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Conserved domains on  [gi|1907173992|ref|XP_036008300|]
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ankyrin repeat and SOCS box protein 15 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-317 9.54e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 9.54e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 128 KTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAK 207
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 208 QGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYG 287
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907173992 288 GSGNVPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:COG0666   243 ADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 553-604 2.90e-24

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03731:

Pssm-ID: 470605  Cd Length: 56  Bit Score: 95.67  E-value: 2.90e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 553 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 604
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQ 52
Ank_2 pfam12796
Ankyrin repeats (3 copies);
301-399 1.46e-13

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 301 IHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIEngfdvnalladHISQSYDDERKTALYFAV 379
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1907173992 380 SNNDIHCTEVLLAAGADPNL 399
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-162 7.55e-07

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 7.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  68 LVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLwefkTCDGETPLTLAVKAGLVEN 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 1907173992 148 VKTLLDKGVWPNTKN 162
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 403-429 6.51e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


:

Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907173992  403 NCLLVAVRANRHEIVRLLLSYGANVNC 429
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-317 9.54e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 9.54e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 128 KTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAK 207
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 208 QGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYG 287
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907173992 288 GSGNVPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:COG0666   243 ADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 553-604 2.90e-24

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 95.67  E-value: 2.90e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 553 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 604
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQ 52
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 120-292 9.87e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 91.98  E-value: 9.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 120 SYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPN-TKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKR 198
Cdd:PHA02875   56 KHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 199 WSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDG-ASVLFEAAGGGNP 277
Cdd:PHA02875  136 FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKI 215

                         170
                  ....*....|....*
gi 1907173992 278 DCISLLLKYGGSGNV 292
Cdd:PHA02875  216 DIVRLFIKRGADCNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
136-228 1.97e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 136 LTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQpcVKRWSAMHEAAKQGRKDIIT 215
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1907173992 216 LLLNHRGNVHLRD 228
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
301-399 1.46e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 301 IHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIEngfdvnalladHISQSYDDERKTALYFAV 379
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1907173992 380 SNNDIHCTEVLLAAGADPNL 399
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 554-595 2.08e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.72  E-value: 2.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173992 554 NPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLL 595
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 268-463 3.21e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.43  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 268 LFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQKSgLTPIHSAAEGQNAQCLEL 347
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYT-LVAIKDAFNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 348 LIENGFDVN----------------------ALLADH---ISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLdPL 402
Cdd:PHA02878  120 ILTNRYKNIqtidlvyidkkskddiieaeitKLLLSYgadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNI-PD 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907173992 403 NC----LLVAVRANRHEIVRLLLSYGANVNCYFMHVNdTRFPSAIQYALNDEImLRLLLNNGYQV 463
Cdd:PHA02878  199 KTnnspLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISVGYCKDYDI-LKLLLEHGVDV 261
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 556-597 3.00e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.63  E-value: 3.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907173992  556 CSLKHLCRLKIRRVMGLqrlcqpasIQMLPLPAAMRRYLLFK 597
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-162 7.55e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 7.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  68 LVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLwefkTCDGETPLTLAVKAGLVEN 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 1907173992 148 VKTLLDKGVWPNTKN 162
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 264-357 9.83e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 9.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 264 GASVLFEAAGGGNP-DCISLLLKYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSKH-------AIQKS---- 328
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKSgplelanDQYTSeftp 127

                          90       100
                  ....*....|....*....|....*....
gi 1907173992 329 GLTPIHSAAEGQNAQCLELLIENGFDVNA 357
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVPA 156
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 133-317 5.03e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.08  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 133 ETPLTLAVKAGLVENVKTLLD-KGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSL-DQPCV----KRWSAMHEAA 206
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvNEPMTsdlyQGETALHIAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 207 KQGRKDIITLLLNHRGNV----------HLRDG----FGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAA 272
Cdd:cd22192    98 VNQNLNLVRELIARGADVvspratgtffRPGPKnliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILV 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907173992 273 GGGN--PDC--ISLLLKYGGSGN------VPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:cd22192   178 LQPNktFACqmYDLILSYDKEDDlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLV 232
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 329-357 5.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 5.78e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173992  329 GLTPIHSAAEGQNAQCLELLIENGFDVNA 357
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 403-429 6.51e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907173992  403 NCLLVAVRANRHEIVRLLLSYGANVNC 429
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 131-159 8.58e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 8.58e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173992  131 DGETPLTLAVKAGLVENVKTLLDKGVWPN 159
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-317 9.54e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 9.54e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 128 KTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAK 207
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 208 QGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYG 287
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907173992 288 GSGNVPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:COG0666   243 ADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-361 6.69e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 6.69e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  89 ALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETP 168
Cdd:COG0666    11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 169 LLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLE 248
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 249 HLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-HAIQK 327
Cdd:COG0666   171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADlNAKDK 250

