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Conserved domains on  [gi|1907195583|ref|XP_036010583|]
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pyruvate kinase PKM isoform X2 [Mus musculus]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 112-600 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 816.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 112 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRT 191
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 192 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGAD-FLVTEVENG 270
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 271 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 350
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 351 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 430
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 431 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQ 510
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 511 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNaWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSG 590
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 1907195583 591 FTNTMRVVPV 600
Cdd:cd00288   471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 112-600 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 816.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 112 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRT 191
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 192 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGAD-FLVTEVENG 270
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 271 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 350
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 351 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 430
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 431 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQ 510
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 511 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNaWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSG 590
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 1907195583 591 FTNTMRVVPV 600
Cdd:cd00288   471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 113-597 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 744.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 113 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTG 192
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 193 LIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGS 272
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 273 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 351
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 352 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 431
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 432 SGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQV 511
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 512 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnaWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTG-WRPGSG 590
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 1907195583 591 FTNTMRV 597
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 113-600 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 658.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 113 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATEsfasdpILYRPVAVALDTKGPEIRTG 192
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAK------ELGRPVAILLDLQGPKIRTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 193 LIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGS 272
Cdd:COG0469    77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 273 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 352
Cdd:COG0469   151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 353 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 432
Cdd:COG0469   231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 433 GETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCsgAIIVLTKSGRSAHQVA 512
Cdd:COG0469   311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAK--AIVAFTESGSTARRIS 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 513 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGF 591
Cdd:COG0469   389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                  ....*....
gi 1907195583 592 TNTMRVVPV 600
Cdd:COG0469   463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 112-465 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 631.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 112 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDpilyrpVAVALDTKGPEIRT 191
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 192 GLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADF-LVTEVENG 270
Cdd:pfam00224  75 GNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 271 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 350
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 351 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 430
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1907195583 431 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 465
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 113-584 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 567.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 113 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRTG 192
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 193 LIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGS 272
Cdd:PRK05826   78 KFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 273 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 351
Cdd:PRK05826  153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 352 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 431
Cdd:PRK05826  233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 432 SGETAKGDYPLEAVRMQHLIAREAEAaiyHLQLFEELRRLAPITSDPTEAAAVGAVEASFK-CCSGAIIVLTKSGRSAHQ 510
Cdd:PRK05826  313 SGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907195583 511 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTG 584
Cdd:PRK05826  390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDS------AADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 112-600 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 816.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 112 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRT 191
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 192 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGAD-FLVTEVENG 270
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 271 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 350
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 351 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 430
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 431 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQ 510
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 511 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNaWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSG 590
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 1907195583 591 FTNTMRVVPV 600
Cdd:cd00288   471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 113-597 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 744.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 113 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTG 192
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 193 LIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGS 272
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 273 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 351
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 352 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 431
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 432 SGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQV 511
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 512 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnaWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTG-WRPGSG 590
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 1907195583 591 FTNTMRV 597
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 113-600 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 658.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 113 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATEsfasdpILYRPVAVALDTKGPEIRTG 192
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAK------ELGRPVAILLDLQGPKIRTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 193 LIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGS 272
Cdd:COG0469    77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 273 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 352
Cdd:COG0469   151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 353 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 432
Cdd:COG0469   231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 433 GETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCsgAIIVLTKSGRSAHQVA 512
Cdd:COG0469   311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAK--AIVAFTESGSTARRIS 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 513 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGF 591
Cdd:COG0469   389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                  ....*....
gi 1907195583 592 TNTMRVVPV 600
Cdd:COG0469   463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 112-465 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 631.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 112 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDpilyrpVAVALDTKGPEIRT 191
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 192 GLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADF-LVTEVENG 270
Cdd:pfam00224  75 GNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 271 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRF 350
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 351 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 430
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1907195583 431 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 465
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 113-584 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 567.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 113 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRTG 192
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 193 LIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGS 272
Cdd:PRK05826   78 KFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 273 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 351
Cdd:PRK05826  153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 352 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 431
Cdd:PRK05826  233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 432 SGETAKGDYPLEAVRMQHLIAREAEAaiyHLQLFEELRRLAPITSDPTEAAAVGAVEASFK-CCSGAIIVLTKSGRSAHQ 510
Cdd:PRK05826  313 SGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907195583 511 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTG 584
Cdd:PRK05826  390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDS------AADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 115-582 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 544.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 115 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATesfASDPILyrpVAVALDTKGPEIRTGLI 194
Cdd:PLN02461   23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAM---ANTGIL---CAVMLDTKGPEIRTGFL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 195 KGSGTaeVELKKGATLKITLDnaYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQV----KEKGadfLVT-EVEN 269
Cdd:PLN02461   97 KDGKP--VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlscdVEAG---TVRcRCEN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 270 GGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVR 348
Cdd:PLN02461  170 SAMLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLD 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 349 RFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADC 428
Cdd:PLN02461  250 NFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDC 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 429 IMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSA 508
Cdd:PLN02461  330 VMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTA 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 509 HQVARYRPRAPIIAV-------------TRNPQTARQAHLYRGIFPVLCKDAVLNAWAEDVDLRVNLAMDVGKARGFFKK 575
Cdd:PLN02461  410 RLVAKYRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKP 489


