|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
42-435 |
6.51e-159 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 454.99 E-value: 6.51e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFihldsQPLAREQRNGPGMLVLTPTRELAL 121
Cdd:COG0513 11 PPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLL-----QRLDPSRPRAPQALILAPTRELAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKYS-YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQ 200
Cdd:COG0513 86 QVAEELRKLAkYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMGFIED 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 201 IMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTlDLVAVSTVKQNIIITTEEEKRTHIQTFLENMSPkDK 280
Cdd:COG0513 166 IERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAP-ENATAETIEQRYYLVDKRDKLELLRRLLRDEDP-ER 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 281 VIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVYNYDFPRNIE 360
Cdd:COG0513 244 AIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPE 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907194084 361 EYVHRVGRTGRAGRTGMSITLITRNDWRvatELINILERANQNIPEELVLMAERYKANKLKREMEKKMGRPQGKP 435
Cdd:COG0513 324 DYVHRIGRTGRAGAEGTAISLVTPDERR---LLRAIEKLIGQKIEEEELPGFEPVEEKRLERLKPKIKEKLKGKK 395
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
23-435 |
1.46e-149 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 436.13 E-value: 1.46e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 23 EKRPIPNPICKFEdaFQSYPE-VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLA 101
Cdd:PTZ00110 121 AGENVPKPVVSFE--YTSFPDyILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLL 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 102 REQrNGPGMLVLTPTRELALQVEAECSKYS-YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKS 180
Cdd:PTZ00110 199 RYG-DGPIVLVLAPTRELAEQIREQCNKFGaSSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRR 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 181 VTYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKE-PMIVYVGTLDLVAVSTVKQNIIIT 259
Cdd:PTZ00110 278 VTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEePVHVNVGSLDLTACHNIKQEVFVV 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 260 TEEEKRTHIQTFLEN-MSPKDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLA 338
Cdd:PTZ00110 358 EEHEKRGKLKMLLQRiMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVA 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 339 SRGLDVHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITLITRNDWRVATELINILERANQNIPEELVLMA-ERYKA 417
Cdd:PTZ00110 438 SRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLARDLVKVLREAKQPVPPELEKLSnERSNG 517
|
410
....*....|....*...
gi 1907194084 418 NKLKRemEKKMGRPQGKP 435
Cdd:PTZ00110 518 TERRR--WGGYGRFSNNV 533
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
44-240 |
3.12e-138 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 394.14 E-value: 3.12e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREQRNGPGMLVLTPTRELALQV 123
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 EAECSKYSYGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMK 203
Cdd:cd17958 81 EAECSKYSYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 1907194084 204 ILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVY 240
Cdd:cd17958 161 ILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
44-239 |
1.44e-96 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 288.11 E-value: 1.44e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLaREQRNGPGMLVLTPTRELALQV 123
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPP-LERGDGPIVLVLAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 EAECSKYSYG-DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIM 202
Cdd:cd17966 80 QQEANKFGGSsRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 1907194084 203 KILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17966 160 KIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
44-239 |
2.22e-96 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 287.42 E-value: 2.22e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPlaREQRNGPGMLVLTPTRELALQV 123
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEP--KKKGRGPQALVLAPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 EAECSKYSYG-DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIM 202
Cdd:cd00268 79 AEVARKLGKGtGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVE 158
|
170 180 190
....*....|....*....|....*....|....*..
gi 1907194084 203 KILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd00268 159 KILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
42-382 |
4.94e-90 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 280.54 E-value: 4.94e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREQRNGPGMLVLTPTRELAL 121
Cdd:PRK10590 10 PDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVRALILTPTRELAA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKYS-YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQ 200
Cdd:PRK10590 90 QIGENVRDYSkYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFIHD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 201 IMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTLDlVAVSTVKQNIIITTEEEKRtHIQTFLENMSPKDK 280
Cdd:PRK10590 170 IRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRN-TASEQVTQHVHFVDKKRKR-ELLSQMIGKGNWQQ 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 281 VIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVYNYDFPRNIE 360
Cdd:PRK10590 248 VLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPE 327
|
330 340
....*....|....*....|..
gi 1907194084 361 EYVHRVGRTGRAGRTGMSITLI 382
Cdd:PRK10590 328 DYVHRIGRTGRAAATGEALSLV 349
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
33-381 |
4.31e-88 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 274.54 E-value: 4.31e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 33 KFEDaFQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLARE-QRNGPGML 111
Cdd:PRK04837 9 KFSD-FALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDrKVNQPRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 112 VLTPTRELALQV--EAECSKYSYGdLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEA 189
Cdd:PRK04837 88 IMAPTRELAVQIhaDAEPLAQATG-LKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 190 DKMLDMGFEPQImKILLDVRPD---RQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTLDLVAVStVKQNIIITTEEEKRT 266
Cdd:PRK04837 167 DRMFDLGFIKDI-RWLFRRMPPanqRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHR-IKEELFYPSNEEKMR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 267 HIQTFLENMSPkDKVIVFVSRK----AVADHLSSDlilRHiSVESLHGNREQSDREKALENFKTGKVRILIATDLASRGL 342
Cdd:PRK04837 245 LLQTLIEEEWP-DRAIIFANTKhrceEIWGHLAAD---GH-RVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGL 319
|
330 340 350
....*....|....*....|....*....|....*....
gi 1907194084 343 DVHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITL 381
Cdd:PRK04837 320 HIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
28-242 |
8.83e-86 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 261.87 E-value: 8.83e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 28 PNPICKFEDAfqSYPE-VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLArEQRN 106
Cdd:cd18049 20 PKPVLNFYEA--NFPAnVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFL-ERGD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 107 GPGMLVLTPTRELALQVEAECSKYSYG-DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLV 185
Cdd:cd18049 97 GPICLVLAPTRELAQQVQQVAAEYGRAcRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLV 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907194084 186 LDEADKMLDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVG 242
Cdd:cd18049 177 LDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
23-386 |
4.53e-84 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 265.62 E-value: 4.53e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 23 EKRPIPNPICKFED-------------AFQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLM 89
Cdd:PRK01297 64 ERKPKPASLWKLEDfvvepqegktrfhDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 90 PGFIHLDSQPLAREQRNG-PGMLVLTPTRELALQVE---AECSKYSygDLKSVCVYGGGDRDGQIQDV-SKGVDIIIATP 164
Cdd:PRK01297 144 SIINQLLQTPPPKERYMGePRALIIAPTRELVVQIAkdaAALTKYT--GLNVMTFVGGMDFDKQLKQLeARFCDILVATP 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 165 GRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKILLDVRP--DRQTIMTSATWPYAVRRLAQSYLKEPMIVYVG 242
Cdd:PRK01297 222 GRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIE 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 243 TLDlVAVSTVKQNIIITTEEEKRTHIQTFLeNMSPKDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALE 322
Cdd:PRK01297 302 PEN-VASDTVEQHVYAVAGSDKYKLLYNLV-TQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLE 379
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907194084 323 NFKTGKVRILIATDLASRGLDVHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITLITRND 386
Cdd:PRK01297 380 GFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDD 443
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
34-438 |
3.61e-83 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 262.19 E-value: 3.61e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 34 FEDaFQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPlaREQRNGPGMLVL 113
Cdd:PRK11192 3 FSE-LELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFP--RRKSGPPRILIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 114 TPTRELALQVEAECSKYS-YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLND-LQMNNFvNLKSVTYLVLDEADK 191
Cdd:PRK11192 80 TPTRELAMQVADQARELAkHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQyIKEENF-DCRAVETLILDEADR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 192 MLDMGFEPQIMKILLDVRPDRQTIMTSATWP-YAVRRLAQSYLKEPMivyvgtlDLVAVSTVKQNIIIT-------TEEE 263
Cdd:PRK11192 159 MLDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPV-------EVEAEPSRRERKKIHqwyyradDLEH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 264 KRTHIQTFLENMSPKdKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLD 343
Cdd:PRK11192 232 KTALLCHLLKQPEVT-RSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGID 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 344 VHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITLITRNDWRvatelinILERanqnipeelvlmAERYKANKLKRE 423
Cdd:PRK11192 311 IDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHL-------LLGK------------IERYIEEPLKAR 371
|
410
....*....|....*
gi 1907194084 424 MEKKMgRPQGKPQKF 438
Cdd:PRK11192 372 VIDEL-RPKTKAPSE 385
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
27-237 |
