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Conserved domains on  [gi|1907073201|ref|XP_036011460|]
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PR domain zinc finger protein 1 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 112-240 8.50e-89

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


:

Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 276.13  E-value: 8.50e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 112 ASLPRNLLFKYAANNsKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWM 191
Cdd:cd19187     1 ASLPRNLTLKYSSVG-REVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907073201 192 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19187    80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
zf-H2C2_2 pfam13465
Zinc-finger double domain;
633-658 3.17e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.17e-06
                          10        20
                  ....*....|....*....|....*.
gi 1907073201 633 NLKTHLRLHSGEKPYQCKVCPAKFTQ 658
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
661-686 3.33e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.33e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907073201 661 HLKLHKRLHTRERPHKCAQCHKSYIH 686
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 112-240 8.50e-89

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 276.13  E-value: 8.50e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 112 ASLPRNLLFKYAANNsKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWM 191
Cdd:cd19187     1 ASLPRNLTLKYSSVG-REVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907073201 192 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19187    80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 132-238 8.42e-24

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 97.41  E-value: 8.42e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201  132 GVVSKEYIPKGTRFGPLIGEVYTNDTVPK--------NANRKYFWRIYSreefHHFIDGFNeeKSNWMRYVNPAHSAREQ 203
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGEIITSEEAEErpkaydtdGAKAFYLFDIDS----DLCIDARR--KGNLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907073201  204 NLAACQNGMN-IYFYTIKPIPANQELLVWYCRDFAE 238
Cdd:smart00317  88 LLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 132-232 3.71e-14

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 69.47  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 132 GVVSKEYIPKGTRFGPLIGE-VYTNDTVPKNANRKYFWRIYSREEFHHF---------IDGFNEEKSNWMRYVNpaHSAR 201
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFtldedseycIDARALYYGNWARFIN--HSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907073201 202 EQNLAACQ---NGMNIYFYTIKPIPANQELLVWY 232
Cdd:pfam00856  81 PNCEVRVVyvnGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
633-658 3.17e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.17e-06
                          10        20
                  ....*....|....*....|....*.
gi 1907073201 633 NLKTHLRLHSGEKPYQCKVCPAKFTQ 658
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
661-686 3.33e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.33e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907073201 661 HLKLHKRLHTRERPHKCAQCHKSYIH 686
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 112-240 8.50e-89

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 276.13  E-value: 8.50e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 112 ASLPRNLLFKYAANNsKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWM 191
Cdd:cd19187     1 ASLPRNLTLKYSSVG-REVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWM 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907073201 192 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19187    80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 132-240 3.23e-32

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 121.57  E-value: 3.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 132 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNAnrkYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNG 211
Cdd:cd19193    21 GVWAEAPIPKGMVFGPYEGEIVEDEEAADSG---YSWQIYKGGKLSHYIDAKDESKSNWMRYVNCARNEEEQNLVAFQYR 97

                          90       100
                  ....*....|....*....|....*....
gi 1907073201 212 MNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19193    98 GKIYYRTCKDIAPGTELLVWYGDEYAKEL 126
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 109-240 7.52e-30

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 114.87  E-value: 7.52e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 109 QAEASLPRNLLFKYAAnnSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVP--KNANRKYFWRIYSREEFHHFIDGFNEE 186
Cdd:cd19189     1 RARLSLPRQLYLRQSE--TGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVAdwTDKAAPHIWKIYHNDVLEFCIITTDEN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907073201 187 KSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19189    79 ECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQL 132
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 110-240 1.76e-29

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 113.60  E-value: 1.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 110 AEASLPRNL-LFKYAANnskeVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNanrkYFWRIYSREEFHH--FIDGFNEE 186
Cdd:cd19194     2 ARASLPLILqIFRFGET----LGGVFAKRRIPKRTQFGPLEGPLVKKSELKDN----KIHPLELEEDDGEdlYFDLSDEN 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907073201 187 KSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19194    74 KCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFL 127
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 114-232 3.20e-28

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 108.44  E-value: 3.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 114 LPRNLLFKYAANnSKEVIGVVSKEYIPKGTRFGPLIGEVytndtvpknanrkyfwriysreefhhfidgfneeksNWMRY 193
Cdd:cd10534     1 LPAGLELVLSSI-PEGGLGVFARRTIPAGTRFGPLEGVV------------------------------------NWMRF 43

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907073201 194 VNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWY 232
Cdd:cd10534    44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 132-232 1.01e-26

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 105.94  E-value: 1.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 132 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGfNEEKSNWMRYVNPAHSAREQNLAACQNG 211
Cdd:cd19198    21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIFEDGKLSHFIDG-RGSTGNWMSYVNCARYAEEQNLIAIQCQ 99