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1907173992 328 SGLTPIHSAAEGQNAQCLELLIENGFDVNALLAD 361
Cdd:COG0666   251 DGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
199-459 2.93e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.22  E-value: 2.93e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 199 WSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPD 278
Cdd:COG0666    22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 279 CISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvtsKH-----AIQKSGLTPIHSAAEGQNAQCLELLIENGF 353
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL----EAgadvnAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 354 DVNALladhisqsyDDERKTALYFAVSNNDIHCTEVLLAAGADPNL---DPLNCLLVAVRANRHEIVRLLLSYGANVNCY 430
Cdd:COG0666   178 DVNAR---------DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                         250       260
                  ....*....|....*....|....*....
gi 1907173992 431 FMHVNDTRFPSAIQYALNDEIMLRLLLNN 459
Cdd:COG0666   249 DKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-301 7.29e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.07  E-value: 7.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  11 LDICVYLPREDMDINDDSNDDHLASYDIQLCIQESIEASQAIFHPKRLVQLSDQNRKLVEAIRQGRIFELQEYVQYKYAL 90
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  91 EEADEKGWFPLHEAVVQPIQQILETVLDAsyKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLL 170
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEA--GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 171 IAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHL 250
Cdd:COG0666   159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907173992 251 IHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPI 301
Cdd:COG0666   239 LEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
151-428 7.96e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.07  E-value: 7.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 151 LLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGF 230
Cdd:COG0666     7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 231 GVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHY 310
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 311 LALKYLIpvtsKH-----AIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIH 385
Cdd:COG0666   167 EIVKLLL----EAgadvnARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK---------DNDGKTALDLAAENGNLE 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1907173992 386 CTEVLLAAGADPNLDPLNC---LLVAVRANRHEIVRLLLSYGANVN 428
Cdd:COG0666   234 IVKLLLEAGADLNAKDKDGltaLLLAAAAGAALIVKLLLLALLLLA 279
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
212-460 1.28e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 1.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 212 DIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGN 291
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 292 VPNRAGHLPIHRAAYEGHYLALKYLIpvtsKH-----AIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNALladhisqs 366
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLL----EAgadvnARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ-------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 367 yDDERKTALYFAVSNNDIHCTEVLLAAGADPNL---DPLNCLLVAVRANRHEIVRLLLSYGANVNcyfMHVNDTRFPSAI 443
Cdd:COG0666   150 -DNDGNTPLHLAAANGNLEIVKLLLEAGADVNArdnDGETPLHLAAENGHLEIVKLLLEAGADVN---AKDNDGKTALDL 225

                         250
                  ....*....|....*..
gi 1907173992 444 QYALNDEIMLRLLLNNG 460
Cdd:COG0666   226 AAENGNLEIVKLLLEAG 242
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 553-604 2.90e-24

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 95.67  E-value: 2.90e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 553 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 604
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQ 52
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 120-292 9.87e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 91.98  E-value: 9.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 120 SYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPN-TKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKR 198
Cdd:PHA02875   56 KHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 199 WSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDG-ASVLFEAAGGGNP 277
Cdd:PHA02875  136 FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKI 215

                         170
                  ....*....|....*
gi 1907173992 278 DCISLLLKYGGSGNV 292
Cdd:PHA02875  216 DIVRLFIKRGADCNI 230
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 553-604 2.26e-16

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 73.34  E-value: 2.26e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 553 ENPCSLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKEFDLYGQ 604
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQ 52
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 134-385 8.85e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 79.71  E-value: 8.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 134 TPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPL-----LIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAA-- 206
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhylsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIsk 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 207 KQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCD--VLEHLIHKGGDVFALaddgasvlfeaagggnpDCISLLL 284
Cdd:PHA03100  117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAK-----------------NRVNYLL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 285 KYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNALladhi 363
Cdd:PHA03100  180 SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLgANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI----- 254

                         250       260
                  ....*....|....*....|..
gi 1907173992 364 sqsyddeRKTALYFAVSNNDIH 385
Cdd:PHA03100  255 -------IETLLYFKDKDLNTI 269
Ank_2 pfam12796
Ankyrin repeats (3 copies);
136-228 1.97e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 136 LTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQpcVKRWSAMHEAAKQGRKDIIT 215
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1907173992 216 LLLNHRGNVHLRD 228
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 134-351 1.28e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.16  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 134 TPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIK--YNTS-LDQPCV-------------- 196
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDngVDTSiLPIPCIekdmiktildcgid 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 197 ------KRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVlehlihkggdvfaladdgasvlfe 270
Cdd:PHA02874  117 vnikdaELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDI------------------------ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 271 aagggnpdcISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQ-KSGLTPIHSAAEgQNAQCLELLI 349
Cdd:PHA02874  173 ---------IKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAII-HNRSAIELLI 242


