|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
22-308 |
4.67e-119 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 353.03 E-value: 4.67e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 22 GIVLPQIMTGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLR 101
Cdd:cd13132 149 GIVLPLVYISLVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLK 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 102 LAIPSMLMLCIEWWAYEVGSFLSGIL-GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISL 180
Cdd:cd13132 229 LAIPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVAL 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 181 IVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIG 260
Cdd:cd13132 309 ILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIG 388
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1907082780 261 LPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKRACQQ 308
Cdd:cd13132 389 LPVGLLLAFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
31-303 |
6.65e-46 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 163.44 E-value: 6.65e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 31 GIAANLVNALANYVFLY-HLH---LGVMGSALANTISQFALAIFLFLYILWRRL--HQATWGGWSWECLQDWASFLRLAI 104
Cdd:cd13131 157 TLLALVLNIPLNYVLIFgKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHKRfrRYRLFARFWRPDWARLKELLRLGL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 105 PSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 184
Cdd:cd13131 237 PIGLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGV 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 185 LFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIG 264
Cdd:cd13131 317 GFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLG 396
|
250 260 270
....*....|....*....|....*....|....*....
gi 1907082780 265 IALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 303
Cdd:cd13131 397 YLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQRR 435
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
32-296 |
1.40e-44 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 159.92 E-value: 1.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 32 IAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRR-LHQATWGGWSWEcLQDWASFLRLAIPSMLML 110
Cdd:COG0534 164 LIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRsLLRLRLRDLRPD-RKILKRILRIGLPAGLQQ 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 111 CIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTF 190
Cdd:COG0534 243 LAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLL 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 191 CVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFa 270
Cdd:COG0534 323 ALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF- 401
|
250 260
....*....|....*....|....*.
gi 1907082780 271 AKLGVIGLWSGIIICTTCQTTCFLAF 296
Cdd:COG0534 402 LGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
22-223 |
1.58e-34 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 130.83 E-value: 1.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 22 GIVLPQIMTGIAANLVNALANYVFLYHLH--LGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASF 99
Cdd:TIGR00797 139 GDTKTPMYITLIGNVINIILNYILIFGKFgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 100 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAIS 179
Cdd:TIGR00797 219 LKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVA 298
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1907082780 180 LIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYA 223
Cdd:TIGR00797 299 LKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
21-297 |
2.62e-33 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 128.98 E-value: 2.62e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 21 TGIVLPQIMTGIAANLVNALANYVFLY---HLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWA 97
Cdd:cd12082 140 EGDTRTAMIISVLSNLLNILLDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLR 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 98 SFLRLAIPSMLMLCIEWWAYEVGSFL-SGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSS 176
Cdd:cd12082 220 RLLRIGLPSAIQNSLLSLGLLIIVAIvAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRIT 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 177 AISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGY 256
Cdd:cd12082 300 WVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSY 379
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1907082780 257 YVIGLPIGIALMFAAkLGVIGLWSGIIICTTCQTTCFLAFI 297
Cdd:cd12082 380 WVVRLPLAYVLAYLG-LGLYGIWLALVISLILAALVLLLFF 419
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
29-303 |
6.17e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 128.01 E-value: 6.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 29 MTGIAANLVNALANYVFLYHLH----LGVMGSALANTISQFALAIFLFLYILWRRLH-QATWGGWSWEcLQDWASFLRLA 103
Cdd:cd13137 154 YIMIIVNVLNIVLDYVLIFGLWgfpgLGVAGAALATVISRVVGALLLLFLLLRGRLPiKISFKGFRLD-RKIIKKLLRIG 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 104 IPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVT 183
Cdd:cd13137 233 LPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLG 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 184 ELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPI 263
Cdd:cd13137 313 VLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPL 392
