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Conserved domains on  [gi|1907137037|ref|XP_036015763|]
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zinc finger protein 106 isoform X4 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
316-592 7.49e-43

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 7.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 316 FEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNIK 393
Cdd:COG2319   116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 394 TRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHGPRaVSCLATAQEGarKLLVVGSYD 468
Cdd:COG2319   193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 469 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 544
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907137037 545 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 592
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
316-592 7.49e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 7.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 316 FEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNIK 393
Cdd:COG2319   116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 394 TRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHGPRaVSCLATAQEGarKLLVVGSYD 468
Cdd:COG2319   193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 469 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 544
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907137037 545 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 592
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-591 1.04e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 1.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 314 GSFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLvthTSGKSSVLYTGSSDHTIRCYN 391
Cdd:cd00200     3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA---ASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 392 IKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 468
Cdd:cd00200    80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 469 CTISVRDARNGLLLRTLEGHSKTVLCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 544
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1907137037 545 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 591
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 349-391 1.74e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907137037  349 SRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 391
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
350-391 1.40e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907137037 350 RKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 391
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
316-592 7.49e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 7.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 316 FEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNIK 393
Cdd:COG2319   116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 394 TRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHGPRaVSCLATAQEGarKLLVVGSYD 468
Cdd:COG2319   193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 469 CTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 544
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907137037 545 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 592
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-591 1.04e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 1.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 314 GSFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLvthTSGKSSVLYTGSSDHTIRCYN 391
Cdd:cd00200     3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA---ASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 392 IKTRECMEQLQL-EDRVLCL--HNRWRTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYD 468
Cdd:cd00200    80 LETGECVRTLTGhTSYVSSVafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 469 CTISVRDARNGLLLRTLEGHSKTVLCMKVVNDL--VFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 544
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1907137037 545 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--VIYTGCYDGSI 591
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
315-592 2.29e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 2.29e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 315 SFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVTHtSGKssVLYTGSSDHTIRCYNI 392
Cdd:COG2319    73 TLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGK--TLASGSADGTVRLWDL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 393 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSY 467
Cdd:COG2319   150 ATGKLLRTLTGhSGAVTSV--AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDG--KLLASGSA 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 468 DCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 543
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLA 304

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907137037 544 TACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIH--KSVIYTGCYDGSIQ 592
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
315-558 6.59e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 6.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 315 SFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNI 392
Cdd:COG2319   157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF---SPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 393 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFEcHGPRAVSCLATAQEGarKLLVVGSY 467
Cdd:COG2319   234 ATGKLLRTLTGhSGSVRSV--AFspdgRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGSD 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 468 DCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 543
Cdd:COG2319   309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLA 388

                         250
                  ....*....|....*
gi 1907137037 544 TACLDKFVRVYELQS 558
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 315-555 1.30e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 1.30e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 315 SFEGHQAAVNAIQI--FGNFLYTCSADTTVRVYNLVSRKCVGVFEGHTSKVNCLLVTHtsgKSSVLYTGSSDHTIRCYNI 392
Cdd:cd00200    46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 393 KTRECMEQLQL-EDRVLCLhnRW----RTLYAGLANGTVVTFDIKNNKRQEIFECHgPRAVSCLATAQEGARklLVVGSY 467
Cdd:cd00200   123 ETGKCLTTLRGhTDWVNSV--AFspdgTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEK--LLSSSS 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 468 DCTISVRDARNGLLLRTLEGHSKTVLCMKV--VNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMV 543
Cdd:cd00200   198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLA 277

                         250
                  ....*....|..
gi 1907137037 544 TACLDKFVRVYE 555
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 352-591 1.57e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 1.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 352 CVGVFEGHTSKVNCLlvtHTSGKSSVLYTGSSDHTIRCYNIKTRECMEQLQLE----DRVLCLHNRwRTLYAGLANGTVV 427
Cdd:cd00200     1 LRRTLKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpvRDVAASADG-TYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 428 TFDIKNNKRQEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKV--VNDLVFSG 505
Cdd:cd00200    77 LWDLETGECVRTLTGH-TSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 506 SSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--V 581
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDgyL 233

                         250
                  ....*....|
gi 1907137037 582 IYTGCYDGSI 591
Cdd:cd00200   234 LASGSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 286-511 4.88e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 4.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 286 TQTVISIKASKHSSEISSEPGD--------DEEPTEGSFEGHQAAVNAIQI--FGNFLYTCSADTTVRVYNLVSRKCVGV 355
Cdd:cd00200    93 TSYVSSVAFSPDGRILSSSSRDktikvwdvETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 356 FEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYNIKTRECMEQLQledrvlcLHNRWrtlyaglangtvvtfdiknnk 435
Cdd:cd00200   173 LTGHTGEVNSVAF---SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-------GHENG--------------------- 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907137037 436 rqeifechgpraVSCLATAQEgaRKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSV 511
Cdd:cd00200   222 ------------VNSVAFSPD--GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
443-592 3.31e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907137037 443 HGPRAVSCLATAQEGARklLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGE 520
Cdd:COG2319    34 GLAAAVASLAASPDGAR--LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907137037 521 LVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 592
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 349-391 1.74e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907137037  349 SRKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 391
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
350-391 1.40e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907137037 350 RKCVGVFEGHTSKVNCLLVthtSGKSSVLYTGSSDHTIRCYN 391
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 315-346 9.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 9.14e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907137037  315 SFEGHQAAVNAIQIF--GNFLYTCSADTTVRVYN 346
Cdd:smart00320   7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-346 1.52e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907137037 314 GSFEGHQAAVNAIQI--FGNFLYTCSADTTVRVYN 346
Cdd:pfam00400   5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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