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Conserved domains on  [gi|1907201060|ref|XP_036011301|]
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kelch domain-containing protein 8B isoform X1 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 19803719)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-340 5.44e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 160.71  E-value: 5.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLADEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 137 ---PDTAPQAQVLVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPSRRA 213
Cdd:COG3055    81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 214 FAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPrslRMRDKRADFVVGSLGGNIVAIGGLGNq 292
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLA---PLPTARAGHAAAVLGGKILVFGGESG- 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907201060 293 pcPLASVESFSLARRRWEVLPAMPTARCSCSSLQAGPRLFVIGGVAQG 340
Cdd:COG3055   218 --FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
4-86 4.73e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.56  E-value: 4.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060   4 GGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLV 83
Cdd:COG3055   180 GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYV 256


                  ...
gi 1907201060  84 VGG 86
Cdd:COG3055   257 IGG 259
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-340 5.44e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 160.71  E-value: 5.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLADEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 137 ---PDTAPQAQVLVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPSRRA 213
Cdd:COG3055    81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 214 FAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPrslRMRDKRADFVVGSLGGNIVAIGGLGNq 292
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLA---PLPTARAGHAAAVLGGKILVFGGESG- 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907201060 293 pcPLASVESFSLARRRWEVLPAMPTARCSCSSLQAGPRLFVIGGVAQG 340
Cdd:COG3055   218 --FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA03098 PHA03098
kelch-like protein; Provisional
 7-210 6.71e-21

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 93.68  E-value: 6.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060   7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGlPLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:PHA03098  319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI-SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  87 VDEVQSPVAAVEAFLADEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQA--QVLVYEPRRDCWLSLPSMPTP 164
Cdd:PHA03098  398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVynIVESYNPVTNKWTELSSLNFP 477

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907201060 165 CYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPS 210
Cdd:PHA03098  478 RINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPK 523
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
4-86 4.73e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.56  E-value: 4.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060   4 GGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLV 83
Cdd:COG3055   180 GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYV 256


                  ...
gi 1907201060  84 VGG 86
Cdd:COG3055   257 IGG 259
Kelch smart00612
Kelch domain;
176-222 6.68e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.32  E-value: 6.68e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907201060  176 KIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPSRRAFAGCAMAEG 222
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 164-209 2.66e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.45  E-value: 2.66e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907201060 164 PCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLP 209
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
32-79 5.90e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 5.90e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907201060   32 HLLVLGGCGRaGLPLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGK 79
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
20-69 1.05e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.24  E-value: 1.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907201060  20 CRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMGSHTWLALAPLPTAR 69
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-340 5.44e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 160.71  E-value: 5.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLADEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 137 ---PDTAPQAQVLVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPSRRA 213
Cdd:COG3055    81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 214 FAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPrslRMRDKRADFVVGSLGGNIVAIGGLGNq 292
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLA---PLPTARAGHAAAVLGGKILVFGGESG- 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907201060 293 pcPLASVESFSLARRRWEVLPAMPTARCSCSSLQAGPRLFVIGGVAQG 340
Cdd:COG3055   218 --FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
11-252 4.62e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 134.51  E-value: 4.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  11 WQVFPPMPTCRVYGTVA-HQDGHLLVLGGCGRA---GLPLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:COG3055    50 WSELAPLPGPPRHHAAAvAQDGKLYVFGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  87 VDEvQSPVAAVEAFLADEGRWERRATLPQAAMGV-ATVERDGMVYALGGMGPDTAPQAqvlvyeprrdcWLSLPSMPTPC 165
Cdd:COG3055   130 WDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSNT-----------WTTLAPLPTAR 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 166 YGASTFLHGNKIYVLGGRQGKLpvTAFEAFDLETRTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGphnfySRPHFV 245
Cdd:COG3055   198 AGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPG-----VRTPLV 270


                  ....*..
gi 1907201060 246 NTVEMFD 252
Cdd:COG3055   271 TSAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 7-210 6.71e-21

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 93.68  E-value: 6.71e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060   7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGlPLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:PHA03098  319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI-SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  87 VDEVQSPVAAVEAFLADEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQA--QVLVYEPRRDCWLSLPSMPTP 164
Cdd:PHA03098  398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVynIVESYNPVTNKWTELSSLNFP 477

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907201060 165 CYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPS 210
Cdd:PHA03098  478 RINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPK 523
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
155-344 3.78e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 83.28  E-value: 3.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 155 WLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLP-SRRAFAGCAMAEGSVFSLGGlqqp 233
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGG---- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 234 gphnfysrphfvntvemFDLEHGSWTklprslrmrdkradfvvgslggnivaigglgnqpcPLASVESFSLARRRWEVLP 313
Cdd:COG3055    79 -----------------FTGANPSST-----------------------------------PLNDVYVYDPATNTWTKLA 106

