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Conserved domains on  [gi|1907079531|ref|XP_036012104|]
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monocarboxylate transporter 7 isoform X3 [Mus musculus]

Protein Classification

monocarboxylate transporter 7( domain architecture ID 13024518)

monocarboxylate transporter 7 (MCT7) is a proton-linked monocarboxylate transporter that catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
24-472 0e+00

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 593.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17422    81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17422   161 LVVGALQLNIVVCGALLR-------------------------------------------------------------- 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17422   179 ------------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFG 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAAG 423
Cdd:cd17422   235 RISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALG 314
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1907079531 424 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17422   315 VYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
 
Name Accession Description Interval E-value
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
24-472 0e+00

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 593.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17422    81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17422   161 LVVGALQLNIVVCGALLR-------------------------------------------------------------- 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17422   179 ------------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFG 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAAG 423
Cdd:cd17422   235 RISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALG 314
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1907079531 424 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17422   315 VYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
19-508 1.25e-88

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 279.70  E-value: 1.25e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  19 PDGGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 98
Cdd:TIGR00892  12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  99 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 178
Cdd:TIGR00892  92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 179 WRYSLLFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelTTSPKNVPSEAK- 257
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPV------------------------------------------GPSQRVSKSKSKe 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 258 -MEQETRAEQQQTLVTAPKHSQmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTM 336
Cdd:TIGR00892 210 gLPPDGSTKKLSKKSTAEKINR----FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSII 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 337 AIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVG 414
Cdd:TIGR00892 286 GFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLthLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLM--DLVG 363
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 415 IEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVRPCkkglCQNSHSGENQTDRQRG 494
Cdd:TIGR00892 364 AQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYI----NYRLLAKEQKAALERE 439
                         490
                  ....*....|....*.
gi 1907079531 495 KAL--QDIPEDFLEMD 508
Cdd:TIGR00892 440 GARdkKDAEGDSRESE 455
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-472 2.29e-34

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 133.47  E-value: 2.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRvYHMYISIGVISGLGYCFSFLPTVTILSQYFDK-RRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:COG2223    84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLrpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveLTTSPKNVPSEAKMEQETR 263
Cdd:COG2223   163 LILGILLLVVAVLAWLF--------------------------------------------LRDPPAGAAAAAKASLRDQ 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 AEqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVF 342
Cdd:COG2223   199 LE----------------------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGAL 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 343 GRIGAGFVLNREPIRKIYieLICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSA 421
Cdd:COG2223   257 GRPLGGWLSDRIGGRRVL--LIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVP--DIFPTKNAGAV 332
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907079531 422 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:COG2223   333 YGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_1 pfam07690
Major Facilitator Superfamily;
31-437 2.11e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.40  E-value: 2.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  31 FFFVEVFTYGIIKSFGVFF-NDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITAS 109
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 110 FSQRVYHMYISiGVISGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGL 188
Cdd:pfam07690  81 FASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 189 LQLNIMVCGALLRPiiiqgpgqSPKAVTLEPRREVQYMLenektrtsidsidsgvelttspknvpseakmeqetraeqqq 268
Cdd:pfam07690 160 LSLLAAVLLLLPRP--------PPESKRPKPAEEARLSL----------------------------------------- 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 269 tlvtapkhsqmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAG 348
Cdd:pfam07690 191 --------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 349 FVLNR-EPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGThiPMLAEDDVVGIEKMSSAAGVYVF 427
Cdd:pfam07690 257 RLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA--LNALVSDLAPKEERGTASGLYNT 334
                         410
                  ....*....|
gi 1907079531 428 IQSISGLAGP 437
Cdd:pfam07690 335 AGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
24-472 0e+00

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 593.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17422    81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17422   161 LVVGALQLNIVVCGALLR-------------------------------------------------------------- 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17422   179 ------------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFG 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAAG 423
Cdd:cd17422   235 RISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEDDVVGIEKMSSALG 314
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1907079531 424 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17422   315 VYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
24-472 1.81e-108

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 327.59  E-value: 1.81e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17352     1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17352    81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17352   161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17352   179 ------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVG 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAG 423
Cdd:cd17352   235 RILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILA--DLVGLEKLSNAYG 312
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1907079531 424 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17352   313 LVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
19-508 1.25e-88

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 279.70  E-value: 1.25e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  19 PDGGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 98
Cdd:TIGR00892  12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  99 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 178
Cdd:TIGR00892  92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 179 WRYSLLFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelTTSPKNVPSEAK- 257
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPV------------------------------------------GPSQRVSKSKSKe 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 258 -MEQETRAEQQQTLVTAPKHSQmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTM 336
Cdd:TIGR00892 210 gLPPDGSTKKLSKKSTAEKINR----FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSII 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 337 AIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVG 414
Cdd:TIGR00892 286 GFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLthLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLM--DLVG 363
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 415 IEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVRPCkkglCQNSHSGENQTDRQRG 494
Cdd:TIGR00892 364 AQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYI----NYRLLAKEQKAALERE 439
                         490
                  ....*....|....*.
gi 1907079531 495 KAL--QDIPEDFLEMD 508
Cdd:TIGR00892 440 GARdkKDAEGDSRESE 455
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
24-468 2.77e-79

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 253.08  E-value: 2.77e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17423     1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17423    81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPIIIQGpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17423   161 LLLSALSLHLVPCGALLRPLALPG-------------------------------------------------------- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17423   185 --------DPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVG 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAG 423
Cdd:cd17423   257 RLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPE--LVGVERVLNATG 334
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1907079531 424 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 468
Cdd:cd17423   335 LLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLIL 379
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
24-470 9.14e-63

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 209.58  E-value: 9.14e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17430     1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17430    81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17430   161 LILGGLLLNCCTCGAVMRP------------------------------------------------------------- 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17430   180 --------------------LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFA 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKIYIELICVILLTASL--FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSA 421
Cdd:cd17430   240 RPACGVVAGLKWVRPRVVYLFSFAMLFNGLtdLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMA--IVGTQKFSSA 317
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1907079531 422 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 470
Cdd:cd17430   318 IGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
24-470 3.25e-59

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 200.00  E-value: 3.25e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17425     1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17425    81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17425   161 LVFGGVLLNCCVCGAVMRPF------------------------------------------------------------ 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsvLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17425   181 -------------------------CSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFM 235
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGfVLNREPI---RKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSS 420
Cdd:cd17425   236 RPLAG-LLSGLPVfkgRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM--DTVEMDRFPS 312
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907079531 421 AAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 470
Cdd:cd17425   313 ALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
24-468 1.80e-53

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 185.02  E-value: 1.80e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17427     1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17427    81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPIiiqGPgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17427   161 LILGGLLLNCCVAGSLMRPL---GP------------------------------------------------------- 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17427   183 ------------------------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFA 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIR---------KIYIELICVILLtaslfafTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVG 414
Cdd:cd17427   239 RPSMGLVANSKWIRpriqyffsfAVMYNGVCHLLC-------PLAEDYTGLVIYAVFFGFAFGMVSSVLFETLM--DLVG 309
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907079531 415 IEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 468
Cdd:cd17427   310 AQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
24-468 2.46e-50

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 176.61  E-value: 2.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17426     1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17426    81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17426   161 LILGGLLLNCCVAGSLMRPI------------------------------------------------------------ 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtAPKhsqmkaPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17426   181 ---------GPK------PFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVA 245
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRK--IYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSA 421
Cdd:cd17426   246 RPSMGIVANTKWVRPriQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLM--DLVGAQRFSSA 323
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1907079531 422 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 468
Cdd:cd17426   324 VGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
24-472 5.67e-44