                          90       100
                  ....*....|....*....|.
gi 1907073201 212 MNIYFYTIKPIPANQELLVWY 232
Cdd:cd19198   100 GQIFYESCKEILQGQELLVWY 120
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 131-243 1.44e-26

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 105.52  E-value: 1.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 131 IGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIY-SREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQ 209
Cdd:cd19196    17 LGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFnEDGTVSHFIDASQENHRSWMTFVNCARNEQEQNLEVVQ 96

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907073201 210 NGMNIYFYTIKPIPANQELLVWYCRDFAERLHYP 243
Cdd:cd19196    97 IGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 132-232 4.55e-26

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 103.71  E-value: 4.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 132 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNA-NRKYFWRIYSRE-EFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQ 209
Cdd:cd19191    18 GICAAQRIPQGTWIGPFEGVLVSPEKQIGAVrNTQHLWEIYDQEgTLQHFIDGGDPSKSSWMRYIRCARHCGEQNLTVVQ 97

                          90       100
                  ....*....|....*....|...
gi 1907073201 210 NGMNIYFYTIKPIPANQELLVWY 232
Cdd:cd19191    98 YRGCIFYRACRDIPRGTELLVWY 120
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 114-232 5.25e-24

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 97.90  E-value: 5.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 114 LPRNLLFKYAANnSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNAnrkYFWRIYSREEFHHFIDGFNEEKSNWMRY 193
Cdd:cd19188     4 LPEELELKPSAV-DKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNV---YMWEIYGPKRGWMCVDASDPTKGNWLRY 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907073201 194 VNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWY 232
Cdd:cd19188    80 VNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 132-238 8.42e-24

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 97.41  E-value: 8.42e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201  132 GVVSKEYIPKGTRFGPLIGEVYTNDTVPK--------NANRKYFWRIYSreefHHFIDGFNeeKSNWMRYVNPAHSAREQ 203
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGEIITSEEAEErpkaydtdGAKAFYLFDIDS----DLCIDARR--KGNLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907073201  204 NLAACQNGMN-IYFYTIKPIPANQELLVWYCRDFAE 238
Cdd:smart00317  88 LLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYAN 123
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 137-241 9.68e-21

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 88.76  E-value: 9.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 137 EYIPKGTRFGPLIGEVYTNDtvpkNANRKYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYF 216
Cdd:cd19195    26 EVIPKGHIFGPYEGQICTQD----KSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYF 101

                          90       100
                  ....*....|....*....|....*
gi 1907073201 217 YTIKPIPANQELLVWYCRDFAERLH 241
Cdd:cd19195   102 RACRDIRPGEKLRVWYSEDYMKRLH 126
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 109-240 5.02e-20

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 86.70  E-value: 5.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 109 QAEASLPRNLLFKYAANNSKeviGVVSKEYIPKGTRFGPLIG-EVYTNDTVPKnanrKYFwRIYSREEFHHFIDGFNEEK 187
Cdd:cd19199     2 RARSSLPDNLEIRQLEDGSE---GVFALVPLVKRTQFGPFEAkRVARLDGFAV----FPL-KVFEKDGSVVYLDTSNEDD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907073201 188 SNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19199    74 CNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 113-236 8.53e-17

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 77.00  E-value: 8.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 113 SLPRNLLFKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVytndtVPKNANRKYFWRIYSRE-EFHHFIDGFNEEKSNWM 191
Cdd:cd19201     2 SLPGELELRKPSQDAGRSGGVWAKQPLPEGTRFGPYPGKL-----VKEPLDPSYEWKVEAQGsKGGEGLLLLTEDSGTWL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907073201 192 RYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDF 236
Cdd:cd19201    77 KLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 120-232 1.05e-15

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 74.25  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 120 FKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIY-SREEFHHFIDGFNEEKSNWMRYVNPAH 198
Cdd:cd19190     9 FSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRgSKGEVLYILDASNPRHSNWLRFVHEAP 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907073201 199 SAREQNLAACQNGMNIYFYTIKPIPANQELLVWY 232
Cdd:cd19190    89 SQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 132-232 3.71e-14

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 69.47  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 132 GVVSKEYIPKGTRFGPLIGE-VYTNDTVPKNANRKYFWRIYSREEFHHF---------IDGFNEEKSNWMRYVNpaHSAR 201
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFtldedseycIDARALYYGNWARFIN--HSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907073201 202 EQNLAACQ---NGMNIYFYTIKPIPANQELLVWY 232
Cdd:pfam00856  81 PNCEVRVVyvnGGPRIVIFALRDIKPGEELTIDY 114
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 131-240 5.41e-14