                  ..
gi 1907173992 350 EN 351
Cdd:PHA02874  243 NN 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
268-357 1.02e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 268 LFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvtsKHAIQK---SGLTPIHSAAEGQNAQC 344
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL----EHADVNlkdNGRTALHYAARSGHLEI 76

                          90
                  ....*....|...
gi 1907173992 345 LELLIENGFDVNA 357
Cdd:pfam12796  77 VKLLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 132-423 1.21e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 132 GETPLTLAVKAGL---VENVKTLLDKGVWPNTKNDKGETPLLIAIKRGS-YDMVSALIKYNTSLDQPCVKRWSAMHE--A 205
Cdd:PHA03095   47 GKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVylS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 206 AKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDV--LEHLIHKGGDVFALADDGASVL------FEAagggNP 277
Cdd:PHA03095  127 GFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAVDDRFRSLLhhhlqsFKP----RA 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 278 DCISLLLKYGGSGNVPNRAGHLPIHRAAYEG---HYLALKYLIPVTSKHAIQKSGLTPIHSAAEGQNAQCLELLIENGFD 354
Cdd:PHA03095  203 RIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGAD 282

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907173992 355 VNALladhisqSYDDErkTALYFAVSNNDIHCTEVLLAagADPNLDP----LNCLLVAVRANRHEIVRLLLSY 423
Cdd:PHA03095  283 INAV-------SSDGN--TPLSLMVRNNNGRAVRAALA--KNPSAETvaatLNTASVAGGDIPSDATRLCVAK 344
Ank_2 pfam12796
Ankyrin repeats (3 copies);
301-399 1.46e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 301 IHRAAYEGHYLALKYLIPV-TSKHAIQKSGLTPIHSAAEGQNAQCLELLIEngfdvnalladHISQSYDDERKTALYFAV 379
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1907173992 380 SNNDIHCTEVLLAAGADPNL 399
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 553-597 1.69e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 64.82  E-value: 1.69e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907173992 553 ENPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 597
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLEL---IKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
235-317 1.98e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 235 LGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNraGHLPIHRAAYEGHYLALK 314
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVK 78


                  ...
gi 1907173992 315 YLI 317
Cdd:pfam12796  79 LLL 81
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 238-436 2.88e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 238 AAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 318 PVTS--KHAIQKSGLTPIHSAAEGQNAQCLELLIENGFDVNA----------------------LLADHISQS--YDDER 371
Cdd:PHA02875   89 DLGKfaDDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIpntdkfsplhlavmmgdikgieLLIDHKACLdiEDCCG 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173992 372 KTALYFAVSNNDIHCTEVLLAAGADPNLDPLN----CLLVAVRANRHEIVRLLLSYGANVNCYFMHVND 436
Cdd:PHA02875  169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgcvaALCYAIENNKIDIVRLFIKRGADCNIMFMIEGE 237
Ank_2 pfam12796
Ankyrin repeats (3 copies);
333-428 3.00e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.52  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 333 IHSAAEGQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIHCTEVLLA-AGADPNLDPLNCLLVAVRA 411
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*..
gi 1907173992 412 NRHEIVRLLLSYGANVN 428
Cdd:pfam12796  72 GHLEIVKLLLEKGADIN 88
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 134-358 7.07e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.63  E-value: 7.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 134 TPLTLAVKA-GLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGsYDM--VSALIKYNTSLDQPCVKRWSAMHEAAKQGR 210
Cdd:PHA02876  275 TPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG-YDTenIRTLIMLGADVNAADRLYITPLHQASTLDR 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 211 -KDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNP-DCISLLLKYGG 288
Cdd:PHA02876  354 nKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGA 433

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173992 289 SGNVPNRaghlpihraayeghYLAlkylipvtskhaiqksglTPIHSAAEGQ-NAQCLELLIENGFDVNAL 358
Cdd:PHA02876  434 NVNSKNK--------------DLS------------------TPLHYACKKNcKLDVIEMLLDNGADVNAI 472
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 87-289 9.08e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 9.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  87 KYALEEA---DEKGWF---PLHEAVVQPIQQILETVLDASYKTlwEFKTCDGETPLTLAVKAGLVEN-----VKTLLDKG 155
Cdd:PHA03100   19 KYIIMEDdlnDYSYKKpvlPLYLAKEARNIDVVKILLDNGADI--NSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 156 VWPNTKNDKGETPLLIAI--KRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKD--IITLLLNHRGNVH------ 225
Cdd:PHA03100   97 ANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvn 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907173992 226 ----------LRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLLKYGGS 289
Cdd:PHA03100  177 yllsygvpinIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
202-294 1.28e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 202 MHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI-HKGGDVFalaDDGASVLFEAAGGGNPDCI 280
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLeHADVNLK---DNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 1907173992 281 SLLLKYGGSGNVPN 294
Cdd:pfam12796  78 KLLLEKGADINVKD 91
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 554-597 2.62e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.33  E-value: 2.62e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907173992 554 NPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 597
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDL---IDKLPLPPRLKDYLLYK 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 101-268 2.06e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.14  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 101 LHEAVVQPIQQILETVLDasYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDM 180
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFE--YGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 181 VSALIKYNTSLDQPCVKRWSAMHEAAKQGRKdIITLLLNHRgNVHLRDGFGVTPLGVAAEYGhC--DVLEHLIHKGGDVF 258
Cdd:PHA02874  206 IKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNA-SINDQDIDGSTPLHHAINPP-CdiDIIDILLYHKADIS 282

                         170
                  ....*....|
gi 1907173992 259 ALADDGASVL 268
Cdd:PHA02874  283 IKDNKGENPI 292
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 554-595 2.08e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.72  E-value: 2.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173992 554 NPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLL 595
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 135-391 3.55e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.67  E-value: 3.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 135 PLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAI----KRGSYDMVSALIKYNTSLDQPCVK------------- 197
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnKLGMKEMIRSINKCSVFYTLVAIKdafnnrnveifki 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 198 ---------RWSAMHEAAKQGRKD-----IITLLLNHRGNVHLRD-GFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALAD 262
Cdd:PHA02878  120 iltnrykniQTIDLVYIDKKSKDDiieaeITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 263 DGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAA-----YEGHYLALKYLIPVTSKHAIQksGLTPIHSAA 337
Cdd:PHA02878  200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgyckdYDILKLLLEHGVDVNAKSYIL--GLTALHSSI 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907173992 338 egQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSN-NDIHCTEVLL 391
Cdd:PHA02878  278 --KSERKLKLLLEYGADINSL---------NSYKLTPLSSAVKQyLCINIGRILI 321
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 34-252 6.05e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 6.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  34 ASYDIQLCI-QESIEASQAIFHPK-RLVQLS--DQNRKLVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAV---- 105
Cdd:PHA02874    1 ASQDLRMCIySGDIEAIEKIIKNKgNCINISvdETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIkiga 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 106 ---------------VQPI----QQILETVLDASYKTlwEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGE 166
Cdd:PHA02874   81 hdiikllidngvdtsILPIpcieKDMIKTILDCGIDV--NIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGC 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 167 TPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHcDV 246
Cdd:PHA02874  159 YPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SA 237


                  ....*.
gi 1907173992 247 LEHLIH 252
Cdd:PHA02874  238 IELLIN 243
PHA03095 PHA03095
ankyrin-like protein; Provisional
 180-459 2.74e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.73  E-value: 2.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 180 MVSALIKYNTSLDQPCVkrwsamheaakqgrkDIITLLLNHRGNVHLRDGFGVTPLGVaaeYGHCdvlehlihKGGDVfa 259
Cdd:PHA03095   11 MEAALYDYLLNASNVTV---------------EEVRRLLAAGADVNFRGEYGKTPLHL---YLHY--------SSEKV-- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 260 laddgasvlfeaagggnPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLA-LKYLIP----VTSKHaiqKSGLTPIH 334
Cdd:PHA03095   63 -----------------KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDvIKLLIKagadVNAKD---KVGRTPLH 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 335 SAAEGQN--AQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIhCTEV---LLAAGADP------NLDPLN 403
Cdd:PHA03095  123 VYLSGFNinPKVIRLLLRKGADVNAL---------DLYGMTPLAVLLKSRNA-NVELlrlLIDAGADVyavddrFRSLLH 192

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907173992 404 CLLVAVRAnRHEIVRLLLSYGANVNCYFMHVNDTRFPSAIQYALNDEIMLRLLLNN 459
Cdd:PHA03095  193 HHLQSFKP-RARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAG 247
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 151-480 2.79e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.16  E-value: 2.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 151 LLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRD-- 228
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDls 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 229 -------------------GFGV--------TPLGVAAEYGHCDVL-EHLIHKGGDVFALADDGASVLFEAAGGG-NPDC 279
Cdd:PHA02876  244 llkairnedletslllydaGFSVnsiddcknTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGyDTEN 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 280 ISLLLKYGGSGNVPNRAGHLPIHRAAYEGHY-----LALKYLIPVTSKHAIQKsglTPIHSAAEGQNAQCLELLIENGFD 354
Cdd:PHA02876  324 IRTLIMLGADVNAADRLYITPLHQASTLDRNkdiviTLLELGANVNARDYCDK---TPIHYAAVRNNVVIINTLLDYGAD 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 355 VNALladhiSQSYDderkTALYFAV-SNNDIHCTEVLLAAGAD---PNLDPLNCLLVAVRAN-RHEIVRLLLSYGANVNC 429
Cdd:PHA02876  401 IEAL-----SQKIG----TALHFALcGTNPYMSVKTLIDRGANvnsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNA 471