3.05e-81 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 249.99 E-value: 3.05e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 27 IPNPICKFEDAFQSYPeVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREQrN 106
Cdd:cd17953 7 CPKPIQKWSQCGLSEK-VLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKPG-E 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 107 GPGMLVLTPTRELALQVEAECSKYSYG-DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLND-LQMNN--FVNLKSVT 182
Cdd:cd17953 85 GPIGLIMAPTRELALQIYVECKKFSKAlGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDiLTANNgrVTNLRRVT 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1907194084 183 YLVLDEADKMLDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPM 237
Cdd:cd17953 165 YVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
37-409 |
9.91e-81 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 259.88 E-value: 9.91e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 37 AFQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQP-LAREQRNGPGMLVLTP 115
Cdd:PRK04537 13 SFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPaLADRKPEDPRALILAP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 116 TRELALQVEAECSKYSyGDL--KSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLND-LQMNNFVNLKSVTYLVLDEADKM 192
Cdd:PRK04537 93 TRELAIQIHKDAVKFG-ADLglRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDyVKQHKVVSLHACEICVLDEADRM 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 193 LDMGFEPQIMKIL--LDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTlDLVAVSTVKQNIIITTEEEKRTHIQT 270
Cdd:PRK04537 172 FDLGFIKDIRFLLrrMPERGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVET-ETITAARVRQRIYFPADEEKQTLLLG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 271 FLENmSPKDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHV 350
Cdd:PRK04537 251 LLSR-SEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYV 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907194084 351 YNYDFPRNIEEYVHRVGRTGRAGRTGMSITLITRndwRVATELINILERANQNIPEELV 409
Cdd:PRK04537 330 YNYDLPFDAEDYVHRIGRTARLGEEGDAISFACE---RYAMSLPDIEAYIEQKIPVEPV 385
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
42-386 |
2.30e-78 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 250.49 E-value: 2.30e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQplareqRNGPGMLVLTPTRELAL 121
Cdd:PRK11776 13 PALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVK------RFRVQALVLCPTRELAD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKYSYG--DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEP 199
Cdd:PRK11776 87 QVAKEIRRLARFipNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDMGFQD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 200 QIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTLDlvAVSTVKQNIIITTEEEKRTHIQTFLENMSPkD 279
Cdd:PRK11776 167 AIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTH--DLPAIEQRFYEVSPDERLPALQRLLLHHQP-E 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 280 KVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVYNYDFPRNI 359
Cdd:PRK11776 244 SCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDP 323
|
330 340
....*....|....*....|....*..
gi 1907194084 360 EEYVHRVGRTGRAGRTGMSITLITRND 386
Cdd:PRK11776 324 EVHVHRIGRTGRAGSKGLALSLVAPEE 350
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
42-243 |
7.58e-78 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 240.85 E-value: 7.58e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMP--GFIHLDSQPLAREQRNG--PGMLVLTPTR 117
Cdd:cd17967 9 ELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPiiSKLLEDGPPSVGRGRRKayPSALILAPTR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 118 ELALQVEAECSKYSYGD-LKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMG 196
Cdd:cd17967 89 ELAIQIYEEARKFSYRSgVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDEADRMLDMG 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1907194084 197 FEPQIMKIL----LDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGT 243
Cdd:cd17967 169 FEPQIRKIVehpdMPPKGERQTLMFSATFPREIQRLAADFLKNYIFLTVGR 219
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
27-430 |
1.46e-75 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 244.70 E-value: 1.46e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 27 IPNPICKFEDAfQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDS-QPLAREQR 105
Cdd:PLN00206 116 VPPPILSFSSC-GLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTiRSGHPSEQ 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 106 NGPGMLVLTPTRELALQVEAECSKYSYG-DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYL 184
Cdd:PLN00206 195 RNPLAMVLTPTRELCVQVEDQAKVLGKGlPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 185 VLDEADKMLDMGFEPQIMKILLDVrPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTLDLVAVStVKQNIIITTEEEK 264
Cdd:PLN00206 275 VLDEVDCMLERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKA-VKQLAIWVETKQK 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 265 RTHIQTFLENMSP-KDKVIVFVSRKAVADHLSSDL-ILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGL 342
Cdd:PLN00206 353 KQKLFDILKSKQHfKPPAVVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGV 432
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 343 DVHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITLITRNDWRVATELINILERANQNIPEELVlmAERYKANKLKR 422
Cdd:PLN00206 433 DLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVALLKSSGAAIPRELA--NSRYLGSGRKR 510
|
....*...
gi 1907194084 423 EMEKKMGR 430
Cdd:PLN00206 511 KKKRRYGS 518
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
28-242 |
1.71e-73 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 231.82 E-value: 1.71e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 28 PNPICKFEDAfqSYPE-VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLArEQRN 106
Cdd:cd18050 58 PKPVFAFHQA--NFPQyVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYL-ERGD 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 107 GPGMLVLTPTRELALQVEAECSKYSYGD-LKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLV 185
Cdd:cd18050 135 GPICLVLAPTRELAQQVQQVADDYGKSSrLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLV 214
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907194084 186 LDEADKMLDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVG 242
Cdd:cd18050 215 LDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
43-406 |
6.11e-72 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 238.21 E-value: 6.11e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 43 EVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAreqrngPGMLVLTPTRELALQ 122
Cdd:PRK11634 16 PILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKA------PQILVLAPTRELAVQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 123 VEAECSKYS--YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQ 200
Cdd:PRK11634 90 VAEAMTDFSkhMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGFIED 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 201 IMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTldlvAVST---VKQNIIITTEEEKRTHIQTFLEnMSP 277
Cdd:PRK11634 170 VETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQS----SVTTrpdISQSYWTVWGMRKNEALVRFLE-AED 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 278 KDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVYNYDFPR 357
Cdd:PRK11634 245 FDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPM 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1907194084 358 NIEEYVHRVGRTGRAGRTGMSITLITRNDWRVateLINILERANQNIPE 406
Cdd:PRK11634 325 DSESYVHRIGRTGRAGRAGRALLFVENRERRL---LRNIERTMKLTIPE 370
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
44-240 |
8.02e-71 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 222.97 E-value: 8.02e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQP--LAREQRNGPGMLVLTPTRELAL 121
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPplDEETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKY-SYGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQ 200
Cdd:cd17945 81 QIEEETQKFaKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 201 IMKIL--LDV---RPD---------------RQTIMTSATWPYAVRRLAQSYLKEPMIVY 240
Cdd:cd17945 161 VTKILdaMPVsnkKPDteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
44-239 |
1.83e-70 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 221.13 E-value: 1.83e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPlAREQRNGPGMLVLTPTRELALQV 123
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQR-ELEKGEGPIAVIVAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 EAECSKYS--YGdLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQI 201
Cdd:cd17952 80 YLEAKKFGkaYN-LRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQV 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 1907194084 202 MKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17952 159 RSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
27-235 |
2.13e-68 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 218.30 E-value: 2.13e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 27 IPNPICKFEDAfQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREQRN 106
Cdd:cd18052 38 PPPAILTFEEA-NLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 107 G---PGMLVLTPTRELALQVEAECSKYSYGD-LKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVT 182
Cdd:cd18052 117 EvqePQALIVAPTRELANQIFLEARKFSYGTcIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLK 196
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907194084 183 YLVLDEADKMLDMGFEPQIMKILLDV----RPDRQTIMTSATWPYAVRRLAQSYLKE 235
Cdd:cd18052 197 YLILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLKE 253
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
252-382 |
5.52e-59 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 189.26 E-value: 5.52e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 252 VKQNIIITTEEEKRTHIQTFLENMSPKDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRI 331
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1907194084 332 LIATDLASRGLDVHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITLI 382
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
27-242 |
3.13e-58 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 191.41 E-value: 3.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 27 IPNPICKFEDAfqSYPE-VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQ----PLA 101
Cdd:cd18051 16 CPPHIETFSDL--DLGEiIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQgpgeSLP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 102 REQRNG------PGMLVLTPTRELALQVEAECSKYSYGDLKSVCV-YGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNN 174
Cdd:cd18051 94 SESGYYgrrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVvYGGADIGQQMRDLERGCHLLVATPGRLVDMLERG 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907194084 175 FVNLKSVTYLVLDEADKMLDMGFEPQIMKILL-DVRP---DRQTIMTSATWPYAVRRLAQSYLKEPMIVYVG 242