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 69.38  E-value: 5.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 131 IGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRI-YSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAA-C 208
Cdd:cd19192    20 TSVVTTTDIPAGTIFGPCVLSFTLGYDIADIALKTTDKRVvPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQNLEAfR 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907073201 209 QNGMNIYFYTIKPIPANQELLVWYCRDFAERL 240
Cdd:cd19192   100 KNEGQVYFRTLRRIRKGEELLVWYSDELAELL 131
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 131-230 1.14e-13

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 68.55  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 131 IGVVSKEYIPKGTRFGPLIGevytndtVPKNA--NRKYFWRIYsrEEFHH---FIDGFNEEKSNWMRYVNPAHSAREQNL 205
Cdd:cd19200    26 LGVWTKVRIEVGEKFGPFVG-------VQRSSvkDPTYAWEIV--DEFGKvkfWIDASEPGTGNWMKYIRSAPSCEQQNL 96

                          90       100
                  ....*....|....*....|....*
gi 1907073201 206 AACQNGMNIYFYTIKPIPANQELLV 230
Cdd:cd19200    97 MACQIDEQIYYKVVRDIQPGEELLL 121
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 139-232 4.97e-10

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 57.14  E-value: 4.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 139 IPKGTRFGPLIGEV----YTNDTvpKNANRKYFWRIYSREefhHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQN--GM 212
Cdd:cd19197     1 IPAGLRLGPVPGIFklgkYLSDR--KEPGNKKKVRRVRGD---YLVDESGSPATEWIGLVRAARNNQEQNLEAIADlpGG 75

                          90       100
                  ....*....|....*....|
gi 1907073201 213 NIYFYTIKPIPANQELLVWY 232
Cdd:cd19197    76 QIFYRALRDIQPGEELTVWY 95
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 113-231 1.17e-09

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 56.66  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 113 SLPRNLlfkyAANNS---KEVIGV--VSKEyIPKGTRFGPLIGEvytndTVPKNANRKYFWRIysrEEFHHFIDGF-NEE 186
Cdd:cd10520     4 SLPPGL----ALGPSlaqEERLGVwcVGDA-LQKGTFLGPLEEE-----LESHDLTEGGSPRQ---EESGQSGDVLaCEQ 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907073201 187 KSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVW 231
Cdd:cd10520    71 SSKWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 131-231 1.38e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 57.58  E-value: 1.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 131 IGVVSKEYIPKGTRFGPLIG-------------EVYTND--TVPKNANRKYFWRIYSREEFhhFIDGFNEEKSNWMRYVN 195
Cdd:cd19213    36 LGVWAKRKIEAGERFGPYTGvqrstlkdtnfgwEQILNDveVSSQEGCITKIVDDLGNEKF--CVDAGQAGAGSWLKYIR 113

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907073201 196 PAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVW 231
Cdd:cd19213   114 VACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 132-232 1.98e-08

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 53.11  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 132 GVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWR-IYSREEFHHFIDGFneEKSNWMRYVNpaHSAREqNLAA--- 207
Cdd:cd10522    16 GLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDPLyPFDLNGDILVIDAG--KKGNLTRFIN--HSDQP-NLELivr 90

                          90       100
                  ....*....|....*....|....*.
gi 1907073201 208 CQNGMN-IYFYTIKPIPANQELLVWY 232
Cdd:cd10522    91 TLKGEQhIGFVAIRDIKPGEELFISY 116
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 131-231 4.23e-07

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 50.32  E-value: 4.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073201 131 IGVVSKEYIPKGTRFGPLIGEVYTNDTVPKnanrkYFWRIYsrEEFHHF---IDGFNEEKSNWMRYVNPAHSAREQNLAA 207
Cdd:cd19214    46 LGIWTKRKIEVGEKFGPYVGEQRSNLKDPS-----YGWEVL--DEFGNVkfcIDASQPDVGSWLKYIRFAGCYDQHNLVA 118

                          90       100
                  ....*....|....*....|....
gi 1907073201 208 CQNGMNIYFYTIKPIPANQELLVW 231
Cdd:cd19214   119 CQINDQIFYRAVADIDPGEELLLF 142
zf-H2C2_2 pfam13465
Zinc-finger double domain;
633-658 3.17e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.17e-06
                          10        20
                  ....*....|....*....|....*.
gi 1907073201 633 NLKTHLRLHSGEKPYQCKVCPAKFTQ 658
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
661-686 3.33e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.33e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907073201 661 HLKLHKRLHTRERPHKCAQCHKSYIH 686
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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