NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907073713|ref|XP_036011545|]
View 

lanosterol synthase isoform X3 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
squalene_cyclas super family cl36976
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
1-507 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


The actual alignment was detected with superfamily member TIGR01787:

Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 773.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPlvqslRQELYVQDyASIdwPAQRNNVSPDEMYTPHSWLLH 80
Cdd:TIGR01787 139 IMLLPKWLPIHPSKSWCRCRMVYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLR 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  81 VVYGLLNL-YERFHSTSLRKWAVQMLYEHIAADDCftkcisIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGL 159
Cdd:TIGR01787 211 ALYGLLNLfYHPFLRKALRKRALQWLYEHIAADGS------IGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQL 284
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 160 DGMKMQGTnGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRK-GGFSFSTLDCGW- 237
Cdd:TIGR01787 285 DGMKMQGT-GSQVWDTAFAIQALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYp 363
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 238 IVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYV 317
Cdd:TIGR01787 364 DVDDTAVVALKAVLLLQE-----DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYV 438
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 318 ECTSAVMQALKHFhehfpDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAE 397
Cdd:TIGR01787 439 DVTARVIQALGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPE 510
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 398 VAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQEN 477
Cdd:TIGR01787 511 VQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEY 590
                         490       500       510
                  ....*....|....*....|....*....|.
gi 1907073713 478 ISGVFN-KSCAISYTSYRNIFPIWALGRFSN 507
Cdd:TIGR01787 591 ITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
 
Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
1-507 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 773.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPlvqslRQELYVQDyASIdwPAQRNNVSPDEMYTPHSWLLH 80
Cdd:TIGR01787 139 IMLLPKWLPIHPSKSWCRCRMVYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLR 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  81 VVYGLLNL-YERFHSTSLRKWAVQMLYEHIAADDCftkcisIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGL 159
Cdd:TIGR01787 211 ALYGLLNLfYHPFLRKALRKRALQWLYEHIAADGS------IGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQL 284
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 160 DGMKMQGTnGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRK-GGFSFSTLDCGW- 237
Cdd:TIGR01787 285 DGMKMQGT-GSQVWDTAFAIQALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYp 363
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 238 IVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYV 317
Cdd:TIGR01787 364 DVDDTAVVALKAVLLLQE-----DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYV 438
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 318 ECTSAVMQALKHFhehfpDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAE 397
Cdd:TIGR01787 439 DVTARVIQALGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPE 510
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 398 VAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQEN 477
Cdd:TIGR01787 511 VQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEY 590
                         490       500       510
                  ....*....|....*....|....*....|.
gi 1907073713 478 ISGVFN-KSCAISYTSYRNIFPIWALGRFSN 507
Cdd:TIGR01787 591 ITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
1-505 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 725.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVspDEMYTPHSWLLH 80
Cdd:cd02892   139 LWLLPSWLPFHPYKFWCWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYRPPWQRLFD 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  81 VVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLD 160
Cdd:cd02892   217 ALDRLLHWYEPLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPE 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 161 GMKMQGTNGSQIWDTSFAIQALLEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVA 240
Cdd:cd02892   297 GMKMCQTNGSQVWDTALAVQALLEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDS 374
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 241 DCTAEGLKAVLLLQNqCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECT 320
Cdd:cd02892   375 DDTAEALKALLRLQE-LPPFGEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECT 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 321 SAVMQALKHFHEHFPDYRAaEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVAQ 400
Cdd:cd02892   454 GSVLEALGLFGKLYPGHRR-EIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRK 529
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 401 ACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISG 480
Cdd:cd02892   530 ACDFLLSKQNPDGGWGESYLSYEDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITG 609
                         490       500
                  ....*....|....*....|....*
gi 1907073713 481 VFNKSCAISYTSYRNIFPIWALGRF 505
Cdd:cd02892   610 VGFPNFYIRYHNYRNYFPLWALGRY 634
PLN03012 PLN03012
Camelliol C synthase
2-505 8.28e-159

