|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
454-699 |
3.99e-86 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
:
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 271.46 E-value: 3.99e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 454 IFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSldpeeptlhssyllSPSDFKIIMGKHWRRRSDE 533
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 534 DEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPS--TEGTMVIVSGWGK-QFLQRFPENLMEIE 610
Cdd:cd00190 67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 611 IPIVNSDTCQEAYtPLKKKVTKDMICAGEKEGGKDACAGDSGGPMVTKDaeRDQWYLVGVVSWGEDCGKKDRYGVYSYIY 690
Cdd:cd00190 147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGSGCARPNYPGVYTRVS 223
|
....*....
gi 1907116859 691 PNKDWIQRI 699
Cdd:cd00190 224 SYLDWIQKT 232
|
|
| CUB |
pfam00431 |
CUB domain; |
190-299 |
2.06e-36 |
|
CUB domain;
:
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 132.42 E-value: 2.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431 1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76
|
90 100 110
....*....|....*....|....*....|....
gi 1907116859 266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431 77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
33-142 |
7.65e-30 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
:
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 114.05 E-value: 7.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041 10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82
|
90 100 110
....*....|....*....|....*....|....
gi 1907116859 109 qEVVLSPGTFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041 83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
306-368 |
2.76e-10 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
:
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 56.32 E-value: 2.76e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907116859 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033 1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
158-186 |
1.97e-08 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
:
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 50.32 E-value: 1.97e-08
10 20
....*....|....*....|....*....
gi 1907116859 158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| PHA02639 super family |
cl31493 |
EEV host range protein; Provisional |
305-438 |
2.97e-06 |
|
EEV host range protein; Provisional
The actual alignment was detected with superfamily member PHA02639:
Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 49.66 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 305 ECPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKV---LKDNEvmdtfQIECLKDGAWSNKIPTCKIVDCGAPAgLKHG 381
Cdd:PHA02639 84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVqysLVGNE-----KITCIQDKSWKPDPPICKMINCRFPA-LQNG 157
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116859 382 LVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNevlkrSLPTCL 438
Cdd:PHA02639 158 YINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
454-699 |
3.99e-86 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 271.46 E-value: 3.99e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 454 IFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSldpeeptlhssyllSPSDFKIIMGKHWRRRSDE 533
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 534 DEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPS--TEGTMVIVSGWGK-QFLQRFPENLMEIE 610
Cdd:cd00190 67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 611 IPIVNSDTCQEAYtPLKKKVTKDMICAGEKEGGKDACAGDSGGPMVTKDaeRDQWYLVGVVSWGEDCGKKDRYGVYSYIY 690
Cdd:cd00190 147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGSGCARPNYPGVYTRVS 223
|
....*....
gi 1907116859 691 PNKDWIQRI 699
Cdd:cd00190 224 SYLDWIQKT 232
|
|
| Tryp_SPc |
smart00020 |
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ... |
453-696 |
1.00e-83 |
|
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Pssm-ID: 214473 Cd Length: 229 Bit Score: 264.93 E-value: 1.00e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 453 RIFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSldpeeptlhssyllSPSDFKIIMGKHwRRRSD 532
Cdd:smart00020 1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSH-DLSSG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 533 EDEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPST--EGTMVIVSGWGKQFL--QRFPENLME 608
Cdd:smart00020 66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNvpAGTTCTVSGWGRTSEgaGSLPDTLQE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 609 IEIPIVNSDTCQEAYtPLKKKVTKDMICAGEKEGGKDACAGDSGGPMVTKDaerDQWYLVGVVSWGEDCGKKDRYGVYSY 688
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGSGCARPGKPGVYTR 221
|
....*...