Cdd:cd18051 174 KIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEqDTMPptgERQTLMFSATFPKEIQMLARDFLDNYIFLAVG 245
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
36-386 |
6.03e-58 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 195.43 E-value: 6.03e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 36 DAFQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREqrngpgMLVLTP 115
Cdd:PTZ00424 31 DALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQ------ALILAP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 116 TRELALQVEAecSKYSYGDLKSV----CVYGGGDRDgQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADK 191
Cdd:PTZ00424 105 TRELAQQIQK--VVLALGDYLKVrchaCVGGTVVRD-DINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 192 MLDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTLDLVAVSTVKQNIIITTEEEKRTHIQTF 271
Cdd:PTZ00424 182 MLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFDTLCDL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 272 LENMSPKDKVIVFVSRKAVaDHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVY 351
Cdd:PTZ00424 262 YETLTITQAIIYCNTRRKV-DYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVI 340
|
330 340 350
....*....|....*....|....*....|....*
gi 1907194084 352 NYDFPRNIEEYVHRVGRTGRAGRTGMSITLITRND 386
Cdd:PTZ00424 341 NYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDD 375
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
38-239 |
4.72e-56 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 184.43 E-value: 4.72e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 38 FQSY---PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSqplaREQRNGPGMLVLT 114
Cdd:cd17959 3 FQSMglsPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKA----HSPTVGARALILS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 115 PTRELALQ---VEAECSKYSygDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADK 191
Cdd:cd17959 79 PTRELALQtlkVTKELGKFT--DLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADR 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1907194084 192 MLDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17959 157 LFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
57-228 |
2.34e-55 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 180.90 E-value: 2.34e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 57 TPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDsqplarEQRNGPGMLVLTPTRELALQVEAECSKY-SYGDL 135
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALD------KLDNGPQALVLAPTRELAEQIYEELKKLgKGLGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 136 KSVCVYGGGDRDGQIQDVsKGVDIIIATPGRLNDLqMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTI 215
Cdd:pfam00270 75 KVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDL-LQERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQIL 152
|
170
....*....|...
gi 1907194084 216 MTSATWPYAVRRL 228
Cdd:pfam00270 153 LLSATLPRNLEDL 165
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
44-242 |
1.93e-54 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 179.71 E-value: 1.93e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLdsqpLAREQRNGPGMLVLTPTRELALQV 123
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKL----GKPRKKKGLRALILAPTRELASQI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 EAECSKYSYGDLKSVCVYGGGDRDGQIQDV--SKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQI 201
Cdd:cd17957 77 YRELLKLSKGTGLRIVLLSKSLEAKAKDGPksITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQT 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1907194084 202 MKILLDVR-PDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVG 242
Cdd:cd17957 157 DEILAACTnPNLQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
42-236 |
1.57e-52 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 175.20 E-value: 1.57e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHL--DSQPLAreqrngpgMLVLTPTREL 119
Cdd:cd17954 9 EELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALleNPQRFF--------ALVLAPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 120 ALQVEAECSKY--SYGdLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLND-LQMNNFVNLKSVTYLVLDEADKMLDMG 196
Cdd:cd17954 81 AQQISEQFEALgsSIG-LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDhLENTKGFSLKSLKFLVMDEADRLLNMD 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1907194084 197 FEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEP 236
Cdd:cd17954 160 FEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNP 199
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
42-235 |
3.08e-51 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 172.00 E-value: 3.08e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQ-GIDLIGVAQTGTGKTLSYLMPGFIHLDSQPlAREQRNGPGMLVLTPTRELA 120
Cdd:cd17964 3 PSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTK-PAGRRSGVSALIISPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 121 LQVEAECSKYSYG--DLKSVCVYGGGDRDGQIQDVSK-GVDIIIATPGRLNDLQMNNFV--NLKSVTYLVLDEADKMLDM 195
Cdd:cd17964 82 LQIAAEAKKLLQGlrKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEADRLLDM 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1907194084 196 GFEPQIMKILLDVRP----DRQTIMTSATWPYAVRRLAQSYLKE 235
Cdd:cd17964 162 GFRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTLKK 205
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
48-246 |
6.76e-51 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 170.75 E-value: 6.76e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 48 IKRAGFQKPTPIQSQAWPIVLQGI-DLIGVAQTGTGKTLSYLMPGFIHLDSQPlareqrnGPGMLVLTPTRELALQVEAE 126
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEALKRGK-------GGRVLVLVPTRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 127 CSKY-SYGDLKSVCVYGGGDRDGQIQDVSKGV-DIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKI 204
Cdd:smart00487 74 LKKLgPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1907194084 205 LLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYVGTLDL 246
Cdd:smart00487 154 LKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPL 195
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
44-239 |
5.30e-49 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 165.98 E-value: 5.30e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIH-LDSQ-PLAREQRNGPGMLVLTPTRELAL 121
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFaLEQEkKLPFIKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKYS-------YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLD 194
Cdd:cd17951 81 QTHEVIEYYCkalqeggYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMID 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1907194084 195 MGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17951 161 MGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
34-236 |
1.90e-48 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 164.39 E-value: 1.90e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 34 FEDaFQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREqrngpgMLVL 113
Cdd:cd17940 1 FED-YGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQ------ALIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 114 TPTRELALQVEAECSKYS-YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKM 192
Cdd:cd17940 74 VPTRELALQTSQVCKELGkHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1907194084 193 LDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEP 236
Cdd:cd17940 154 LSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNP 197
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
47-239 |
8.80e-48 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 162.33 E-value: 8.80e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 47 NIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHldsqplAREQRNGPGMLVLTPTRELALQVEAE 126
Cdd:cd17962 4 NLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIR------CLTEHRNPSALILTPTRELAVQIEDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 127 CSKYSYG--DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKI 204
Cdd:cd17962 78 AKELMKGlpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDI 157
|
170 180 190
....*....|....*....|....*....|....*
gi 1907194084 205 LLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17962 158 LENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
52-239 |
4.09e-47 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 161.21 E-value: 4.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 52 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQP--LAREQrnGPGMLVLTPTRELALQVEAECSK 129
Cdd:cd17949 10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEprVDRSD--GTLALVLVPTRELALQIYEVLEK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 130 YsygdLKSV------CVYGGGDRDGQIQDVSKGVDIIIATPGRLND-LQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIM 202
Cdd:cd17949 88 L----LKPFhwivpgYLIGGEKRKSEKARLRKGVNILIATPGRLLDhLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDIT 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1907194084 203 KIL--LDVRPD-----------RQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17949 164 KILelLDDKRSkaggekskpsrRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
52-236 |
3.51e-45 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 155.49 E-value: 3.51e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 52 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFihldsQPLAREQRNGPG--MLVLTPTRELALQVEAECSK 129
Cdd:cd17947 9 GFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPIL-----ERLLYRPKKKAAtrVLVLVPTRELAMQCFSVLQQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 130 YS-YGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNF-VNLKSVTYLVLDEADKMLDMGFEPQIMKILLD 207
Cdd:cd17947 84 LAqFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPsFDLDSIEILVLDEADRMLEEGFADELKEILRL 163
|
170 180
....*....|....*....|....*....
gi 1907194084 208 VRPDRQTIMTSATWPYAVRRLAQSYLKEP 236
Cdd:cd17947 164 CPRTRQTMLFSATMTDEVKDLAKLSLNKP 192
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
48-241 |
1.12e-44 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 154.37 E-value: 1.12e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 48 IKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREqrNGPGMLVLTPTRELALQV-EAE 126
Cdd:cd17941 5 LKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPE--DGLGALIISPTRELAMQIfEVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 127 CSKYSYGDLKSVCVYGGGDRDGQIQDVSkGVDIIIATPGRLndLQ-MNNFVNLKS--VTYLVLDEADKMLDMGFEPQIMK 203
Cdd:cd17941 83 RKVGKYHSFSAGLIIGGKDVKEEKERIN-RMNILVCTPGRL--LQhMDETPGFDTsnLQMLVLDEADRILDMGFKETLDA 159
|
170 180 190
....*....|....*....|....*....|....*...
