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Conserved domains on  [gi|1720416879|ref|XP_030110985|]
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voltage-dependent L-type calcium channel subunit alpha-1C isoform X28 [Mus musculus]

Protein Classification

voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1273-1531 5.95e-73

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 243.71  E-value: 5.95e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1273 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG-YFSDPWNVFDFLIVIGSI 1350
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1351 IDVILSETNSaeensRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIA 1430
Cdd:pfam00520   81 ISLVLSSVGS-----LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1431 LNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFL 1510
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|.
gi 1720416879 1511 IINLFVAVIMDNFDYLTRDWS 1531
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
153-446 4.97e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 229.46  E-value: 4.97e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  153 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 232
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  233 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  313 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 392
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720416879  393 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 446
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
954-1231 3.05e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.05e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  954 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 1033
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1034 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1112
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1113 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1192
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1720416879 1193 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1231
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
578-819 3.31e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 184.39  E-value: 3.31e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  578 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 655
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  656 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 734
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  735 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 814
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 1720416879  815 ESLTS 819
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1603-1677 3.10e-38

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 430200  Cd Length: 77  Bit Score: 137.72  E-value: 3.10e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720416879 1603 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1677
Cdd:pfam08763    1 TATLFALIRTALSIKMApaGEMDQADAELRKIIKKIWPLLSKKMLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1697-2132 1.73e-35

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 435629 [Multi-domain]  Cd Length: 356  Bit Score: 140.06  E-value: 1.73e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1697 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkEAVSAASEDDIFRRAgglfgNHVTYyqSDSRGNFPQTfatQRPLHINK 1776
Cdd:pfam16885    1 AGLRTLQDLGPEMRQALTCDLEEEEE------GAEEEQEGDDEEASA-----APETP--KDPIGSQPPS---RSRISVSL 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1777 TGNNQADTESPSHEklvDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHgpplspavRVQEAawkls 1856
Cdd:pfam16885   65 PVGDRLPDSLPSDD---DGGAPNSRQPSGGQSGSHTHRRSSGVLMFTIPEEGSSQPKGTKGQ--------DKQDE----- 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1857 skrchsresqgatvNQEIFPDETRSVRmSEEAEYCSEPSLLSTdmfsyqedeHRqltcPEEDKREIQPsPKRSFLRSASL 1936
Cdd:pfam16885  129 --------------EEEVPVQDQLAYL-DEQAGTPSRPVLLPP---------HR----PQRYVNGHHY-PRRRLLPPTPA 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1937 GRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRPLRPiPTLR 2016
Cdd:pfam16885  180 GRKPSFTIQCLRRQ-------GSCDDLPIPGTYHRG----GNSGPS-RAQGSWA----------TPPQRGRLLYA-PLLL 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 2017 LEGAESSEKLNSSFPSihcsswSEETTACsgsssmarrarpvsLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQD 2096
Cdd:pfam16885  237 VEEGAAGEGYLGKSPG------PLRTFTC--------------LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARD 296
                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1720416879 2097 PKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2132
Cdd:pfam16885  297 PKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 332
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1540-1593 5.77e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 435642  Cd Length: 54  Bit Score: 116.22  E-value: 5.77e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720416879 1540 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1593
Cdd:pfam16905    1 EFVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1273-1531 5.95e-73

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 243.71  E-value: 5.95e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1273 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG-YFSDPWNVFDFLIVIGSI 1350
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1351 IDVILSETNSaeensRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIA 1430
Cdd:pfam00520   81 ISLVLSSVGS-----LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1431 LNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFL 1510
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|.
gi 1720416879 1511 IINLFVAVIMDNFDYLTRDWS 1531
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
153-446 4.97e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 229.46  E-value: 4.97e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  153 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 232
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  233 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  313 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 392
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720416879  393 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 446
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
954-1231 3.05e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.05e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  954 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 1033
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1034 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1112
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1113 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1192
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1720416879 1193 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1231
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
578-819 3.31e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 184.39  E-value: 3.31e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  578 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 655
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  656 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 734
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  735 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 814
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 1720416879  815 ESLTS 819
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1603-1677 3.10e-38