                  ....*..
gi 1907195583 576 GDVVIVL 582
Cdd:PLN02461  490 GDSVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
113-597 0e+00

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 531.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 113 RNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFAsdpilyRPVAVALDTKGPEIRTg 192
Cdd:PRK09206    2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTG------KKAAILLDTKGPEIRT- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 193 lIKGSGTAEVELKKGATLKITLDNAYMEkcDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGS 272
Cdd:PRK09206   75 -MKLEGGNDVSLKAGQTFTFTTDKSVVG--NKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 273 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGE-KGKNIKIISKIENHEGVRRFD 351
Cdd:PRK09206  152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 352 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 431
Cdd:PRK09206  232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 432 SGETAKGDYPLEAVRMQHLIAREAEAA----IYHLQLFEELRrlapITSdpteaaavgaveasfKCCSGA---------- 497
Cdd:PRK09206  312 SGESAKGKYPLEAVSIMATICERTDRVmnsrLESNNDNRKLR----ITE---------------AVCRGAvetaekldap 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 498 -IIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKG 576
Cdd:PRK09206  373 lIVVATQGGKSARSVRKYFPDATILALTTNEKTARQLVLSKGVVPQLVKE------IASTDDFYRLGKELALQSGLAQKG 446

                         490       500
                  ....*....|....*....|.
gi 1907195583 577 DVVIVLTGWRPGSGFTNTMRV 597
Cdd:PRK09206  447 DVVVMVSGALVPSGTTNTASV 467
PRK06354 PRK06354
pyruvate kinase; Provisional
 100-597 2.85e-177

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 514.47  E-value: 2.85e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 100 MCRLDidsapiTARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATEsfasdpILYRPVA 179
Cdd:PRK06354    1 MSLRD------LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASK------KLGKTVG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 180 VALDTKGPEIRTGLIKGSGtaeVELKKGATLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKE-- 257
Cdd:PRK06354   69 ILQDLQGPKIRLGRFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEvd 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 258 KGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK-GKNIK 336
Cdd:PRK06354  143 KADGELHCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIP 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 337 IISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGS 416
Cdd:PRK06354  223 IIAKIEKQEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEAS 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 417 DVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLapiTSDPTEAAAVGAVEASFKCCSG 496
Cdd:PRK06354  303 DVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEF---TTTITNAISQAVSHIALQLDAA 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 497 AIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKG 576
Cdd:PRK06354  380 AIVTLTKSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLD------APSTDETFDAAINVAQESGLLKQG 453

                         490       500
                  ....*....|....*....|..
gi 1907195583 577 DVVIVLTGWRPG-SGFTNTMRV 597
Cdd:PRK06354  454 DLVVITAGTLVGeSGSTDLMKV 475
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 139-600 2.13e-170

