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Conserved domains on  [gi|1907095523|ref|XP_036014171|]
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zinc finger protein 431-like [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.12e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.12e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907095523   4 VTYDDVRVNFTEEEWDLLDPSQKSLYEEVMLETYQNITAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-450 1.73e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 101 KPYECNQCGKAFSQQSSLQYHKRTHAGQKPYECNQCGKALSCQR--SLQYHKRTHTGEKPYEC-HQCGKAFVSPSQLQKH 177
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 178 KRTHTGEKPYECNQCGKAFANHNNLQRHKRTHTGEKPYECNQCGKAFAN----------------------HNNLQCHKR 235
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 236 THTGEKPFECNQCGK--------------------------AFAWQCTLQKHKRTHTGEKL--------YQCNQCDKAFS 281
Cdd:COG5048   192 VSTSIPSSSENSPLSssysipssssdqnlensssslplttnSQLSPKSLLSQSPSSLSSSDssssasesPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 282 QHSTLQYHKRIHTG-EKPYECNQCGKAFAWQSSLDMHKRK--HTGE--KPYECD--QCGKAFTWQSSLNMHKRKHTGEKP 354
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 355 YEC--DQCGKAFQ-----WQYSLHIHKRIHTGEKPYEC--NECGKAFAGHTGLQSHKRAHTGEKPYQCD--QCGKAFAHE 423
Cdd:COG5048   352 AKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*..
gi 1907095523 424 NNLKYHKRTHTGKNSYECNQCGKAFAS 450
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRD 458
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.12e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.12e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907095523   4 VTYDDVRVNFTEEEWDLLDPSQKSLYEEVMLETYQNITAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 2.52e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.01  E-value: 2.52e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907095523    4 VTYDDVRVNFTEEEWDLLDPSQKSLYEEVMLETYQNITAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.53e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 1.53e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907095523   4 VTYDDVRVNFTEEEWDLLDPSQKSLYEEVMLETYQNIT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-450 1.73e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 101 KPYECNQCGKAFSQQSSLQYHKRTHAGQKPYECNQCGKALSCQR--SLQYHKRTHTGEKPYEC-HQCGKAFVSPSQLQKH 177
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 178 KRTHTGEKPYECNQCGKAFANHNNLQRHKRTHTGEKPYECNQCGKAFAN----------------------HNNLQCHKR 235
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 236 THTGEKPFECNQCGK--------------------------AFAWQCTLQKHKRTHTGEKL--------YQCNQCDKAFS 281
Cdd:COG5048   192 VSTSIPSSSENSPLSssysipssssdqnlensssslplttnSQLSPKSLLSQSPSSLSSSDssssasesPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 282 QHSTLQYHKRIHTG-EKPYECNQCGKAFAWQSSLDMHKRK--HTGE--KPYECD--QCGKAFTWQSSLNMHKRKHTGEKP 354
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 355 YEC--DQCGKAFQ-----WQYSLHIHKRIHTGEKPYEC--NECGKAFAGHTGLQSHKRAHTGEKPYQCD--QCGKAFAHE 423
Cdd:COG5048   352 AKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*..
gi 1907095523 424 NNLKYHKRTHTGKNSYECNQCGKAFAS 450
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 5.74e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.74e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907095523 201 NLQRHKRTHTGEKPYECNQCGKAFAN 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 23-154 4.53e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523  23 PSQKS---LYEEVMLETYQNItaigynledHHIEEHSQSSRRHERHERIHIGEKPYERNQWGKAFASDNHLQIHKKTN-- 97
Cdd:COG5189   272 PSQGSaelFEESSLGFDYEFI---------HKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRml 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523  98 --TGEKPYECN--QCGKAFSQQSSLQYHK-------RTH------------AGQKPYECNQCGKALSCQRSLQYHkRTHT 154
Cdd:COG5189   343 kvKDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.12e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.12e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907095523   4 VTYDDVRVNFTEEEWDLLDPSQKSLYEEVMLETYQNITAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 2.52e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.01  E-value: 2.52e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907095523    4 VTYDDVRVNFTEEEWDLLDPSQKSLYEEVMLETYQNITAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.53e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 1.53e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907095523   4 VTYDDVRVNFTEEEWDLLDPSQKSLYEEVMLETYQNIT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-450 1.73e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 101 KPYECNQCGKAFSQQSSLQYHKRTHAGQKPYECNQCGKALSCQR--SLQYHKRTHTGEKPYEC-HQCGKAFVSPSQLQKH 177
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 178 KRTHTGEKPYECNQCGKAFANHNNLQRHKRTHTGEKPYECNQCGKAFAN----------------------HNNLQCHKR 235
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 236 THTGEKPFECNQCGK--------------------------AFAWQCTLQKHKRTHTGEKL--------YQCNQCDKAFS 281
Cdd:COG5048   192 VSTSIPSSSENSPLSssysipssssdqnlensssslplttnSQLSPKSLLSQSPSSLSSSDssssasesPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 282 QHSTLQYHKRIHTG-EKPYECNQCGKAFAWQSSLDMHKRK--HTGE--KPYECD--QCGKAFTWQSSLNMHKRKHTGEKP 354
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 355 YEC--DQCGKAFQ-----WQYSLHIHKRIHTGEKPYEC--NECGKAFAGHTGLQSHKRAHTGEKPYQCD--QCGKAFAHE 423
Cdd:COG5048   352 AKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*..
gi 1907095523 424 NNLKYHKRTHTGKNSYECNQCGKAFAS 450
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
73-225 1.53e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523  73 KPYERNQWGKAFASDNHLQIHKKTN--TGE--KPYEC--NQCGKAFSQQSSLQYHKRTHAGQKPYECNQC-------GKA 139
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVnhSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 140 LSCQRSLQYHKRTHTGEKPYEC--HQCGKAFVSPSQLQKHKRTHTGEKPYECN--QCGKAFANHNNLQRHKRTHTGEKPY 215
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|
gi 1907095523 216 ECNQCGKAFA 225
Cdd:COG5048   448 LCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-466 5.99e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 174 LQKHKRTHTGE----KPYECNQCGKAFANHNNLQRHKRTHTGEKPYECNQCGKAFA---NHNNLQCHKRTHTGEKPFECN 246
Cdd:COG5048    17 SSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsrPLELSRHLRTHHNNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 247 QCGKAFAWQCTLQKHKRTHTGEKLYQCNQCDKAFSQHSTLQYHKRIHTGEKPYECNQCGKAFA----------------- 309
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpansl 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 310 -----WQSSLDMHKRKHTGEKPYECDQCGKAFTWQSSLNMHKRKHTGEKPYECDQCGKAF------QWQYSLHIHKRIHT 378
Cdd:COG5048   177 skdpsSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 379 GEKPYECNECGKAFAGHTGLQSHKRAHTG-EKPYQCDQCGKAFAHENNLKYHKRT--HTGKNSYEC----NQCGKAFASH 451
Cdd:COG5048   257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFscpySLCGKLFSRN 336

                         330
                  ....*....|....*
gi 1907095523 452 SHLQVHERTHFRKKP 466
Cdd:COG5048   337 DALKRHILLHTSISP 351
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-441 1.48e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 128 QKPYECNQCGKALSCQRSLQYHKRTHTGEKPYECHQ--CGKAFVSPSQLQKHKRTHTGEKPYECNQCgkafanhNNLQRH 205
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS-------LPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 206 KRTHtgekpYECNQCGKAFANHNNLQCHKRTHTGEKPFECNQCGKAFAWQCTLQKHKRTHTGEKLYQC-------NQCDK 278
Cdd:COG5048   104 KASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpaNSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 279 AFSQHSTLQYHKRIHTGEKPYECNQCGKAFAWQSSLDMHKRKHTGEKPYECDQCGKAFT------WQSSLNMHKRKHTGE 352
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 353 KPYECDQCGKAFQWQYSLHIHKRIHTG-EKPYECNECGKAFAGHTGLQSHKRA--HTGE--KPYQCD--QCGKAFAHENN 425
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDA 338

                         330
                  ....*....|....*.
gi 1907095523 426 LKYHKRTHTGKNSYEC 441
Cdd:COG5048   339 LKRHILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 127-210 9.41e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 9.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 127 GQKPYECN--QCGKALSCQRSLQYHKRthtgekpyECHQCGKAFVSPSQlQKHKRTHTGEKPYECNQCGKAFANHNNLQR 204
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML--------HGHQNQKLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1907095523 205 HkRTHT 210
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 5.74e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.74e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907095523 201 NLQRHKRTHTGEKPYECNQCGKAFAN 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 351-434 1.20e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 351 GEKPYECD--QCGKAFQWQYSLHIHkRIHtgekpyecNECGKAFAGHTGLQSHKRAHTGEKPYQCDQCGKAFAHENNLKY 428
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1907095523 429 HkRTHT 434
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 3.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.74e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907095523 145 SLQYHKRTHTGEKPYECHQCGKAFVS 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-198 4.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.00e-04
                          10        20
                  ....*....|....*....|....*
gi 1907095523 174 LQKHKRTHTGEKPYECNQCGKAFAN 198
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 23-154 4.53e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523  23 PSQKS---LYEEVMLETYQNItaigynledHHIEEHSQSSRRHERHERIHIGEKPYERNQWGKAFASDNHLQIHKKTN-- 97
Cdd:COG5189   272 PSQGSaelFEESSLGFDYEFI---------HKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRml 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523  98 --TGEKPYECN--QCGKAFSQQSSLQYHK-------RTH------------AGQKPYECNQCGKALSCQRSLQYHkRTHT 154
Cdd:COG5189   343 kvKDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-337 7.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....*
gi 1907095523 313 SLDMHKRKHTGEKPYECDQCGKAFT 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 171-238 8.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907095523 171 PSQLQKHKrthtGEKPYECN--QCGKAFANHNNLQRHK-------RTH------------TGEKPYECNQCGKAFANHNN 229
Cdd:COG5189   338 PSRMLKVK----DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNG 413


                  ....*....
gi 1907095523 230 LQCHkRTHT 238
Cdd:COG5189   414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-309 9.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.21e-04
                          10        20
                  ....*....|....*....|....
gi 1907095523 286 LQYHKRIHTGEKPYECNQCGKAFA 309
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-364 9.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.87e-04
                          10        20
                  ....*....|....*....|....
gi 1907095523 341 SLNMHKRKHTGEKPYECDQCGKAF 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-422 3.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|....*
gi 1907095523 398 LQSHKRAHTGEKPYQCDQCGKAFAH 422
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 3.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1907095523 258 LQKHKRTHTGEKLYQCNQCDKAFSQ 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 3.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907095523 425 NLKYHKRTHTGKNSYECNQCGKAFAS 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-253 4.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.31e-03
                          10        20
                  ....*....|....*....|....*
gi 1907095523 229 NLQCHKRTHTGEKPFECNQCGKAFA 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-393 5.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.78e-03
                          10        20
                  ....*....|....*....|.
gi 1907095523 373 HKRIHTGEKPYECNECGKAFA 393
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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