gi 1907194084 204 ILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYV 241
Cdd:cd17941 160 IVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
45-242 |
2.13e-44 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 153.67 E-value: 2.13e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 45 MENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPG--FIHldsqPLAREQRNGPGMLVLTPTRELALQ 122
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAieLLY----KLKFKPRNGTGVIIISPTRELALQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 123 ---VEAECSKY---SYGdlksvCVYGGGDRDGQIQDVSKGVDIIIATPGRLND-LQ-MNNFV--NLKSvtyLVLDEADKM 192
Cdd:cd17942 78 iygVAKELLKYhsqTFG-----IVIGGANRKAEAEKLGKGVNILVATPGRLLDhLQnTKGFLykNLQC---LIIDEADRI 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1907194084 193 LDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIvYVG 242
Cdd:cd17942 150 LEIGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKKPL-YVG 198
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
44-236 |
6.80e-43 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 149.65 E-value: 6.80e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLdSQPLAREQRNGPGMLVLTPTRELALQV 123
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEIL-LKRKANLKKGQVGALIISPTRELATQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 EAECS---KYSYGDLKSVCVYGGGDRDGQIQDVS-KGVDIIIATPGRLNDL--QMNNFVNLKSVTYLVLDEADKMLDMGF 197
Cdd:cd17960 80 YEVLQsflEHHLPKLKCQLLIGGTNVEEDVKKFKrNGPNILVGTPGRLEELlsRKADKVKVKSLEVLVLDEADRLLDLGF 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 1907194084 198 EPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEP 236
Cdd:cd17960 160 EADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNP 198
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
46-237 |
3.32e-40 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 142.75 E-value: 3.32e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 46 ENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPgfIhldsqpLAREQRNGPGM--LVLTPTRELALQV 123
Cdd:cd17955 12 KQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALP--I------LQRLSEDPYGIfaLVLTPTRELAYQI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 eAEcSKYSYG---DLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNN---FVNLKSVTYLVLDEADKMLDMGF 197
Cdd:cd17955 84 -AE-QFRALGaplGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSddtTKVLSRVKFLVLDEADRLLTGSF 161
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1907194084 198 EPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPM 237
Cdd:cd17955 162 EDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
44-220 |
1.51e-39 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 141.99 E-value: 1.51e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWP-IVLQGIDLIGVAQTGTGKTLSYLMP---GFIHLDSQPLAREQRNGPGMLVLTPTREL 119
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPileRLLSQKSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 120 ALQV----EAECskySYGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDL-QMNN--FVNLKSVTYLVLDEADKM 192
Cdd:cd17946 81 AVQVkdhlKAIA---KYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELiQEGNehLANLKSLRFLVLDEADRM 157
|
170 180 190
....*....|....*....|....*....|....*
gi 1907194084 193 LDMG-FEP--QIMKILLDVRP----DRQTIMTSAT 220
Cdd:cd17946 158 LEKGhFAEleKILELLNKDRAgkkrKRQTFVFSAT 192
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
45-234 |
2.54e-39 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 140.37 E-value: 2.54e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 45 MENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGF--IHLDSQPLAREQrnGPGMLVLTPTRELALQ 122
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIekLQEDQQPRKRGR--APKVLVLAPTRELANQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 123 VEAECSKYSYgDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIM 202
Cdd:cd17944 80 VTKDFKDITR-KLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVE 158
|
170 180 190
....*....|....*....|....*....|....*..
gi 1907194084 203 KIL-----LDVRPDRQTIMTSATWPYAVRRLAQSYLK 234
Cdd:cd17944 159 EILsvsykKDSEDNPQTLLFSATCPDWVYNVAKKYMK 195
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
44-239 |
8.43e-39 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 138.55 E-value: 8.43e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYlmpGFIHLDSqpLAREQRnGPGMLVLTPTRELALQV 123
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVF---VVIALES--LDLERR-HPQVLILAPTREIAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 124 eAECSKY---SYGDLKsVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQ 200
Cdd:cd17943 75 -HDVFKKigkKLEGLK-CEVFIGGTPVKEDKKKLKGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKD 152
|
170 180 190
....*....|....*....|....*....|....*....
gi 1907194084 201 IMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17943 153 VNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
48-239 |
2.29e-35 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 130.01 E-value: 2.29e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 48 IKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREQRNGPGMLVLTPTRELALQVEAEC 127
Cdd:cd17961 9 IAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQGTRALILVPTRELAQQVSKVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 128 SK---YSYGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLND-LQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMK 203
Cdd:cd17961 89 EQltaYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLShLESGSLLLLSTLKYLVIDEADLVLSYGYEEDLKS 168
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907194084 204 ILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17961 169 LLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
44-228 |
5.12e-35 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 129.79 E-value: 5.12e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPgFIH--LDSQPLAREQRNGPGMLVLTPTRELAL 121
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLP-IIQrlLRYKLLAEGPFNAPRGLVITPSRELAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKYSYG-DLKSVCVyGGGDRDGQIQDVSKG-VDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEP 199
Cdd:cd17948 80 QIGSVAQSLTEGlGLKVKVI-TGGRTKRQIRNPHFEeVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNE 158
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1907194084 200 QIMKIL----LDVRPDR---------QTIMTSATWPYAVRRL 228
Cdd:cd17948 159 KLSHFLrrfpLASRRSEntdgldpgtQLVLVSATMPSGVGEV 200
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
42-239 |
1.26e-34 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 127.69 E-value: 1.26e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGID--LIGVAQTGTGKTLSYLMPGFIHLDsqplarEQRNGPGMLVLTPTREL 119
Cdd:cd17963 3 PELLKGLYAMGFNKPSKIQETALPLILSDPPenLIAQSQSGTGKTAAFVLAMLSRVD------PTLKSPQALCLAPTREL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 120 ALQVEAECSKY-SYGDLKSVCVYGGGDRDGqiqdvSKGVD--IIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDM- 195
Cdd:cd17963 77 ARQIGEVVEKMgKFTGVKVALAVPGNDVPR-----GKKITaqIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTq 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1907194084 196 GFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17963 152 GHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
38-241 |
3.35e-33 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 123.99 E-value: 3.35e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 38 FQSY---PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPlareqrNGPGMLVLT 114
Cdd:cd17950 4 FRDFllkPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVD------GQVSVLVIC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 115 PTRELALQVEAE---CSKYsYGDLKSVCVYGGGDRDGQIQDVSKGV-DIIIATPGRLNDLQMNNFVNLKSVTYLVLDEAD 190
Cdd:cd17950 78 HTRELAFQISNEyerFSKY-MPNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECD 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1907194084 191 KML-DMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIVYV 241
Cdd:cd17950 157 KMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
52-239 |
1.08e-32 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 122.43 E-value: 1.08e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 52 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSylmpgFIHLDSQPLAREQRNgPGMLVLTPTRELALQVEAECSKY- 130
Cdd:cd17939 16 GFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTAT-----FSIGALQRIDTTVRE-TQALVLAPTRELAQQIQKVVKALg 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 131 SYGDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKILLDVRP 210
Cdd:cd17939 90 DYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPP 169
|
170 180
....*....|....*....|....*....
gi 1907194084 211 DRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd17939 170 ETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
263-373 |
5.89e-32 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 117.31 E-value: 5.89e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 263 EKRTHIQTFLENmSPKDKVIVFVSRKavaDHLSSDLILR--HISVESLHGNREQSDREKALENFKTGKVRILIATDLASR 340
Cdd:pfam00271 1 EKLEALLELLKK-ERGGKVLIFSQTK---KTLEAELLLEkeGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110
....*....|....*....|....*....|...