gi 1907116859 689 IYPNKDWI 696
Cdd:smart00020 222 VSSYLDWI 229
|
|
| Trypsin |
pfam00089 |
Trypsin; |
454-696 |
3.78e-77 |
|
Trypsin;
Pssm-ID: 459667 [Multi-domain] Cd Length: 219 Bit Score: 247.36 E-value: 3.78e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 454 IFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHqsldpeeptlhssyllSPSDFKIIMGKHWRRRSDE 533
Cdd:pfam00089 1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 534 DEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPST--EGTMVIVSGWGKQFLQRFPENLMEIEI 611
Cdd:pfam00089 65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDlpVGTTCTVSGWGNTKTLGPSDTLQEVTV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 612 PIVNSDTCQEAYtplKKKVTKDMICAGekEGGKDACAGDSGGPMVTKDAerdqwYLVGVVSWGEDCGKKDRYGVYSYIYP 691
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSS 214
|
....*
gi 1907116859 692 NKDWI 696
Cdd:pfam00089 215 YLDWI 219
|
|
| COG5640 |
COG5640 |
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ... |
452-701 |
1.24e-61 |
|
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444365 [Multi-domain] Cd Length: 262 Bit Score: 207.58 E-value: 1.24e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 452 SRIFNGRPAQKGTMPWIAMLSHLNG--QPFCGGSLLGSNWVLTAAHCLhqsldpeeptlhssYLLSPSDFKIIMGKHwrR 529
Cdd:COG5640 29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHCV--------------DGDGPSDLRVVIGST--D 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 530 RSDEDEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPrlnDFVMPVCLP--EQPSTEGTMVIVSGWGK--QFLQRFPEN 605
Cdd:COG5640 93 LSTSGGTVVKVARIVVHPDYDPATPGNDIALLKLATPV---PGVAPAPLAtsADAAAPGTPATVAGWGRtsEGPGSQSGT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 606 LMEIEIPIVNSDTCQeAYTPLkkkVTKDMICAGEKEGGKDACAGDSGGPMVTKDAerDQWYLVGVVSWGEDCGKKDRYGV 685
Cdd:COG5640 170 LRKADVPVVSDATCA-AYGGF---DGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCAAGYPGV 243
|
250
....*....|....*.
gi 1907116859 686 YSYIYPNKDWIQRITG 701
Cdd:COG5640 244 YTRVSAYRDWIKSTAG 259
|
|
| CUB |
pfam00431 |
CUB domain; |
190-299 |
2.06e-36 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 132.42 E-value: 2.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431 1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76
|
90 100 110
....*....|....*....|....*....|....
gi 1907116859 266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431 77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
190-301 |
7.69e-35 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 128.30 E-value: 7.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 190 CSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:cd00041 1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGpstsSPLLGRFC 77
|
90 100 110
....*....|....*....|....*....|....*.
gi 1907116859 266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSYRA 301
Cdd:cd00041 78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
200-299 |
6.80e-30 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 113.64 E-value: 6.80e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 200 GTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFCGEKSPEP-IS 274
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGpsasSPLLGRFCGSEAPPPvIS 77
|
90 100
....*....|....*....|....*
gi 1907116859 275 TQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:smart00042 78 SSSNSLTLTFVSDSSVQKRGFSARY 102
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
33-142 |
7.65e-30 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 114.05 E-value: 7.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041 10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82
|
90 100 110
....*....|....*....|....*....|....
gi 1907116859 109 qEVVLSPGTFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041 83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
34-140 |
2.29e-29 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 112.10 E-value: 2.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 34 GQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 109
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73
|
90 100 110
....*....|....*....|....*....|.
gi 1907116859 110 EVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:smart00042 74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
|
|
| CUB |
pfam00431 |
CUB domain; |
28-140 |
7.89e-22 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 90.82 E-value: 7.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 28 ELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 103
Cdd:pfam00431 4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 1907116859 104 eqtpGQEVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:pfam00431 80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
306-368 |
2.76e-10 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 56.32 E-value: 2.76e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907116859 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033 1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
306-367 |
1.20e-09 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 54.43 E-value: 1.20e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907116859 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:pfam00084 1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
306-367 |
1.39e-09 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 54.45 E-value: 1.39e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907116859 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
158-186 |
1.97e-08 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 50.32 E-value: 1.97e-08
10 20
....*....|....*....|....*....
gi 1907116859 158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| PHA02639 |
PHA02639 |
EEV host range protein; Provisional |
305-438 |
2.97e-06 |
|
EEV host range protein; Provisional
Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 49.66 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 305 ECPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKV---LKDNEvmdtfQIECLKDGAWSNKIPTCKIVDCGAPAgLKHG 381
Cdd:PHA02639 84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVqysLVGNE-----KITCIQDKSWKPDPPICKMINCRFPA-LQNG 157
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116859 382 LVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNevlkrSLPTCL 438
Cdd:PHA02639 158 YINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
372-437 |
2.13e-05 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 42.45 E-value: 2.13e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907116859 372 CGAPAGLKHGLVTFSTRNnlTTYKSEIRYSCqQPYYKMLHNTTgvYTCSAHGTWTNEVlkrslPTC 437
Cdd:cd00033 1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGSST--ITCTENGGWSPPP-----PTC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
372-437 |
2.32e-05 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 42.49 E-value: 2.32e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907116859 372 CGAPAGLKHGLVtfSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:pfam00084 1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSPTI---TCQEDGTWSPPF-----PEC 56
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
144-186 |
5.12e-05 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 5.12e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907116859 144 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 186
Cdd:smart00179 1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
|
|
| PHA02954 |
PHA02954 |
EEV membrane glycoprotein; Provisional |
284-387 |
1.68e-04 |
|
EEV membrane glycoprotein; Provisional
Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 44.31 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 284 FRSDNSGENRGWRLSYRAAGNECPKLQPPvYGKIEPSQAVYSFKDQVLVSCDTGYkvlkdnEVMDTFQIECLKDgAWsNK 363
Cdd:PHA02954 108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGY------EVIGASYISCTAN-SW-NV 178
|
90 100
....*....|....*....|....
