFLASCG-DRAVRLFHNTPG 215
Cdd:cd00200    74 tIRLWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETG 125
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-119 2.85e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 2.85e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1720413731   85 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 119
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
86-119 7.34e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 7.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720413731  86 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 119
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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