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 159.21  E-value: 5.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17424     1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17424    81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPIIIQGpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17424   161 LILGGFVLNLCVCGALMRFLLMPD-------------------------------------------------------- 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17424   185 ------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIG 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKI--YIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIgGTHIPMLAEdDVVGIEKMSSA 421
Cdd:cd17424   235 NITFGWLTDRRCLKKYryFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAY-VALIPVVTS-DVVGTSSLSSA 312
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907079531 422 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17424   313 LGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
24-471 5.79e-43

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 156.91  E-value: 5.79e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17421     1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFaVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17421    81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17421   160 LIFGGIMLNLVASGMLLRPI------------------------------------------------------------ 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkapllDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17421   180 ---------------------DFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVA 238
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAG 423
Cdd:cd17421   239 QLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLV--DLVGVTKVNSSLG 316
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1907079531 424 VYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 471
Cdd:cd17421   317 FSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLE 364
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-472 2.29e-34

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 133.47  E-value: 2.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRvYHMYISIGVISGLGYCFSFLPTVTILSQYFDK-RRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:COG2223    84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLrpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveLTTSPKNVPSEAKMEQETR 263
Cdd:COG2223   163 LILGILLLVVAVLAWLF--------------------------------------------LRDPPAGAAAAAKASLRDQ 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 AEqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVF 342
Cdd:COG2223   199 LE----------------------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGAL 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 343 GRIGAGFVLNREPIRKIYieLICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSA 421
Cdd:COG2223   257 GRPLGGWLSDRIGGRRVL--LIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVP--DIFPTKNAGAV 332
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907079531 422 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:COG2223   333 YGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
24-472 5.59e-33

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 129.70  E-value: 5.59e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17355     1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGY-CFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYS 182
Cdd:cd17355    81 GLVLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 183 LLFVGLLQLNIMVcgallrpiiiqgpgqspkAVTLEPRREvqymlenektrtsidsidsgvelttspknvPSEAKMEQET 262
Cdd:cd17355   161 LLVLALLALLVLV------------------PVLLLLRRR------------------------------PADLALRAYD 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 263 RAEQQQTLVTAPKhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVF 342
Cdd:cd17355   193 DASPASPGSTLKE------------ALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIV 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 343 GRIGAGFVLNRepIRKIYIELICVILLTASLFAFTFATE-FWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSA 421
Cdd:cd17355   261 GRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGWGATVPLTAALAAR--YFGARSYGTL 336
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907079531 422 AGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAgMCLAAVCLALVR 472
Cdd:cd17355   337 FGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVA-LGLIAALLVLPI 386
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
24-473 8.23e-32

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 125.71  E-value: 8.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17429     1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17429    81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17429   161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLSTMAIAEVF 342
Cdd:cd17429   179 ------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIF 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 343 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggTHIPMLAEdDVVGIEKMSSAA 422
Cdd:cd17429   235 GKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYF--SLMPVVTE-DLVGIKNLANAY 311
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907079531 423 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLaLVRP 473
Cdd:cd17429   312 GIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICL-LLKP 361
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
24-470 3.94e-31

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 123.77  E-value: 3.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17428     1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17428    81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17428   161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqqtlvtapkhsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAF-LLSTMAIAEVF 342
Cdd:cd17428   179 ------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAI 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 343 GRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGgthIPMLAEDDVVGIEKMSSAA 422
Cdd:cd17428   235 GKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS---IFPYVTTKTVGIEKLGHAY 311
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1907079531 423 GVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLAL 470
Cdd:cd17428   312 GILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
21-473 1.52e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 116.51  E-value: 1.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  21 GGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLL 100
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 101 ISLGMITASFSQRVYHMYISIgVISGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGW 179
Cdd:COG2271    85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 180 RYSLLFVGLlqlnIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakme 259
Cdd:COG2271   164 RAAFLILGL----PGLLLALLR---------------------------------------------------------- 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 260 qetraeqqqtlvtapkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLYIIP-LGISLGIDPDRAAFLLSTMAI 338
Cdd:COG2271   182 ----------------------------------FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFL 227
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 339 AEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKM 418
Cdd:COG2271   228 AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE--LFPKKAR 305
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907079531 419 SSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRAFYSCAAGMCLAAVCLALVRP 473
Cdd:COG2271   306 GTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLR 359
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
44-473 6.01e-28

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 115.36  E-value: 6.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  44 SFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYISIGV 123
Cdd:COG2807    36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 124 IsGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAvFAFAPAITA-LKEHIGWRYSLLFVGLLQLNIMVcgaLLRP 202
Cdd:COG2807   116 I-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLG-AALAAGLTVpLAAALGWRGALAVWALLALLALL---LWLP 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 203 IIIQGPGQSPKAVTLEPRRevqymlenektrtsidsidsgvelttspknvpseakmeqetraeqqqtlvtapkhsqmkap 282
Cdd:COG2807   191 LLRRRPAAAAAAPAAASLR------------------------------------------------------------- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 283 lldfSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIe 362
Cdd:COG2807   210 ----SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLL- 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 363 LICVILLTASLFAFTFATEFWgLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvgiekmSSAAGVYVFIQSISGL---AG 436
Cdd:COG2807   285 LLLGLLGLAGLLGLLLAPGSL-PWLWAVLLGLGQGglfPLALTLIGLRARTP-------AEAAALSGMAQSVGYLlaaLG 356
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1907079531 437 PPLAGLLVDQSKIYSRAFYSCAAGMCLAAVC-LALVRP 473
Cdd:COG2807   357 PLLVGALHDATGSWTAALLLLAALAVLMLVAgLLAGRP 394
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
24-471 5.88e-27

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 112.62  E-value: 5.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF-----DESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 98
Cdd:cd17420     1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  99 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 178
Cdd:cd17420    81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 179 WRYSLLFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveLTTSPKNVPSEAKM 258
Cdd:cd17420   161 LEGTLRVLSLFMFVLILCSFTYRP------------------------------------------LHPSPEDPKSKPGR 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 259 EQETRAeqqqtlvtapKHSQMKApLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAI 338
Cdd:cd17420   199 RTLHSR----------INLFLRK-IFNVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGI 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 339 AEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEK 417
Cdd:cd17420   268 TSGIGRLIFGVIADMPPgVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFE--LVGPSG 345
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907079531 418 MSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 471
Cdd:cd17420   346 ASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
24-471 9.37e-24

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 102.88  E-value: 9.37e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17314     1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 104 GMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17314    81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqetr 263
Cdd:cd17314   161 TILGILAAIVLSVVSLLGF------------------------------------------------------------- 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeQQQTLVTAPKHSQMKAPLLDFSVLKEKSF-ICYALFGLFATlGFFAPSLYIIPLGISLGID-PDRAAFLLSTMAIAEV 341
Cdd:cd17314   180 --KEPPDNQARLHVQKKKTQTMGEIFRDKVFwILFIAIFLVLI-GGFLFIANMASLVRSLQLDaPSFVTKLMSIYGLFNA 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 342 FGRIGAGFVLNREpIRKIYIELICVILLTASLFAFTFATEF--WGLMLCSVFFGSMVGtiGGTHIPMLAEDDVVGIEKMS 419
Cdd:cd17314   257 FGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYG--GLFTVYPATVSTVFGTESFA 333
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907079531 420 SAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 471
Cdd:cd17314   334 TLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
25-471 1.53e-23

