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Conserved domains on  [gi|1907092532|ref|XP_036013754|]
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iroquois-class homeodomain protein IRX-1 isoform X1 [Mus musculus]

Protein Classification

homeodomain and IRO domain-containing protein( domain architecture ID 10209743)

homeodomain and IRO domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
homeodomain super family cl00084
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
1-23 6.04e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


The actual alignment was detected with superfamily member pfam05920:

Pssm-ID: 469608  Cd Length: 39  Bit Score: 45.20  E-value: 6.04e-07
                          10        20
                  ....*....|....*....|...
gi 1907092532   1 MLAIITKMTLTQVSTWFANARRR 23
Cdd:pfam05920  17 ELAKETGLSRKQISNWFINARRR 39
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
148-165 1.73e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


:

Pssm-ID: 214716  Cd Length: 18  Bit Score: 35.25  E-value: 1.73e-03
                           10
                   ....*....|....*...
gi 1907092532  148 APHSKPKIWSLAETATSP 165
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
DNA_pol_phi super family cl47903
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
34-96 2.36e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


The actual alignment was detected with superfamily member pfam04931:

Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.53  E-value: 2.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907092532  34 ARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQ-IDERDGDQSNEDEEDKAEAP----RARVA 96
Cdd:pfam04931 625 ARENPEGQQELFEDEDEDEEDDDEEEDDDDEDDEDSEEdDDEDDDDEDEEDDDDEDVDEidelRAKLA 692
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
1-23 6.04e-07

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 45.20  E-value: 6.04e-07
                          10        20
                  ....*....|....*....|...
gi 1907092532   1 MLAIITKMTLTQVSTWFANARRR 23
Cdd:pfam05920  17 ELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
2-28 2.76e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.07  E-value: 2.76e-05
                          10        20
                  ....*....|....*....|....*..
gi 1907092532   2 LAIITKMTLTQVSTWFANARRRLKKEN 28
Cdd:cd00086    33 LAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
2-25 3.09e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.00  E-value: 3.09e-04
                           10        20
                   ....*....|....*....|....
gi 1907092532    2 LAIITKMTLTQVSTWFANARRRLK 25
Cdd:smart00389  34 LAKKLGLSERQVKVWFQNRRAKWK 57
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
148-165 1.73e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 35.25  E-value: 1.73e-03
                           10
                   ....*....|....*...
gi 1907092532  148 APHSKPKIWSLAETATSP 165
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
34-96 2.36e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.53  E-value: 2.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907092532  34 ARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQ-IDERDGDQSNEDEEDKAEAP----RARVA 96
Cdd:pfam04931 625 ARENPEGQQELFEDEDEDEEDDDEEEDDDDEDDEDSEEdDDEDDDDEDEEDDDDEDVDEidelRAKLA 692
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
1-23 6.04e-07

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 45.20  E-value: 6.04e-07
                          10        20
                  ....*....|....*....|...
gi 1907092532   1 MLAIITKMTLTQVSTWFANARRR 23
Cdd:pfam05920  17 ELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
2-28 2.76e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.07  E-value: 2.76e-05
                          10        20
                  ....*....|....*....|....*..
gi 1907092532   2 LAIITKMTLTQVSTWFANARRRLKKEN 28
Cdd:cd00086    33 LAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
2-25 3.09e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.00  E-value: 3.09e-04
                           10        20
                   ....*....|....*....|....
gi 1907092532    2 LAIITKMTLTQVSTWFANARRRLK 25
Cdd:smart00389  34 LAKKLGLSERQVKVWFQNRRAKWK 57
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
148-165 1.73e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 35.25  E-value: 1.73e-03
                           10
                   ....*....|....*...
gi 1907092532  148 APHSKPKIWSLAETATSP 165
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
34-96 2.36e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.53  E-value: 2.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907092532  34 ARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQ-IDERDGDQSNEDEEDKAEAP----RARVA 96
Cdd:pfam04931 625 ARENPEGQQELFEDEDEDEEDDDEEEDDDDEDDEDSEEdDDEDDDDEDEEDDDDEDVDEidelRAKLA 692
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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