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1907082780 264 GIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 303
Cdd:cd13137 393 AYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-304 |
2.15e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 124.15 E-value: 2.15e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 29 MTGIAANLVNALANYVFLY----HLHLGVMGSALANTISQFA---LAIFLFLYILWRRLHQATWGGWSWECLQDwasFLR 101
Cdd:cd13134 156 YVSLIMNILNIVGNYLLIFgwfgLPKLGVAGVAISTVISRAVglvLLFILLFRKLKIRFRLKDLRPFPKKLLKK---ILK 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 102 LAIPSMLmlciEWWAYEVGSFLS----GILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSA 177
Cdd:cd13134 233 IGLPSAG----EELSYNLSQTVItafiARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVL 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 178 ISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYY 257
Cdd:cd13134 309 KSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMW 388
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1907082780 258 VIGLPIGIALMFAAKLGVIGLWSGIIICttcqtTCFLAFIARLNWKR 304
Cdd:cd13134 389 GISVPLAYLLGIVLGLGLLGVWIAFAAD-----EWVRGIIMLWRWRS 430
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-302 |
4.90e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 123.02 E-value: 4.90e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 17 SCFPTGIVLPQI--MTGIAANLVNALANYVFLY-HL---HLGVMGSALANTISQFALAIFLFLYILWRRLHQ--ATWGGW 88
Cdd:cd13133 144 RAFFSGIGRTRVvmVANLVMVVVNIVLDYALIFgKLgfpAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRrfGLRRAW 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 89 SWEcLQDWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGN 168
Cdd:cd13133 224 RFD-RELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGR 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 169 IDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIY---AVSHLFEGLACTCGGILRGTGNQ 245
Cdd:cd13133 303 PDLAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLLrfvAAYILFDALALVFAGALRGAGDT 382
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907082780 246 KVGAIVNAIGYYVIGLPIGIALMFaAKLGVIGLWSGIIICTTCQTTCFLAFIARLNW 302
Cdd:cd13133 383 RFVMLAELIVAWLYLLPPAYLLVV-LGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
32-303 |
5.25e-27 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 111.40 E-value: 5.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 32 IAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRLH-QATWGGWSWEcLQDWASFLRLAIPSMLML 110
Cdd:cd13138 160 IIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPfKLSLKDFRFD-KEILKEILKIGLPSALQQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 111 CIewwayevgSFLSGIL--------GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIV 182
Cdd:cd13138 239 SL--------VSISFLIinsivnsyGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIII 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 183 TELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLP 262
Cdd:cd13138 311 SLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIP 390
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1907082780 263 IGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 303
Cdd:cd13138 391 LAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
31-284 |
5.31e-27 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 111.83 E-value: 5.31e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 31 GIAANLVNALANYVFLY-HL---HLGVMGSALANTISQFALAIFLFLYILWRRlHQAT---WGGWSWECLQDWASFLRLA 103
Cdd:PRK01766 167 GFLGLLINIPLNYIFIYgKFgfpELGGVGCGVATAIVYWVMFLAMLIYIKRAR-RFRDfrlFKGLYKPDWAVIKRLLKLG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 104 IPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVT 183
Cdd:PRK01766 246 LPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVG 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 184 ELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPI 263
Cdd:PRK01766 326 LGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPL 405
|
250 260
....*....|....*....|.
gi 1907082780 264 GIALMFAAKLGVIGLWSGIII 284
Cdd:PRK01766 406 GYILALTDPMGPFGFWIGLII 426
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
105-264 |
4.00e-25 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 100.33 E-value: 4.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 105 PSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 184
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 185 LFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyYVIGLPIG 264
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
32-284 |
5.84e-22 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 96.86 E-value: 5.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 32 IAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIfLFLYILWRRLHQATWGGWSweCLQDWASFLRLAIPS----- 106
Cdd:cd13136 160 IVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGAL-LGLWLLRRRVRLLGKSLSR--RLPSKAALKRLFKLNrdifi 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 107 -MLMLCIewwAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTEL 185
Cdd:cd13136 237 rTLALLA---AFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLG 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 186 FAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGnqKVGAIVNAIgyyVIGLPIGI 265
Cdd:cd13136 314 LGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGAT--DTRYLRNSM---LVSLAVFL 388
|
250 260
....*....|....*....|.