gi 1907194084 341 GLDVHDITHVYNYDFPRNIEEYVHRVGRTGRAG 373
Cdd:pfam00271 77 GLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
42-239 |
1.96e-30 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 116.65 E-value: 1.96e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPgFIHLDSQplareqrngpgmLVLTPTRELAL 121
Cdd:cd17938 8 PELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLP-VLQIVVA------------LILEPSRELAE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKYSY----GDLKSVCVYGGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGF 197
Cdd:cd17938 75 QTYNCIENFKKyldnPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGN 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1907194084 198 EPQIMKIL-----LDVRPDR-QTIMTSATW-PYAVRRLAQSYLKEPMIV 239
Cdd:cd17938 155 LETINRIYnripkITSDGKRlQVIVCSATLhSFEVKKLADKIMHFPTWV 203
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
36-236 |
1.07e-29 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 114.47 E-value: 1.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 36 DAFQSYPEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQplareqRNGPGMLVLTP 115
Cdd:cd18046 2 DDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTS------LKATQALVLAP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 116 TRELALQVEAECSkySYGDLKSV----CVYGGGDRDgQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADK 191
Cdd:cd18046 76 TRELAQQIQKVVM--ALGDYMGIkchaCIGGTSVRD-DAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADE 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1907194084 192 MLDMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEP 236
Cdd:cd18046 153 MLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDP 197
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
292-373 |
7.15e-28 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 105.37 E-value: 7.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 292 DHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVYNYDFPRNIEEYVHRVGRTGR 371
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 1907194084 372 AG 373
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
44-228 |
2.24e-27 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 108.87 E-value: 2.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 44 VMENIKRAGFQKPTPIQSQAWPIVLQGI---------DLIGVAQTGTGKTLSYLMPgFIHLDSQPLAREQRngpgMLVLT 114
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSSkstppyrpgDLCVSAPTGSGKTLAYVLP-IVQALSKRVVPRLR----ALIVV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 115 PTRELALQVEAECSKYSYG-DLKSVCVygGGDRD----------GQIQDVSKGVDIIIATPGRLND-LQMNNFVNLKSVT 182
Cdd:cd17956 76 PTKELVQQVYKVFESLCKGtGLKVVSL--SGQKSfkkeqklllvDTSGRYLSRVDILVATPGRLVDhLNSTPGFTLKHLR 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907194084 183 YLVLDEADKMLDMGFE---PQIMKILLDVRPDRQTIMTSA----TWPYAVRRL 228
Cdd:cd17956 154 FLVIDEADRLLNQSFQdwlETVMKALGRPTAPDLGSFGDAnlleRSVRPLQKL 206
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
43-239 |
1.25e-26 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 106.01 E-value: 1.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 43 EVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDsqPLAREqrngPGMLVLTPTRELALQ 122
Cdd:cd18045 9 DLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLD--IQVRE----TQALILSPTRELAVQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 123 VEAECskYSYGDLKSVCVY---GGGDRDGQIQDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEP 199
Cdd:cd18045 83 IQKVL--LALGDYMNVQCHaciGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGFKE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1907194084 200 QIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd18045 161 QIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
36-222 |
2.04e-22 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 95.91 E-value: 2.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 36 DAFQSYPEVMENIKRA---------GFQKPTPIQSQAWPIVLQG-----------------IDLIGvAQTGTGKTLSYLM 89
Cdd:cd17965 2 DQLKLLPSVREAIIKEilkgsnktdEEIKPSPIQTLAIKKLLKTlmrkvtkqtsneepkleVFLLA-AETGSGKTLAYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 90 PGFIHL----------DSQPLAREQRNG-PGMLVLTPTRELALQVEA------ECSKYSYGDLKSvcvyGGGDRDGQIQD 152
Cdd:cd17965 81 PLLDYLkrqeqepfeeAEEEYESAKDTGrPRSVILVPTHELVEQVYSvlkklsHTVKLGIKTFSS----GFGPSYQRLQL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907194084 153 VSKG-VDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTIMTSATWP 222
Cdd:cd17965 157 AFKGrIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIP 227
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
76-368 |
4.55e-20 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 92.78 E-value: 4.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 76 VAQTGTGKTLSYLMpgfihldsqpLAREQRNGPGMLVLTPTRELALQVEAECSKYSYGDLksvcvYGGGDRDgqiqdvsK 155
Cdd:COG1061 106 VAPTGTGKTVLALA----------LAAELLRGKRVLVLVPRRELLEQWAEELRRFLGDPL-----AGGGKKD-------S 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 156 GVDIIIATPGRL-NDLQMNNFVNlkSVTYLVLDEA--------DKMLDMgFEPqimKILLDV-----RPDRQTIMT---- 217
Cdd:COG1061 164 DAPITVATYQSLaRRAHLDELGD--RFGLVIIDEAhhagapsyRRILEA-FPA---AYRLGLtatpfRSDGREILLflfd 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 218 ----SATWPYAvrrLAQSYLKEPMIVYVGT------LDLVAVSTVKQNIIITTEEEKRTHIQTFLENMSPKDKVIVFVSR 287
Cdd:COG1061 238 givyEYSLKEA---IEDGYLAPPEYYGIRVdltderAEYDALSERLREALAADAERKDKILRELLREHPDDRKTLVFCSS 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 288 KAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVYnydFPRNIE---EYVH 364
Cdd:COG1061 315 VDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI---LLRPTGsprEFIQ 391
|
....
gi 1907194084 365 RVGR 368
Cdd:COG1061 392 RLGR 395
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
43-239 |
1.47e-18 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 84.30 E-value: 1.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 43 EVMENIKRAGFQKPTPIQSQAWPIVLQG--IDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAreqrngPGMLVLTPTRELA 120
Cdd:cd18048 28 ELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY------PQCLCLSPTFELA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 121 LQ---VEAECSKYSYGdlKSVCVYGGGDRDGQIQDVSKgvDIIIATPGRLNDLQMN-NFVNLKSVTYLVLDEADKMLDM- 195
Cdd:cd18048 102 LQtgkVVEEMGKFCVG--IQVIYAIRGNRPGKGTDIEA--QIVIGTPGTVLDWCFKlRLIDVTNISVFVLDEADVMINVq 177
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1907194084 196 GFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd18048 178 GHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNII 221
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
76-220 |
2.78e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 72.82 E-value: 2.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 76 VAQTGTGKTLSYLMPGFIHLDSQplareqrnGPGMLVLTPTRELALQVEAECSKYSYGDLKsVCVYGGGDRDGQIQDVSK 155
Cdd:cd00046 7 TAPTGSGKTLAALLAALLLLLKK--------GKKVLVLVPTKALALQTAERLRELFGPGIR-VAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907194084 156 G-VDIIIATPGRL-NDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKILLD--VRPDRQTIMTSAT 220
Cdd:cd00046 78 GdADIIIATPDMLlNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRkaGLKNAQVILLSAT 146
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
67-422 |
3.36e-15 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 77.49 E-value: 3.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 67 VLQGIDLIGVAQTGTGKTLSYLMPGfihldsqpLAREqrnGPGmLVLTPTreLAL---QVEAecskysygdLKS-----V 138
Cdd:COG0514 29 VLAGRDALVVMPTGGGKSLCYQLPA--------LLLP---GLT-LVVSPL--IALmkdQVDA---------LRAagiraA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 139 CVYGGGDRDGQ---IQDVSKG-VDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEA--------DkmldmgFEPQIMKI-- 204