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 430200  Cd Length: 77  Bit Score: 137.72  E-value: 3.10e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720416879 1603 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1677
Cdd:pfam08763    1 TATLFALIRTALSIKMApaGEMDQADAELRKIIKKIWPLLSKKMLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1697-2132 1.73e-35

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 435629 [Multi-domain]  Cd Length: 356  Bit Score: 140.06  E-value: 1.73e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1697 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkEAVSAASEDDIFRRAgglfgNHVTYyqSDSRGNFPQTfatQRPLHINK 1776
Cdd:pfam16885    1 AGLRTLQDLGPEMRQALTCDLEEEEE------GAEEEQEGDDEEASA-----APETP--KDPIGSQPPS---RSRISVSL 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1777 TGNNQADTESPSHEklvDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHgpplspavRVQEAawkls 1856
Cdd:pfam16885   65 PVGDRLPDSLPSDD---DGGAPNSRQPSGGQSGSHTHRRSSGVLMFTIPEEGSSQPKGTKGQ--------DKQDE----- 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1857 skrchsresqgatvNQEIFPDETRSVRmSEEAEYCSEPSLLSTdmfsyqedeHRqltcPEEDKREIQPsPKRSFLRSASL 1936
Cdd:pfam16885  129 --------------EEEVPVQDQLAYL-DEQAGTPSRPVLLPP---------HR----PQRYVNGHHY-PRRRLLPPTPA 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1937 GRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRPLRPiPTLR 2016
Cdd:pfam16885  180 GRKPSFTIQCLRRQ-------GSCDDLPIPGTYHRG----GNSGPS-RAQGSWA----------TPPQRGRLLYA-PLLL 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 2017 LEGAESSEKLNSSFPSihcsswSEETTACsgsssmarrarpvsLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQD 2096
Cdd:pfam16885  237 VEEGAAGEGYLGKSPG------PLRTFTC--------------LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARD 296
                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1720416879 2097 PKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2132
Cdd:pfam16885  297 PKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 332
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1540-1593 5.77e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 435642  Cd Length: 54  Bit Score: 116.22  E-value: 5.77e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720416879 1540 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1593
Cdd:pfam16905    1 EFVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1655-1685 3.25e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.25e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1720416879  1655 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1685
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1273-1531 5.95e-73

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 243.71  E-value: 5.95e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1273 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG-YFSDPWNVFDFLIVIGSI 1350
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1351 IDVILSETNSaeensRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIA 1430
Cdd:pfam00520   81 ISLVLSSVGS-----LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1431 LNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFL 1510
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|.
gi 1720416879 1511 IINLFVAVIMDNFDYLTRDWS 1531
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
153-446 4.97e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 229.46  E-value: 4.97e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  153 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 232
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  233 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  313 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 392
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720416879  393 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 446
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
954-1231 3.05e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.05e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  954 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 1033
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1034 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1112
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1113 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1192
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1720416879 1193 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1231
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
578-819 3.31e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 184.39  E-value: 3.31e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  578 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 655
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  656 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 734
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  735 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 814
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 1720416879  815 ESLTS 819
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1603-1677 3.10e-38

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 430200  Cd Length: 77  Bit Score: 137.72  E-value: 3.10e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720416879 1603 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1677
Cdd:pfam08763    1 TATLFALIRTALSIKMApaGEMDQADAELRKIIKKIWPLLSKKMLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1697-2132 1.73e-35