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173992 430 YFMHvndTRFPSAIqyALNDEIMLRLLLNNGYQV---ELCFDCMHGNIFGNSFV 480
Cdd:PHA02876  472 INIQ---NQYPLLI--ALEYHGIVNILLHYGAELrdsRVLHKSLNDNMFSFRYI 520
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 242-463 3.00e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 3.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 242 GHCDVLEHLIHKGGDVFALA-DDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvt 320
Cdd:PHA02874   12 GDIEAIEKIIKNKGNCINISvDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI--- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 321 sKHAIQKSGLtPIHSAaegqNAQCLELLIENGFDVNalladhisqSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLD 400
Cdd:PHA02874   89 -DNGVDTSIL-PIPCI----EKDMIKTILDCGIDVN---------IKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907173992 401 PLNC---LLVAVRANRHEIVRLLLSYGANVNcyfmhVNDTRFPSAIQYALN--DEIMLRLLLNNGYQV 463
Cdd:PHA02874  154 DDNGcypIHIAIKHNFFDIIKLLLEKGAYAN-----VKDNNGESPLHNAAEygDYACIKLLIDHGNHI 216
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 177-464 7.81e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 7.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 177 SYDMVSALIKYNTSLDqpcvkrwsamhEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGD 256
Cdd:PHA02876  135 HYDKINESIEYMKLIK-----------ERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGAD 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 257 VFALADDGASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSkhaIQKSGLTPIHSA 336
Cdd:PHA02876  204 VNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNS---IDDCKNTPLHHA 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 337 AEGQN-AQCLELLIENGFDVNAlladhisqsYDDERKTALYFAVSNN-DIHCTEVLLAAGADPN------LDPLNcllVA 408
Cdd:PHA02876  281 SQAPSlSRLVPKLLERGADVNA---------KNIKGETPLYLMAKNGyDTENIRTLIMLGADVNaadrlyITPLH---QA 348

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173992 409 VRANRH-EIVRLLLSYGANVNcyfmhVNDTRFPSAIQYAL--NDEIMLRLLLNNGYQVE 464
Cdd:PHA02876  349 STLDRNkDIVITLLELGANVN-----ARDYCDKTPIHYAAvrNNVVIINTLLDYGADIE 402
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 84-257 1.15e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.83  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  84 VQYKYALEEADEKGWFPLHEAVVQPIQQ--ILETVLDASYKTlwEFKTCDGETPLTLAVKAGLVEN--VKTLLDKGVWPN 159
Cdd:PHA03100   93 LEYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGANV--NIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDIN 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 160 TKNDkgetplliaikrgsydmVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAA 239
Cdd:PHA03100  171 AKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI 233

                         170
                  ....*....|....*...
gi 1907173992 240 EYGHCDVLEHLIHKGGDV 257
Cdd:PHA03100  234 LNNNKEIFKLLLNNGPSI 251
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 169-317 7.19e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 58.73  E-value: 7.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 169 LLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLE 248
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 249 HLIHkggdvFALADD---GASVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:PLN03192  609 ILYH-----FASISDphaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 232-460 1.66e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.98  E-value: 1.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 232 VTPLGVAAEYGHCDVLEHLIHKGGDV--FALADDGASVLFEAAG---GGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAY 306
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADInsSTKNNSTPLHYLSNIKynlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 307 E--GHYLALKYLIPVTSKHAIQKS-GLTPIHSAAEG--QNAQCLELLIENGFDVNAlladhisqsydderktalyfavsn 381
Cdd:PHA03100  116 KksNSYSIVEYLLDNGANVNIKNSdGENLLHLYLESnkIDLKILKLLIDKGVDINA------------------------ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 382 ndihCTEV--LLAAGADPNLdPLNC----LLVAVRANRHEIVRLLLSYGANVNcYFMHVNDTrfPSAIQYALNDEIMLRL 455
Cdd:PHA03100  172 ----KNRVnyLLSYGVPINI-KDVYgftpLHYAVYNNNPEFVKYLLDLGANPN-LVNKYGDT--PLHIAILNNNKEIFKL 243