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 102.30  E-value: 1.53e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVeVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:cd17353     3 WLVLLGAVLM-HLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLL 184
Cdd:cd17353    82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 185 FVGLLQLNIMVCGALLrpIIIQGPGQSPKAVTleprrevqymlenektrtsidsidsgvelttsPKNVPSEAKMEQETRA 264
Cdd:cd17353   162 ILGIIFLIIIVIGAFL--IRDPPKGWVPPGVD--------------------------------PLANNAENSPRDYTPR 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 265 EqqqtlvtapkhsqmkaplldfsVLKEKSFIC-YALFGLFATLGFFAPSlYIIPLGISL-GIDPDRAAFLLSTMAIAEVF 342
Cdd:cd17353   208 E----------------------MLRTPTFWLlWLMFFLNATAGLMLIG-QAKPIGQEFaGLDAGIAALAVSILSIFNGG 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 343 GRIGAGFVLNREPIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAA 422
Cdd:cd17353   265 GRPFWGWLSDKIGRKNTLS-IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTA--DFFGTKNAGTNY 341
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1907079531 423 GVYVFIQSISGLAGPPLAGlLVDQSKIYSRAFYSCAAGMCLAAVCLALV 471
Cdd:cd17353   342 GLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALLL 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
25-433 2.12e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 98.51  E-value: 2.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVeVFTYGIIksfGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:COG2814    13 LALALGAFLS-GLGIGIV---LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRVYHMYISiGVISGLGYCFSFLPTVTILSQYFD-KRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:COG2814    89 SLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpseakmeqETR 263
Cdd:COG2814   168 LVNAVLALLALLLLLRLLP----------------------------------------------------------ESR 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 AEQQQTLVTAPKHsqmkaplldfsVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVF 342
Cdd:COG2814   190 PAARARLRGSLRE-----------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVL 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 343 GRIGAGFVLNREPIRKIYIelICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAA 422
Cdd:COG2814   259 GALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE--LAPPEARGRAS 334
                         410
                  ....*....|.
gi 1907079531 423 GVYVFIQSISG 433
Cdd:COG2814   335 GLYNSAFFLGG 345
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
31-468 6.28e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 94.42  E-value: 6.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  31 FFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASF 110
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 111 SQRVYHMYIsIGVISGLGYCFSFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLL 189
Cdd:cd06174    81 APSFWLLLL-GRFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 190 QLNIMVCGALLRPIiiqgpgqspkavtLEPRREVQYMLENEKTRTSIDSIdsgvelttspknvpseakmeqetraeqqqt 269
Cdd:cd06174   160 ALALLAAILLLLVV-------------PDPPESARAKNEEASSKSVLKLL------------------------------ 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 270 lvtapkhsqmkaplldFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAG 348
Cdd:cd06174   197 ----------------KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLG 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 349 FVLNREPIRK--IYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTiggthIPMLAEDDVVGIEKMSSAAGVYV 426
Cdd:cd06174   261 LLSDRLIGRKplLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP-----LSFALIAELFPPEIRGTAFGLLN 335
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1907079531 427 FIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCL 468
Cdd:cd06174   336 TFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_1 pfam07690
Major Facilitator Superfamily;
31-437 2.11e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.40  E-value: 2.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  31 FFFVEVFTYGIIKSFGVFF-NDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITAS 109
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 110 FSQRVYHMYISiGVISGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGL 188
Cdd:pfam07690  81 FASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 189 LQLNIMVCGALLRPiiiqgpgqSPKAVTLEPRREVQYMLenektrtsidsidsgvelttspknvpseakmeqetraeqqq 268
Cdd:pfam07690 160 LSLLAAVLLLLPRP--------PPESKRPKPAEEARLSL----------------------------------------- 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 269 tlvtapkhsqmkapLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAG 348
Cdd:pfam07690 191 --------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLG 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 349 FVLNR-EPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGThiPMLAEDDVVGIEKMSSAAGVYVF 427
Cdd:pfam07690 257 RLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA--LNALVSDLAPKEERGTASGLYNT 334
                         410
                  ....*....|
gi 1907079531 428 IQSISGLAGP 437
Cdd:pfam07690 335 AGSLGGALGP 344
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
24-455 2.35e-18

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 87.16  E-value: 2.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF-DESNS----KISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 98
Cdd:cd17464     1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgSKDDAqmrfKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  99 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 178
Cdd:cd17464    81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 179 WRYSLLFVGLLQLNIMVCGALLRPIIiqgpgqspkavtlePRREvqymlenektrtsiDSIDSGVELTTSPKNvpseakm 258
Cdd:cd17464   161 LFNTLRVLCIFMFVLFLAGFTYKPLV--------------PMKK--------------DKEGKKRKFKCPPLK------- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 259 eqetraeqqqtlvtapkhsqmkaPLLDFSVLKEKSFICYAlFGLFATL-GFFAPSLYIIPLGISLGIDPDRAAFLLSTMA 337
Cdd:cd17464   206 -----------------------KIFNFNIWKSTGYRIWA-FGIPAALfGYFVPYVHLMNHVKERFGEDVNKEVLLMCIG 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 338 IAEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIE 416
Cdd:cd17464   262 ITSGIGRLIFGRVADYIPgVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFE--LVGAQ 339
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1907079531 417 KMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFY 455
Cdd:cd17464   340 NVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFY 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
32-472 2.13e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.78  E-value: 2.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  32 FFVEVFTYGIIksfGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFS 111
Cdd:cd17325     5 LFLDMLGYGII---IPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 112 QRVYHMYISIgVISGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGEcFAVFAFAPAI-TALKEHIGWRYSLLFVGLL 189
Cdd:cd17325    82 TSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAI-GLGFLIGPLLgGLLADALGYRAPFLVCAAL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 190 QLNIMVCGALLRPiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknvpsEAKMEQETRAEQQQT 269
Cdd:cd17325   160 ALLALVLALLLLP----------------------------------------------------EPRPPPNKRAVSAAR 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 270 LVTAPKHSQMKAPLLdfsvlkeksFICYALFGLFATLGFFAP--SLYIIPLGislGIDPDRAAFLLSTMAIAEVFGRIGA 347
Cdd:cd17325   188 LRSGLRLLLRDRRLL---------ALFLAIFVLAFAFGALEPflPLYAAELG---GLSPAQIGLLFGAQGLASALSQPPA 255
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 348 GFVLNRePIRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVF 427
Cdd:cd17325   256 GKLSDR-IGRKPLI-LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA--DIVPPEGRGTAMGLFNT 331
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1907079531 428 IQSISGLAGPPLAGLLVDQSKIYSrAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17325   332 AFSLGMVLGPLLGGFLYDAFGFAT-PFLAAAALLLLAAVLFLLLR 375
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
24-455 3.86e-13

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 70.98  E-value: 3.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  24 GWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNS-----KISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGG 98
Cdd:cd17465     1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDqavqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  99 LLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIG 178
Cdd:cd17465    81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 179 WRYSLLFVGLLQLnimvcgallrpiiiqgpgqspkavtleprreVQYMLEnektrtsidsidsgvelttspknvpseakm 258
Cdd:cd17465   161 LAHTFQVLSLFMF-------------------------------IQIFLS------------------------------ 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 259 eqetraeqqqtlvtapkhsqmkaplLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAI 338
Cdd:cd17465   180 -------------------------LTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGA 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 339 AEVFGRIGAGFVLNREP-IRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEK 417
Cdd:cd17465   235 SSGIGRLMSGKIGDLIPgLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFE--LVGPMQ 312
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1907079531 418 MSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFY 455
Cdd:cd17465   313 ASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFY 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
292-473 2.41e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.08  E-value: 2.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 292 KSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTA 371
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--LLGLLLFAL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 372 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYS 451
Cdd:COG2814    88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIA--DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
                         170       180
                  ....*....|....*....|..
gi 1907079531 452 rAFYSCAAGMCLAAVCLALVRP 473
Cdd:COG2814   166 -VFLVNAVLALLALLLLLRLLP 186
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
52-469 5.41e-11

