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Conserved domains on  [gi|1720419185|ref|XP_030111542|]
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centrosomal protein of 41 kDa isoform X5 [Mus musculus]

Protein Classification

rhodanese-like domain-containing protein( domain architecture ID 10456811)

rhodanese-like domain-containing protein may have sulfurtransferase activity if an active site cysteine is present

CATH:  3.40.250.10
PubMed:  12151332|17454295

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhodanese pfam00581
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ...
 170-239 5.78e-10

Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.


:

Pssm-ID: 425764 [Multi-domain]  Cd Length: 92  Bit Score: 55.57  E-value: 5.78e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720419185 170 DCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKN-AHGKIIILYDEDERLASQAATTM 239
Cdd:pfam00581   3 DGKVVLIDVRPPEEYAKGHIPGAVNVPLSSLSLPPLPLLELLEKLLElLKDKPIVVYCNSGNRAAAAAALL 73
 
Name Accession Description Interval E-value
Rhodanese pfam00581
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ...
 170-239 5.78e-10

Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.


Pssm-ID: 425764 [Multi-domain]  Cd Length: 92  Bit Score: 55.57  E-value: 5.78e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720419185 170 DCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKN-AHGKIIILYDEDERLASQAATTM 239
Cdd:pfam00581   3 DGKVVLIDVRPPEEYAKGHIPGAVNVPLSSLSLPPLPLLELLEKLLElLKDKPIVVYCNSGNRAAAAAALL 73
RHOD cd00158
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese ...
 170-239 3.84e-09

Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.


Pssm-ID: 238089 [Multi-domain]  Cd Length: 89  Bit Score: 53.07  E-value: 3.84e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419185 170 DCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRtmnpysnDILEYKNAHGKIIILYDEDERLASQAATTM 239
Cdd:cd00158     8 DEDAVLLDVREPEEYAAGHIPGAINIPLSELEE-------RAALLELDKDKPIVVYCRSGNRSARAAKLL 70
RHOD smart00450
Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The ...
 173-239 4.45e-07

Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions with a loss of the cysteine are also seen in Dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases. These are likely to play a role in protein interactions.


Pssm-ID: 197731 [Multi-domain]  Cd Length: 100  Bit Score: 47.45  E-value: 4.45e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720419185  173 FLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNA-----HGKIIILYDEDERLASQAATTM 239
Cdd:smart00450   5 VVLLDVRSPEEYEGGHIPGAVNIPLSELLDRRGELDILEFEELLKrlgldKDKPVVVYCRSGNRSAKAAWLL 76
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 172-239 1.19e-05

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 43.80  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720419185 172 PFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDileyknahgKIIILYDEDERLASQAATTM 239
Cdd:COG0607    19 DAVLLDVREPEEFAAGHIPGAINIPLGELAERLDELPKD---------KPIVVYCASGGRSAQAAALL 77
 
Name Accession Description Interval E-value
Rhodanese pfam00581
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ...
 170-239 5.78e-10

Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.


Pssm-ID: 425764 [Multi-domain]  Cd Length: 92  Bit Score: 55.57  E-value: 5.78e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720419185 170 DCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKN-AHGKIIILYDEDERLASQAATTM 239
Cdd:pfam00581   3 DGKVVLIDVRPPEEYAKGHIPGAVNVPLSSLSLPPLPLLELLEKLLElLKDKPIVVYCNSGNRAAAAAALL 73
RHOD cd00158
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese ...
 170-239 3.84e-09

Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.


Pssm-ID: 238089 [Multi-domain]  Cd Length: 89  Bit Score: 53.07  E-value: 3.84e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720419185 170 DCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRtmnpysnDILEYKNAHGKIIILYDEDERLASQAATTM 239
Cdd:cd00158     8 DEDAVLLDVREPEEYAAGHIPGAINIPLSELEE-------RAALLELDKDKPIVVYCRSGNRSARAAKLL 70
RHOD smart00450
Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The ...
 173-239 4.45e-07

Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions with a loss of the cysteine are also seen in Dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases. These are likely to play a role in protein interactions.


Pssm-ID: 197731 [Multi-domain]  Cd Length: 100  Bit Score: 47.45  E-value: 4.45e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720419185  173 FLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNA-----HGKIIILYDEDERLASQAATTM 239
Cdd:smart00450   5 VVLLDVRSPEEYEGGHIPGAVNIPLSELLDRRGELDILEFEELLKrlgldKDKPVVVYCRSGNRSAKAAWLL 76
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 172-239 1.19e-05

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 43.80  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720419185 172 PFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDileyknahgKIIILYDEDERLASQAATTM 239
Cdd:COG0607    19 DAVLLDVREPEEFAAGHIPGAINIPLGELAERLDELPKD---------KPIVVYCASGGRSAQAAALL 77
4RHOD_Repeats cd01529
Member of the Rhodanese Homology Domain superfamily. This CD includes putative ...
 175-236 3.84e-03

Member of the Rhodanese Homology Domain superfamily. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. Only the second and most of the fourth repeats contain the putative catalytic Cys residue. This CD aligns the 1st , 2nd, 3rd, and 4th repeats.


Pssm-ID: 238787 [Multi-domain]  Cd Length: 96  Bit Score: 36.50  E-value: 3.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720419185 175 LLDVRDRDSYQQCHIVGAYSYPIATLsrtmnPYSNDILEYKNAHGKI--IILYDEDERLASQAA 236
Cdd:cd01529    15 LLDVRAEDEYAAGHLPGKRSIPGAAL-----VLRSQELQALEAPGRAtrYVLTCDGSLLARFAA 73
RHOD_PspE2 cd01521
Member of the Rhodanese Homology Domain superfamily. This CD includes the putative ...
 173-196 8.02e-03

Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins.


Pssm-ID: 238779 [Multi-domain]  Cd Length: 110  Bit Score: 35.79  E-value: 8.02e-03
                          10        20
                  ....*....|....*....|....
gi 1720419185 173 FLLLDVRDRDSYQQCHIVGAYSYP 196
Cdd:cd01521    26 FVLVDVRSAEAYARGHVPGAINLP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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