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Conserved domains on  [gi|1907115577|ref|XP_036015620|]
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RNA polymerase I-specific transcription initiation factor RRN3 isoform X1 [Mus musculus]

Protein Classification

RNA polymerase I-specific transcription initiation factor RRN3 family protein( domain architecture ID 10526375)

RNA polymerase I-specific transcription initiation factor RRN3 family protein similar to human RRN3 that is required for efficient transcription initiation by RNA polymerase I, and for the formation of the competent preinitiation complex (PIC).

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 3-484 1.30e-135

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


:

Pssm-ID: 461623  Cd Length: 548  Bit Score: 405.07  E-value: 1.30e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577   3 LTKDFEQLINIILRLPWLNRSQRVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIvkeggiDVSDSDDEDDNLPA 82
Cdd:pfam05327  63 LDRSCSGLVEAILSLSWLGRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPES------SGRLPGYPPVTRRE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577  83 IFDTCHRALQIITRYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISLYFPTLRREILELVIEKLLKLDVS--VS 160
Cdd:pfam05327 137 VYERVHEALKYILRLIPTAPSVLLPILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEiqVE 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 161 RQDIED-AEEKAAQTCGGTDTTEGLFNMDEDEDTDPEKKADQEQPN-----QMAHPTAERLDVLLCLLLSYIEDVCR--V 232
Cdd:pfam05327 217 LEDLDDdEDEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgS 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 233 HGKIDNNKTKDLYRDLISIFDKLLLPTHASCHVQFFMFFLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFL 312
Cdd:pfam05327 297 PEELNEGEGVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFV 376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 313 ARAKFIPLITVKTCLDLLVNWLHMYLTNQDSGTKAfCDVALHGPFYSACQAVFYTVVFRHKQLL---SGNLKQGLQYLQS 389
Cdd:pfam05327 377 ARAKFVSRSQVRFVLSYLCDWLNRYVDEREEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPG 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 390 LN--FERIVLSQLNPLKICLPQVVNFFAAITNKYQLVFCYTIMERNSRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCV 467
Cdd:pfam05327 456 LDefLQRAIYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYL 528

                         490
                  ....*....|....*..
gi 1907115577 468 LKRSKKFIDPIYQIWED 484
Cdd:pfam05327 529 LPRSKRWIEPDYVEWSE 545
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 3-484 1.30e-135

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 405.07  E-value: 1.30e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577   3 LTKDFEQLINIILRLPWLNRSQRVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIvkeggiDVSDSDDEDDNLPA 82
Cdd:pfam05327  63 LDRSCSGLVEAILSLSWLGRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPES------SGRLPGYPPVTRRE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577  83 IFDTCHRALQIITRYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISLYFPTLRREILELVIEKLLKLDVS--VS 160
Cdd:pfam05327 137 VYERVHEALKYILRLIPTAPSVLLPILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEiqVE 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 161 RQDIED-AEEKAAQTCGGTDTTEGLFNMDEDEDTDPEKKADQEQPN-----QMAHPTAERLDVLLCLLLSYIEDVCR--V 232
Cdd:pfam05327 217 LEDLDDdEDEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgS 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 233 HGKIDNNKTKDLYRDLISIFDKLLLPTHASCHVQFFMFFLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFL 312
Cdd:pfam05327 297 PEELNEGEGVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFV 376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 313 ARAKFIPLITVKTCLDLLVNWLHMYLTNQDSGTKAfCDVALHGPFYSACQAVFYTVVFRHKQLL---SGNLKQGLQYLQS 389
Cdd:pfam05327 377 ARAKFVSRSQVRFVLSYLCDWLNRYVDEREEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPG 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 390 LN--FERIVLSQLNPLKICLPQVVNFFAAITNKYQLVFCYTIMERNSRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCV 467
Cdd:pfam05327 456 LDefLQRAIYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYL 528

                         490
                  ....*....|....*..
gi 1907115577 468 LKRSKKFIDPIYQIWED 484
Cdd:pfam05327 529 LPRSKRWIEPDYVEWSE 545
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 3-484 1.30e-135

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 405.07  E-value: 1.30e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577   3 LTKDFEQLINIILRLPWLNRSQRVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIvkeggiDVSDSDDEDDNLPA 82
Cdd:pfam05327  63 LDRSCSGLVEAILSLSWLGRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPES------SGRLPGYPPVTRRE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577  83 IFDTCHRALQIITRYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISLYFPTLRREILELVIEKLLKLDVS--VS 160
Cdd:pfam05327 137 VYERVHEALKYILRLIPTAPSVLLPILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEiqVE 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 161 RQDIED-AEEKAAQTCGGTDTTEGLFNMDEDEDTDPEKKADQEQPN-----QMAHPTAERLDVLLCLLLSYIEDVCR--V 232
Cdd:pfam05327 217 LEDLDDdEDEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgS 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 233 HGKIDNNKTKDLYRDLISIFDKLLLPTHASCHVQFFMFFLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFL 312
Cdd:pfam05327 297 PEELNEGEGVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFV 376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 313 ARAKFIPLITVKTCLDLLVNWLHMYLTNQDSGTKAfCDVALHGPFYSACQAVFYTVVFRHKQLL---SGNLKQGLQYLQS 389
Cdd:pfam05327 377 ARAKFVSRSQVRFVLSYLCDWLNRYVDEREEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPG 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907115577 390 LN--FERIVLSQLNPLKICLPQVVNFFAAITNKYQLVFCYTIMERNSRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCV 467
Cdd:pfam05327 456 LDefLQRAIYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYL 528

                         490
                  ....*....|....*..
gi 1907115577 468 LKRSKKFIDPIYQIWED 484
Cdd:pfam05327 529 LPRSKRWIEPDYVEWSE 545
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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