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 64.18  E-value: 5.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  52 LMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRvYHMYISIGVISGLGYCF 131
Cdd:cd17475    22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVGAGYGS 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 132 SFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLLqlnIMVCGALlrpiiiqgpgq 210
Cdd:cd17475   101 VQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV---SILAAVL----------- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 211 spkavtleprrevqYMLenektrtsidsidsgvelttspknvpseakMEQETRAEQQQTLVTAPKHSQMKAPLLDFSVLK 290
Cdd:cd17475   167 --------------FWL------------------------------FYREPPAASAATESASTLLRSLKEVLRNRDVWL 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 291 eksfICYALFGL----FATLGFFapslyIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNR--EPIRKIYIELI 364
Cdd:cd17475   203 ----IAIAGALLvapqFALLTFL-----LLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVIT 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 365 -CVILLTASLFAF-TFATEFWGLMLCSVFFGsmVGTIG--GTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLA 440
Cdd:cd17475   274 aAIAAAALLVLSLlSPGTPLWLLVLLLILLG--LFAIGwnGLYLTLVAE--SAGPEQAGTALGLANTINFIGIAIGPPLF 349
                         410       420
                  ....*....|....*....|....*....
gi 1907079531 441 GLLVDQSKIYSRAFYSCAAGMCLAAVCLA 469
Cdd:cd17475   350 GLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
51-467 1.35e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.95  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  51 DLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRvYHMYISIGVISGLGYC 130
Cdd:cd17324    24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-FALLLLARALAGLAHG 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 131 FSFLPTVTILSQYFDK-RRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLLQLNIMVCGALLRPiiiqgPG 209
Cdd:cd17324   103 GFWAIAAAYAADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLP-----SL 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 210 QSPKAVTLEPRREVQYMLENEKTRTSIdsidsgvelttspknvpseakmeqetraeqqqtLVTApkhsqmkaplldfsvl 289
Cdd:cd17324   178 PPKKPGSLGLLSSLLLLLRNPRLRLAY---------------------------------LITF---------------- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 290 keksFICYALFGLFATLGFFAPSLYiiplgislGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyieLICVILL 369
Cdd:cd17324   209 ----LLFGGFFALYTYLAPFLTDVP--------GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL---LIALLLL 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 370 TASLFAFTFATEFW-----GLMLCSVFFGSMVgTIGGTHIPMLAEDDVvgiekmSSAAGVYVFIQSISGLAGPPLAGLLV 444
Cdd:cd17324   274 AAALLLLTLLGPSPllllvGLVLWGLGFFAAH-SALQTRVLRLAPEAR------GLASSLYLAAYNLGGALGAALGGLVL 346
                         410       420
                  ....*....|....*....|...
gi 1907079531 445 DQSKiYSRAFYSCAAGMCLAAVC 467
Cdd:cd17324   347 DHGG-WAGVGWVGAALLLLALLL 368
MFS_1 pfam07690
Major Facilitator Superfamily;
294-473 4.00e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.28  E-value: 4.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 294 FICYALFGLFATLgffAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 373
Cdd:pfam07690   2 FLAAFLAALGRSL---LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL--IGLLLFALGL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 374 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSrA 453
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA--DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-A 153
                         170       180
                  ....*....|....*....|
gi 1907079531 454 FYSCAAGMCLAAVCLALVRP 473
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP 173
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
52-471 4.45e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 61.43  E-value: 4.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  52 LMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRvYHMYISIGVISGLGYCF 131
Cdd:cd17474    25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS-FALLLAGRALQGIGAAG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 132 SFLPTVTILSQYF--DKRRSVV---TAVASTGEcfavfAFAPAITALKEHIGWRYSLLFVGLLQLNIMVCGALLRPiiiq 206
Cdd:cd17474   104 LGPLALTLIGDLFegGERAKAMglyEAALGLGI-----AVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLP---- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 207 gpgqspkavtlEPRREVQymlenektrtsidsidsgvelttspknvpseakmeqetraEQQQTLVTAPKHSQMKAPLLDF 286
Cdd:cd17474   175 -----------EPKEKAK----------------------------------------SSSATKLRDLKKALRGRGLLTF 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 287 SVLkekSFICYalFGLFATLGFFApslyiIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREpIRKIYIELICV 366
Cdd:cd17474   204 LVS---AFLYF--FLYFAFLTYLP-----FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR-FGARRILVIGL 272
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 367 ILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQ 446
Cdd:cd17474   273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE--LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
                         410       420
                  ....*....|....*....|....*
gi 1907079531 447 SKIYSrAFYSCAAGMCLAAVCLALV 471
Cdd:cd17474   351 FGLSA-PFLVGAAIALAAAVLLALL 374
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
23-471 8.26e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 60.64  E-value: 8.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  23 WGWAVAVSFFFvevFTYGII-KSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLI 101
Cdd:COG0738     7 RRALIAIYLLF---FLWGFAtALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 102 SLGMITASFSQRVYHMYISIGVIsglGYCFSFL-----PTVTILSQyfDKRRSVVT---AVASTGECFAVFAFApAITAL 173
Cdd:COG0738    84 ALGLLLFALAPSYPLLLLALFLL---GLGLGLLdvaanPYVAALGP--ETAASRLNllhAFFSLGALLGPLLGG-LLILL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 174 KEHIGWRYSLLFVGLLQLnIMVCGALLRPIiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttsPKNVP 253
Cdd:COG0738   158 GLSLSWHLPYLILAVLLL-LLALLFLRSKL---------------------------------------------PEIEE 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 254 SEAKMEQETRAEqqqtlvtapkhsqmkaplldFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFL 332
Cdd:COG0738   192 EEEEAAGSAASL--------------------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALG 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 333 LSTMAIAEVFGRIGAGFVLNREPIRKIYI--ELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTI---GGTHIPML 407
Cdd:COG0738   252 LSLFWGGMTIGRFLGGFLLKRFGPVRLLRlsALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIfslALDGLGKR 331
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907079531 408 AeddvvgiekmSSAAGVYVFIQSISGLAGPPLAGLLVDQskiysrafYSCAAGMCLAAVCLALV 471
Cdd:COG0738   332 T----------AAAVSAVLIMGIVGGAIGPPLIGFLADA--------FGLRAAFLVPLVCYLLI 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
295-473 3.77e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 58.36  E-value: 3.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 295 ICYALFGLFATLGFFAPslyIIPLGI-SLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASL 373
Cdd:cd17325     1 LSLALFLDMLGYGIIIP---ILPLYAeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLL--LGLLLLAVST 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 374 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 453
Cdd:cd17325    76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIA--DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAP 152
                         170       180
                  ....*....|....*....|
gi 1907079531 454 FYSCAAGMCLAAVCLALVRP 473
Cdd:cd17325   153 FLVCAALALLALVLALLLLP 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
274-445 3.97e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 58.76  E-value: 3.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 274 PKHSQMKAPLLDF--SVLKEKSFICYALFGLFATLGFFAPSLYIIPLGIS-LGIDPDRAAFLLSTMAIAEVFGRIGAGFV 350
Cdd:COG2211   208 PVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRL 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 351 LNREPIRKIYIelICVILLTASLFAFTFA--TEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVV-------GIEKMSSA 421
Cdd:COG2211   288 AKRFGKKKAFI--IGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLA--DVVdydewktGRRREGLY 363
                         170       180
                  ....*....|....*....|....
gi 1907079531 422 AGVYVFIQSISGLAGPPLAGLLVD 445
Cdd:COG2211   364 FGIFTFAIKLGQALAGALAGLLLA 387
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
25-471 1.44e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.81  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRVYHMYIsIGVISGLGYCFSFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17319    82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 184 LFVGLLQLnIMVCGALLRpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgvelttspknVPseakmeqetr 263
Cdd:cd17319   161 IIEGLLGL-LLAVLWWFY--------------------------------------------------LR---------- 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 264 aeqqQTLVTApkhsqmkaplldfsvlkeksFICYALFGLFATLGFFAPSLyiipLGISLGIDPDRAAFLLSTMAIAEVFG 343
Cdd:cd17319   180 ----QVWGLA--------------------LGYFGINYALYGLLTWLPTY----LKQARGFSLKQVGLLAAIPFLAGAIG 231
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 344 RIGAGFVLNR-EPIRKIYIELICVILLTASLFAFTFATEFWG--LMLCSVFFGSMVGTIGGTHIPMlaedDVVGIEKMSS 420
Cdd:cd17319   232 MILGGRLSDRlLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVavILLSLAGFGIGAASPVFWSLPA----DLLPGEAAAT 307
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907079531 421 AAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALV 471
Cdd:cd17319   308 AGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
23-189 3.26e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 55.20  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  23 WGWAVAVSF-FFVEVFTYGIIksfGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLI 101
Cdd:COG0477    13 RRALLALALgTFLEGLDFTIV---NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 102 SLGMITASFSQRVYHMYISIgVISGLGYCFSFLPTVTILSQYFDKRR-----SVVTAVASTGecfavFAFAPAIT-ALKE 175
Cdd:COG0477    90 GLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFPARErgralGLWGAAIGLG-----LALGPLLGgLLVA 163
                         170
                  ....*....|....
gi 1907079531 176 HIGWRYSLLFVGLL 189
Cdd:COG0477   164 ALGWRWIFLINAPL 177
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
298-469 3.96e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 55.26  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 298 ALFGLFATlGFFAPSLY-IIPL-GISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPiRKIYIELICVILLTASLFA 375
Cdd:cd17477   193 ALLGAFVA-GFLEGAFYsLLPLyGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD-RRRVLLGCALLGALAALLL 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 376 FTFATEFWGLMLCSVFFGSMVG---TIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiySR 452
Cdd:cd17477   271 PLVPGLPLALLVLLFLWGGAAGplyTLALALA-----GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG--PH 343
                         170
                  ....*....|....*..
gi 1907079531 453 AFYSCAAGMCLAAVCLA 469
Cdd:cd17477   344 GLFLFLAAVALLFLLFL 360
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
37-471 6.19e-08

