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Conserved domains on  [gi|1907116591|ref|XP_036015672|]
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guanine nucleotide-binding protein subunit beta-like protein 1 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
76-219 3.51e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 3.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  76 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 153
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116591 154 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:COG2319   209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
76-219 3.51e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 3.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  76 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 153
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116591 154 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:COG2319   209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-219 1.31e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  71 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 150
Cdd:cd00200    18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591 151 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:cd00200    95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 70-219 2.71e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  70 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 148
Cdd:PLN00181  541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907116591 149 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 219
Cdd:PLN00181  617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 180-218 3.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 3.54e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907116591  180 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
181-218 1.75e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.75e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907116591 181 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
76-219 3.51e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 3.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  76 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 153
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116591 154 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:COG2319   209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
76-219 4.53e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 4.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  76 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 153
Cdd:COG2319   260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 334

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116591 154 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:COG2319   335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
76-219 2.30e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 2.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  76 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIA 153
Cdd:COG2319   176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLL--ASGSADGTVRLWDLATGKLLRTLTGHS---GSVR 250

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116591 154 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-219 1.31e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  71 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 150
Cdd:cd00200    18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591 151 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:cd00200    95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
71-219 5.33e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 5.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  71 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 150
Cdd:COG2319    45 SPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT---G 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591 151 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:COG2319   122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWDL 191
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-218 6.53e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 6.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  76 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIAEV 155
Cdd:cd00200   149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE---NGVNSV 225

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907116591 156 TIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 218
Cdd:cd00200   226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-219 2.64e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 2.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  71 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHELtnp 150
Cdd:cd00200   102 SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG--- 178

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591 151 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:cd00200   179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-219 8.24e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 8.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  99 QITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHELtnpGIAEVTIRPDHKILATAGWDHRIRVFHW 178
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---PVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907116591 179 RTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 219
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
76-180 1.29e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  76 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIAEV 155
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT---GAVTSV 378

                          90       100
                  ....*....|....*....|....*
gi 1907116591 156 TIRPDHKILATAGWDHRIRVFHWRT 180
Cdd:COG2319   379 AFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 70-219 2.71e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591  70 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 148
Cdd:PLN00181  541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907116591 149 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 219
Cdd:PLN00181  617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 180-218 3.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 3.54e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907116591  180 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
181-218 1.75e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.75e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907116591 181 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-222 9.44e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 9.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907116591 190 HSAPVYCVAFAADG-LLAAGSKDQRISIWSLYPC 222
Cdd:cd00200     8 HTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
135-216 2.96e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 37.75  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591 135 DQQSLQVKKTHELtNPGIAEVTIRPD-HKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPvYCVAFAADG--LLAAGSKD 211
Cdd:COG3391    96 DLATGKVVATIPV-GGGPRGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGkrLYVANSGS 173


                  ....*
gi 1907116591 212 QRISI 216
Cdd:COG3391   174 NTVSV 178
WD40 COG2319
WD40 repeat [General function prediction only];
117-219 3.79e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.58  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116591 117 AKGISGSAGKVLAVWSLDDQQSLQVKKTHELTNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYC 196
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100
                  ....*....|....*....|....
gi 1907116591 197 VAFAADG-LLAAGSKDQRISIWSL 219
Cdd:COG2319    84 VAFSPDGrLLASASADGTVRLWDL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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