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907201060 314 AMPTARCSCSSLQAGPRLFVIGGVAQGPSQA 344
Cdd:COG3055   107 PMPTPRGGATALLLDGKIYVVGGWDDGGNVA 137
PHA03098 PHA03098
kelch-like protein; Provisional
 23-259 2.03e-16

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.20  E-value: 2.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  23 YGTVAHQDgHLLVLGGCGRAGLPLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLA 102
Cdd:PHA03098  288 FGSVVLNN-VIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYN-SISLNTVESWKP 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 103 DEGRWERRATL--PQAAMGVATVerDGMVYALGGMGPDTAPQAQVLVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVL 180
Cdd:PHA03098  366 GESKWREEPPLifPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVI 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 181 GGR---QGKLPVTAFEAFDLETRTWTRHPSLPSRRAFAGCAMAEGSVFSLGGlqqpgphnfYSRPHFVNTVEMFDLEHGS 257
Cdd:PHA03098  444 GGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG---------DKYEYYINEIEVYDDKTNT 514


                  ..
gi 1907201060 258 WT 259
Cdd:PHA03098  515 WT 516
PHA03098 PHA03098
kelch-like protein; Provisional
 129-336 2.04e-14

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 74.03  E-value: 2.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 129 VYALGGMGPDTAPQAQVLVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSL 208
Cdd:PHA03098  297 IYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPL 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 209 PSRRAFAGCAMAEGSVFSLGGLQQPGphnfysrpHFVNTVEMFDLEHGSWTKLprsLRMRDKRADFVVGSLGGNIVAIGG 288
Cdd:PHA03098  377 IFPRYNPCVVNVNNLIYVIGGISKND--------ELLKTVECFSLNTNKWSKG---SPLPISHYGGCAIYHDGKIYVIGG 445

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907201060 289 LG--NQPCPLASVESFSLARRRWEVLPAMPTARCSCSSLQAGPRLFVIGG 336
Cdd:PHA03098  446 ISyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG 495
PLN02153 PLN02153
epithiospecifier protein
 114-336 9.61e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 71.17  E-value: 9.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 114 PQAAMGVATVerDGMVYALGG-MGPDTAPQAQVLVYEPRRDCWLSLPSMPTP----CYGASTFLHGNKIYVLGGRQGKLP 188
Cdd:PLN02153   22 PRCSHGIAVV--GDKLYSFGGeLKPNEHIDKDLYVFDFNTHTWSIAPANGDVprisCLGVRMVAVGTKLYIFGGRDEKRE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 189 VTAFEAFDLETRTWTRHPSL-----PSRRAFAGCAMAEGSVFSLGGLQQPGPHNfysRPHFVNTVEMFDLEHGSWTKLPR 263
Cdd:PLN02153  100 FSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGLMK---TPERFRTIEAYNIADGKWVQLPD 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 264 SLRMRDKR--ADFVVgsLGGNIVAIGGLGNQPCPLA-------SVESFSLARRRW---EVLPAMPTARCSCSSLQAGPRL 331
Cdd:PLN02153  177 PGENFEKRggAGFAV--VQGKIWVVYGFATSILPGGksdyesnAVQFFDPASGKWtevETTGAKPSARSVFAHAVVGKYI 254


                  ....*
gi 1907201060 332 FVIGG 336
Cdd:PLN02153  255 IIFGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 73-288 6.89e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 69.41  E-value: 6.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  73 AAVVLGKQVLVVGGVDEVQSPVAAVEAFLADEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDtAPQAQVLVYEPRR 152
Cdd:PHA03098  289 GSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 153 DCWLSLPSMPTPCYGASTFLHGNKIYVLGG-RQGKLPVTAFEAFDLETRTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLq 231
Cdd:PHA03098  368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGI- 446

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907201060 232 qpgphNFYSRPHFVNTVEMFDLEHGSWTKLPrslRMRDKRADFVVGSLGGNIVAIGG 288
Cdd:PHA03098  447 -----SYIDNIKVYNIVESYNPVTNKWTELS---SLNFPRINASLCIFNNKIYVVGG 495
PHA03098 PHA03098
kelch-like protein; Provisional
 155-337 4.27e-12