gi 1907082780 266 ALMFAAK--LGVIGLWSGIII 284
Cdd:cd13136 389 PLLFLLVplWGNHGLWLALIL 409
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
32-321 |
4.97e-21 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 94.43 E-value: 4.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 32 IAANLVNALANYVFLYHL--------HLGVMGSALANTISQFALAIFLFLYILWRRLHQA--TWGGWSWECLQDWASFLR 101
Cdd:PRK00187 161 MVISLAGAVANLLLNYALiegwfglpKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAypLRKGLSRPSRAALRELWR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 102 LAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISL- 180
Cdd:PRK00187 241 LGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIg 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 181 ---IVTELFAVTFcvlLLGCKDLVGYIFTTD----RDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNA 253
Cdd:PRK00187 321 fgaVVMLLFAGLF---WLLPEAIIGLFLDRNdpafAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGL 397
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907082780 254 IGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTtcfLAFIARLNWKRACQQAQVHANLKVNVAL 321
Cdd:PRK00187 398 ACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAA---VALTLAFEWKTARLLRKARASEAVALSA 462
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
29-279 |
6.60e-21 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 93.73 E-value: 6.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 29 MTGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRR-LHQATWGGWSWEcLQDWASFLRLAIPSM 107
Cdd:cd13143 158 LGMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKsLLKLSLLRFKLS-LKIIKEILALGFPSF 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 108 LMlciewwayEVGSFLSGIL---------GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAI 178
Cdd:cd13143 237 LM--------QLSSSVVTIVlnltllgygGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKL 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 179 SLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYV 258
Cdd:cd13143 309 ALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGL 388
|
250 260
....*....|....*....|.
gi 1907082780 259 igLPIGIALMFAAKLGVIGLW 279
Cdd:cd13143 389 --FLIPLLLILPRLFGLDGIW 407
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
50-304 |
8.76e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 93.80 E-value: 8.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 50 HLGVMGSALANTISQFALAIFLfLYILWRRLH------QATWGGWSWeclqdWASFLRLAIPSMLMLCIEWWAYEVGSFL 123
Cdd:cd13142 190 GLGVAGAALATVISRGIAAVIG-LYLLFKGRVglkislRDLKPDWEW-----LKKIFRIGLPSSIEQSARALGFTVMTAL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 124 SGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGY 203
Cdd:cd13142 264 VAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVR 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 204 IFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGII 283
Cdd:cd13142 344 VFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMA 423
|
250 260
....*....|....*....|.
gi 1907082780 284 ICTTCQTTCFLAFIARLNWKR 304
Cdd:cd13142 424 ISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-303 |
4.29e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 79.49 E-value: 4.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 36 LVNALANYVFLYHL----HLGVMGSALANTISQfALAIFLFLYILwRRLHQATWGGWSWECL--QDWASFLRLAIP---- 105
Cdd:cd13140 166 VLNIILDPLLIFGFgpfpALGVAGAALATVLAQ-AIVFLLFLYAL-KKKKGLFLKIRILKRPdrKYIKEILKLGLPvalq 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 106 SMLMLCIEWWayeVGSFLSGiLGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTEL 185
Cdd:cd13140 244 SILFALISMI---LARIIAS-FGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASA 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 186 FAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVnAIGYYVIGLPIGI 265
Cdd:cd13140 320 IGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAII-SIVFNGLRIPLAL 398
|
250 260 270
....*....|....*....|....*....|....*...
gi 1907082780 266 ALMFAAkLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 303
Cdd:cd13140 399 LLSPTG-LGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-304 |
1.44e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 74.96 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 34 ANLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLFLYILW-------RRLHQAtwggWSWECLQdwaSFLRL 102
Cdd:cd13139 172 ANGLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQLYHLFKgkgriqiRRRHLK----LDWAIIK---KIIKI 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 103 AIPSMLMLCIEwwayeVGSFLSGILGMVELGAQSIT-YELAIIVYM---IPS-GFSVAANVRVGNALGAGNIDQAKKSsa 177
Cdd:cd13139 245 AVGGILQFLIA-----SSSWIFLVRIIAEFGSTALAgYTIAIRIIMfalLPAwGLSNAAATLVGQNLGAGQPDRAEKS-- 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 178 isLIVTELFAVTFC-----VLLLGCKDLVGyIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVN 252
Cdd:cd13139 318 --VWRAGKYNMVFLgivslVFFLFAEPLVS-FFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLIN 394
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1907082780 253 AIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKR 304
Cdd:cd13139 395 LVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
26-284 |
4.70e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 73.48 E-value: 4.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 26 PQIMTGIAANLVNALANYVFLY-HL---HLGVMGSALANTISQFALAIFLFLYIL-WRRLHQATWGGWS-WECLQDWASF 99
Cdd:cd13135 151 PIMYGGIIKNLLNVILDYVLIFgNFgfpRLGIIGAAIATTIANVLNLIILVYLCRkIKKLTFKLSNTKVlKANIRPYKFT 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 100 LRLAIPSMLMLcIEWWAYE--VGSFLSGIlGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSA 177
Cdd:cd13135 231 IKLGLPLGGEE-FLWNIGNlaVIRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGN 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 178 ISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyY 257
Cdd:cd13135 309 ICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIG-T 387
|
250 260
....*....|....*....|....*..
