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Conserved domains on  [gi|1907180494|ref|XP_036008904|]
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katanin-interacting protein isoform X3 [Mus musculus]

Protein Classification

KATNIP family protein( domain architecture ID 10384633)

KATNIP family protein is a DUF4457 domain-containing protein; similar to Homo sapiens katanin-interacting protein (KATNIP, also known as KIAA0556), which is a ciliary basal body component, and may influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 1179-1498 0e+00

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 611.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1179 LNLTASWGDLHYIGLTGLEVVGKDGEALPIQPHQLSASPRDLNDLPEYNDDSRTLDKLIDGMNITTEDEHMWLIPFSPGL 1258
Cdd:pfam14652    1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIPIQLSNITASPRDLNDLPGYSGDYRTLDKLIDGTNVTTDDEHMWLIPFSPGK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1259 DHVVMIHFDRAQSIAGLRLWNYNKSPEDTYRGVKIAHVSLDGLCVSPAEGFLIRKGPGNCHFDFAQEILFG--DYLQTRL 1336
Cdd:pfam14652   81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPEGFLLRKAPGNCHFDFAQTISFPnvDKVNPPS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1337 PPAPTR-RLDAKSLERASMDYEAPLMPCGFIFQFQLLSSWGDPYYIGLTGLELYDEHGERIPLSQNNIAAFPDSVNALEG 1415
Cdd:pfam14652  161 KQSESQlRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1416 VCGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFGLLVDDLLVYNGIL 1495
Cdd:pfam14652  241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNGIL 320


                   ...
gi 1907180494 1496 AMV 1498
Cdd:pfam14652  321 RKA 323
DUF4457 super family cl20613
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 929-1073 6.84e-37

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


The actual alignment was detected with superfamily member pfam14652:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 142.41  E-value: 6.84e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  929 DFKIPVLPYGQHLVIDIKSTWGDRHYVGLNGIEIFSSSGEPVQI--SSITADPPDINILPAYGKDPRVVSNLIDGVNRTQ 1006
Cdd:pfam14652  180 DYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLteNNIAAFPDSVNVLDGVSGDVRTPDKLIDGVNNTN 259

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907180494 1007 DDMHVWLAPFTPGMTHTISIEFTHPCQVALIRIWNYNKSrihSFRGVKDITMLLDTQCIFEGEIAKA 1073
Cdd:pfam14652  260 DGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKT---PSRGVKEFAILVDDLLIYNGILRKA 323
DUF4457 super family cl20613
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 427-579 1.58e-04

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


The actual alignment was detected with superfamily member pfam14652:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 45.73  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  427 TEKPVPNSEEKWKARVDEIEDAI--YVT----------MEILSNWGNASWVGLTEVQFFDLNN--IKLYVS-----PHDV 487
Cdd:pfam14652  156 VNPPSKQSESQLRSSSKCSSQASqdYETplmpcgfifkFQLLSTWGDPYYIGLNGLELYDENGelIPLTENniaafPDSV 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  488 DIRNAVL-----PGELGCLVNrdlVSKKDPPVWTCPFHPPL--QLYFIIHnmrqlRDFGLTMIKVRNYW-TADGdldiGA 559
Cdd:pfam14652  236 NVLDGVSgdvrtPDKLIDGVN---NTNDGRHMWLAPILPGLvnRIYVIFD-----QPITVSMIKIWNYSkTPSR----GV 303

                          170       180
                   ....*....|....*....|
gi 1907180494  560 KNVKLYVNKSLIFDGVLEKG 579
Cdd:pfam14652  304 KEFAILVDDLLIYNGILRKA 323
 
Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 1179-1498 0e+00

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 611.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1179 LNLTASWGDLHYIGLTGLEVVGKDGEALPIQPHQLSASPRDLNDLPEYNDDSRTLDKLIDGMNITTEDEHMWLIPFSPGL 1258
Cdd:pfam14652    1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIPIQLSNITASPRDLNDLPGYSGDYRTLDKLIDGTNVTTDDEHMWLIPFSPGK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1259 DHVVMIHFDRAQSIAGLRLWNYNKSPEDTYRGVKIAHVSLDGLCVSPAEGFLIRKGPGNCHFDFAQEILFG--DYLQTRL 1336
Cdd:pfam14652   81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPEGFLLRKAPGNCHFDFAQTISFPnvDKVNPPS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1337 PPAPTR-RLDAKSLERASMDYEAPLMPCGFIFQFQLLSSWGDPYYIGLTGLELYDEHGERIPLSQNNIAAFPDSVNALEG 1415
Cdd:pfam14652  161 KQSESQlRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1416 VCGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFGLLVDDLLVYNGIL 1495
Cdd:pfam14652  241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNGIL 320


                   ...
gi 1907180494 1496 AMV 1498
Cdd:pfam14652  321 RKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 929-1073 6.84e-37