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 492.26  E-value: 2.13e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 139 MNVARLNFSHGTHEYHAETIKNVREATESFASDpilyrpVAVALDTKGPEIRTGLIKGSGTAeveLKKGATLKITLDNAY 218
Cdd:PTZ00300    1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGGEAV---MERGATCYVTTDPAF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 219 MEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADF-LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQ 297
Cdd:PTZ00300   72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 298 DLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVF 377
Cdd:PTZ00300  152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 378 LAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEA 457
Cdd:PTZ00300  232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 458 AIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYR 537
Cdd:PTZ00300  312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907195583 538 GIFPVLCkDAVLNAWAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 600
Cdd:PTZ00300  392 GVESVFF-DAERLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 78-601 6.33e-167

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 485.42  E-value: 6.33e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583  78 AGTAFIQTQQLHAAmADTFLEHMCRlDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAET 157
Cdd:PTZ00066    5 ASTSSVMGCSLGKA-TNISLDKILE-PISDNDLRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 158 IKNVREATESfasdpilyRP---VAVALDTKGPEIRTGLIKGSgtAEVELKKGATLKITLDnaYMEKCDENILWLDYKNI 234
Cdd:PTZ00066   83 LNNVREAAKA--------RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTD--YTFLGDETCISCSYKKL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 235 CKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFAS 313
Cdd:PTZ00066  151 PQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 314 FIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKP 393
Cdd:PTZ00066  231 FVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKP 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 394 VICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 473
Cdd:PTZ00066  311 VITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVP 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 474 ITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIfpvlcKDAVLNAWa 553
Cdd:PTZ00066  391 TPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGV-----TTYVVNSF- 464

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1907195583 554 EDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVVPVP 601
Cdd:PTZ00066  465 QGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKIP 513
PRK06247 PRK06247
pyruvate kinase; Provisional
 112-597 2.91e-153

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 448.99  E-value: 2.91e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 112 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRT 191
Cdd:PRK06247    4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDE------TGRPIGILADLQGPKLRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 192 GLIKGSgtaEVELKKGATLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGG 271
Cdd:PRK06247   78 GRFADG---KVQLANGQTFRLDVDDA---PGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 272 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKgknIKIISKIENHEGVRRFD 351
Cdd:PRK06247  152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 352 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 431
Cdd:PRK06247  229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 432 SGETAKGDYPLEAVRMQHLIAREAEA-----AIYHLQLFEEL-----------RRLAPITSDPteaaavgaveasfkccs 495
Cdd:PRK06247  309 SAETASGKYPVEAVRTMARIIRQVERdptypPLIHAQRPQPEatkrdaisyaaRDIAERLDLA----------------- 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 496 gAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKK 575
Cdd:PRK06247  372 -ALVAYTSSGDTALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDD------ARDTDDMVRRADRIALAEGFYKR 444

                         490       500
                  ....*....|....*....|...
gi 1907195583 576 GDVVIVLTGWRPG-SGFTNTMRV 597
Cdd:PRK06247  445 GDRVVIVAGVPPGtPGSTNMLRI 467
PLN02765 PLN02765
pyruvate kinase
 115-581 1.45e-113

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 348.97  E-value: 1.45e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 115 TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESfasdpiLYRPVAVALDTKGPEIRtglI 194
Cdd:PLN02765   30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPELQ---V 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 195 KGSGTAEVELKKGATLKITLDNayMEKCDENILWLDYKNICKVVEVGSKIYVDDGLIS--------LQVKEKGADFLVTE 266
Cdd:PLN02765  101 INKTEKPISLKAGNTVTLTPDQ--SKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCT 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 267 VENGGSL-GSKKGVNLPGAAVDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIEN 343
Cdd:PLN02765  179 VKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIEN 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 344 HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVIcATQMLESMIKKPRPTRAEGSDVANAVL 423
Cdd:PLN02765  259 VEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVL 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 424 DGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFeelRRLAPITSDPTEAA---AVGAVEASFKCCSGAIIV 500
Cdd:PLN02765  338 DGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYF---KKTVKYVGEPMSHLesiASSAVRAAIKVKASVIIV 414

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 501 LTKSGRSAHQVARYRPRAPIIAV-----TRNP--------QTARQAHLYRGIFPVLCK---DAVLNAWAEDVDLRVnlAM 564
Cdd:PLN02765  415 FTSSGRAARLIAKYRPTMPVLSVviprlKTNQlkwsftgaFQARQCLIVRGLFPMLADprhSAESTSATNESVLKV--AL 492