gi 1907082780 258 VIGLPIGIALMFAAKLGVIGLWSGIII 284
Cdd:cd13135 388 IIVVSVALLLIFVFKLGLAGVYITLFI 414
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
96-304 |
4.28e-13 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 70.17 E-value: 4.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 96 WASFLRLAIPSMLMLCIEWwAYE-VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKK 174
Cdd:COG0534 7 LKLLLRLALPIILGNLLQS-LYGlVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 175 SSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAI 254
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1907082780 255 GyYVIGLPIGIALMFAAKLGVIGL-WSGIIicttCQTTCFLAFIARLNWKR 304
Cdd:COG0534 166 G-NVLNIVLDPLLIFGGGLGVAGAaLATVI----SQAVSALLLLYYLFRKR 211
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
26-284 |
7.49e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 60.40 E-value: 7.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 26 PQIMTGIAAnLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLfLYILWRRLHQATWGGWSW-ECLQDWASFL 100
Cdd:cd13149 160 PSLVMLGAA-LVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAA-LYFLHYHHRLIDFSEPSLkALFRSWKDIL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 101 RLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISL 180
Cdd:cd13149 238 SIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 181 IVTELF-AVTFCVLLLGCKDLVGyIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVI 259
Cdd:cd13149 318 KFSLIYgAILGIVLALFAGWLAS-LFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLL 396
|
250 260
....*....|....*....|....*
gi 1907082780 260 GLPigIALMFAAKLGVIGLWSGIII 284
Cdd:cd13149 397 YIP--LAYVGSHLLGFAGVFIGALA 419
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
100-277 |
1.63e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 59.17 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 100 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAIS 179
Cdd:cd13144 11 LTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANNG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 180 LIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGN-------QKVGAIVN 252
Cdd:cd13144 91 LLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNtitpmiaQLIGAIIN 170
|
170 180
....*....|....*....|....*.
gi 1907082780 253 aigyyVIGLPIGI-ALMFAAKLGVIG 277
Cdd:cd13144 171 -----IILDPILIfGLFGFPAMGIAG 191
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
22-300 |
1.94e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 58.95 E-value: 1.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 22 GIVLPQIMTGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWR----RLHQATWGGwSWECLqdwA 97
Cdd:cd13146 157 GRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGksnvTIHIKLSNI-SSSVI---V 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 98 SFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSA 177
Cdd:cd13146 233 EILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILM 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 178 ISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYY 257
Cdd:cd13146 313 TAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHV 392
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1907082780 258 VIGLPIGIALMFAAKLGVIGLWSGIIICTTcqTTCFLAFIARL 300
Cdd:cd13146 393 FLSVPVVYLLAYVFGKGITGVYFGIVSANF--FTALLAMFWGL 433
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
100-304 |
5.31e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 57.52 E-value: 5.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 100 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAIS 179
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 180 LIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VGAIVN 252
Cdd:cd13137 84 LLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKtpmyimiIVNVLN 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1907082780 253 AIGYYVIGLPIGIALmfaaKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKR 304
Cdd:cd13137 164 IVLDYVLIFGLWGFP----GLGVAGAALATVISRVVGALLLLFLLLRGRLPI 211
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
144-277 |
1.34e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 56.36 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 144 IVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYA 223
Cdd:cd13134 50 LLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVG 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907082780 224 VSHLFEGLACTCGGILRGTGNQK-------VGAIVNAIG-YYVIGLPIGIalmfaAKLGVIG 277
Cdd:cd13134 130 GSLFLQALSLTLSAILRSHGRTKipmyvslIMNILNIVGnYLLIFGWFGL-----PKLGVAG 186
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-279 |
2.84e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 55.32 E-value: 2.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 32 IAANLVNALANYVFLYHLH----LGVMGSALANTISQFALAIFLFLYILWR--------RLHQATWggwsweclQDWASF 99
Cdd:cd13144 164 LIGAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKnkdvqpdlRLFRPSL--------RIIKEI 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 100 LRLAIPSMLMLCIewwayevGSFLSGILGMVELG-------AQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQA 172
Cdd:cd13144 236 YAVGLPSIIMQAI-------SSVMVFGLNKILAGfgptavaVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRI 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 173 KKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVN 252
Cdd:cd13144 309 REAIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIIS 388
|
250 260
....*....|....*....|....*..