Cdd:COG0514 86 FLNSSLSAEERrevLRALRAGeLKLLYVAPERLLNPRFLELLRRLKISLFAIDEAhcisqwghD------FRPDYRRLge 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 205 LLDVRPDRQTIMTSATWPYAVRR--LAQSYLKEPMiVYVGTLDlvavstvKQNI----IITTEEEKRTHIQTFLENMSPK 278
Cdd:COG0514 160 LRERLPNVPVLALTATATPRVRAdiAEQLGLEDPR-VFVGSFD-------RPNLrlevVPKPPDDKLAQLLDFLKEHPGG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 279 DKVIVFVSRKAVaDHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATdlaSR---GLDVHDITHVYNYDF 355
Cdd:COG0514 232 SGIVYCLSRKKV-EELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT---IAfgmGIDKPDVRFVIHYDL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907194084 356 PRNIEEYVHRVGRTGRAGRTGMSITLITRNDWRVATELInileraNQNIPEELVLMAERYKANKLKR 422
Cdd:COG0514 308 PKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQRFFI------EQSPPDEERKRVERAKLDAMLA 368
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
42-239 |
2.45e-14 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 71.67 E-value: 2.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGI--DLIGVAQTGTGKTLSYLMPGFIHLDsqPLAREQRngpgMLVLTPTREL 119
Cdd:cd18047 10 PQLLQGVYAMGFNRPSKIQENALPLMLAEPpqNLIAQSQSGTGKTAAFVLAMLSQVE--PANKYPQ----CLCLSPTYEL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 120 ALQ---VEAECSKYSYGDLKSVCVYGGG-DRDGQIQDvskgvDIIIATPGRLNDLQMN-NFVNLKSVTYLVLDEADKML- 193
Cdd:cd18047 84 ALQtgkVIEQMGKFYPELKLAYAVRGNKlERGQKISE-----QIVIGTPGTVLDWCSKlKFIDPKKIKVFVLDEADVMIa 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1907194084 194 DMGFEPQIMKILLDVRPDRQTIMTSATWPYAVRRLAQSYLKEPMIV 239
Cdd:cd18047 159 TQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
52-377 |
3.45e-13 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 71.28 E-value: 3.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 52 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIhldsqplareqRNGPgMLVLTPTREL---------ALQ 122
Cdd:PRK11057 22 GYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALV-----------LDGL-TLVVSPLISLmkdqvdqllANG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 123 VEAECSKYSYGDLKSVCVYGGGdRDGQIQdvskgvdIIIATPGRlndLQMNNFVNLKSVTYLVL---DEADKMLDMG--F 197
Cdd:PRK11057 90 VAAACLNSTQTREQQLEVMAGC-RTGQIK-------LLYIAPER---LMMDNFLEHLAHWNPALlavDEAHCISQWGhdF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 198 EPQIMKI-LLDVR-PDRQTIMTSATWPYAVRR--LAQSYLKEPMIvYVGTLDlvavstvKQNIIITTEEEKR--THIQTF 271
Cdd:PRK11057 159 RPEYAALgQLRQRfPTLPFMALTATADDTTRQdiVRLLGLNDPLI-QISSFD-------RPNIRYTLVEKFKplDQLMRY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 272 LENMSPKDKVIVFVSRKAVADhLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLASRGLDVHDITHVY 351
Cdd:PRK11057 231 VQEQRGKSGIIYCNSRAKVED-TAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVV 309
|
330 340
....*....|....*....|....*.
gi 1907194084 352 NYDFPRNIEEYVHrvgRTGRAGRTGM 377
Cdd:PRK11057 310 HFDIPRNIESYYQ---ETGRAGRDGL 332
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
282-372 |
5.32e-11 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 60.30 E-value: 5.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 282 IVFVSRKAVADHLSSDL-----ILRHISVESL--HGNR--------EQSDREKALENFKTGKVRILIATDLASRGLDVHD 346
Cdd:cd18802 29 IIFVERRATAVVLSRLLkehpsTLAFIRCGFLigRGNSsqrkrslmTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPA 108
|
90 100
....*....|....*....|....*.
gi 1907194084 347 ITHVYNYDFPRNIEEYVHRVGRtGRA 372
Cdd:cd18802 109 CNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
276-367 |
8.07e-11 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 59.41 E-value: 8.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 276 SPKDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGK--VRILIATDLASRGLDVHDITHVYNY 353
Cdd:cd18793 25 EPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPdiRVFLLSTKAGGVGLNLTAANRVILY 104
|
90 100
....*....|....*....|
gi 1907194084 354 DFPRN--IEEY----VHRVG 367
Cdd:cd18793 105 DPWWNpaVEEQaidrAHRIG 124
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
259-381 |
9.17e-10 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 56.45 E-value: 9.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 259 TTEEEKRTHIQTFLENmSPKDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGKVRILIATDLA 338
Cdd:cd18794 12 DKKDEKLDLLKRIKVE-HLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAF 90
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1907194084 339 SRGLDVHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITL 381
Cdd:cd18794 91 GMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILF 133
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
42-373 |
2.19e-09 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 59.14 E-value: 2.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWP-IVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAreqrngpgmLVLTPTRELA 120
Cdd:COG1204 9 EKVIEFLKERGIEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKA---------LYIVPLRALA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 121 LQVEAECSK-YSYGDLKSVCVYGGGDRDGqiqDVSKGVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEAdKMLDmgfEP 199
Cdd:COG1204 80 SEKYREFKRdFEELGIKVGVSTGDYDSDD---EWLGRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEA-HLID---DE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 200 Q-------IMKILLDVRPDRQTIMTSATWPyAVRRLAQsYLKEPMIV--YVGTLDLVAVstVKQNIIITTEEEKRTHIQT 270
Cdd:COG1204 153 SrgptlevLLARLRRLNPEAQIVALSATIG-NAEEIAE-WLDAELVKsdWRPVPLNEGV--LYDGVLRFDDGSRRSKDPT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 271 F---LENMSPKDKVIVFVSR--------KAVADHLSSDLI------LRHISVESL-----------------------HG 310
Cdd:COG1204 229 LalaLDLLEEGGQVLVFVSSrrdaeslaKKLADELKRRLTpeereeLEELAEELLevseethtnekladclekgvafhHA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 311 NREQSDREKALENFKTGKVRILIATD-------LASRGLDVHDITHVYNYDFPrnIEEYVHRVGRTGRAG 373
Cdd:COG1204 309 GLPSELRRLVEDAFREGLIKVLVATPtlaagvnLPARRVIIRDTKRGGMVPIP--VLEFKQMAGRAGRPG 376
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
277-385 |
2.88e-09 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 59.36 E-value: 2.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 277 PKDKVIVFVSRKAVADHLSSDLILRHISVESLHG--NREQSD------REKALENFKTGKVRILIATDLASRGLDVHDIT 348
Cdd:COG1111 352 PDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqaSKEGDKgltqkeQIEILERFRAGEFNVLVATSVAEEGLDIPEVD 431
|
90 100 110
....*....|....*....|....*....|....*...
gi 1907194084 349 HVYNYD-FPRNIeEYVHRVGRTGRaGRTGMSITLITRN 385
Cdd:COG1111 432 LVIFYEpVPSEI-RSIQRKGRTGR-KREGRVVVLIAKG 467
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
42-386 |
4.22e-09 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 58.69 E-value: 4.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 42 PEVMENIKRAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREqrngpgmLVLTPTRELAL 121
Cdd:COG1205 43 PELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPGATA-------LYLYPTKALAR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 QVEAECSKY-SYGDLK-SVCVYGGgDRDGQI-QDVSKGVDIIIATPGRLNdLQM--------NNFVNLKsvtYLVLDEA- 189
Cdd:COG1205 116 DQLRRLRELaEALGLGvRVATYDG-DTPPEErRWIREHPDIVLTNPDMLH-YGLlphhtrwaRFFRNLR---YVVIDEAh 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 190 --------------DKML----DMGFEPQImkilldvrpdrqtIMTSATW--PyavRRLAQSYLKEPMIVyV-------G 242
Cdd:COG1205 191 tyrgvfgshvanvlRRLRricrHYGSDPQF-------------ILASATIgnP---AEHAERLTGRPVTV-VdedgsprG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 243 TLDLVAVstvkqNIIITTEEEKRTHIQT----FLENMSPKDKVIVFV-SRKAV---ADHLSSDLILRHI--SVESLHGNR 312
Cdd:COG1205 254 ERTFVLW-----NPPLVDDGIRRSALAEaarlLADLVREGLRTLVFTrSRRGAellARYARRALREPDLadRVAAYRAGY 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 313 EQSDReKALEN-FKTGKVRILIAT-------DLAsrGLDVhdithVYNYDFPRNIEEYVHRVGRTGRAGRTGMSItLITR 384
Cdd:COG1205 329 LPEER-REIERgLRSGELLGVVSTnalelgiDIG--GLDA-----VVLAGYPGTRASFWQQAGRAGRRGQDSLVV-LVAG 399
|
..