                         490
                  ....*....|....*..
gi 1907195583 565 DVGKARGFFKKGDVVIV 581
Cdd:PLN02765  493 DHGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 24-587 2.23e-111

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 345.37  E-value: 2.23e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583  24 GRTSSSGQSILHSERSFQVRPPSHTESTKQQYAIRSPDPENQRTSGTMPKPHSEAGTAFIQTQQLHAAMADTFLEHMCRL 103
Cdd:PLN02623   13 SSILSSSSGSVSLDLLSPLSFASKVLGSEARARRRVAVRRRAVTAASLRSKSQETEVIPVSPEDGGANFVEDNEEVLLEI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 104 DID--------SAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIly 175
Cdd:PLN02623   93 QQLgetavgmwSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNVI-- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 176 rpvAVALDTKGPEIRTGLIKgsgtAEVELKKGATLKITLDNAY-MEKCdeniLWLDYKNICKVVEVGSKIYVDDGLISLQ 254
Cdd:PLN02623  171 ---AIMLDTKGPEVRSGDLP----QPIMLEEGQEFTFTIKRGVsTEDC----VSVNYDDFVNDVEVGDMLLVDGGMMSLA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 255 VKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKN 334
Cdd:PLN02623  240 VKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNAD 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 335 IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAE 414
Cdd:PLN02623  320 IHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAE 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 415 GSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFkcc 494
Cdd:PLN02623  400 VSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTL--- 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 495 SGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKdavlnaWAEDVDLRVNLAMDVGKARGFFK 574
Cdd:PLN02623  477 GTSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQ------FSDDAEETFARALSLLLNKGMVK 550

                         570
                  ....*....|....
gi 1907195583 575 KGD-VVIVLTGWRP 587
Cdd:PLN02623  551 EGEeVALVQSGRQP 564
PRK06739 PRK06739
pyruvate kinase; Validated
 118-456 1.95e-100

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 309.18  E-value: 1.95e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 118 ICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESfasdpilyrpVAVALDTKGPEIRTGLIKGS 197
Cdd:PRK06739    6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKGE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 198 gtaEVELKKGATLKITLDNAYMEKCDENIlwlDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSKK 277
Cdd:PRK06739   76 ---QITLQAGDSFILHTQPVTGSSTEASV---DYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 278 GVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNI-KIISKIENHEGVRRFDEILEA 356
Cdd:PRK06739  150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 357 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETA 436
Cdd:PRK06739  230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                         330       340
                  ....*....|....*....|
gi 1907195583 437 KGDYPLEAVRMQHLIAREAE 456
Cdd:PRK06739  310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 112-601 1.55e-87

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 280.86  E-value: 1.55e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 112 ARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATES--FAsdpilyrpVAVALDTKGPEI 189
Cdd:PLN02762   24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEkgFA--------VAVMMDTEGSEI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 190 RTGLIKGSGTAEVElkKGATLKITLdNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEK-GADFLVTEVE 268
Cdd:PLN02762   96 HMGDLGGASSAKAE--DGEEWTFTV-RKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKiGPDVKCKCTD 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 269 NG-------------GSLGSKKGVNlpgaavdLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKN- 334
Cdd:PLN02762  173 PGlllpranltfwrdGSLVRERNAM-------LPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDs 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 335 -IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 413
Cdd:PLN02762  246 dIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRA 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 414 EGSDVANAVLDGADCIMLSGETAKGDYPLEAV--------RMQHLIAREAEAAIYHLQlfeelrRLAPITSDPTeaaavg 485
Cdd:PLN02762  326 EVADVSEAVRQRADALMLSGESAMGLYPEKALsvlrsvslRMELWSREEKRHEALELP------QLSSSLSDRI------ 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 486 aveaSFKCCSG-----------AIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCkdavlnAWAE 554
Cdd:PLN02762  394 ----SEEICNSaakmannlgvdAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSD 463

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1907195583 555 DVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPgSGFTNTMRVVPVP 601
Cdd:PLN02762  464 DMESNLNKTFSLLKARGMIKSGDLVIAVSDLTP-SSMLQSIQVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 108-448 3.82e-51