gi 1907082780 253 AIGYYVIGLPigIALMFAAKLGVIGLW 279
Cdd:cd13144 389 VARQLVVLLP--LAWLLAKMFGLNGVW 413
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
96-266 |
7.06e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 54.00 E-value: 7.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 96 WASFLRLAIPSMLMLCIE--------WWayeVGSFLsgilGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAG 167
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQqlynlvdlLI---VGQFL----GVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 168 NIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK- 246
Cdd:cd13138 75 DEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKt 154
|
170 180
....*....|....*....|....*...
gi 1907082780 247 ------VGAIVNAIG--YYVIGLPIGIA 266
Cdd:cd13138 155 plyfviIACVLNIILdlLFIAVFHMGVA 182
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
99-277 |
1.97e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 52.90 E-value: 1.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 99 FLRLAIPSMLMLCIEWwAYEV--GSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSS 176
Cdd:cd13143 6 FLKFALPAIIGMLVNG-LYNIvdGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 177 AISLIVTELFAVTFCVL-LLGCKDLVgYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VG 248
Cdd:cd13143 85 STALLLSLILGLLLTILgLLFLDPLL-RLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKlamlgmlIG 163
|
170 180
....*....|....*....|....*....
gi 1907082780 249 AIVNAIGYYViglpigiaLMFAAKLGVIG 277
Cdd:cd13143 164 AVLNIILDPL--------FIFVLGLGIAG 184
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
98-255 |
1.96e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 49.50 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 98 SFLRLAIPSML--MLCIewwAYE-VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKK 174
Cdd:cd13142 12 TLLKLAWPIIVsnLLQV---AYNlADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 175 SSAISLIVTELFAVTFCVL-LLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNA 253
Cdd:cd13142 89 VAGQTFSFVIILSLILAVLgYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMF 168
|
..
gi 1907082780 254 IG 255
Cdd:cd13142 169 GS 170
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-299 |
3.83e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 48.85 E-value: 3.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 21 TGIVLPQIMTGIAANLVNALANYVFLY----HLHLGVMGSALANTISQFALAIFLFLYILW-RRLHQATWGGWSWEcLQD 95
Cdd:cd13141 156 TGIVKPFMVIQILAVLLNIILAPILITgwgtGRALGVAGAGLASSISVAIAVVLLLYYFLRlEKYLRLDLALWRPD-LPT 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 96 WASFLRLAIPS----MLMLC----IEWWAYEVGS-----FLSG--ILGMVELGAQSITYELAIIVymipsgfsvaanvrv 160
Cdd:cd13141 235 WKRLLKIGLPSggefLLTFVymavIYWALRPFGAaaqagFGIGsrIMQSLFLPAMAIAFAAPAIA--------------- 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 161 GNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILR 240
Cdd:cd13141 300 GQNFGAGNYDRVRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQ 379
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1907082780 241 GTGNQKVGAIVNAIGYYVIGLPIgIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIAR 299
Cdd:cd13141 380 ALGNTWPSLLSSASRLLTFALPV-IWLSAQPDFRIEQIWYLSVATTILQAALSLLLLRR 437
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
119-277 |
4.01e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 48.47 E-value: 4.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 119 VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCK 198
Cdd:cd12082 17 VDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLLFFS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 199 DLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYY--VIGLPIGIALMFAAKLGVI 276
Cdd:cd12082 97 PLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLlnILLDPLLIFGLGPPELGIA 176
|
.
gi 1907082780 277 G 277
Cdd:cd12082 177 G 177
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
31-148 |
7.06e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 47.84 E-value: 7.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 31 GIAANLVNALANYVFLYHLhlGVMGSALANTISQFALAIFLFlYILWRRLHQATWGGWsweclqdWASFLRLAIPSMLML 110
Cdd:COG0728 382 AVIAVVVNIVLNLLLVPPL--GHAGLALATSLSALVNALLLL-VLLRRRLGGLPLRGI-------LRTLLKLLLASLVMG 451
|
90 100 110
....*....|....*....|....*....|....*...
