|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
10-322 |
6.08e-120 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 360.00 E-value: 6.08e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 10 KEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANH 89
Cdd:cd00186 67 KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILEAREYIQAIY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 90 PYWADSVKQLLAeGINRPRKGHDAGDHPPITPMK----SATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIG 165
Cdd:cd00186 147 GKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKvaptPELEANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 166 PEHFTCMGKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPV 245
Cdd:cd00186 226 GEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLKEGDELKLEEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYAS 305
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907117376 246 HINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKRKF 322
Cdd:cd00186 306 IIETLLDRGYVEKE-KKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
19-273 |
1.05e-109 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 329.21 E-value: 1.05e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 19 RKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHP-YWADSVK 97
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGkEYLDLAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 98 QLLAEGInrPRKGHDA-GDHPPITPMKSAT----EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCM 172
Cdd:smart00437 82 VLLKPRK--PRKGKKAqGAHEAIRPTKPIFtpelEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 173 GKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQ 252
Cdd:smart00437 160 GKTLLFDGWLKVYPEEKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|.
gi 1907117376 253 RNYVTVEsGRRLKPTNLGIVL 273
Cdd:smart00437 240 RGYVTKK-KKKLIPTELGIAV 259
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
9-311 |
2.37e-101 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 313.03 E-value: 2.37e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 9 EKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQ-GYISYPRTETTHYPENFDLKGSLR-QQ 86
Cdd:pfam01131 105 KGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDDATLKAILEyLT 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 87 ANHPYWADSVKQLLAEG-INRPRKGHDAGDHPPITPMKSAT-EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRI 164
Cdd:pfam01131 185 KNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPvLPELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEV 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 165 GPEHFTCMGKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIP 244
Cdd:pfam01131 265 GGEEFRASGKVILEDGWLKVYPYEKKEDEEELPELKEGEELKVTQVEVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRA 344
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907117376 245 VHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDaELVLPTIRSAVEKQLNLIAQGKADYHQVL 311
Cdd:pfam01131 345 TIIETLLERGYVERK-KKSLVPTELGKALVEALEKFP-DLVDPELTAELEEKLDEIAEGKLDWKDVL 409
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
7-420 |
5.31e-81 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 271.49 E-value: 5.31e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 7 KLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQ 86
Cdd:PRK07219 261 KGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKL 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 87 ANHPYWADSVKQLLAEGINRPRKG-HDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIG 165
Cdd:PRK07219 341 SKKKEYGPYAESILEQENIKPTEGkKETTDHPPIHPVDVPKREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVN 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 166 PEHFTCMGKTVISPGFTEIMPWQSvPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPV 245
Cdd:PRK07219 421 GEIFKASGSRLVEEGWHEVYPYEK-FDEKELPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHD 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 246 HINNICQRNYVTveSGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKRKFHYF 325
Cdd:PRK07219 500 IIEKLYKRGYVI--EGDPPRPTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSEL 577
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 326 VDSIAGM-DELMEvSFSPLAATGKPLSRCGKCHRFMKYIQAKPSR--LHCS---HCDETYTLPQNGTIKLYKELrCPLDD 399
Cdd:PRK07219 578 KEKRKEIgDHLAG-SLKAENRSLKTIGKCPECGGDLIIIRTDKGSrfVGCSgypDCRNTFPLPSTGRIKVLDEV-CEKCG 655
|
410 420
....*....|....*....|...