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 470.27  E-value: 8.28e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   2 WLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHV 81
Cdd:PLN03012  244 WILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDL 323
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  82 VYGLLNLY-ERF-----HSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPAFQEHVSRIKDYL 155
Cdd:PLN03012  324 IWDCLYIFaEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYL 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 156 WLGLDGMKMQgTNGSQIWDTSFAIQALLEAGAHHrpEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRHMRKGGFSFSTLD 234
Cdd:PLN03012  403 WIAEDGMKMQ-SFGSQLWDSGFALQALLASNLSN--EIPDVLRRGHDFIKNSQVGENpSGDFKNMYRHISKGAWTFSDRD 479
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 235 CGWIVADCTAEGLKAVLLLQNQCPSITEhiPR---ERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIM 311
Cdd:PLN03012  480 HGWQASDCTAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIV 557
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 312 IDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQD 391
Cdd:PLN03012  558 IEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND 637
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 392 gaaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSA--RSQVHSTCWALMGLM----AVRHPdiTAQERGIRCLLG 465
Cdd:PLN03012  638 ---CEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIIN 712
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1907073713 466 KQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 505
Cdd:PLN03012  713 SQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEY 752
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
1-509 2.00e-152

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 449.65  E-value: 2.00e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVQDYASID--WPAQRnnvspdeMYTPHSWL 78
Cdd:COG1657   162 IMLLPRWFPFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPR-------DRSPWSRF 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  79 LHVVYGLLNLYERFHSTSLRKWAVQ-----MLyEHIAADDCFtkcISIGP-ISKTINMLvRWSVDGPSSPAFQEHVSRIK 152
Cdd:COG1657   233 FLALDRLLRAYERLPPKPLRRRALRkaedwIL-ERLEGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALE 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 153 DYLWLGLDGMKMQGtNGSQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFST 232
Cdd:COG1657   308 KLLVETEDGARCQP-CVSPVWDTALAVQALQEAG---LPEDHPALERAADWLLSKQILVK-GDWAVKRPDVEPGGWAFQF 382
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 233 LDCGWIVADCTAEGLKAVLLLQNQcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEvFGdIMI 312
Cdd:COG1657   383 ANDHYPDVDDTAVVLMALLRLRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALL 456
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 313 DYTYVECTSAVMQALKHfhehfpdYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDG 392
Cdd:COG1657   457 DPPTADVTARCLEMLGQ-------LGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDP 529
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 393 AacaeVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGD 472
Cdd:COG1657   530 A----IRRAVAWLLSIQNADGGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGS 605
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907073713 473 WPQENISGV-FNKSCAISYTSYRNIFPIWALGRFSNLY 509
Cdd:COG1657   606 WDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLR 643
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
170-507 3.09e-52

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 179.84  E-value: 3.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 170 SQIWDTSFAIQALLEAGAhhrPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglkA 249
Cdd:pfam13243   2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVK-GDWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 250 VLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 327
Cdd:pfam13243  74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 328 KHFHehFPDYRAAEVRetlnqGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLS 407
Cdd:pfam13243 150 GQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY----IRKAVDWLKS 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 408 QQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMA---VRHPditAQERGIRCLLGKQLPNGDWPQENISGV-FN 483
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAageVDSP---AVRRGIQYLLETQKPDGTWDEPYFTGTgFP 295
                         330       340
                  ....*....|....*....|....
gi 1907073713 484 KSCAISYTSYRNIFPIWALGRFSN 507
Cdd:pfam13243 296 RVFYLKYHGYRNYFPLWALARYRN 319
 
Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
1-507 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 773.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPlvqslRQELYVQDyASIdwPAQRNNVSPDEMYTPHSWLLH 80
Cdd:TIGR01787 139 IMLLPKWLPIHPSKSWCRCRMVYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLR 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  81 VVYGLLNL-YERFHSTSLRKWAVQMLYEHIAADDCftkcisIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGL 159
Cdd:TIGR01787 211 ALYGLLNLfYHPFLRKALRKRALQWLYEHIAADGS------IGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQL 284
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 160 DGMKMQGTnGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRK-GGFSFSTLDCGW- 237
Cdd:TIGR01787 285 DGMKMQGT-GSQVWDTAFAIQALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYp 363
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 238 IVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYV 317
Cdd:TIGR01787 364 DVDDTAVVALKAVLLLQE-----DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYV 438
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 318 ECTSAVMQALKHFhehfpDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAE 397
Cdd:TIGR01787 439 DVTARVIQALGAF-----GHRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPE 510
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 398 VAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQEN 477
Cdd:TIGR01787 511 VQKACDWLLSRQMPDGGWGEDCFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEY 590
                         490       500       510
                  ....*....|....*....|....*....|.
gi 1907073713 478 ISGVFN-KSCAISYTSYRNIFPIWALGRFSN 507
Cdd:TIGR01787 591 ITGVGFpKNFYLKYTNYRNIFPLWALGRYRQ 621
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
1-505 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 725.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVspDEMYTPHSWLLH 80
Cdd:cd02892   139 LWLLPSWLPFHPYKFWCWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYRPPWQRLFD 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  81 VVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLD 160
Cdd:cd02892   217 ALDRLLHWYEPLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPE 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 161 GMKMQGTNGSQIWDTSFAIQALLEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVA 240
Cdd:cd02892   297 GMKMCQTNGSQVWDTALAVQALLEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDS 374
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 241 DCTAEGLKAVLLLQNqCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECT 320
Cdd:cd02892   375 DDTAEALKALLRLQE-LPPFGEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECT 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 321 SAVMQALKHFHEHFPDYRAaEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaaCAEVAQ 400
Cdd:cd02892   454 GSVLEALGLFGKLYPGHRR-EIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRK 529
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 401 ACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISG 480
Cdd:cd02892   530 ACDFLLSKQNPDGGWGESYLSYEDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITG 609
                         490       500
                  ....*....|....*....|....*
gi 1907073713 481 VFNKSCAISYTSYRNIFPIWALGRF 505
Cdd:cd02892   610 VGFPNFYIRYHNYRNYFPLWALGRY 634
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
170-505 1.86e-171

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 487.50  E-value: 1.86e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 170 SQIWDTSFAIQALLEAGAHhrPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKA 249
Cdd:cd02889    23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 250 VLLLQNqCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELlnPSEVFGDIMIDYTYVECTSAVMQALKH 329
Cdd:cd02889   101 LLRLQK-KPPDGKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 330 FHEHFPDYRAaEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTyqdgAACAEVAQACNFLLSQQ 409
Cdd:cd02889   178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED----ENSPYVRKACDWLLSKQ 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 410 MADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAIS 489
Cdd:cd02889   253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
                         330
                  ....*....|....*.
gi 1907073713 490 YTSYRNIFPIWALGRF 505
Cdd:cd02889   333 YHNYRNYFPLWALGRY 348
osq_cycl TIGR03463
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ...
1-505 4.56e-171

2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.


Pssm-ID: 274591 [Multi-domain]  Cd Length: 634  Bit Score: 497.21  E-value: 4.56e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASE-DPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLL 79
Cdd:TIGR03463 133 LFLLPESLPFHPSRFWCHCRLIYLGIAWLSGRGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVL 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  80 HVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDgPSSPAFQEHVSRIKDYLWLGL 159
Cdd:TIGR03463 213 KAANDLLAGYERLAGKALRARALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHD-PDGPDLAAHLEGLEAWFWEDD 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 160 D-GMKMQGTNGSQIWDTSFAIQALLEAGaHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWI 238
Cdd:TIGR03463 292 AeGLRMNGANSNALWDTAFAVQALAALG-ELDEEAKHALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWP 370
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 239 VADCTAEGLKAVLLLQNQ-CPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYV 317
Cdd:TIGR03463 371 ISDCAAEALKALFALEELgDNRISEALGAARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYV 450
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 318 ECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacae 397
Cdd:TIGR03463 451 ECTAACLGALAAWLKHHPDLPDAKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPADMA---- 526
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 398 VAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQEN 477
Cdd:TIGR03463 527 LQAAAAFLLEKQRADGAWGEHVESCLEARWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEG 606
                         490       500
                  ....*....|....*....|....*...
gi 1907073713 478 ISGVFNKSCAISYTSYRNIFPIWALGRF 505
Cdd:TIGR03463 607 IAGIFFGAAAIDYDAYLRIFPTWALARC 634
PLN03012 PLN03012
Camelliol C synthase
2-505 8.28e-159