gi 1907082780 111 CIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMI 148
Cdd:COG0728 452 AVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
44-277 |
7.47e-06 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 47.92 E-value: 7.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 44 VFLYHLHLGVMGSALANTISQFALAIFLFlYILWRRLHQATWGGWSWEClqdWASFLRLAIPSMLMLCIEWWAYEVGSF- 122
Cdd:cd13128 157 LILVLLGGGLIGFALAYLIASVLSAILLL-YIYRKKILLPKFFSFDLKL---AKELLRFSIPLALSGIFSLIYTRIDTIm 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 123 LSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALgAGNIDQAKKSSAISLIVTELFAVTFCVLL-LGCKDLV 201
Cdd:cd13128 233 LGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLfLFAEPII 311
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907082780 202 GYIFTTDrdiVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyyvIGLPIGIALMFAAKLGVIG 277
Cdd:cd13128 312 TLLFGEE---YLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIG---ALLNVILNLLLIPKYGIIG 381
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
122-254 |
8.95e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 47.68 E-value: 8.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 122 FLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLV 201
Cdd:cd13149 34 FFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPL 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 202 GYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VGAIVNAI 254
Cdd:cd13149 114 FSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKrpslvmlGAALVNVI 173
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
119-267 |
3.35e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 45.67 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 119 VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCK 198
Cdd:cd13145 31 VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 199 DLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VGAIVNAI-------GYYVI---GL 261
Cdd:cd13145 111 PPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKsyrnfliIGFFLNIIldplfifGGGGIpamGV 190
|
....*.
gi 1907082780 262 PiGIAL 267
Cdd:cd13145 191 S-GIAL 195
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
100-299 |
6.50e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 44.96 E-value: 6.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 100 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSG-FSVAANVRVGNALGAGNIDQAKKSSAI 178
Cdd:cd13148 15 LRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGaMGGGVSSAIARALGAGDRERAEALVWH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 179 SLIVTELFAVTFCVL-LLGCKDLVGYIFTTDRDIVA-------LVAQVIPIYAVSHLfeglactcGGILRGTGNQKVGAI 250
Cdd:cd13148 95 ALVIALAGGLVFSLLfLLFGPALYRLLGGRGEALDAalaysnvLFSGAILIWLVNLL--------AAALRGTGNMRVPAL 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1907082780 251 VNAIGyYVIGLPIGIALMF----AAKLGVIGLWSGIIICTTCQTTCFLAFIAR 299
Cdd:cd13148 167 VTLVG-AVVQIPLSPGLILgwgpLPRLGVAGAAVAAVLYYALAALVLLRYLAS 218
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-299 |
1.28e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 43.74 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 29 MTGIAANLV-NALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSM 107
Cdd:cd13145 165 IIGFFLNIIlDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFPAS 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 108 L-MLCIEWWAYEVGSFLSGiLGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELF 186
Cdd:cd13145 245 LnMMTIGLGIFVITYFVGQ-FGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVI 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 187 AVTFCVLLLGCKDLVGYIFTTDRDIVALVAQ-------VIPIYAVshLFeglacTCGGILRGTGNQKVGAIVNAIGYYVI 259
Cdd:cd13145 324 MVVATVFLLFFAEPLMSLFTNDPAVIAIGAGylridalIFYAYVV--LF-----ISVSVLQGLKRPIFALWIGLYRQLVG 396
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1907082780 260 GLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIAR 299
Cdd:cd13145 397 PALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
119-279 |
1.38e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 43.77 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 119 VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCK 198
Cdd:TIGR00797 15 VDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLVGYFFI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 199 DLVGYIFTTDrDIVALVAQV--------IPIYAVSHLFEglactcgGILRGTGNQKVGAIVNaigyyVIGLPIGIALMFA 270
Cdd:TIGR00797 95 DPLLSLMGAD-GEVAELAQDylrililgIPAYLLNFVLR-------GFLRGQGDTKTPMYIT-----LIGNVINIILNYI 161
|
....*....