gi 1907117376 400 FELVLWssgSRGKSYPL--CPYC 420
Cdd:PRK07219 656 LPVIKI---LRGKQTFVvgCPDC 675
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
5-323 |
5.58e-62 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 213.80 E-value: 5.58e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 5 MTKLEKEAW-VEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPEnfDLKGSL 83
Cdd:COG0550 223 LAALKGKTFtVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSE--DAVAAA 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 84 RQQANhpywADSVKQLLAEGINRPRKGHDA-GDHPPITP-MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTIS 161
Cdd:COG0550 301 REYIE----ALYGKEYLPEKPRVYKTSKNAqEAHEAIRPtGVTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVT 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 162 FRIGPEHFTCMGKTVISPGFTEIMPWQSVPLEE----SLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGI 237
Cdd:COG0550 377 IEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEeeekRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGI 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 238 G---TDASIpvhINNICQRNYVTVEsGRRLKPTNLGIV---LVHGYYKidaELVLPTIRSAVEKQLNLIAQGKADYHQVL 311
Cdd:COG0550 457 GrpsTYASI---IETLQDRGYVERE-GKRLVPTELGFIvidLLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVL 529
|
330
....*....|..
gi 1907117376 312 GHtldiFKRKFH 323
Cdd:COG0550 530 EE----FYKPFK 537
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
10-322 |
6.08e-120 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 360.00 E-value: 6.08e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 10 KEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANH 89
Cdd:cd00186 67 KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILEAREYIQAIY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 90 PYWADSVKQLLAeGINRPRKGHDAGDHPPITPMK----SATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIG 165
Cdd:cd00186 147 GKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKvaptPELEANLSEDEFKLYELIWRRFLASQMADAKYEETTVTLEIG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 166 PEHFTCMGKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPV 245
Cdd:cd00186 226 GEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLKEGDELKLEEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYAS 305
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907117376 246 HINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKRKF 322
Cdd:cd00186 306 IIETLLDRGYVEKE-KKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
19-273 |
1.05e-109 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 329.21 E-value: 1.05e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 19 RKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHP-YWADSVK 97
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGkEYLDLAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 98 QLLAEGInrPRKGHDA-GDHPPITPMKSAT----EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCM 172
Cdd:smart00437 82 VLLKPRK--PRKGKKAqGAHEAIRPTKPIFtpelEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 173 GKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQ 252
Cdd:smart00437 160 GKTLLFDGWLKVYPEEKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|.
gi 1907117376 253 RNYVTVEsGRRLKPTNLGIVL 273
Cdd:smart00437 240 RGYVTKK-KKKLIPTELGIAV 259
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
9-311 |
2.37e-101 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 313.03 E-value: 2.37e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 9 EKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQ-GYISYPRTETTHYPENFDLKGSLR-QQ 86
Cdd:pfam01131 105 KGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDDATLKAILEyLT 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 87 ANHPYWADSVKQLLAEG-INRPRKGHDAGDHPPITPMKSAT-EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRI 164
Cdd:pfam01131 185 KNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPvLPELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEV 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 165 GPEHFTCMGKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIP 244
Cdd:pfam01131 265 GGEEFRASGKVILEDGWLKVYPYEKKEDEEELPELKEGEELKVTQVEVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRA 344
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907117376 245 VHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDaELVLPTIRSAVEKQLNLIAQGKADYHQVL 311
Cdd:pfam01131 345 TIIETLLERGYVERK-KKSLVPTELGKALVEALEKFP-DLVDPELTAELEEKLDEIAEGKLDWKDVL 409
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
7-420 |
5.31e-81 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 271.49 E-value: 5.31e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 7 KLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQ 86
Cdd:PRK07219 261 KGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKL 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 87 ANHPYWADSVKQLLAEGINRPRKG-HDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIG 165
Cdd:PRK07219 341 SKKKEYGPYAESILEQENIKPTEGkKETTDHPPIHPVDVPKREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVN 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 166 PEHFTCMGKTVISPGFTEIMPWQSvPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPV 245
Cdd:PRK07219 421 GEIFKASGSRLVEEGWHEVYPYEK-FDEKELPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHD 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 246 HINNICQRNYVTveSGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKRKFHYF 325
Cdd:PRK07219 500 IIEKLYKRGYVI--EGDPPRPTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSEL 577
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 326 VDSIAGM-DELMEvSFSPLAATGKPLSRCGKCHRFMKYIQAKPSR--LHCS---HCDETYTLPQNGTIKLYKELrCPLDD 399
Cdd:PRK07219 578 KEKRKEIgDHLAG-SLKAENRSLKTIGKCPECGGDLIIIRTDKGSrfVGCSgypDCRNTFPLPSTGRIKVLDEV-CEKCG 655
|
410 420
....*....|....*....|...