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 470.27  E-value: 8.28e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   2 WLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHV 81
Cdd:PLN03012  244 WILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDL 323
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  82 VYGLLNLY-ERF-----HSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPAFQEHVSRIKDYL 155
Cdd:PLN03012  324 IWDCLYIFaEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYL 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 156 WLGLDGMKMQgTNGSQIWDTSFAIQALLEAGAHHrpEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRHMRKGGFSFSTLD 234
Cdd:PLN03012  403 WIAEDGMKMQ-SFGSQLWDSGFALQALLASNLSN--EIPDVLRRGHDFIKNSQVGENpSGDFKNMYRHISKGAWTFSDRD 479
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 235 CGWIVADCTAEGLKAVLLLQNQCPSITEhiPR---ERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIM 311
Cdd:PLN03012  480 HGWQASDCTAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIV 557
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 312 IDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQD 391
Cdd:PLN03012  558 IEHEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND 637
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 392 gaaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSA--RSQVHSTCWALMGLM----AVRHPdiTAQERGIRCLLG 465
Cdd:PLN03012  638 ---CEAIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIIN 712
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1907073713 466 KQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 505
Cdd:PLN03012  713 SQLENGDFPQQEATGAFLKNCLLHYAAYRNIFPLWALAEY 752
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
1-509 2.00e-152

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 449.65  E-value: 2.00e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVQDYASID--WPAQRnnvspdeMYTPHSWL 78
Cdd:COG1657   162 IMLLPRWFPFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPR-------DRSPWSRF 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  79 LHVVYGLLNLYERFHSTSLRKWAVQ-----MLyEHIAADDCFtkcISIGP-ISKTINMLvRWSVDGPSSPAFQEHVSRIK 152
Cdd:COG1657   233 FLALDRLLRAYERLPPKPLRRRALRkaedwIL-ERLEGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALE 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 153 DYLWLGLDGMKMQGtNGSQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFST 232
Cdd:COG1657   308 KLLVETEDGARCQP-CVSPVWDTALAVQALQEAG---LPEDHPALERAADWLLSKQILVK-GDWAVKRPDVEPGGWAFQF 382
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 233 LDCGWIVADCTAEGLKAVLLLQNQcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEvFGdIMI 312
Cdd:COG1657   383 ANDHYPDVDDTAVVLMALLRLRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALL 456
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 313 DYTYVECTSAVMQALKHfhehfpdYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDG 392
Cdd:COG1657   457 DPPTADVTARCLEMLGQ-------LGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDDP 529
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 393 AacaeVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGD 472
Cdd:COG1657   530 A----IRRAVAWLLSIQNADGGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGS 605
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907073713 473 WPQENISGV-FNKSCAISYTSYRNIFPIWALGRFSNLY 509
Cdd:COG1657   606 WDEEYFTGTgFPRVFYLRYHLYRQYFPLWALARYRNLR 643
PLN02993 PLN02993
lupeol synthase
1-505 1.29e-144

lupeol synthase


Pssm-ID: 215537 [Multi-domain]  Cd Length: 763  Bit Score: 433.95  E-value: 1.29e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   1 MWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLH 80
Cdd:PLN02993  243 IWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQD 322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713  81 VVYGLLNLYERFHSTS------LRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWsVDGPSSPAFQEHVSRIKDY 154
Cdd:PLN02993  323 LIWDTLHNFVEPFLTRwplnklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDY 401
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 155 LWLGLDGMKMQgTNGSQIWDTSFAIQALLeaGAHHRPEFLPCLQKAHEFLRLSQVPEN-CPDYQKYYRHMRKGGFSFSTL 233
Cdd:PLN02993  402 MWVAEDGMKMQ-SFGSQLWDTGFAIQALL--ASDLSDETDDVLRRGHNYIKKSQVRENpSGDFKSMYRHISKGAWTLSDR 478
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 234 DCGWIVADCTAEGLKAVLLLQNQCPSIT-EHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMI 312
Cdd:PLN02993  479 DHGWQVSDCTAEALKCCMLLSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMV 558
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 313 DYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDg 392
Cdd:PLN02993  559 EREYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND- 637
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 393 aaCAEVAQACNFLLSQQMADGGWGEDFESCEQRRYV--QSARSQVHSTCWALMGLMAVRHP--DITAQERGIRCLLGKQL 468
Cdd:PLN02993  638 --CLAMRKGVHFLLTIQRDDGGWGESYLSCPEQRYIplEGNRSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQL 715
                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1907073713 469 PNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRF 505
Cdd:PLN02993  716 ENGDFPQQEILGAFMNTCMLHYATYRNTFPLWALAEY 752
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
148-505 1.41e-53