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 67.10  E-value: 4.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 155 WLSLPSMPTPCYGASTFLHgNKIYVLGGRQGK-LPVTAFEAFDLETRTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQP 233
Cdd:PHA03098  276 INTIIDIHYVYCFGSVVLN-NVIYFIGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 234 GPhnfysrphfVNTVEMFDLEHGSWTKLPRslrMRDKRADFVVGSLGGNIVAIGGLGNQPCPLASVESFSLARRRWEVLP 313
Cdd:PHA03098  355 IS---------LNTVESWKPGESKWREEPP---LIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGS 422

                         170       180
                  ....*....|....*....|....
gi 1907201060 314 AMPTARCSCSSLQAGPRLFVIGGV 337
Cdd:PHA03098  423 PLPISHYGGCAIYHDGKIYVIGGI 446
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
4-86 4.73e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.56  E-value: 4.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060   4 GGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLV 83
Cdd:COG3055   180 GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYV 256


                  ...
gi 1907201060  84 VGG 86
Cdd:COG3055   257 IGG 259
Kelch smart00612
Kelch domain;
176-222 6.68e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.32  E-value: 6.68e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907201060  176 KIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLPSRRAFAGCAMAEG 222
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 164-209 2.66e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.45  E-value: 2.66e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907201060 164 PCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLETRTWTRHPSLP 209
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
164-212 3.57e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.48  E-value: 3.57e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907201060 164 PCYGASTFLHGNKIYVLGGR-QGKLPVTAFEAFDLETRTWTRHPSLPSRR 212
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PLN02193 PLN02193
nitrile-specifier protein
 114-353 6.40e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 47.64  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 114 PQAAMGVATVerDGMVYALGG-MGPDTAPQAQVLVYEPRRDCWLSLPS---MPT-PCYGASTFLHGNKIYVLGGRQGKLP 188
Cdd:PLN02193  165 LRCSHGIAQV--GNKIYSFGGeFTPNQPIDKHLYVFDLETRTWSISPAtgdVPHlSCLGVRMVSIGSTLYVFGGRDASRQ 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 189 VTAFEAFDLETRTW---TRHPSLPSRRAFAGCAMAEGSVFSLGGLqqpgphnfySRPHFVNTVEMFDLEHGSWTKLPRSL 265
Cdd:PLN02193  243 YNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGV---------SATARLKTLDSYNIVDKKWFHCSTPG 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 266 RMRDKRADFVVGSLGGNIVAIGGLGNqpCPLASVESFSLARRRW---EVLPAMPTARCSCSSLQAGPRLFVIGG-VAQGP 341
Cdd:PLN02193  314 DSFSIRGGAGLEVVQGKVWVVYGFNG--CEVDDVHYYDPVQDKWtqvETFGVRPSERSVFASAAVGKHIVIFGGeIAMDP 391

                         250
                  ....*....|..
gi 1907201060 342 SQAVEALCLRDG 353
Cdd:PLN02193  392 LAHVGPGQLTDG 403
PRK14131 PRK14131
N-acetylneuraminate epimerase;
102-182 9.40e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.93  E-value: 9.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 102 ADEGRWERRATLP-QAAMGVATVERDGMVYALGGMGP---DTAPQAQ--VLVYEPRRDCWLSLPSM-PTPCYGASTF-LH 173
Cdd:PRK14131   59 APSKGWTKIAAFPgGPREQAVAAFIDGKLYVFGGIGKtnsEGSPQVFddVYKYDPKTNSWQKLDTRsPVGLAGHVAVsLH 138


                  ....*....
gi 1907201060 174 GNKIYVLGG 182
Cdd:PRK14131  139 NGKAYITGG 147
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 271-316 1.79e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 1.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907201060 271 RADFVVGSLGGNIVAIGGLGNQpCPLASVESFSLARRRWEVLPAMP 316
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
283-324 2.12e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907201060  283 IVAIGGL-GNQPcpLASVESFSLARRRWEVLPAMPTARCSCSS 324
Cdd:smart00612   2 IYVVGGFdGGQR--LKSVEVYDPETNKWTPLPSMPTPRSGHGV 42
Kelch_6 pfam13964
Kelch motif;
278-319 3.42e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 3.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907201060 278 SLGGNIVAIGGLGNQPCPLASVESFSLARRRWEVLPAMPTAR 319
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
32-79 5.90e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 5.90e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907201060   32 HLLVLGGCGRaGLPLDTAETLDMGSHTWLALAPLPTARAGAAAVVLGK 79
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
129-174 7.69e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.85  E-value: 7.69e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907201060  129 VYALGGMGPDTApQAQVLVYEPRRDCWLSLPSMPTP-CYGASTFLHG 174
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNKWTPLPSMPTPrSGHGVAVING 47
PHA02790 PHA02790
Kelch-like protein; Provisional
 49-258 8.01e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 44.26  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  49 AETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSpvaaVEAFLADEGRWERRATLPQAAMGVATVERDGM 128
Cdd:PHA02790  289 AIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTS----VERWFHGDAAWVNMPSLLKPRCNPAVASINNV 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 129 VYALGGMGpDTAPQAQVLVyePRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQgklpvtafEAFDLETRTWT--RHP 206
Cdd:PHA02790  365 IYVIGGHS-ETDTTTEYLL--PNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRNA--------EFYCESSNTWTliDDP 433