                  ....*
gi 1907173992 456 LLNNG 460
Cdd:PHA03100  244 LLNNG 248
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 268-463 3.21e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.43  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 268 LFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKHAIQKSgLTPIHSAAEGQNAQCLEL 347
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYT-LVAIKDAFNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 348 LIENGFDVN----------------------ALLADH---ISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLdPL 402
Cdd:PHA02878  120 ILTNRYKNIqtidlvyidkkskddiieaeitKLLLSYgadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNI-PD 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907173992 403 NC----LLVAVRANRHEIVRLLLSYGANVNCYFMHVNdTRFPSAIQYALNDEImLRLLLNNGYQV 463
Cdd:PHA02878  199 KTnnspLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISVGYCKDYDI-LKLLLEHGVDV 261
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 553-597 5.67e-08

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 49.25  E-value: 5.67e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907173992 553 ENPCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 597
Cdd:cd03719     1 AEPHSLLHLSRLCVRHALGDTRLGQ---VSALPLPPAMKRYLLYQ 42
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 555-597 1.50e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 48.07  E-value: 1.50e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173992 555 PCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLLFK 597
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRL---EEIEQLPLPPSLKNYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
134-185 1.51e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 134 TPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALI 185
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 557-598 2.12e-07

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 47.86  E-value: 2.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173992 557 SLKHLCRLKIRRVMGLQRLCQPASIQMLPLPAAMRRYLLFKE 598
Cdd:cd03722     5 SLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSD 46
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 556-597 3.00e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.63  E-value: 3.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907173992  556 CSLKHLCRLKIRRVMGLqrlcqpasIQMLPLPAAMRRYLLFK 597
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 132-192 3.78e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 3.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173992 132 GETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLD 192
Cdd:PHA03100  192 GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank_4 pfam13637
Ankyrin repeats (many copies);
198-251 5.24e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 5.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173992 198 RWSAMHEAAKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 251
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-162 7.55e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 7.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992  68 LVEAIRQGRIFELQEYVQYKYALEEADEKGWFPLHEAVVQPIQQILETVLDASYKTLwefkTCDGETPLTLAVKAGLVEN 147
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 1907173992 148 VKTLLDKGVWPNTKN 162
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 553-595 8.06e-07

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 45.75  E-value: 8.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907173992  553 ENPCSLKHLCRLKIRRVMGLQrlcqpaSIQMLPLPAAMRRYLL 595
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTD------QIKTLPLPPKLKDYLS 41
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 555-597 2.27e-06

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 44.44  E-value: 2.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173992 555 PCSLKHLCRLKIRRVMGLQRLcqPASIQMLPLPAAMRRYLLFK 597
Cdd:cd03727     3 PGTLKALARYAVRRSLGVQYL--PEAVKQLPLPRSVKEYLLLL 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
329-391 3.16e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 3.16e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907173992 329 GLTPIHSAAEGQNAQCLELLIENGFDVNALladhisqsyDDERKTALYFAVSNNDIHCTEVLL 391
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAV---------DGNGETALHFAASNGNVEVLKLLL 54
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 557-597 3.26e-06

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 44.03  E-value: 3.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907173992 557 SLKHLCRLKIRRVMGLQRlcqpasIQMLPLPAAMRRYLLFK 597
Cdd:cd03746     5 SLQHLCRMAIRRVMPTQQ------VKELPIPSKLLEFLTYR 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
266-317 3.45e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 3.45e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 266 SVLFEAAGGGNPDCISLLLKYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 132-257 5.58e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 132 GETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKY------NTSLDQPCvkrwsamhEA 205
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFasisdpHAAGDLLC--------TA 629

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 206 AKQGRKDIITLLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDV 257
Cdd:PLN03192  630 AKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 557-597 6.27e-06

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 43.18  E-value: 6.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907173992 557 SLKHLCRLKIRRVMGLQRlcqpasIQMLPLPAAMRRYLLFK 597
Cdd:cd03733     5 SLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTYR 39
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 555-597 1.46e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 42.28  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173992 555 PCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 597
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSE---IHTLPLPASLKNYLLYQ 42
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 554-595 1.54e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.43  E-value: 1.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173992 554 NPCSLKHLCRLKIRRVMGlqRLCQpASIQMLPLPAAMRRYLL 595
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLG--SRCH-KLVPQLSLPTSLKNYLL 40
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 553-598 2.41e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.77  E-value: 2.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907173992 553 ENPCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLLFKE 598
Cdd:cd03721     1 EPPRPLAHLCRLKVRTLIGINRI---KLIDTLPLPPRLIRYLNHQE 43
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 554-595 2.70e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 41.64  E-value: 2.70e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907173992 554 NPCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLL 595
Cdd:cd03720     2 NPRSLLSLCRIAVRRALGKQRL---SLICSLPLPDPIKKFLL 40
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 555-597 7.22e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 40.32  E-value: 7.22e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907173992 555 PCSLKHLCRLKIRRVMGLQRLCQpasIQMLPLPAAMRRYLLFK 597
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLHH---IQSLPLPQTLKNYLQYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 100-238 9.45e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.26  E-value: 9.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 100 PLHEAVVQPIQQILETVLdaSYKTLWEFKTCDGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKR-GSY 178
Cdd:PHA02878  171 ALHYATENKDQRLTELLL--SYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDY 248