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 183.14  E-value: 1.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 148 VSRIKDYL--WLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAH--HRPEFLPCLQKAHEFLRLSQVPencpdyqkyyrhm 223
Cdd:cd00688     1 IEKHLKYLlrYPYGDGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLS------------- 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 224 rKGGFSFSTLDcGWIVADCTAEGLKAVLLLQNqcpsiTEHIPRERLCDAVDVLLSLRNADGGFATYEKkrggyllellnp 303
Cdd:cd00688    68 -DGGFSGWGGN-DYPSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDGP------------ 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 304 seVFGDIMIDYTYVECTSAVMQALKHFHEHFPDyraaevrETLNQGLDFCRRKQRADGSWeGSWGVCFTYGTWFGLEAFA 383
Cdd:cd00688   129 --GNHRIGGDESDVRLTAYALIALALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALA 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 384 CMGHTYQDgaacaEVAQACNFLLSQQMADGGWGEdfesceqRRYVQSARSQVHSTCWALMGLMA-VRHPDITAQERGIRC 462
Cdd:cd00688   199 LLGDLDSP-----DAKKALRWLLSRQRPDGGWGE-------GRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKW 266
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1907073713 463 LLGKQLPNGDWPQENIsgvfnkscaISYTSYRNIFPIWALGRF 505
Cdd:cd00688   267 LLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
170-507 3.09e-52

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 179.84  E-value: 3.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 170 SQIWDTSFAIQALLEAGAhhrPEFLPCLQKAHEFLRLSQVPENcPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglkA 249
Cdd:pfam13243   2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVK-GDWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 250 VLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 327
Cdd:pfam13243  74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 328 KHFHehFPDYRAAEVRetlnqGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLS 407
Cdd:pfam13243 150 GQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNRPY----IRKAVDWLKS 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 408 QQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMA---VRHPditAQERGIRCLLGKQLPNGDWPQENISGV-FN 483
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAageVDSP---AVRRGIQYLLETQKPDGTWDEPYFTGTgFP 295
                         330       340
                  ....*....|....*....|....
gi 1907073713 484 KSCAISYTSYRNIFPIWALGRFSN 507
Cdd:pfam13243 296 RVFYLKYHGYRNYFPLWALARYRN 319
hopene_cyclase TIGR01507
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ...
170-508 1.92e-38

squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273661 [Multi-domain]  Cd Length: 635  Bit Score: 148.88  E-value: 1.92e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 170 SQIWDTSFAIQALLEAGahhRPEFLPCLQKAHEFLRLSQVpeNCP-DYQKYYRHMRKGGFSFSTLDCGWIVADCTAeglk 248
Cdd:TIGR01507 314 SPVWDTALAVLALREAG---LPADHDALVKAGEWLLDKQI--TVPgDWAVKRPNLEPGGWAFQFDNVYYPDVDDTA---- 384
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 249 AVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNpsevFGDI--MIDYTYVECTSAVMQA 326
Cdd:TIGR01507 385 VVVWALNGLRLPDERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLEC 460
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 327 LKHFHEHFPdyraaevRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDgaacAEVAQACNFLL 406
Cdd:TIGR01507 461 LGSFGYDDA-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGIDTRE----PYIQKALAWLE 529
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 407 SQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGV-FNKS 485
Cdd:TIGR01507 530 SHQNPDGGWGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGD 609
                         330       340
                  ....*....|....*....|...
gi 1907073713 486 CAISYTSYRNIFPIWALGRFSNL 508
Cdd:TIGR01507 610 FYLGYHMYRHVFPLLALARYKQA 632
squa_tetra_cyc TIGR04277
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ...
271-505 4.36e-17

squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.