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 54.63  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  37 FTYGIIKSF-GVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVY 115
Cdd:cd17333     6 FSNGLTDALlGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 116 HMYISIGVIsglGYCFSFLPT------VTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALkehIGWRYSLLFVGLL 189
Cdd:cd17333    86 LFVVLMFLA---GLGAGILDTgantfvGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSE---LSWSWAYLIIGLI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 190 QLNIMVCgallrpiiiqgpgqspkavtleprrevqymlenektrtsidsidsgveltTSPKNVPSEAKMEQETRAEQQQT 269
Cdd:cd17333   160 YLLLAIL--------------------------------------------------ILLTLFPELPSARNPQQSVGAFS 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 270 LVTAPKHSQMKapLLDFSVLkeksFICYAlfGLFATLGFFAPSLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGF 349
Cdd:cd17333   190 ASASRLLRNPS--IILGALA----LFLYV--GAETAFSSWVPSYLVEKKHVSDGL----AGYLLSGFWVGITIGRLLGGP 257
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 350 VLNREPIRKiYIELICV---ILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIekmssaaGVYV 426
Cdd:cd17333   258 ISRRIKPHT-LLVLSGSgalLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGT-------SVLL 329
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1907079531 427 FIQSISGLAGPPLAGLLVDQSKIYSraFYSCAAGMCLAAVCLALV 471
Cdd:cd17333   330 AAGSIGGAIIPFIMGFIAEAVGIQT--AMLLITILYAIIFVLALL 372
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
25-191 1.72e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.35  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSfdeSNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:cd17325   202 LALFLAIFVLAFAFGALEPFLPLYAAELGGL---SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRVYHMYISIgVISGLGYCFSFLPTVTILSQYFDKR-RSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17325   279 LLLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPPEgRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357

                  ....*...
gi 1907079531 184 LFVGLLQL 191
Cdd:cd17325   358 LAAAALLL 365
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
297-473 2.25e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.20  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 297 YALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAf 376
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 377 tFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSR-AFY 455
Cdd:cd06174    80 -FAPSFWLLLLGRFLLGLGSGLIDPAVLALIA--DLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFL 156
                         170
                  ....*....|....*...
gi 1907079531 456 SCAAGMCLAAVCLALVRP 473
Cdd:cd06174   157 IAAALALLAAILLLLVVP 174
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
271-471 1.57e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.29  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 271 VTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDpdRAAFLLSTMAIAEVFGRIGAGFV 350
Cdd:cd17489   173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKL 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 351 LNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIggthIPMLAED--DVVGIEKMSSAAGVYVFI 428
Cdd:cd17489   251 SDR--KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLL----FPALQALavDLVPPHRRGAANGTFFIF 324
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907079531 429 QSISGLAGPPLAGLLVDQSKiYSRAFYSCAagmCLAAVCLALV 471
Cdd:cd17489   325 FDLGIGLGGLLLGLVAELFG-YRAMFLLAA---VVVLLALVLY 363
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
297-473 2.79e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.47  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 297 YALFGLFATLGFFAPSL--YIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLF 374
Cdd:COG0738    11 IAIYLLFFLWGFATALWgpLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL--LGLLLMALGLL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 375 AFTFATEFWGLMLCSVFFGSMVG---TIGGTHIPMLAEDDvvGIEKMSSAAGVYvfiqSISGLAGPPLAGLLVDQSKIYS 451
Cdd:COG0738    89 LFALAPSYPLLLLALFLLGLGLGlldVAANPYVAALGPET--AASRLNLLHAFF----SLGALLGPLLGGLLILLGLSLS 162
                         170       180
                  ....*....|....*....|...
gi 1907079531 452 -RAFYSCAAGMCLAAVCLALVRP 473
Cdd:COG0738   163 wHLPYLILAVLLLLLALLFLRSK 185
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
281-446 3.58e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 49.11  E-value: 3.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 281 APLLDFSVLKEKSFICYALFGLFATLGFFApSLYIIP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK 358
Cdd:cd17503   167 APLLDLRLFKDRNFTLGLLLSFLLGLGLFG-AMFLLPlyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRL 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 359 IYIelICVILLTASLFAFTFATE---FWGLMLCSVFFGSMVG-------TIGGTHIPMlaeddvvgiEKMSSAAGVYVFI 428
Cdd:cd17503   246 LLL--AGLLLLALGTLLLAFLTPdtsLWLIILPLFIRGLGMGlvfmplnTLALNSLPP---------EQIGDATALFNTI 314
                         170
                  ....*....|....*...
gi 1907079531 429 QSISGLAGPPLAGLLVDQ 446
Cdd:cd17503   315 RQLGGSIGTALLATLLTN 332
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
299-473 4.59e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 48.70  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 299 LFGLFATLGFFAPSLYII-----PLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASL 373
Cdd:cd17324     1 LLALALAAFAIGTTEYVIqgllpDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLL--LVLLLLFILGN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 374 FAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYSRA 453
Cdd:cd17324    79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA--DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAA 155
                         170       180
                  ....*....|....*....|
gi 1907079531 454 FYSCAAGMCLAAVCLALVRP 473
Cdd:cd17324   156 FLAIAVLALLAALLLWRLLP 175
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
287-472 8.19e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.99  E-value: 8.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 287 SVLKEKSFICYALFGLFATLGFFAPSLYI-IPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelIC 365
Cdd:cd17329   195 IVLRDRAFLLFLLASFLISLIYFQLESTLpVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILM--IG 272
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 366 VILLTASLFAFTFATEFWGLMLCSVFFgSMVGTIGGTHIPMLAeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVD 445
Cdd:cd17329   273 ILLFAIGFAVLAFANTLAVLILAMIVL-TLGEMLVFPAVQTLV-AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD 350
                         170       180
                  ....*....|....*....|....*..
gi 1907079531 446 QSkIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17329   351 LL-GPGLPWLILAALGLIAAALLLGLQ 376
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
71-470 9.90e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 48.00  E-value: 9.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  71 VFVLTFT--APLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYIS-IGVISGLGYCFSFLPTvtILSQYFDK- 146
Cdd:cd17328    42 VFIISYMvlSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFrALVGIGEASYSPIAPT--IIADLFPKe 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 147 RRSVVTAV---ASTGECFAVFAFAPAITALKehIGWRYSLLFVGLLQLnimVCGALLrpiiiqgpgqspKAVTLEPRREV 223
Cdd:cd17328   120 KRTRALGVfyfAIPLGSGLGYVVGGLVAQAT--GGWRWAFRVTGVLGV---LLAILL------------LLFVREPPRGA 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 224 qymlenektrtsidsIDSGVELTTSPKNVPSEAKMeqetraeqqqtlvtapkhsqmkaplldfsVLKEKSFICYAL---F 300
Cdd:cd17328   183 ---------------AEGGVMAKSTATSFLADLKA-----------------------------LAKNPSFILSTLgftA 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 301 GLFAT--LGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIE-LICVILLTASLFAFT 377
Cdd:cd17328   219 VSFVTgaLAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADpLVCAVGLLAAAPFLF 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 378 FATEF--------WGLMLCSVFFGSMvgtiggTHIPMLAEDDVVGIEKM-SSAAGVYVFIQSISGLAGPPLAG-----LL 443
Cdd:cd17328   299 LALVLalsnlllaWVLLFLGEFLLSL------NWAPVFAILLYVVIPTRrSTASAIQILLSHLLGDAGSPYLIglisdLL 372
                         410       420
                  ....*....|....*....|....*..
gi 1907079531 444 VDQSKIYSRAFYSCAAGMCLAAVCLAL 470
Cdd:cd17328   373 RQNKDSPLAEAASLQYALLLCSFVLVL 399
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
299-468 1.27e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 47.54  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 299 LFGLFATLGFFAPSLYII--PLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKiyieLICVILLTASLF 374
Cdd:cd17471   203 LLFAAFTLLFAANSMYIIamPLYVTneLGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR----LLLAGFLAGVLF 278
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 375 --AFTFATEFWGLMLCSVFFGSMVGTIGGthIPMLAEDDVVGiEKMSSAAGVYVFIQSISGLAGPPLAGLLVdQSKIYSR 452
Cdd:cd17471   279 ylGLALATSLWQLIALQLLNAIFIGITAG--LGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIA-QYFGYRA 354
                         170
                  ....*....|....*.
gi 1907079531 453 AFYSCAAGMCLAAVCL 468
Cdd:cd17471   355 VFLVCAVLALLALVLL 370
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
25-191 1.91e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 46.88  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:cd17312     2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRVYHMYISIGViSGLGYCFSFLPTVTILSQYF-DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSL 183
Cdd:cd17312    82 NIFMGFSTSLWFFAVLWGL-NGLFQSMGWPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160