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907173992 179 DMVSALIKYNTSLD-QPCVKRWSAMHEAAKQGRKdiITLLLNHRGNVHLRDGFGVTPLGVA 238
Cdd:PHA02878  249 DILKLLLEHGVDVNaKSYILGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSA 307
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 264-357 9.83e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 9.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 264 GASVLFEAAGGGNP-DCISLLLKYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSKH-------AIQKS---- 328
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKSgplelanDQYTSeftp 127

                          90       100
                  ....*....|....*....|....*....
gi 1907173992 329 GLTPIHSAAEGQNAQCLELLIENGFDVNA 357
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVPA 156
Ank_4 pfam13637
Ankyrin repeats (many copies);
300-349 1.03e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173992 300 PIHRAAYEGHYLALKYLI----PVtskHAIQKSGLTPIHSAAEGQNAQCLELLI 349
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLekgaDI---NAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
231-284 1.13e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907173992 231 GVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLL 284
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02730 PHA02730
ankyrin-like protein; Provisional
 343-448 1.44e-04

ankyrin-like protein; Provisional


Pssm-ID: 165098 [Multi-domain]  Cd Length: 672  Bit Score: 45.02  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 343 QCLELLIENGFDVNALLADHISQsYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLNCLLVAV------RANRHEI 416
Cdd:PHA02730  435 HCYETILIDVFDILSKYMDDIDM-IDNENKTLLYYAVDVNNIQFARRLLEYGASVNTTSRSIINTAIqkssyrRENKTKL 513

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907173992 417 VRLLLSY---------GANVNCYFMH------------VNDTRFPSAIQYALN 448
Cdd:PHA02730  514 VDLLLSYhptletmidAFNRDIRYLYpepllaciryalILDNDFPSKVKYDIA 566
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 148-284 1.96e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 44.35  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 148 VKTLLDKGVWP-NTKNDKGETPLLIAIKRG----SYDMVSALIKYNTSLDQPCVKRWSAM------HEAAKQGRKDIITL 216
Cdd:PHA02989  163 IKILLSFGVNLfEKTSLYGLTPMNIYLRNDidviSIKVIKYLIKKGVNIETNNNGSESVLesfldnNKILSKKEFKVLNF 242

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907173992 217 LLNHRgNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISLLL 284
Cdd:PHA02989  243 ILKYI-KINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRIL 309
PHA03095 PHA03095
ankyrin-like protein; Provisional
 130-285 2.73e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 130 CDGETPLTLAVKAG--LVENVKTLLDKGVWPNTKNDKGETPLLIAIK--RGSYDMVSALIKYNTSLDQPCVKRWSAMHEA 205
Cdd:PHA03095  150 LYGMTPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDMLGNTPLHSM 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 206 AKQG---RKDIITLLLNHRGnVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAAGGGNPDCISL 282
Cdd:PHA03095  230 ATGSsckRSLVLPLLIAGIS-INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308