Pssm-ID: 212000 [Multi-domain]  Cd Length: 624  Bit Score: 84.30  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 271 DAVDVLLSLRNADGGFATYEK-KRGGYLL--------ELLNPSEVFgdimiDYTYVECTSAVMQALKHFhehfpDYRAAe 341
Cdd:TIGR04277 387 EGAEFLFSMQNDDGGFPAFDKgKMEDNLLfkfafkiaGIADSAEIF-----DPSCPDITAHILEGLGEF-----GDQAN- 455
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 342 vRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAacaeVAQACNFLLSQQMADGGWGEDFES 421
Cdd:TIGR04277 456 -HDQIQKMIKYFMDTQEKFGSWEARWGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLS 530
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 422 C-EQRRYVQSARSQVHSTCWALMGLMAVR-HPDIT--AQERGIRCLLGK-QLPNGDWPQENISGVFNKSCA-ISYTSYRN 495
Cdd:TIGR04277 531 YnDPEKWNGIGKSTVTQTSWGLLALLAVEdHNDQIkeAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQ 610
                         250
                  ....*....|
gi 1907073713 496 IFPIWALGRF 505
Cdd:TIGR04277 611 SFPLIALGRF 620
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
3-115 1.50e-08

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 55.95  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713   3 LFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPlvQSLRQELYVQDYASIDWPAQRnnvspdemYTPHSW--LLH 80
Cdd:pfam13249 140 LLPRWFPFNIYKFSSWARTTIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRYYPRP--------HRLFSWtnLFL 209
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1907073713  81 VVYGLLNLYERFHSTSLRKWAVQ-----MLyEHIAADDCF 115
Cdd:pfam13249 210 GLDRVLKLYERLPPKPLRRRALRkaeewIL-ERQEGDGGL 248
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
264-471 5.12e-08

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 53.94  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 264 IPRERLCDAVDVLLSLRNADGGFATYEkkrggyllellNPSEVFgdimidYTYVECTSAVMQALKHFHEHFPdyraaevr 343
Cdd:COG5029    16 STADFTDSHLDYLRASQNPDGGFAGRS-----------GPSDLY------STYYAVRTLALLGESPKWRDRV-------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 344 etlnqgLDFCRRKQRADGSW----EGSWGvcFTYGTWFGLEAFACMGhtyqdgAACAEVAQACNFLLSQQMADGGWGEDF 419
Cdd:COG5029    71 ------ADLLSSLRVEDGGFakapEGGAG--STYHTYLATLLAELLG------RPPPDPDRLVRFLISQQNDDGGFEISP 136
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907073713 420 esceqrryvqSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNG 471
Cdd:COG5029   137 ----------GRRSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
347-386 2.70e-07

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 47.12  E-value: 2.70e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907073713 347 NQGLDFCRRKQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 386
Cdd:pfam00432   4 EKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
398-444 3.52e-05

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 40.96  E-value: 3.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907073713 398 VAQACNFLLSQQMADGGWGEDFESCeqrryVQSARSQVHSTCWALMG 444
Cdd:pfam00432   3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
AF1543 COG1689
Class II terpene cyclase family protein AF1543 [General function prediction only];
203-362 2.64e-04

Class II terpene cyclase family protein AF1543 [General function prediction only];


Pssm-ID: 441295 [Multi-domain]  Cd Length: 272  Bit Score: 42.79  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 203 FLRLSQVPENCPDYQKYYRHMRK--GGFSFS---TLDCGWivadctaeglkAVLLLQnqcpSITEHIPRERlcDAVDVLL 277
Cdd:COG1689   127 LEALGASEPEREKIREFLLSLRRpdGGFGGKkpnLEDTYW-----------ALAALR----RLGRDLPPAD--RVIAFIL 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 278 SLRNADGGFAtyekkrggyllelLNPSevfgdimiDYTYVECTSAVMQALKHFHEHFPDYRAAevretlnqgLDFCRRKQ 357
Cdd:COG1689   190 ACQNEDGGFS-------------KTPG--------SYSDLEATYYALRALKLLGEPPKNVDKL---------LEFIASCQ 239

                  ....*
gi 1907073713 358 RADGS 362
Cdd:COG1689   240 NSDGG 244
hopene_cyclase TIGR01507
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ...
340-415 1.57e-03

squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273661 [Multi-domain]  Cd Length: 635  Bit Score: 41.03  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907073713 340 AEVRETLNQGLDFCRRKQRADGSWegswgvcftygtWFGLEAFACMG------HTYQDGAACAEVAQACNFLLSQQMADG 413
Cdd:TIGR01507  12 ARTVEAIDRAVDYLLSCQKDEGYW------------WGELESNVTIEaeyvllCHILDRVDRDRMEKIRNYLLHEQREDG 79

                  ..
gi 1907073713 414 GW 415
Cdd:TIGR01507  80 TW 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH