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Conserved domains on  [gi|1907093763|ref|XP_036013940|]
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cell division cycle protein 20 homolog B isoform X6 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-480 2.48e-20

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 2.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQ 400
Cdd:COG2319   171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTG-HS 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 401 STAVKLAFSRtplpvlllgtlqamewcpwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIAT 479
Cdd:COG2319   247 GSVRSVAFSP-------------------DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLAS 305


                  .
gi 1907093763 480 G 480
Cdd:COG2319   306 G 306
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-480 2.48e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 2.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQ 400
Cdd:COG2319   171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTG-HS 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 401 STAVKLAFSRtplpvlllgtlqamewcpwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIAT 479
Cdd:COG2319   247 GSVRSVAFSP-------------------DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLAS 305


                  .
gi 1907093763 480 G 480
Cdd:COG2319   306 G 306
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-480 1.65e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200    15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAG 389
Cdd:cd00200    90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 390 VqglPLKVIPQSTavklafsrtplpvlllGTLQAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSL 468
Cdd:cd00200   168 K---CVATLTGHT----------------GEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSV 225

                         250
                  ....*....|..
gi 1907093763 469 IWLPKTKEIATG 480
Cdd:cd00200   226 AFSPDGYLLASG 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 1.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.72e-05
                           10        20
                   ....*....|....*....|....*....
gi 1907093763  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 6.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.71e-05
                          10        20
                  ....*....|....*....|....*....
gi 1907093763 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-480 2.48e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 2.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQ 400
Cdd:COG2319   171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTG-HS 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 401 STAVKLAFSRtplpvlllgtlqamewcpwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIAT 479
Cdd:COG2319   247 GSVRSVAFSP-------------------DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLAS 305


                  .
gi 1907093763 480 G 480
Cdd:COG2319   306 G 306
WD40 COG2319
WD40 repeat [General function prediction only];
235-480 2.81e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 2.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 235 NTLDWS--SQNLVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLH 312
Cdd:COG2319   166 TSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 313 GHLSVVGALSWNH--CTLSSGSRLGRVHHHDVRvAQHRVGTL-YHKEAVCSLKWSPDGRLLSSGCNDGLLTIWPHDPGAG 389
Cdd:COG2319   244 GHSGSVRSVAFSPdgRLLASGSADGTVRLWDLA-TGELLRTLtGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 390 VQGLPLKVIPQSTavkLAFSRtplpvlllgtlqamewcpwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPST-QSQICSL 468
Cdd:COG2319   323 LRTLTGHTGAVRS---VAFSP-------------------DGKTLASGSD--DGTVRLWDLATGELLRTLTGhTGAVTSV 378

                         250
                  ....*....|..
gi 1907093763 469 IWLPKTKEIATG 480
Cdd:COG2319   379 AFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
237-480 2.45e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 2.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 237 LDWSSQNLVAVALGTSVYIWNGQNHSWIENIDLSVCCHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLS 316
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 317 VVGALSW--NHCTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGL 393
Cdd:COG2319   122 AVRSVAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLR 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 394 PLKViPQSTAVKLAFSRtplpvlllgtlqamewcpwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLP 472
Cdd:COG2319   199 TLTG-HTGAVRSVAFSP-------------------DGKLLASGSA--DGTVRLWDLATGKLLRTlTGHSGSVRSVAFSP 256


                  ....*...
gi 1907093763 473 KTKEIATG 480
Cdd:COG2319   257 DGRLLASG 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-480 1.65e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200    15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAG 389
Cdd:cd00200    90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 390 VqglPLKVIPQSTavklafsrtplpvlllGTLQAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSL 468
Cdd:cd00200   168 K---CVATLTGHT----------------GEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSV 225

                         250
                  ....*....|..
gi 1907093763 469 IWLPKTKEIATG 480
Cdd:cd00200   226 AFSPDGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
235-382 3.73e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 3.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 235 NTLDWSSQN--LVAVALGTSVYIWNGQNHSWIENidLSVCCHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLH 312
Cdd:COG2319   250 RSVAFSPDGrlLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093763 313 GHLSVVGALSW--NHCTLSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:COG2319   328 GHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 235-382 2.05e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 2.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 235 NTLDWSSQN-LVAVALG-TSVYIWNGQNHSWIENIDLsvccH--YVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRN 310
Cdd:cd00200   139 NSVAFSPDGtFVASSSQdGTIKLWDLRTGKCVATLTG----HtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907093763 311 LHGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRvAQHRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:cd00200   215 LRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLR-TGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
276-480 2.71e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 276 VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVG--ALSWNHCTLSSGSRLGRVHHHDVRVAQHRVGTLY 353
Cdd:COG2319    39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQSTAVKLAFSRtplpvlllgtlqamewcpwQSEV 433
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTG-HSGAVTSVAFSP-------------------DGKL 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907093763 434 LAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATG 480
Cdd:COG2319   177 LASGSD--DGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASG 222
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-491 5.22e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 274 HYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW--NHCTLSSGSRlgrvhHHDVRV----AQH 347
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSS-----DKTIRLwdleTGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 348 RVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPhdpgaGVQGLPLKVIP--QSTAVKLAFSRTplpvlllGTLqam 424
Cdd:cd00200    85 CVRTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-----VETGKCLTTLRghTDWVNSVAFSPD-------GTF--- 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907093763 425 ewcpwqsevlaVGGGVKDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAPKNDVALW 491
Cdd:cd00200   150 -----------VASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-394 6.13e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 6.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 233 YLNTLDWSSQNLVAVALGT--SVYIWNgqnhswienIDLSVCCH-------YVSSVTWMREGSCLAVGTSEGEVQLWDAI 303
Cdd:cd00200    95 YVSSVAFSPDGRILSSSSRdkTIKVWD---------VETGKCLTtlrghtdWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 304 TKKQLRNLHGHLSVVGALSWNH--CTLSSGSRLGRVHHHDVRVAQHrVGTL-YHKEAVCSLKWSPDGRLLSSGCNDGLLT 380
Cdd:cd00200   166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKC-LGTLrGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                         170
                  ....*....|....
gi 1907093763 381 IWPHDPGAGVQGLP 394
Cdd:cd00200   245 VWDLRTGECVQTLS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 1.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.72e-05
                           10        20
                   ....*....|....*....|....*....
gi 1907093763  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 6.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.71e-05
                          10        20
                  ....*....|....*....|....*....
gi 1907093763 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
288-480 3.50e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 288 LAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSWNHC--TLSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSP 365
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 366 DGRLLSSGCNDGLLTIWPHDPGAGVQGLplkVIPQSTAVKLAFSRtplpvlllgtlqamewcpwQSEVLAVGGGvkDGCL 445
Cdd:COG2319    89 DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSP-------------------DGKTLASGSA--DGTV 144

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1907093763 446 HVLDINTGKNIQTPST-QSQICSLIWLPKTKEIATG 480
Cdd:COG2319   145 RLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASG 180
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-491 3.48e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 3.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093763 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPHDPGAGVQGLplkvipqstavklafsrtplpVLLLGTLQAMEWCPWQSEV 433
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---------------------KGHTGPVRDVAASADGTYL 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093763 434 LAVGggvKDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATGQGApkNDVALW 491
Cdd:cd00200    67 ASGS---SDKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRD--KTIKVW 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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