gi 1907116859 364 IPTCKiVDCGAPAgLKHGLVTFST 387
Cdd:PHA02954 179 IPSCQ-QKCDIPS-LSNGLISGST 200
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
144-181 |
2.08e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.16 E-value: 2.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1907116859 144 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 181
Cdd:cd00054 1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
372-437 |
6.39e-04 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 38.28 E-value: 6.39e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907116859 372 CGAPAGLKHGLVTFSTRNnlTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:smart00032 1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTLIGSSTI---TCLENGTWSPPP-----PTC 56
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
454-699 |
3.99e-86 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 271.46 E-value: 3.99e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 454 IFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSldpeeptlhssyllSPSDFKIIMGKHWRRRSDE 533
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 534 DEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPS--TEGTMVIVSGWGK-QFLQRFPENLMEIE 610
Cdd:cd00190 67 GGQVIKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEVN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 611 IPIVNSDTCQEAYtPLKKKVTKDMICAGEKEGGKDACAGDSGGPMVTKDaeRDQWYLVGVVSWGEDCGKKDRYGVYSYIY 690
Cdd:cd00190 147 VPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGSGCARPNYPGVYTRVS 223
|
....*....
gi 1907116859 691 PNKDWIQRI 699
Cdd:cd00190 224 SYLDWIQKT 232
|
|
| Tryp_SPc |
smart00020 |
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ... |
453-696 |
1.00e-83 |
|
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Pssm-ID: 214473 Cd Length: 229 Bit Score: 264.93 E-value: 1.00e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 453 RIFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSldpeeptlhssyllSPSDFKIIMGKHwRRRSD 532
Cdd:smart00020 1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSH-DLSSG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 533 EDEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPST--EGTMVIVSGWGKQFL--QRFPENLME 608
Cdd:smart00020 66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNvpAGTTCTVSGWGRTSEgaGSLPDTLQE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 609 IEIPIVNSDTCQEAYtPLKKKVTKDMICAGEKEGGKDACAGDSGGPMVTKDaerDQWYLVGVVSWGEDCGKKDRYGVYSY 688
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGSGCARPGKPGVYTR 221
|
....*...
gi 1907116859 689 IYPNKDWI 696
Cdd:smart00020 222 VSSYLDWI 229
|
|
| Trypsin |
pfam00089 |
Trypsin; |
454-696 |
3.78e-77 |
|
Trypsin;
Pssm-ID: 459667 [Multi-domain] Cd Length: 219 Bit Score: 247.36 E-value: 3.78e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 454 IFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHqsldpeeptlhssyllSPSDFKIIMGKHWRRRSDE 533
Cdd:pfam00089 1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 534 DEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPST--EGTMVIVSGWGKQFLQRFPENLMEIEI 611
Cdd:pfam00089 65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDlpVGTTCTVSGWGNTKTLGPSDTLQEVTV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 612 PIVNSDTCQEAYtplKKKVTKDMICAGekEGGKDACAGDSGGPMVTKDAerdqwYLVGVVSWGEDCGKKDRYGVYSYIYP 691
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSS 214
|
....*
gi 1907116859 692 NKDWI 696
Cdd:pfam00089 215 YLDWI 219
|
|
| COG5640 |
COG5640 |
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ... |
452-701 |
1.24e-61 |
|
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444365 [Multi-domain] Cd Length: 262 Bit Score: 207.58 E-value: 1.24e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 452 SRIFNGRPAQKGTMPWIAMLSHLNG--QPFCGGSLLGSNWVLTAAHCLhqsldpeeptlhssYLLSPSDFKIIMGKHwrR 529
Cdd:COG5640 29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHCV--------------DGDGPSDLRVVIGST--D 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 530 RSDEDEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPrlnDFVMPVCLP--EQPSTEGTMVIVSGWGK--QFLQRFPEN 605
Cdd:COG5640 93 LSTSGGTVVKVARIVVHPDYDPATPGNDIALLKLATPV---PGVAPAPLAtsADAAAPGTPATVAGWGRtsEGPGSQSGT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 606 LMEIEIPIVNSDTCQeAYTPLkkkVTKDMICAGEKEGGKDACAGDSGGPMVTKDAerDQWYLVGVVSWGEDCGKKDRYGV 685
Cdd:COG5640 170 LRKADVPVVSDATCA-AYGGF---DGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCAAGYPGV 243
|
250
....*....|....*.