                  ....*...
gi 1907079531 184 LFVGLLQL 191
Cdd:cd17312   161 LVPGIVGL 168
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
295-475 2.25e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.82  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 295 ICYALFGLFATLGFFAP--SLYIIPLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTAS 372
Cdd:cd17489     1 ILLANFFFFLSFYLLLPvlPLYAHDLGGSEAV----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLL--LIGLLIFALA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 373 LFAFTFATEFWGLMLCSVFFG---SMVGTIGGTHIpmlaeDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkI 449
Cdd:cd17489    75 TLLYLLATSVALLLVLRLIHGigwGAFTTAAATLV-----ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-G 148
                         170       180
                  ....*....|....*....|....*.
gi 1907079531 450 YSRAFYSCAAgmcLAAVCLALVRPCK 475
Cdd:cd17489   149 FAVLFIVAAV---LALLALLLVFLVK 171
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
286-447 2.63e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 46.41  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 286 FSVLKEKSFICYALFGLFATLGFF-----APSLYIIPLGISlgidPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY 360
Cdd:cd17320   195 KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIEQLGLS----PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 361 IE---LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGG--THIPMLAEDDVVGiekmsSAAGVYVFIQSISGLA 435
Cdd:cd17320   271 RLgllLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPnaTSLALEPFPHVAG-----TASALLGFLQFLIGAL 345
                         170
                  ....*....|..
gi 1907079531 436 GPPLAGLLVDQS 447
Cdd:cd17320   346 AGALVGLLPNGT 357
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
301-466 3.42e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.07  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 301 GLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLFAFTFAT 380
Cdd:cd06173   218 ALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL--IGALLLGLALLVLGLSP 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 381 EFWGLMLCSVFFGSMVGTIG---GTHIPMLAEDDVVGiekmsSAAGVYVFIQSISGLAGPPLAGLLVDQSKIySRAFYSC 457
Cdd:cd06173   296 SLWLLLAALFLLGLAGGLFNvplNTLLQLRVPDELRG-----RVFSVYNALNSGAMPLGALLAGLLADALGL-SAVFLLA 369

                  ....*....
gi 1907079531 458 AAGMCLAAV 466
Cdd:cd06173   370 GALLLLAAL 378
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
42-191 3.56e-05

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 46.03  E-value: 3.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  42 IKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQrVYHMYI-- 119
Cdd:cd17339    15 ITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGG-IALLFLgt 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 120 -----SIGVISGLgycfsfLPTVtiLSQYFDKRRSVVTAVASTGECFAVfAFAPAIT---ALKEHIGWRYSLLFVGLLQL 191
Cdd:cd17339    94 alagaGIAVGNVL------LPSL--IKRDFPRRVGLMTGLYTTSMNLGA-ALASGLSvplAQALGGGWRGALAIWALPAL 164
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
293-474 3.87e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 45.68  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 293 SFICYALFGLFATLGFFAPSLYIIPLGISL---------------------GIDPDRAAFLLSTMAIAEVFGRIGAGFVL 351
Cdd:cd17390   153 ALLCSAIFILNAGLVWFLLSKLWDLLLVRFlmgfsvllfrsnfslyleerfDLSPKTIGYLISYSGVLGALSGFLVGRIL 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 352 NREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFgSMVGTIGGTHIPMLaEDDVVGIEKMSSAAGVYVFIQSI 431
Cdd:cd17390   233 KLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPL-SISSAVLRTCSTSL-LLSRGKSKERGTLLGVGQSVTSL 310
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907079531 432 SGLAGPPLAGLLVDQSKIYSRAFyscAAGMCLAAVCLALVRPC 474
Cdd:cd17390   311 ARILAPLLSGLLQEFSVSGPGLL---GAVLALAAILLMLARQR 350
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
281-473 4.18e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 45.65  E-value: 4.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 281 APLLDFSVLKEKSFICYALFGLFATLGFFA-----PSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP 355
Cdd:cd17504   166 VPLIDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 356 IRKIYIeLICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLA 435
Cdd:cd17504   246 PRRVLL-IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVE--SVPPDRTGIATGMNTVLRTIGSAI 322
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907079531 436 GPPLAGLLVDQSKI------------YSRAFYSCAAgMCLAAVCLALVRP 473
Cdd:cd17504   323 GPAIAGAILTTYTVsitsggvptegaYVLAFLIGAA-LALAALLLSLLIP 371
2_A_01_02 TIGR00880
Multidrug resistance protein;
76-202 6.50e-05