                  ...
gi 1907173992 283 LLK 285
Cdd:PHA03095  309 ALA 311
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 557-595 3.38e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 38.35  E-value: 3.38e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907173992 557 SLKHLCRLKIRRVMGLQrlcqpaSIQMLPLPAAMRRYLL 595
Cdd:cd03717     5 SLQHLCRFVIRQCTRRD------LIDQLPLPRRLKDYLK 37
Ank_5 pfam13857
Ankyrin repeats (many copies);
216-268 4.02e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 4.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907173992 216 LLLNHRGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVL 268
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 133-317 5.03e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.08  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 133 ETPLTLAVKAGLVENVKTLLD-KGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSL-DQPCV----KRWSAMHEAA 206
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvNEPMTsdlyQGETALHIAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 207 KQGRKDIITLLLNHRGNV----------HLRDG----FGVTPLGVAAEYGHCDVLEHLIHKGGDVFALADDGASVLFEAA 272
Cdd:cd22192    98 VNQNLNLVRELIARGADVvspratgtffRPGPKnliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILV 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907173992 273 GGGN--PDC--ISLLLKYGGSGN------VPNRAGHLPIHRAAYEGHYLALKYLI 317
Cdd:cd22192   178 LQPNktFACqmYDLILSYDKEDDlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLV 232
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 122-253 5.97e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 5.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 122 KTLWEFKTCD-------GETPLTLAVKAGLVENVKTLLDKGvwPNTKND-------KGETPLLIAIKRGSYDMVSALIKY 187
Cdd:cd22192    34 KKLLKCPSCDlfqrgalGETALHVAALYDNLEAAVVLMEAA--PELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIAR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 188 NTSLDQPCVK----RWSA----------MHEAAKQGRKDIITLLLNHRGNVHLRDGF----------------------- 230
Cdd:cd22192   112 GADVVSPRATgtffRPGPknliyygehpLSFAACVGNEEIVRLLIEHGADIRAQDSLgntvlhilvlqpnktfacqmydl 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907173992 231 --------------------GVTPLGVAAEYGHCDVLEHLIHK 253
Cdd:cd22192   192 ilsydkeddlqpldlvpnnqGLTPFKLAAKEGNIVMFQHLVQK 234
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-172 8.32e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 8.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907173992 132 GETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIA 172
Cdd:pfam13857  16 GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
151-205 9.18e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 9.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907173992 151 LLDKGVW-PNTKNDKGETPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEA 205
Cdd:pfam13857   1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 334-423 1.00e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 334 HSAAEGqNAQCLELLIENGFDVNalladhiSQSYDDerKTALYFAVSNNDIHCTEVLLAAGADPNL---DPLNCLLVAVR 410
Cdd:PTZ00322   88 QLAASG-DAVGARILLTGGADPN-------CRDYDG--RTPLHIACANGHVQVVRVLLEFGADPTLldkDGKTPLELAEE 157

                          90
                  ....*....|...
gi 1907173992 411 ANRHEIVRLLLSY 423
Cdd:PTZ00322  158 NGFREVVQLLSRH 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
167-218 1.09e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 1.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907173992 167 TPLLIAIKRGSYDMVSALIKYNTSLDQPCVKRWSAMHEAAKQGRKDIITLLL 218
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 345-428 4.43e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 39.72  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 345 LELLIENGFDVNalladhiSQSYDDERKTAL---YFAVSNNDIHCTEVLLAAGADPNLDPLN------CLLVAVRANRHE 415
Cdd:PHA02989   53 VKLLIDNGADVN-------YKGYIETPLCAVlrnREITSNKIKKIVKLLLKFGADINLKTFNgvspivCFIYNSNINNCD 125

                          90
                  ....*....|...
gi 1907173992 416 IVRLLLSYGANVN 428
Cdd:PHA02989  126 MLRFLLSKGINVN 138
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 557-601 4.56e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 35.32  E-value: 4.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907173992 557 SLKHLCRLKIRRVMglqrlcqpASIQMLPLPAAMRRYLLFKEFDL 601
Cdd:cd03734     5 SLQHLCRLVINRLV--------TDVDCLPLPRRMADYLRQYPFQL 41
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 555-600 5.12e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 35.21  E-value: 5.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907173992 555 PCSLKHLCRLKIRRVMGLQRLcqpASIQMLPLPAAMRRYLLFKEFD 600
Cdd:cd03726     3 PRTLQDLCRIKIRHCIGLQNL---KLLDELPIAKVMKDYLKHKFDD 45
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 131-187 5.74e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 5.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907173992 131 DGETPLTLAVKAGLVENVKTLLDKGVWPNTKNDKGETPLLIAIKRGSYDMVSALIKY 187
Cdd:PTZ00322  114 DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 329-357 5.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 5.78e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173992  329 GLTPIHSAAEGQNAQCLELLIENGFDVNA 357
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 403-429 6.51e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|....*..
gi 1907173992  403 NCLLVAVRANRHEIVRLLLSYGANVNC 429
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 356-466 6.76e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.26  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173992 356 NALLADHISQSYDDERKTALYFAVSNNDIHCTEVLLAAGADPNLDPLN--CLLVAVRANRH------EIVRLLLSYGANV 427
Cdd:PHA03100   20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNnsTPLHYLSNIKYnltdvkEIVKLLLEYGANV 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907173992 428 NCYFMHVNdTRFPSAIQYALNDEIMLRLLLNNGYQVELC 466
Cdd:PHA03100  100 NAPDNNGI-TPLLYAISKKSNSYSIVEYLLDNGANVNIK 137
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 131-159 8.58e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 8.58e-03
                           10        20
                   ....*....|....*....|....*....
gi 1907173992  131 DGETPLTLAVKAGLVENVKTLLDKGVWPN 159
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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