gi 1907117376 400 FELVLWssgSRGKSYPL--CPYC 420
Cdd:PRK07219 656 LPVIKI---LRGKQTFVvgCPDC 675
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
5-387 |
5.48e-64 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 223.48 E-value: 5.48e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 5 MTKLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSaLGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLR 84
Cdd:PRK07220 253 FEKLGKTAEVTEVEKGTKTDKPPTPFNTTEFISAANS-IGFSAANAMRIAESLYTNGYISYPRTDNTVYPESLDLREQIE 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 85 QQANHPYwADSVKQLLAEGINRPRKG-HDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFR 163
Cdd:PRK07220 332 IFAEGPF-GEYAQKLLEKGELVPTRGkKETTDHPPIYPASLAKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFD 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 164 IGPEHFTCMGKTVISPGFTEIMPWqSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASI 243
Cdd:PRK07220 411 IGGEEFRANGSRLTEPGWRWYYPY-NAPEDRLLPELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATR 489
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 244 PVHINNICQRNYVtveSGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKRKFH 323
Cdd:PRK07220 490 HEIISKLYSRAYI---HGNPIQPTNTAFAVVDALEKYAPTITKPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFD 566
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907117376 324 YFVDSiagMDELMEVSFSPLAATgKPLSRCGKC-HRFMKYIQAKPSR-LHCS---HCDETYTLPQNGTI 387
Cdd:PRK07220 567 ELDKN---REKIRESLREGLRED-KIIGKCPLCgSDLMVRRSKRGSRfIGCEgypECTFSLPLPKSGQI 631
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
5-323 |
5.58e-62 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 213.80 E-value: 5.58e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 5 MTKLEKEAW-VEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPEnfDLKGSL 83
Cdd:COG0550 223 LAALKGKTFtVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSE--DAVAAA 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 84 RQQANhpywADSVKQLLAEGINRPRKGHDA-GDHPPITP-MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTIS 161
Cdd:COG0550 301 REYIE----ALYGKEYLPEKPRVYKTSKNAqEAHEAIRPtGVTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVT 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 162 FRIGPEHFTCMGKTVISPGFTEIMPWQSVPLEE----SLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGI 237
Cdd:COG0550 377 IEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEeeekRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGI 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 238 G---TDASIpvhINNICQRNYVTVEsGRRLKPTNLGIV---LVHGYYKidaELVLPTIRSAVEKQLNLIAQGKADYHQVL 311
Cdd:COG0550 457 GrpsTYASI---IETLQDRGYVERE-GKRLVPTELGFIvidLLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVL 529
|
330
....*....|..
gi 1907117376 312 GHtldiFKRKFH 323
Cdd:COG0550 530 EE----FYKPFK 537
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
17-350 |
3.37e-46 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 175.04 E-value: 3.37e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 17 TSRKEKAKQ--RPLALNTVEMLrVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWAD 94
Cdd:PRK14973 262 TEVKEGHKVdrAPTPFDTTTFI-VAASRLGFSAANAMRIAEDLYMNGYISYPRTDNTIYPKSLDLNGVLATLAKGAFSKD 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 95 sVKQLLAEGINRPRKGH-DAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMG 173
Cdd:PRK14973 341 -VAWVKDNRRPVPTRGKkSSTDHPPIHPTGVATREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATG 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 174 KTVISPGFTEIMPWqSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQR 253
Cdd:PRK14973 420 GRLLEAGWRTVYPY-SEAKENILPAFALGEKLPILAVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSR 498
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 254 NYVtveSGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKRKFHYFVDSIAGM- 332
Cdd:PRK14973 499 KYI---EGNPLRPTLVGRAVTESLEEHAGTITEPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAFDELEANEAVIg 575
|
330 340
....*....|....*....|...