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907201060 207 SLPsrRAFAGCAMAEGSVFSLGGlqqpgphnFYsRPHFVNTVEMFDLEHGSW 258
Cdd:PHA02790  434 IYP--RDNPELIIVDNKLLLIGG--------FY-RGSYIDTIEVYNNRTYSW 474
Kelch_6 pfam13964
Kelch motif;
20-69 1.05e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.24  E-value: 1.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907201060  20 CRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMGSHTWLALAPLPTAR 69
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
174-218 1.43e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 1.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907201060 174 GNKIYVLGG--RQGKLPVTAFEAFDLETRTWTRHPSLPSRRAFAGCA 218
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
Kelch_4 pfam13418
Galactose oxidase, central domain;
165-210 2.40e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 2.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907201060 165 CYGASTFLHGNKIYVLGGRQGKLPVTAF-EAFDLETRTWTRHPSLPS 210
Cdd:pfam13418   3 AYHTSTSIPDDTIYLFGGEGEDGTLLSDlWVFDLSTNEWTRLGSLPS 49
Kelch_6 pfam13964
Kelch motif;
114-164 3.66e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 3.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907201060 114 PQAAMGVATVerDGMVYALGGMGPDTAPQAQVLVYEPRRDCWLSLPSMPTP 164
Cdd:pfam13964   1 PRTFHSVVSV--GGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 211-262 8.39e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 8.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907201060 211 RRAFAGCAMAEGSVFSLGGlqqpgphnfYSRPHFVNTVEMFDLEHGSWTKLP 262
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG---------FDGNQSLNSVEVYDPETNTWSKLP 43
Kelch smart00612
Kelch domain;
239-281 1.79e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 1.79e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907201060  239 YSRPHFVNTVEMFDLEHGSWTKLPrslRMRDKRADFVVGSLGG 281
Cdd:smart00612   8 FDGGQRLKSVEVYDPETNKWTPLP---SMPTPRSGHGVAVING 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
126-173 2.13e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 2.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907201060 126 DGMVYALGGMGPDTAP-QAQVLVYEPRRDCWLSLPSMPTPCYGASTFLH 173
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
30-77 4.46e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 4.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907201060  30 DGHLLVLGGCGRAG-LPLDTAETLDMGSHTWLALAPLPTARAGAAAVVL 77
Cdd:pfam13415   1 GDKLYIFGGLGFDGqTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
271-317 5.30e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.51  E-value: 5.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1907201060 271 RADFVVGSLG-GNIVAIGGLGNQPCPLASVESFSLARRRWEVLPAMPT 317
Cdd:pfam13418   2 RAYHTSTSIPdDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
PHA02790 PHA02790
Kelch-like protein; Provisional
 11-108 5.98e-03

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 38.49  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060  11 WQVFPPMPTCRVYGTVAHQDGHLLVLGgcgraGLPLDTA-ETLDMGSHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDE 89
Cdd:PHA02790  299 WIPIPPMNSPRLYASGVPANNKLYVVG-----GLPNPTSvERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSE 373

                          90
                  ....*....|....*....
gi 1907201060  90 VQSpvaAVEAFLADEGRWE 108
Cdd:PHA02790  374 TDT---TTEYLLPNHDQWQ 389
PHA02713 PHA02713
hypothetical protein; Provisional
 234-339 6.54e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 38.45  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907201060 234 GPHNFySRPHfVNTVEMFDLEHGSWTKLPRslrMRDKRADFVVGSLGGNIVAIGGlGNQPCPLASVESFSLARRRWEVLP 313
Cdd:PHA02713  310 GGYNF-NNPS-LNKVYKINIENKIHVELPP---MIKNRCRFSLAVIDDTIYAIGG-QNGTNVERTIECYTMGDDKWKMLP 383

                          90       100
                  ....*....|....*....|....*.
gi 1907201060 314 AMPTARCSCSSLQAGPRLFVIGGVAQ 339
Cdd:PHA02713  384 DMPIALSSYGMCVLDQYIYIIGGRTE 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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