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 142.41  E-value: 6.84e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  929 DFKIPVLPYGQHLVIDIKSTWGDRHYVGLNGIEIFSSSGEPVQI--SSITADPPDINILPAYGKDPRVVSNLIDGVNRTQ 1006
Cdd:pfam14652  180 DYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLteNNIAAFPDSVNVLDGVSGDVRTPDKLIDGVNNTN 259

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907180494 1007 DDMHVWLAPFTPGMTHTISIEFTHPCQVALIRIWNYNKSrihSFRGVKDITMLLDTQCIFEGEIAKA 1073
Cdd:pfam14652  260 DGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKT---PSRGVKEFAILVDDLLIYNGILRKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 427-579 1.58e-04

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 45.73  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  427 TEKPVPNSEEKWKARVDEIEDAI--YVT----------MEILSNWGNASWVGLTEVQFFDLNN--IKLYVS-----PHDV 487
Cdd:pfam14652  156 VNPPSKQSESQLRSSSKCSSQASqdYETplmpcgfifkFQLLSTWGDPYYIGLNGLELYDENGelIPLTENniaafPDSV 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  488 DIRNAVL-----PGELGCLVNrdlVSKKDPPVWTCPFHPPL--QLYFIIHnmrqlRDFGLTMIKVRNYW-TADGdldiGA 559
Cdd:pfam14652  236 NVLDGVSgdvrtPDKLIDGVN---NTNDGRHMWLAPILPGLvnRIYVIFD-----QPITVSMIKIWNYSkTPSR----GV 303

                          170       180
                   ....*....|....*....|
gi 1907180494  560 KNVKLYVNKSLIFDGVLEKG 579
Cdd:pfam14652  304 KEFAILVDDLLIYNGILRKA 323
 
Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 1179-1498 0e+00

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 611.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1179 LNLTASWGDLHYIGLTGLEVVGKDGEALPIQPHQLSASPRDLNDLPEYNDDSRTLDKLIDGMNITTEDEHMWLIPFSPGL 1258
Cdd:pfam14652    1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIPIQLSNITASPRDLNDLPGYSGDYRTLDKLIDGTNVTTDDEHMWLIPFSPGK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1259 DHVVMIHFDRAQSIAGLRLWNYNKSPEDTYRGVKIAHVSLDGLCVSPAEGFLIRKGPGNCHFDFAQEILFG--DYLQTRL 1336
Cdd:pfam14652   81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPEGFLLRKAPGNCHFDFAQTISFPnvDKVNPPS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1337 PPAPTR-RLDAKSLERASMDYEAPLMPCGFIFQFQLLSSWGDPYYIGLTGLELYDEHGERIPLSQNNIAAFPDSVNALEG 1415
Cdd:pfam14652  161 KQSESQlRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494 1416 VCGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFGLLVDDLLVYNGIL 1495
Cdd:pfam14652  241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNGIL 320


                   ...
gi 1907180494 1496 AMV 1498
Cdd:pfam14652  321 RKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 929-1073 6.84e-37

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 142.41  E-value: 6.84e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  929 DFKIPVLPYGQHLVIDIKSTWGDRHYVGLNGIEIFSSSGEPVQI--SSITADPPDINILPAYGKDPRVVSNLIDGVNRTQ 1006
Cdd:pfam14652  180 DYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLteNNIAAFPDSVNVLDGVSGDVRTPDKLIDGVNNTN 259

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907180494 1007 DDMHVWLAPFTPGMTHTISIEFTHPCQVALIRIWNYNKSrihSFRGVKDITMLLDTQCIFEGEIAKA 1073
Cdd:pfam14652  260 DGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKT---PSRGVKEFAILVDDLLIYNGILRKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 427-579 1.58e-04

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 45.73  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  427 TEKPVPNSEEKWKARVDEIEDAI--YVT----------MEILSNWGNASWVGLTEVQFFDLNN--IKLYVS-----PHDV 487
Cdd:pfam14652  156 VNPPSKQSESQLRSSSKCSSQASqdYETplmpcgfifkFQLLSTWGDPYYIGLNGLELYDENGelIPLTENniaafPDSV 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180494  488 DIRNAVL-----PGELGCLVNrdlVSKKDPPVWTCPFHPPL--QLYFIIHnmrqlRDFGLTMIKVRNYW-TADGdldiGA 559
Cdd:pfam14652  236 NVLDGVSgdvrtPDKLIDGVN---NTNDGRHMWLAPILPGLvnRIYVIFD-----QPITVSMIKIWNYSkTPSR----GV 303

                          170       180
                   ....*....|....*....|
gi 1907180494  560 KNVKLYVNKSLIFDGVLEKG 579
Cdd:pfam14652  304 KEFAILVDDLLIYNGILRKA 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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