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 435629 [Multi-domain]  Cd Length: 356  Bit Score: 140.06  E-value: 1.73e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1697 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkEAVSAASEDDIFRRAgglfgNHVTYyqSDSRGNFPQTfatQRPLHINK 1776
Cdd:pfam16885    1 AGLRTLQDLGPEMRQALTCDLEEEEE------GAEEEQEGDDEEASA-----APETP--KDPIGSQPPS---RSRISVSL 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1777 TGNNQADTESPSHEklvDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHgpplspavRVQEAawkls 1856
Cdd:pfam16885   65 PVGDRLPDSLPSDD---DGGAPNSRQPSGGQSGSHTHRRSSGVLMFTIPEEGSSQPKGTKGQ--------DKQDE----- 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1857 skrchsresqgatvNQEIFPDETRSVRmSEEAEYCSEPSLLSTdmfsyqedeHRqltcPEEDKREIQPsPKRSFLRSASL 1936
Cdd:pfam16885  129 --------------EEEVPVQDQLAYL-DEQAGTPSRPVLLPP---------HR----PQRYVNGHHY-PRRRLLPPTPA 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1937 GRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRPLRPiPTLR 2016
Cdd:pfam16885  180 GRKPSFTIQCLRRQ-------GSCDDLPIPGTYHRG----GNSGPS-RAQGSWA----------TPPQRGRLLYA-PLLL 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 2017 LEGAESSEKLNSSFPSihcsswSEETTACsgsssmarrarpvsLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQD 2096
Cdd:pfam16885  237 VEEGAAGEGYLGKSPG------PLRTFTC--------------LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARD 296
                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1720416879 2097 PKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2132
Cdd:pfam16885  297 PKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 332
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1540-1593 5.77e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 435642  Cd Length: 54  Bit Score: 116.22  E-value: 5.77e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720416879 1540 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1593
Cdd:pfam16905    1 EFVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1655-1685 3.25e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.25e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1720416879  1655 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1685
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1301-1524 3.28e-09

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 61.59  E-value: 3.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1301 LFKIAMNILNMLFTGLFTVEMILKLIAFKPKgYFSDPWNVFDFLIVIGSIIDVIL---------SETNSAEENSRISITF 1371
Cdd:pfam08016  207 LFILLCEIVFVVFFLYFVVEEILKIRKHRPS-YLRSVWNLLDLAIVILSVVLIVLniyrdflvdRLIKSVEASPVTFIDF 285
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1372 FRLFRV----------------MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGkialndtt 1435
Cdd:pfam08016  286 DRVAQLdnlyriilaflvfltwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-------- 357
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879 1436 eiNRNNNFQTFPQAVLLLFR-CATGEAWQDImlacmpgkkcapESepsnstegetpCGSSFAVFYFISFYMLCAFLIINL 1514
Cdd:pfam08016  358 --TQAPNFSNFVKSILTLFRtILGDFGYNEI------------FS-----------GNRVLGPLLFLTFVFLVIFILLNL 412
                          250
                   ....*....|
gi 1720416879 1515 FVAVIMDNFD 1524
Cdd:pfam08016  413 FLAIINDSYV 422
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
193-434 2.32e-03

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 42.72  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  193 EYLFLIIFTVEAFLKVIAYGLLFHPN--AYLRNGWNLLDFIIVVVGLFSAILE--QATKADG----ANALGGKGAGFD-- 262
Cdd:pfam08016  209 ILLCEIVFVVFFLYFVVEEILKIRKHrpSYLRSVWNLLDLAIVILSVVLIVLNiyRDFLVDRliksVEASPVTFIDFDrv 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  263 ---------VKALRAFRV-LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFmgkmhktcynqe 332
Cdd:pfam08016  289 aqldnlyriILAFLVFLTwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLF------------ 356
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416879  333 giidvpaeedpspcaletghgrqcqnGTvckpgwdgpkhGITNFDNFAFAMLTVFQ-CITMEGWTDVLYwmqdaMGYELP 411
Cdd:pfam08016  357 --------------------------GT-----------QAPNFSNFVKSILTLFRtILGDFGYNEIFS-----GNRVLG 394
                          250       260
                   ....*....|....*....|...
gi 1720416879  412 WVYFVSLVIFGSFFVLNLVLGVL 434
Cdd:pfam08016  395 PLLFLTFVFLVIFILLNLFLAII 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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