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Conserved domains on  [gi|1785381212|ref|XP_031761910|]
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ubiquitin carboxyl-terminal hydrolase 40-like isoform X1 [Xenopus tropicalis]

Protein Classification

ubiquitin carboxyl-terminal hydrolase family protein( domain architecture ID 913)

ubiquitin carboxyl-terminal hydrolase family protein is a C19 family peptidase that may deubiquitinate polyubiquitinated target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C19 super family cl02553
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 41-152 9.74e-19

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


The actual alignment was detected with superfamily member cd02659:

Pssm-ID: 470612 [Multi-domain]  Cd Length: 334  Bit Score: 80.76  E-value: 9.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785381212  41 RLSGLRNQGGTCYLNSLLRTLFFTPEFRgsarsalkkaeswpntklnpgfEALFALgpkelgsLEEKDTPESQVRIIPLQ 120
Cdd:cd02659     1 GYVGLKNQGATCYMNSLLQQLYMTPEFR----------------------NAVYSI-------PPTEDDDDNKSVPLALQ 51

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1785381212 121 LQRLFAQLLLLDQQALSTTDLTESFGWNSSEV 152
Cdd:cd02659    52 RLFLFLQLSESPVKTTELTDKTRSFGWDSLNT 83
 
Name Accession Description Interval E-value
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 41-152 9.74e-19

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 80.76  E-value: 9.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785381212  41 RLSGLRNQGGTCYLNSLLRTLFFTPEFRgsarsalkkaeswpntklnpgfEALFALgpkelgsLEEKDTPESQVRIIPLQ 120
Cdd:cd02659     1 GYVGLKNQGATCYMNSLLQQLYMTPEFR----------------------NAVYSI-------PPTEDDDDNKSVPLALQ 51

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1785381212 121 LQRLFAQLLLLDQQALSTTDLTESFGWNSSEV 152
Cdd:cd02659    52 RLFLFLQLSESPVKTTELTDKTRSFGWDSLNT 83
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 44-151 1.05e-09

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 56.03  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785381212   44 GLRNQGGTCYLNSLLRTLFFTPEFRgsarsalkkaeswpntklnpgfEALFALgpkelgsleEKDTPESQvRIIPLQLQR 123
Cdd:COG5077    195 GLRNQGATCYMNSLLQSLFFIAKFR----------------------KDVYGI---------PTDHPRGR-DSVALALQR 242

                           90       100
                   ....*....|....*....|....*...
gi 1785381212  124 lFAQLLLLDQQALSTTDLTESFGWNSSE 151
Cdd:COG5077    243 -LFYNLQTGEEPVDTTELTRSFGWDSDD 269
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
44-68 9.08e-07

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 47.05  E-value: 9.08e-07
                          10        20
                  ....*....|....*....|....*
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFR 26
 
Name Accession Description Interval E-value
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 41-152 9.74e-19

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 80.76  E-value: 9.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785381212  41 RLSGLRNQGGTCYLNSLLRTLFFTPEFRgsarsalkkaeswpntklnpgfEALFALgpkelgsLEEKDTPESQVRIIPLQ 120
Cdd:cd02659     1 GYVGLKNQGATCYMNSLLQQLYMTPEFR----------------------NAVYSI-------PPTEDDDDNKSVPLALQ 51

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1785381212 121 LQRLFAQLLLLDQQALSTTDLTESFGWNSSEV 152
Cdd:cd02659    52 RLFLFLQLSESPVKTTELTDKTRSFGWDSLNT 83
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 44-151 1.05e-09

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 56.03  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785381212   44 GLRNQGGTCYLNSLLRTLFFTPEFRgsarsalkkaeswpntklnpgfEALFALgpkelgsleEKDTPESQvRIIPLQLQR 123
Cdd:COG5077    195 GLRNQGATCYMNSLLQSLFFIAKFR----------------------KDVYGI---------PTDHPRGR-DSVALALQR 242

                           90       100
                   ....*....|....*....|....*...
gi 1785381212  124 lFAQLLLLDQQALSTTDLTESFGWNSSE 151
Cdd:COG5077    243 -LFYNLQTGEEPVDTTELTRSFGWDSDD 269
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
44-68 9.08e-07

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 47.05  E-value: 9.08e-07
                          10        20
                  ....*....|....*....|....*
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFR 26
UCH_1 pfam13423
Ubiquitin carboxyl-terminal hydrolase;
43-78 1.48e-04

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 463872 [Multi-domain]  Cd Length: 305  Bit Score: 40.72  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1785381212  43 SGLRNQGGTCYLNSLLRTLFFTPEFRGSARSALKKA 78
Cdd:pfam13423   1 SGLETHIPNSYTNSLLQLLRFIPPLRNLALSHLATE 36
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 44-63 1.53e-04

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 40.54  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFF 63
Cdd:cd02257     1 GLNNLGNTCYLNSVLQALFS 20
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 44-68 2.60e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 39.78  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|....*
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:cd02664     1 GLINLGNTCYMNSVLQALFMAKDFR 25
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 42-68 3.51e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 39.49  E-value: 3.51e-04
                          10        20
                  ....*....|....*....|....*..
gi 1785381212  42 LSGLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:cd02671    24 FVGLNNLGNTCYLNSVLQVLYFCPGFK 50
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 44-68 4.09e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 39.33  E-value: 4.09e-04
                          10        20
                  ....*....|....*....|....*
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:cd02668     1 GLKNLGATCYVNSFLQLWFMNLEFR 25
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 44-68 4.31e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 39.23  E-value: 4.31e-04
                          10        20
                  ....*....|....*....|....*
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:cd02658     1 GLRNLGNSCYLNSVLQVLFSIPSFQ 25
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
42-68 1.51e-03

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 37.94  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*..
gi 1785381212  42 LSGLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:COG5560   265 TCGLRNLGNTCYMNSALQCLMHTWELR 291
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
44-67 1.70e-03

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 37.47  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|....*
gi 1785381212  44 GLRNQGGTCYLNSLLRTL-FFTPEF 67
Cdd:COG5533     1 GLPNLGNTCFMNSVLQILaLYLPKL 25
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 44-68 2.69e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 36.93  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|....*
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFFTPEFR 68
Cdd:cd02657     1 GLTNLGNTCYLNSTLQCLRSVPELR 25
Peptidase_C19J cd02666
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 44-96 5.69e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239131 [Multi-domain]  Cd Length: 343  Bit Score: 35.93  E-value: 5.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1785381212  44 GLRNQGGTCYLNSLLRTLFFTPEFR----GSARSALKKAESWPNTKLNPGFEALFAL 96
Cdd:cd02666     3 GLDNIGNTCYLNSLLQYFFTIKPLRdlvlNFDESKAELASDYPTERRIGGREVSRSE 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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