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 43.02  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  76 FTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYISiGVISGLGYCFsFLPTVTIL--SQYFDKRRSVVTA 153
Cdd:TIGR00880  13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAF-ALVAGAALiaDIYPPEERGVALG 90
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907079531 154 VASTGeCFAVFAFAPAITA-LKEHIGWRYSLLFVGLLQLNIMVCGALLRP 202
Cdd:TIGR00880  91 LMSAG-IALGPLLGPPLGGvLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
25-201 7.02e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.23  E-value: 7.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVeVFTYGIIKSFGVFFndLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLG 104
Cdd:COG0738   213 LLGGLAIFLY-VGAEGAIGDWLPLY--LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 105 MITASFSQRVYHMYISIgVISGLGYCFSFlPTV-TILSQYFDKRR----SVVTAVASTGecfavFAFAPAIT-ALKEHIG 178
Cdd:COG0738   290 LLLALLAPGPWLALIGL-ALVGLGLSLMF-PTIfSLALDGLGKRTaaavSAVLIMGIVG-----GAIGPPLIgFLADAFG 362
                         170       180
                  ....*....|....*....|...
gi 1907079531 179 WRYSLLFVGLLQLNIMVCGALLR 201
Cdd:COG0738   363 LRAAFLVPLVCYLLILLLALALK 385
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
51-181 7.61e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.86  E-value: 7.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  51 DLMDSFDESNSKISWIISIcvFVLTFTAPLSTV--LSNRFGHRLVVMAGGLLISLGMITASFSQRVyHMYISIGVISGLG 128
Cdd:cd17321    21 TIARDLGASPSQLQWVVNA--YLLAFAALLLLAgrLGDRFGRKRVFLIGLALFGLASLLCALAPSL-AFLIAARALQGIG 97
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079531 129 YCFSFLPTVTILSQYFDKRR-----SVVTAVASTGecfavFAFAPAIT-ALKEHIGWRY 181
Cdd:cd17321    98 AAAIMPASLALIAATFPGERrgralGLWGAVVGIG-----AALGPLLGgLLLELFGWRW 151
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
61-180 1.29e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.54  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  61 SKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYhMYISIGVISGLGYCFSFLPTVTIL 140
Cdd:cd06179    32 SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVN-MLIGGQALIGIGAGTQGLGAAVAS 110
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1907079531 141 SQYFDKRRSVVTAVASTGeCFAVFAFAPAIT---ALKEHIGWR 180
Cdd:cd06179   111 ELVPNKYRGLVQGVVNLV-ASPGSALGPLIAgalVEANAAGWR 152
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
46-196 1.52e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.11  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  46 GVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVyHMYISIGVIS 125
Cdd:cd17365    19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSV-LQLALLRFLT 97
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907079531 126 GLGYCFSfLPTV-TILSQYF-DKRRSVVTAVASTGecfavFAFAPAITA-----LKEHIGWRYSLLFVGLLQLNIMVC 196
Cdd:cd17365    98 GLGLGAA-MPNAiTLVSEYApARRRSLAVTLMFCG-----YPLGAALGGflaaaLIPAFGWRSVFLLGGVPPLILLPL 169
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
292-470 1.85e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.74  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 292 KSFICYALFGLFATLGFFAPSLYIiP--LGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILL 369
Cdd:cd17316   177 RRTLLLILLWFFISFGYYGLTTFL-PtyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 370 TASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEkmSSAAGVYVFIQSISGLAGPPLAGLLVDQSKI 449
Cdd:cd17316   256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR--ATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
                         170       180
                  ....*....|....*....|.
gi 1907079531 450 YSRAFYScAAGMCLAAVCLAL 470
Cdd:cd17316   334 TGVPALI-LALLAIVALIVAL 353
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
52-440 2.63e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 43.52  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  52 LMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYIS---IGVISGLG 128
Cdd:TIGR00711  28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFrviQGFGGGPL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 129 YCFSFlptVTILSQYFDKRRSVVTAVASTGECFAVfAFAPAITA-LKEHIGWRYslLFVGLLQLNIMVCgaLLRPIIIqg 207
Cdd:TIGR00711 108 IPLSF---STLLNIYPPEKRGRAMAIWGLTVLVAP-ALGPTLGGwIIENYHWRW--IFLINVPIGIIVV--VVAFFIL-- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 208 PGQSPKAvtLEPRREVQYMLENEKTRTSIDSIDSGVEL-TTSPKNVPSEAKME---------QETRAEQqqtlvtapkhs 277
Cdd:TIGR00711 178 PRDKPAA--SENFDFLGLLLLSVGLGSLLYGLSEGPERgWFDSNEILILSITGlvaiiafvvWELTDDN----------- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 278 qmkaPLLDFSVLKEKSFICYALFGLFATLGFFApSLYIIPLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREP 355
Cdd:TIGR00711 245 ----PLVDLRLFKYRNFTIGCVYMSLLGLGLYG-SFYLLPLYLQqvLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 356 IRKIYIELICVILLTASLFAFTFA--TEFWGLMLCSVF--FGSMVGTIGGTHIPMlaedDVVGIEKMSSAAGVYVFIQSI 431
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRAFTFTpdTPFLAIALPQFIrgFGMGCFFMPLTTIAL----SGLPPHKIARGSSLSNFTRQL 395