gi 1907116859 686 YSYIYPNKDWIQRITG 701
Cdd:COG5640 244 YTRVSAYRDWIKSTAG 259
|
|
| CUB |
pfam00431 |
CUB domain; |
190-299 |
2.06e-36 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 132.42 E-value: 2.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431 1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76
|
90 100 110
....*....|....*....|....*....|....
gi 1907116859 266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431 77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
190-301 |
7.69e-35 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 128.30 E-value: 7.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 190 CSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:cd00041 1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGpstsSPLLGRFC 77
|
90 100 110
....*....|....*....|....*....|....*.
gi 1907116859 266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSYRA 301
Cdd:cd00041 78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
200-299 |
6.80e-30 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 113.64 E-value: 6.80e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 200 GTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFCGEKSPEP-IS 274
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGpsasSPLLGRFCGSEAPPPvIS 77
|
90 100
....*....|....*....|....*
gi 1907116859 275 TQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:smart00042 78 SSSNSLTLTFVSDSSVQKRGFSARY 102
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
33-142 |
7.65e-30 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 114.05 E-value: 7.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041 10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82
|
90 100 110
....*....|....*....|....*....|....
gi 1907116859 109 qEVVLSPGTFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041 83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
34-140 |
2.29e-29 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 112.10 E-value: 2.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 34 GQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 109
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73
|
90 100 110
....*....|....*....|....*....|.
gi 1907116859 110 EVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:smart00042 74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
|
|
| CUB |
pfam00431 |
CUB domain; |
28-140 |
7.89e-22 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 90.82 E-value: 7.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 28 ELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 103
Cdd:pfam00431 4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 1907116859 104 eqtpGQEVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:pfam00431 80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
|
|
| eMpr |
COG3591 |
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ... |
468-699 |
2.05e-11 |
|
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 442810 [Multi-domain] Cd Length: 194 Bit Score: 63.54 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 468 IAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSLDPEEPTlhssyllspsDFKIIMGkhwrrRSDEDEQHLHVKRTTLHP 547
Cdd:COG3591 2 VGRLETDGGGGVCTGTLIGPNLVLTAGHCVYDGAGGGWAT----------NIVFVPG-----YNGGPYGTATATRFRVPP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 548 LYNPST-FENDLGLVELSESPRLNDFVMPVcLPEQPSTEGTMVIVSGWGkqflQRFPENL-MEIEIPIVNSDTCQEAYTp 625
Cdd:COG3591 67 GWVASGdAGYDYALLRLDEPLGDTTGWLGL-AFNDAPLAGEPVTIIGYP----GDRPKDLsLDCSGRVTGVQGNRLSYD- 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907116859 626 lkkkvtkdmiCagekeggkDACAGDSGGPMVTKDAERdqWYLVGVVSWGEDcgkkDRYGVYSYIypNKDWIQRI 699
Cdd:COG3591 141 ----------C--------DTTGGSSGSPVLDDSDGG--GRVVGVHSAGGA----DRANTGVRL--TSAIVAAL 188
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
306-368 |
2.76e-10 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 56.32 E-value: 2.76e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907116859 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033 1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
306-367 |
1.20e-09 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 54.43 E-value: 1.20e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907116859 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:pfam00084 1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
306-367 |
1.39e-09 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 54.45 E-value: 1.39e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907116859 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
158-186 |
1.97e-08 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 50.32 E-value: 1.97e-08
10 20
....*....|....*....|....*....
gi 1907116859 158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| PHA02639 |
PHA02639 |
EEV host range protein; Provisional |
305-438 |
2.97e-06 |
|
EEV host range protein; Provisional
Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 49.66 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 305 ECPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKV---LKDNEvmdtfQIECLKDGAWSNKIPTCKIVDCGAPAgLKHG 381
Cdd:PHA02639 84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVqysLVGNE-----KITCIQDKSWKPDPPICKMINCRFPA-LQNG 157
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907116859 382 LVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNevlkrSLPTCL 438
Cdd:PHA02639 158 YINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
372-437 |
2.13e-05 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 42.45 E-value: 2.13e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907116859 372 CGAPAGLKHGLVTFSTRNnlTTYKSEIRYSCqQPYYKMLHNTTgvYTCSAHGTWTNEVlkrslPTC 437
Cdd:cd00033 1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGSST--ITCTENGGWSPPP-----PTC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
372-437 |
2.32e-05 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 42.49 E-value: 2.32e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907116859 372 CGAPAGLKHGLVtfSTRNNLTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:pfam00084 1 CPPPPDIPNGKV--SATKNEYNYGASVSYECDPGYRLVGSPTI---TCQEDGTWSPPF-----PEC 56
|
|
| PHA02817 |
PHA02817 |
EEV Host range protein; Provisional |
311-437 |
4.12e-05 |
|
EEV Host range protein; Provisional
Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 45.70 E-value: 4.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 311 PP--VYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEVMDTfQIECLKDGAWSNKIPTCKIVDCGAPAgLKHGLVTFSTR 388
Cdd:PHA02817 27 PPsiKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEK-NIICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNGIPD 104
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1907116859 389 NNLTTYKSEIRYSCQQPYykmLHNTTGVYTCSAHGTWTNEVlkrslPTC 437
Cdd:PHA02817 105 SKKFYYESEVSFSCKPGF---VLIGTKYSVCGINSSWIPKV-----PIC 145
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
144-186 |
5.12e-05 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 5.12e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907116859 144 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 186
Cdd:smart00179 1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
|
|
| PHA02954 |
PHA02954 |
EEV membrane glycoprotein; Provisional |
284-387 |
1.68e-04 |
|
EEV membrane glycoprotein; Provisional
Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 44.31 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 284 FRSDNSGENRGWRLSYRAAGNECPKLQPPvYGKIEPSQAVYSFKDQVLVSCDTGYkvlkdnEVMDTFQIECLKDgAWsNK 363
Cdd:PHA02954 108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGY------EVIGASYISCTAN-SW-NV 178
|
90 100
....*....|....*....|....
gi 1907116859 364 IPTCKiVDCGAPAgLKHGLVTFST 387
Cdd:PHA02954 179 IPSCQ-QKCDIPS-LSNGLISGST 200
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
144-181 |
2.08e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.16 E-value: 2.08e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1907116859 144 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 181
Cdd:cd00054 1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
|
|
| PHA02927 |
PHA02927 |
secreted complement-binding protein; Provisional |
294-455 |
2.43e-04 |
|
secreted complement-binding protein; Provisional
Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 43.49 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 294 GWRLSYRAAGNECPKLQPPVYGKIEPSQAvySFKDQVLVSCDTGYKVLkdNEVMDTFQIECLKDGAWSNKIPTCKIVDCG 373
Cdd:PHA02927 74 GWTLFNQCIKRRCPSPRDIDNGQLDIGGV--DFGSSITYSCNSGYQLI--GESKSYCELGSTGSMVWNPEAPICESVKCQ 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907116859 374 APAGLKHGlvTFSTRNNLTTYKSEIRYSCQQPYykMLHNTTGVyTCSAhGTWTNEvlkrslPTCLPV-CGVPKFSRKQIS 452
Cdd:PHA02927 150 SPPSISNG--RHNGYEDFYTDGSVVTYSCNSGY--SLIGNSGV-LCSG-GEWSDP------PTCQIVkCPHPTISNGYLS 217
|
...
gi 1907116859 453 RIF 455
Cdd:PHA02927 218 SGF 220
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
372-437 |
6.39e-04 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 38.28 E-value: 6.39e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907116859 372 CGAPAGLKHGLVTFSTRNnlTTYKSEIRYSCQQPYYKMLHNTTgvyTCSAHGTWTNEVlkrslPTC 437
Cdd:smart00032 1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTLIGSSTI---TCLENGTWSPPP-----PTC 56
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
144-176 |
5.21e-03 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 34.91 E-value: 5.21e-03
10 20 30
....*....|....*....|....*....|....*
gi 1907116859 144 DVDECkerEDEELSCDH--YCHNYIGGYYCSCRFG 176
Cdd:pfam07645 1 DVDEC---ATGTHNCPAntVCVNTIGSFECRCPDG 32
|
|
| vWA_Matrilin |
cd01475 |
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
121-185 |
6.35e-03 |
|
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.
Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 38.91 E-value: 6.35e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907116859 121 VTFRSDFSNEERFTGFDAHYMAVDVDECKEredEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 185
Cdd:cd01475 163 VFYVEDFSTIEELTKKFQGKICVVPDLCAT---LSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
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