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Conserved domains on  [gi|1785350575|ref|XP_031753091|]
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thrombospondin type-1 domain-containing protein 1 [Xenopus tropicalis]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641280)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

CATH:  2.20.100.10
SCOP:  4003415

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 343-392 3.32e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.53  E-value: 3.32e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1785350575  343 WGLWQSWSPCSVTCGDGERERFRECLTTSSEKPA--CRGRAKETSLCSLEEC 392
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgpCTGEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 343-392 3.32e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.53  E-value: 3.32e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1785350575  343 WGLWQSWSPCSVTCGDGERERFRECLTTSSEKPA--CRGRAKETSLCSLEEC 392
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgpCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
344-392 1.66e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.96  E-value: 1.66e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1785350575 344 GLWQSWSPCSVTCGDGERERFRECLTTSSEKPACRGRAKETSLCSLEEC 392
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 330-392 3.28e-06

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 50.73  E-value: 3.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785350575 330 AKECVGIRReIESWGLWQSWSPCSVTCGDGERERFRECLttsseKPACRGRAKETslCSLEEC 392
Cdd:PTZ00441  228 AKVCTEVER-TASCGPWDEWTPCSVTCGKGTHSRSRPIL-----HEGCTTHMVEE--CEEEEC 282
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 343-392 3.32e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.53  E-value: 3.32e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1785350575  343 WGLWQSWSPCSVTCGDGERERFRECLTTSSEKPA--CRGRAKETSLCSLEEC 392
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGgpCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
344-392 1.66e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.96  E-value: 1.66e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1785350575 344 GLWQSWSPCSVTCGDGERERFRECLTTSSEKPACRGRAKETSLCSLEEC 392
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 346-392 4.88e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 47.27  E-value: 4.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1785350575 346 WQSWSPCSVTCGDGERERFRECLTtsseKPACRGRA----KETSLCSLEEC 392
Cdd:pfam19028   6 WSEWSECSVTCGGGVQTRTRTVIV----EPQNGGRPcpelLERRPCNLPPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 330-392 3.28e-06

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 50.73  E-value: 3.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785350575 330 AKECVGIRReIESWGLWQSWSPCSVTCGDGERERFRECLttsseKPACRGRAKETslCSLEEC 392
Cdd:PTZ00441  228 AKVCTEVER-TASCGPWDEWTPCSVTCGKGTHSRSRPIL-----HEGCTTHMVEE--CEEEEC 282
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 349-392 1.47e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.43  E-value: 1.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1785350575 349 WSPCSVTCGDGERERFRECLTTSSEKP----ACRGRAK--ETSLCSLEEC 392
Cdd:pfam19030   6 WGECSVTCGGGVQTRLVQCVQKGGGSIvpdsECSAQKKppETQSCNLKPC 55
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 348-392 2.30e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 36.54  E-value: 2.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1785350575 348 SWSPCSVTCGDGERERfrecltTSSEKPACRGRaKETSLCSLEEC 392
Cdd:pfam19035   7 EWSPCSKTCGMGVSTR------VSNDNAECKLV-TETRLCQLRPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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