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 183.68  E-value: 3.82e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 108 APITARNTGIICTI-GPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFAsdpilyRPVAVALDTKG 186
Cdd:PRK08187  128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATG------RRCKILMDLAG 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 187 PEIRTGLIKGsGTAEVELKKGATLKITLDNAyMEKCDENILWLDykniCKV------VEVGSKIYVDDGLISLQVKEKGA 260
Cdd:PRK08187  202 PKIRTGAVAG-PLGKTRLYTGDRLALVAQGP-PRRIDEEHFQVT----CTLpeilarLAVGARVWIDDGKLGARVERVGP 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 261 DFLVTEV----ENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQdVDMVFASFIRKAADVHEVRKVLGEKGKN-- 334
Cdd:PRK08187  276 GGALLEVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALAARRPDdw 354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 335 --IKIISKIENHEGVRRFDEILEASDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKK 407
Cdd:PRK08187  355 rkLGLVLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKK 434

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1907195583 408 PRPTRAEGSDVANAvlDGADCIMLSgetaKGDYPLEAV--------RMQ 448
Cdd:PRK08187  435 GLPSRAEMTDAAMA--ARAECVMLN----KGPYLVEAVtflddllaRMD 477
PRK14725 PRK14725
pyruvate kinase; Provisional
 108-472 2.85e-41

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 158.19  E-value: 2.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 108 APITARNTGIICTI-GPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESfasdpiLYRPVAVALDTKG 186
Cdd:PRK14725  134 PPPSGRPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEE------LGRRCRIAMDLAG 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 187 PEIRTG---------------------------LIKGSGTAEVE-----------------LKKGATL----------KI 212
Cdd:PRK14725  208 PKLRTGpiapgprviklrptrdalgrvltparlWLTASESPPPSpppgpvglpvdpewlarLEPGDELrftdargkkrKL 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 213 TL-------------DNAYMEkcDENILWLDYKNICKV------------------------------------------ 237
Cdd:PRK14725  288 TVtevddegvlaegsQTAYLA--NGTLLRLGRHDSTRVgglppveqklrlkvgdrlvltrddapgdpaqgdapparisct 365

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 238 -------VEVGSKIYVDDGLISLQVKEKGADFLVTEVENGGSLGSK----KGVNLPGAAVDLPAVSEKDIQDLKFGVEQd 306
Cdd:PRK14725  366 lpeafraARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKH- 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 307 VDMVFASFIRKAADVHEVRKVLGE-KGKNIKIISKIENHEGVRRFDEI-LEA----SDGIMVARGDLGIEIPAEKVFLAQ 380
Cdd:PRK14725  445 ADIVALSFVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRIlLEAmrhpRFGVMIARGDLAVEVGFERLAEVQ 524

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 381 KMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLdgADCIMLSgetaKGDYPLEAVRMQHLIAREAEAaiY 460
Cdd:PRK14725  525 EEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE--H 596

                         490
                  ....*....|..
gi 1907195583 461 HLQLFEELRRLA 472
Cdd:PRK14725  597 QRKKRSLLRRLR 608
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
386-600 1.62e-39

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 147.35  E-value: 1.62e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 386 RCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 465
Cdd:COG3848     1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 466 EElRRLAPITSDPTeaaavgavEASFKCCS-------GAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRG 538
Cdd:COG3848    81 VP-RAKESSTTITD--------AISHAVATtaadlgaAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWG 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907195583 539 IFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKGDVVI----VLTGwrpGSGFTNTMRVVPV 600
Cdd:COG3848   152 VYPLLVEE------SASTDEMFAVAVALALEAGLVKDGDLVVitagVPVG---VSGTTNLLKVHVV 208
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 497-598 1.64e-36

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 131.83  E-value: 1.64e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907195583 497 AIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDavlnawAEDVDLRVNLAMDVGKARGFFKKG 576
Cdd:pfam02887  18 AIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEMLRRAVKVAKEAGLVKKG 91

                          90       100
                  ....*....|....*....|...
gi 1907195583 577 DVVIVLTGWRPG-SGFTNTMRVV 598
Cdd:pfam02887  92 DLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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