                  ....*....
gi 1907079531 432 SGLAGPPLA 440
Cdd:TIGR00711 396 GGSIGTALI 404
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
42-443 2.67e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 43.40  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  42 IKSFGVFFND-LMDSFDE--SNSKISWIISICVFVL----TFTAPLSTVLSNRFGHRLVVMAGGLL--ISLGMITASFSQ 112
Cdd:cd17357    23 QEVFKEFINDtLVDRYGLnlSDSELDLLWSLIVSIFfiggAIGSFISAFLANRFGRKNGLLISNALlvVSSLLMFLSKSA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 113 RVYHMYIS----IGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECF--AVFAFaPAITALKEHigWRYSLLFV 186
Cdd:cd17357   103 KSPELLIFgrflVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILlgQVFGL-PSVLGTETL--WPYLLFFP 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 187 GLLqlnIMVCGALLrPIIiqgpGQSPKAVTLEPRREVQYMLENEKTRTSIDSIDsgvelttspknvPSEAKMEQETRAEQ 266
Cdd:cd17357   180 GIP---ALLQLAAL-PFF----PESPKFLLISKGDEEEAEKSLKFLRGIEDDVD------------QELEEIKKESEQMG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 267 QQTLVTapkhsqMKAPLLDFSVLKEKSFICYALFGLfATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIG 346
Cdd:cd17357   240 DQKQVS------LMQLLRDPSLRLPLLLVLVVSASQ-QFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIV 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 347 AGFVLNREPIRKIYIE-----LICVILLTASLFAFTFATEF-WGLMLCSVFFGsMVGTIGGTHIPMLAEDDVVGIEKMSS 420
Cdd:cd17357   313 GPFLIEKVGRRPLLLIslsvcAVALLLMSVFLFLSEQNSWMsYGCIVAIFLFI-FFFAIGLGPIPWFIGAELFPQAPRSA 391
                         410       420
                  ....*....|....*....|....*..
gi 1907079531 421 AAGVYVFIQS----ISGLAGPPLAGLL 443
Cdd:cd17357   392 AQSLGSSVNWtsnfIVGMAFPPLQSIG 418
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
293-472 3.15e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.94  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 293 SFICYALFGLFATLGFFAPSLYIiPL---GIsLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRK--IYIELICVI 367
Cdd:cd17502   168 TILLSSIFGFLFGGALFGLIYYL-PLyfqLV-LGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKplIVIGTILMS 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 368 LLTASLFAFTFATEFWGLMLCSVFFGSMVGTigGTHIPMLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAgllvdqs 447
Cdd:cd17502   246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGI--GFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT------- 316
                         170       180
                  ....*....|....*....|....*
gi 1907079531 448 kiysRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17502   317 ----DVFLVALALAALAFLLSLFLP 337
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
271-472 4.46e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 271 VTAPKHSQMKAPLLDFSVLkeksFICYALFGLFATLgffapslYIIPLGISL------GIDPDRAAFLLSTMAIAEVFGR 344
Cdd:cd17473   182 SAASPGAATAAALPWKRVL----PIYFLAFLAMLLF-------YVIPIQLPFllqergGGSAALIGLALAIASLAGAIGA 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 345 IGAGFVLNRepIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGV 424
Cdd:cd17473   251 LLFGRLKRR--LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS--LVPPELRGRAMGI 326
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907079531 425 YVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVR 472
Cdd:cd17473   327 VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
363-473 7.65e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.83  E-value: 7.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 363 LICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGL 442
Cdd:cd06173    73 LRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPE--LVPKEQLVRANALNSLATQLARIIGPALGGL 150
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907079531 443 LVDQSKIYSrAFYSCAAGMCLAAVCLALVRP 473
Cdd:cd06173   151 LVALLGPGG-AFAINALSFLLSALLLLFIRR 180
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
23-167 7.99e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 7.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  23 WGWAVAVSFFFVevFTYGIIKSFGVFFndLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLIS 102
Cdd:COG2211   230 FLLLLLAYLLFF--LALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079531 103 LGMITASFSQR--VYHMYIsIGVISGLGYCFSFLPTVTILSQYFDKRRsVVTAVASTGECFAVFAFA 167
Cdd:COG2211   306 LGLLLLFFLGPgnLWLLLV-LAALAGIGLGAILVLPWAMLADVVDYDE-WKTGRRREGLYFGIFTFA 370
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
298-473 8.26e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 298 ALFGLFATLGFFAPSLYIIPLGIS--LGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTASLFA 375
Cdd:cd17321   173 AVLAAFLLGAALGGLLFLLPLYLQgvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV--AGLLLTAVGLLL 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 376 FTFATE-------FWGLMLCSVFFGSMVGTIGGThipMLAeddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLV---- 444
Cdd:cd17321   251 LALLGAdssvwllLPGLVLLGLGLGLFATPLTNA---ALS---SVPKEKAGAASGILNTARQLGGALGVALLGALLtagl 324
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907079531 445 --------------DQSKIYSRAF---YSCAAGMCLAAVCLALVRP 473
Cdd:cd17321   325 sanlgdsgvaallsAAAAAFAAGFhlaFLVAAALALLAALLALLLP 370
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
292-466 9.37e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.37  E-value: 9.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 292 KSFICYALFGLFATLGFFAPSLYIIPLGiSLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIelICVILLTA 371
Cdd:cd17370   200 KAFWLYLLAVALFALGNFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI--LGYLSLAL 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 372 SLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKiYS 451
Cdd:cd17370   277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA--DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PS 353
                         170
                  ....*....|....*
gi 1907079531 452 RAFYSCAAGMCLAAV 466
Cdd:cd17370   354 AAFLFSAVLALIALL 368
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
294-497 1.06e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.38  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 294 FICYALFGLfaTLGFFAP--SLYIIPlgiSLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIeLICVILLTA 371
Cdd:cd17471     2 LLATLLTGL--AGAFVLPylSLFLTE---ELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLI-LLALLAGAL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 372 SLFAFTFATEFWGLMLCSVFFGSmvgtIGGTHIPML------------AEDDVVGIEKMSSAAgvyvfiqSISGLAGPPL 439
Cdd:cd17471    76 GYLLFAFLRNYWVLLLVGVVLLS----LGAAAFPQLfalareyadrssGRDATLFNSVLRAAF-------SLAWVIGPPL 144
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907079531 440 AGLLVDQSKiYSRAFYSCAAGMCLAAVCLALVRPCKKGLCQNSHSGENQTDRQRGKAL 497
Cdd:cd17471   145 AFLLLDVLG-FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRL 201
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
294-471 1.58e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 294 FICYALFGLFATLGFFAPSlyiiplgiSLGIDPDRAAFLLSTMAIAEVFGRIG-AGFVLNREPIRKIYIelICVILLTAS 372
Cdd:cd17330   185 LIALAFAGLESVFSLFLKD--------RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLR--LGLLLAIIG 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 373 LFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEddVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLvdQSKIYSR 452
Cdd:cd17330   255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK--SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL--YSFLGPG 330
                         170
                  ....*....|....*....
gi 1907079531 453 AFYSCAAGMCLAAVCLALV 471
Cdd:cd17330   331 VPFLLAAGLLLIALFLLSL 349
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
25-129 1.64e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  25 WAVAVSFFFVEvFTYGIIKSFgvffndLMDSFDESNSKISWIISICV-FVLTFTAPLSTVLSNRFGHRLVVMAGGLLISL 103
Cdd:cd17489   197 LPPALILFLAS-IAYGAISTF------LPLYAAERGISNAGLFFTVYaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL 269
                          90       100
                  ....*....|....*....|....*.
gi 1907079531 104 GMITASFSQRVYHMYISiGVISGLGY 129
Cdd:cd17489   270 GLLLLSFAGSPWMLLLA-AVLYGLGF 294
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
33-196 1.73e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531  33 FVEVFTYgiiksFGVFfndLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQ 112
Cdd:cd17324   214 FFALYTY-----LAPF---LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGP 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 113 RVYHMYISIgVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTgeCF----AVFAFAPAItaLKEHIGWRYSLLFVGL 188
Cdd:cd17324   286 SPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLA--AYnlggALGAALGGL--VLDHGGWAGVGWVGAA 360

                  ....*...
gi 1907079531 189 LQLNIMVC 196
Cdd:cd17324   361 LLLLALLL 368
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
300-481 2.03e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 300 FGLFATLGFFAP--SLYiiplGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIyIELICVILLTASLFAFT 377
Cdd:cd17335     7 FFFFAALGSLLPflSVY----LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKA-LLLLSLLAAVLFFLSLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 378 F-ATEFWGLMLCSVFFGSMVGTiggthIPMLAEDDVVGIEKMSSAA-GVYVFIQSISGLAGPPLAGLLVDQSKI---YSR 452
Cdd:cd17335    82 FvAQIFWLLLLLVILGAFFSAP-----VVPLVDSITLQYLGEERERyGKQRLWGSIGFGIAALLVGILIDRSSTyknYTI 156
                         170       180
                  ....*....|....*....|....*....
gi 1907079531 453 AFYSCAAGMCLAAVCLALVRPCKKGLCQN 481
Cdd:cd17335   157 AFYVFAVLMLLALLLALKFPFRPKHPEPN 185
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
300-473 3.43e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.90  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 300 FGLFATLGFFApsLYII-PLGISLGIdpdrAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYieLICVILLTASLFAFTF 378
Cdd:cd17329    13 LGFFMVWPFMA--IYLHqQLGLSASI----VGLVLALSAVAGIVASLIGGRLADRFGRKPVM--LAGLLLRALGFALLGF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 379 ATEFWGLMLCSV---FFGSMVGTIGGThipMLAedDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSkiYSRAFY 455
Cdd:cd17329    85 AHSPWLFAIALVltgFGGGLFEPASEA---MIA--DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS--FRLLFL 157
                         170
                  ....*....|....*...
gi 1907079531 456 SCAAGMCLAAVCLALVRP 473
Cdd:cd17329   158 AAAVLFLLAALVLLFLLP 175
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
271-443 4.24e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.51  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 271 VTAPKHSQMKAPLLD--FSVLKEKSFICYALFGLFATLGFFAP-SLYIIPLGISLGIDPDrAAFLLSTMAIAEVFGRIGA 347
Cdd:cd17332   198 VVPPEEEKSKLPLLKslKALLKNRPFLILLLAYLLYFLAFNIVnTVLVYYFKYVLGGRAE-LVLLLLLILSGALLALLPW 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079531 348 GFVLNREPIRKIYIELICVILLTASLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAedDVVGIEKMSS------- 420
Cdd:cd17332   277 PPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA--DVIDYGELKTgkrregi 354
                         170       180
                  ....*....|....*....|...
gi 1907079531 421 AAGVYVFIQSISGLAGPPLAGLL 443
Cdd:cd17332   355 FYSVMTFFRKLGLALAGALVGLI 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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