gi 1907082780 271 AKLGVIGLW 279
Cdd:TIGR00797 162 LIFGKFGFL 170
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
32-297 |
4.28e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 42.14 E-value: 4.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 32 IAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRR-------LHQATwggWSWECLQDwasFLRLAI 104
Cdd:cd13147 164 VAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKdtyvslsLKNFK---FDKKIVKD---ILKVGI 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 105 PSMLMLCIewWAYeVGSFLSGILGMVelgaqSITYelAIIVY----------MIPS-GFSVAANVRVGNALGAGNIDQAK 173
Cdd:cd13147 238 PASLEQLI--MSV-LMIILNLILVIV-----AGTD--GVAVYtagwrivsfaIIPLiGIATAVTSVTGAAYGARNYEKLK 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 174 KSSAISLIVTELFAVTFCVLLLGCKDLVGYIFT---TDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAI 250
Cdd:cd13147 308 TAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTyseESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLI 387
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1907082780 251 VNAIgyYVIGLPIGIALMFAA--KLGVIGLWSGIIICTTCqtTCFLAFI 297
Cdd:cd13147 388 ITIL--RELIFQVLFAYLFAIvlGLGLFGVWWGIVLGNAI--GSIVGYL 432
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
30-278 |
1.79e-03 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 40.13 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 30 TGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYiLWRRlhqatwgGWSWECLQDWAS-----FLRLAI 104
Cdd:cd13123 151 APVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPA-LRRL-------GFRFRPRLDFRDpgvrrVLKLML 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 105 PSMLMLCIewwaYEVGSFLSGILG-MVELGAQSITYeLAIIVYMIPSG-FSVAanvrVGNAL--------GAGNIDQAKK 174
Cdd:cd13123 223 PALLGVSV----SQINLLVDTILAsFLPEGSISALY-YADRLYQLPLGiFGVA----IATALlprlsrlaAAGDLDEFRR 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 175 --SSAISLIVTELFAVTFCVLLLGcKDLVGYIF----TTDRDiVALVAQVIPIYAVSHLFEGLActcgGIL-RG---TGN 244
Cdd:cd13123 294 tlSRGLRLVLFLLLPAAVGLIVLA-EPIVRLLFergaFTAED-TLMTASALAAYALGLPAFALV----KLLsRAfyaLKD 367
|
250 260 270
....*....|....*....|....*....|....
gi 1907082780 245 QKVGAIVNAIGyyvIGLPIGIALMFAAKLGVIGL 278
Cdd:cd13123 368 TKTPVKIAVIA---VAVNILLNLLLIKPLGHVGL 398
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
26-279 |
3.15e-03 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 39.59 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 26 PQIMTG--IAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRlhqaTWGGWSWECLQDWASFLR-- 101
Cdd:PRK09575 161 PNLATGlmVIGALINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSR----ANIRLTLKELRFNWSLAPki 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 102 --LAIPSMLMlciewwaYEVGSF---LSGILGM-----VELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQ 171
Cdd:PRK09575 237 vlLGSSSFFM-------YLYGSFvvaLHNRLFMeygsaLTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDN 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 172 AKKSSAISLIVTELFAVTFCVLL-LGCKDLVGYIFTTDRDIVALVAQVIPIyavsHLF----EGLACTCGGILRGTgNQK 246
Cdd:PRK09575 310 IKKLLKLAMKVTVLAGIAWVLLLnLFPETMIALFNSGDSELIAETIVGIRL----HLFamflDGFLVLASAYFMAV-NQG 384
|
250 260 270
....*....|....*....|....*....|....
gi 1907082780 247 VGAIVNAIGYYVIGLPIgiaLMFAAK-LGVIGLW 279
Cdd:PRK09575 385 GKALFISIGNMLIQLPF---LFILPKwLGVDGVW 415
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
100-255 |
7.33e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 38.28 E-value: 7.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 100 LRLAIPSMLMLCIE--------WWAYEVGS--------------FLSGILGMVELGAQsityelaiivymipsgfsvaan 157
Cdd:cd13140 8 LRLALPIMGTSFIQmaynltdmFWVGRLGSdavaavgtagffvwLAYALALLSKIGAQ---------------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907082780 158 VRVGNALGAGNIDQAKKSSAISLIVTELFAVTFC-VLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCG 236
Cdd:cd13140 66 VKVSQSIGAKDEKEARKYARNALQLNLLLGILYGlLLLLFAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFT 145
|
170
....*....|....*....
gi 1907082780 237 GILRGTGNQKVGAIVNAIG 255
Cdd:cd13140 146 GIFNALGDSKTPFIINAIG 164
|
|
| |