gi 1907194084 385 ND 386
Cdd:COG1205 400 DD 401
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
331-373 |
1.08e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.94 E-value: 1.08e-08
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907194084 331 ILIATDLASRGLDVHDITHVYNYDFPRNIEEYVHRVGRTGRAG 373
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGG 67
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
57-189 |
2.29e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 53.42 E-value: 2.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 57 TPIQSQAW-PIVLQGIDLIGVAQTGTGKTL-SYLMpgfihldsqpLAREQRNGPG-MLVLTPTRELALQVEAECSKySYG 133
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLiAELA----------ILRALATSGGkAVYIAPTRALVNQKEADLRE-RFG 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907194084 134 DLKSVCVYGGGDRDGQIQDVSKGvDIIIATPGRLnDLQMNNF--VNLKSVTYLVLDEA 189
Cdd:cd17921 72 PLGKNVGLLTGDPSVNKLLLAEA-DILVATPEKL-DLLLRNGgeRLIQDVRLVVVDEA 127
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
273-385 |
2.44e-08 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 56.39 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 273 ENMSPKDKVIVFVSRKAVADHLSSDLILRHISVESLHGNREQSDREKALENFKTGK--VRILIATDLASRGLDVHDITHV 350
Cdd:COG0553 544 ELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGEGLNLTAADHV 623
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1907194084 351 YNYDFPRN--IEEYvhrvgRTGRAGRTG-----MSITLITRN 385
Cdd:COG0553 624 IHYDLWWNpaVEEQ-----AIDRAHRIGqtrdvQVYKLVAEG 660
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
241-382 |
4.96e-08 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 51.88 E-value: 4.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 241 VGTLDLVAVSTVKQNIIITTEEEKRTHIQTFLENMSPKDKVIVFV-SRKAV-----------ADHLSSDLILRHisvesl 308
Cdd:cd18796 1 KKKLDIKVILPVAPEIFPWAGESGADAYAEVIFLLERHKSTLVFTnTRSQAerlaqrlrelcPDRVPPDFIALH------ 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907194084 309 HGNREQSDREKALENFKTGKVRILIAT---DLasrGLDVHDITHVYNYDFPRNIEEYVHRVGRTGRAGRTGMSITLI 382
Cdd:cd18796 75 HGSLSRELREEVEAALKRGDLKVVVATsslEL---GIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGAASKGRLV 148
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
276-385 |
4.52e-07 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 52.18 E-value: 4.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 276 SPKDKVIVFV-SR---KAVADHLSSDlilrHISVESLHGnreQSDRE-----------KALENFKTGKVRILIATDLASR 340
Cdd:PRK13766 363 NPDSRIIVFTqYRdtaEKIVDLLEKE----GIKAVRFVG---QASKDgdkgmsqkeqiEILDKFRAGEFNVLVSTSVAEE 435
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1907194084 341 GLDVHDITHVYNYDfP-----RNIEeyvhRVGRTGRaGRTGMSITLITRN 385
Cdd:PRK13766 436 GLDIPSVDLVIFYE-PvpseiRSIQ----RKGRTGR-QEEGRVVVLIAKG 479
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
53-120 |
1.26e-06 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 50.87 E-value: 1.26e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907194084 53 FQKPTPIQSQAWPIVLQGID-LIgVAQTGTGKTLSYLMPGFIHLDSQPLAREQRNGPGMLVLTPTRELA 120
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGEStLL-IAPTGSGKTLAAFLPALDELARRPRPGELPDGLRVLYISPLKALA 89
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
268-374 |
5.33e-06 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 46.09 E-value: 5.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 268 IQTFLENMSPKDKVIVFvsrkavADHLSSdliLRHIS----VESLHGNREQSDREKALENFKTGKVRILIATDLASRGLD 343
Cdd:cd18789 39 LEELLKRHEQGDKIIVF------TDNVEA---LYRYAkrllKPFITGETPQSEREEILQNFREGEYNTLVVSKVGDEGID 109
|
90 100 110
....*....|....*....|....*....|....*
gi 1907194084 344 VHD----ITHVYNYDFPRnieEYVHRVGRTGRAGR 374
Cdd:cd18789 110 LPEanvaIQISGHGGSRR---QEAQRLGRILRPKK 141
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
74-189 |
1.82e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 45.34 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 74 IGVAQTGTGKTLSYLMpgFIHLDSQPLAREQRNGPGMLVLTPTRELALQvEAECSKySYGDLKSVCVYGGGDRDGQIQDV 153
Cdd:cd18034 20 IVVLPTGSGKTLIAVM--LIKEMGELNRKEKNPKKRAVFLVPTVPLVAQ-QAEAIR-SHTDLKVGEYSGEMGVDKWTKER 95
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1907194084 154 SKGV----DIIIATPGRLNDLQMNNFVNLKSVTYLVLDEA 189
Cdd:cd18034 96 WKEElekyDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
254-382 |
3.36e-05 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 43.50 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 254 QNIIITTE-EEKRTHIQTFLENMSPKDKVIVFVSrkavadhlssdlilrHISVESLHGnREQSDREKALENFKTGKVRIL 332
Cdd:cd18801 31 TRVIIFSEfRDSAEEIVNFLSKIRPGIRATRFIG---------------QASGKSSKG-MSQKEQKEVIEQFRKGGYNVL 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1907194084 333 IATDLASRGLDVHDITHVYNYDFPRNIEEYVHRVGRTGRaGRTGMSITLI 382
Cdd:cd18801 95 VATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVVVLL 143
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
278-428 |
4.47e-05 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 43.83 E-value: 4.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 278 KDKVIVFVSR---KAVADHLSSDLILRHISVESLHgnreqSDREKALENFKTGKVRILIATdlAS------RGLDV-HDI 347
Cdd:cd18798 24 GDGGLIFVSIdygKEYAEELKEFLERHGIKAELAL-----SSTEKNLEKFEEGEIDVLIGV--ASyygvlvRGIDLpERI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 348 THVYNYDFPrnIEEYVHRVGRTGR--AGR--TGMSITLITrndwrvATELINIL-ERANQNIPEELVLMAERYKANKLKR 422
Cdd:cd18798 97 KYAIFYGVP--VTTYIQASGRTSRlyAGGltKGLSVVLVD------DPELFEALkKRLKLILDEFIFKELEEVDLEELLS 168
|
....*.
gi 1907194084 423 EMEKKM 428
Cdd:cd18798 169 EIDESR 174
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
55-207 |
5.20e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 43.96 E-value: 5.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 55 KPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPlareQRNGPGMLVLTPTRELALQVEAECSKYsYGD 134
Cdd:cd17927 2 KPRNYQLELAQPALKGKNTIICLPTGSGKTFVAVLICEHHLKKFP----AGRKGKVVFLANKVPLVEQQKEVFRKH-FER 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907194084 135 LKSVCVYGGGDRDGQI--QDVSKGVDIIIATPGRL-NDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKILLD 207
Cdd:cd17927 77 PGYKVTGLSGDTSENVsvEQIVESSDVIIVTPQILvNDLKSGTIVSLSDFSLLVFDECHNTTKNHPYNEIMFRYLD 152
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
46-245 |
5.60e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 44.06 E-value: 5.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 46 ENIKRAGFQKPTPIQSQAwpI--VLQGIDLIGVAQTGTGKTLSYLMPGFIhldsqplareqRNGPGmLVLTPTreLAL-- 121
Cdd:cd17920 3 ILKEVFGYDEFRPGQLEA--InaVLAGRDVLVVMPTGGGKSLCYQLPALL-----------LDGVT-LVVSPL--ISLmq 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 122 -QVEAECSKysygDLKSVCVYGGGDRDGQIQDVSK----GVDIIIATPGRLNDLQMNNFVN----LKSVTYLVLDEADKM 192
Cdd:cd17920 67 dQVDRLQQL----GIRAAALNSTLSPEEKREVLLRikngQYKLLYVTPERLLSPDFLELLQrlpeRKRLALIVVDEAHCV 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907194084 193 LDMG--FEPQIMKI--LLDVRPDRQTIMTSATWPYAVRRLAQSYLK-EPMIVYVGTLD 245
Cdd:cd17920 143 SQWGhdFRPDYLRLgrLRRALPGVPILALTATATPEVREDILKRLGlRNPVIFRASFD 200
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
60-189 |
6.12e-05 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 43.73 E-value: 6.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 60 QSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREqrngpgmLVLTPTRELALQVEAECSKYSYGDLKSVC 139
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGSRA-------LYLYPTKALAQDQLRSLRELLEQLGLGIR 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907194084 140 V--YGG----GDRDGQIqdvSKGVDIIIATPGRLN-------DLQMNNFVNLKsvtYLVLDEA 189
Cdd:cd17923 78 VatYDGdtprEERRAII---RNPPRILLTNPDMLHyallphhDRWARFLRNLR---YVVLDEA 134
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
76-189 |
6.69e-05 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 43.27 E-value: 6.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 76 VAQTGTGKTLSYLMPGfihldsqpLAREQRNGPGMLVLTPTRELALQVEAECSKYSYGDLKSVCVYGGGDRDGQIQDVSK 155
Cdd:cd18035 22 VLPTGLGKTIIAILVA--------ADRLTKKGGKVLILAPSRPLVEQHAENLKRVLNIPDKITSLTGEVKPEERAERWDA 93
|
90 100 110
....*....|....*....|....*....|....*
gi 1907194084 156 GvDIIIATPGRL-NDLqMNNFVNLKSVTYLVLDEA 189
Cdd:cd18035 94 S-KIIVATPQVIeNDL-LAGRITLDDVSLLIFDEA 126
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
67-220 |
3.33e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 41.17 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 67 VLQGIDLIGVAQTGTGKTLSYLMPGFIHLDsqplareqrNGPGMLVLTPTRELALQVEAECSKYSYGDLKsvCVYGGGDR 146
Cdd:cd18028 14 LLKGENLLISIPTASGKTLIAEMAMVNTLL---------EGGKALYLVPLRALASEKYEEFKKLEEIGLK--VGISTGDY 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907194084 147 DGQIQDVSKgVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQ---IMKILLDVRPDRQTIMTSAT 220
Cdd:cd18028 83 DEDDEWLGD-YDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTlesIVARLRRLNPNTQIIGLSAT 158
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
55-207 |
8.10e-04 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 40.54 E-value: 8.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 55 KPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHLDSQPLAREQRNgpgMLVLTPTRELALQVEAECSKYSYGD 134
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAGEKGR---VVVLVNKVPLVEQQLEKFFKYFRKG 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907194084 135 LKSVCVYGGGDRDGQIQDVSKGVDIIIATP----GRLNDLQMNNFVNLKSVTYLVLDEADKMLDMGFEPQIMKILLD 207
Cdd:cd18036 79 YKVTGLSGDSSHKVSFGQIVKASDVIICTPqiliNNLLSGREEERVYLSDFSLLIFDECHHTQKEHPYNKIMRMYLD 155
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
52-189 |
1.08e-03 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 39.93 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 52 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLSYLMPGFIHldsqplareQRNGPGM-LVLTPTreLAL---QVEAEC 127
Cdd:cd18018 9 GHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLL---------RRRGPGLtLVVSPL--IALmkdQVDALP 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 128 SKysygdLKSVCVYGG---GDRDGQIQDVSKG-VDIIIATPGRLNDlqmNNFVNL----KSVTYLVLDEA 189
Cdd:cd18018 78 RA-----IKAAALNSSltrEERRRILEKLRAGeVKILYVSPERLVN---ESFRELlrqtPPISLLVVDEA 139
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
55-192 |
2.45e-03 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 38.94 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 55 KPTPIQSQAWPIVLQGI------DLIGVAQTGTGKTLSYLMPGFIHLDsqplareqrNGPGMLVLTPTRELALQVEAECS 128
Cdd:cd17918 15 SLTKDQAQAIKDIEKDLhspepmDRLLSGDVGSGKTLVALGAALLAYK---------NGKQVAILVPTEILAHQHYEEAR 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907194084 129 KYsYGDLKSVCVYGggdrdGQIQDVSKGVDIIIATPGRLNDLqmnnfVNLKSVTYLVLDEADKM 192
Cdd:cd17918 86 KF-LPFINVELVTG-----GTKAQILSGISLLVGTHALLHLD-----VKFKNLDLVIVDEQHRF 138
|
|
| PRK05580 |
PRK05580 |
primosome assembly protein PriA; Validated |
318-376 |
2.47e-03 |
|
primosome assembly protein PriA; Validated
Pssm-ID: 235514 [Multi-domain] Cd Length: 679 Bit Score: 40.14 E-value: 2.47e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907194084 318 EKALENFKTGKVRILIATDLASRGLDVHDITHV---------YNYDFpRNIEEYV---HRV-GRTGRAGRTG 376
Cdd:PRK05580 470 EQLLAQFARGEADILIGTQMLAKGHDFPNVTLVgvldadlglFSPDF-RASERTFqllTQVaGRAGRAEKPG 540
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
184-374 |
2.72e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 39.72 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 184 LVLDEADKMLD--MGFEPQIMKILLDVrpDRQTIMTSATWPYAVRRLAQSYLkepMIVYVGTLDLVAVSTVKQNIIITTE 261
Cdd:cd09639 127 LIFDEVHFYDEytLALILAVLEVLKDN--DVPILLMSATLPKFLKEYAEKIG---YVEENEPLDLKPNERAPFIKIESDK 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 262 EEKRTHIQTFLENMSPKDKVIVFVSRKAVADHLSSDLILRHISVES--LHGNREQSDREKA----LENFKTGKVRILIAT 335
Cdd:cd09639 202 VGEISSLERLLEFIKKGGSVAIIVNTVDRAQEFYQQLKEKGPEEEImlIHSRFTEKDRAKKeaelLLEFKKSEKFVIVAT 281
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1907194084 336 DLASRGLDVhdithvyNYDF----PRNIEEYVHRVGRTGRAGR 374
Cdd:cd09639 282 QVIEASLDI-------SVDVmiteLAPIDSLIQRLGRLHRYGE 317
|
|
| dinG |
PRK11747 |
ATP-dependent DNA helicase DinG; Provisional |
39-104 |
5.03e-03 |
|
ATP-dependent DNA helicase DinG; Provisional
Pssm-ID: 236966 [Multi-domain] Cd Length: 697 Bit Score: 39.42 E-value: 5.03e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907194084 39 QSYPEVMENIKraGFqKPTPIQSQ-AWPI--VLQGIDL----IGVAQ--TGTGKTLSYLMPGFihldsqPLAREQ 104
Cdd:PRK11747 12 QAYKALQEQLP--GF-IPRAGQRQmIAEVakTLAGEYLkdgrILVIEagTGVGKTLSYLLAGI------PIARAE 77
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
280-374 |
6.02e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 37.24 E-value: 6.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 280 KVIVFV-SRKAVadhlssDLILRHISVESLHGNRE------------QSDREKALENFKTGKVRILIATDLASRGLDVHD 346
Cdd:cd18797 37 KTIVFCrSRKLA------ELLLRYLKARLVEEGPLaskvasyragylAEDRREIEAELFNGELLGVVATNALELGIDIGG 110
|
90 100
....*....|....*....|....*...
gi 1907194084 347 ITHVYNYDFPRNIEEYVHRVGRTGRAGR 374
Cdd:cd18797 111 LDAVVLAGYPGSLASLWQQAGRAGRRGK 138
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
76-189 |
6.28e-03 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 36.90 E-value: 6.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194084 76 VAQTGTGKTLSylmpgfihldSQPLAREQRNGPgMLVLTPTRELALQVEAECSKYSYGDlkSVCVYGGGDRDGQIqdvsk 155
Cdd:cd17926 24 VLPTGSGKTLT----------ALALIAYLKELR-TLIVVPTDALLDQWKERFEDFLGDS--SIGLIGGGKKKDFD----- 85
|
90 100 110
....*....|....*....|....*....|....
gi 1907194084 156 GVDIIIATPGRLNDLQMNNFVNLKSVTYLVLDEA 189
Cdd:cd17926 86 DANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEA 119
|
|
| |