gi 1907117376 333 DELM-----EVSFSPLAATGKPL 350
Cdd:PRK14973 576 RDIMertaeELTIGPCPVCGKDL 598
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
2-358 |
2.65e-41 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 158.62 E-value: 2.65e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 2 FLNMTKLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKG 81
Cdd:PRK05776 250 ILEEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSQKLPPTLNIRN 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 82 SLRQQANHPYWADSVKQLLAE--GINRPRKG-HDAGDHPPITPMKSATEaELGGDAWRLYEYITRHFIATVSHDCKYLQS 158
Cdd:PRK05776 330 ILKGLSRSPQYRPLVNLLLKEtkGVLKPVQGpKDDPAHPAIYPTGEPPK-NLSKDEFKLYDLIVRRFLASFAAPAVLSNT 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 159 TISFRIG--PEHFTCMGKTVISPGFTEIMPWqSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHG 236
Cdd:PRK05776 409 IVTLRVPgfPLVFSASGQRIEERGWLKYYPF-HKFDEEELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVG 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 237 IGTDASIPVHINNICQRNYVTvESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHT-- 314
Cdd:PRK05776 488 IGTEATRARIIETLFKRGYLT-SNGKYIEVTPLGFGVAEVLEKYFPDIVSVELTRDFEEKLEMIRTGKATREEVIEEAke 566
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1907117376 315 -----LDIFKRKFHYFVDSIAGMDELMevsfsplaatgKPLSRCGKCHR 358
Cdd:PRK05776 567 tlnklLEEFKKNKDEIGEELAKALGLI-----------KPVGKCKICGR 604
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
10-375 |
6.20e-36 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 142.99 E-value: 6.20e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 10 KEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLY-TQGYISYPRTETTHYPEnfDLKGSLRQ--- 85
Cdd:PRK07726 261 QPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYeTHKLITYPRTDSRYLPE--DMVATLPEvln 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 86 --QANHPYwadsvKQLLAEGINRPRKGH---DA--GDHPPITP-MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQ 157
Cdd:PRK07726 339 aiSKVDPY-----LLLAPPVLDPSIRSRawnDKkvTAHHAIIPtEQPPNLSKLSEDERKVYDLIARRYLAQFLPPAEYDK 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 158 STISFRIGPEHFTCMGKTVISPGFTEIMPWQSVPLEES--LPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLM--- 232
Cdd:PRK07726 414 TTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEKEqpLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMeni 493
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 233 --------------EKHGIGTDA---SIpvhINNICQRNYVTVEsGRRLKPTNLGIVLvhgyykIDA---ELVLPTIRSA 292
Cdd:PRK07726 494 arfvqdkelkktlkETDGLGTEAtraGI---IEKLFKRGYLEKK-GKYIHATDKGKQL------IDAlpeELTSPDMTAK 563
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 293 VEKQLNLIAQGKADYHQvlghtldifkrkfhyFVDSIAG-MDELME---VSFSPLAATGKPLSRCGKCHRFMKyiQAKPS 368
Cdd:PRK07726 564 WEQALDQISEGQLSYQD---------------FMQPLKQwLKQLVEqakQSSEKYKFDNLTGPKCPDCGKPML--KVKGK 626
|
....*..
gi 1907117376 369 RLHCSHC 375
Cdd:PRK07726 627 NGKMLVC 633
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
7-360 |
2.88e-29 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 123.36 E-value: 2.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 7 KLEKEAWVeATSRKEKAKQR-PLALNTVEMLR-VASSALGMGPQHAMQIAERLYTQGYISYPRTetthypenfdlkgslr 84
Cdd:PRK07561 247 ALEGARYS-VASVEDKPTTRkPSAPFTTSTLQqEASRKLGFSVKKTMRIAQRLYEAGYITYMRT---------------- 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 85 qqanhpywaDSVkQLLAEGINRPRK--GHDAGDH--PPiTP------MKSATEA-----------------ELGGDAWRL 137
Cdd:PRK07561 310 ---------DST-NLSQEAINAARGyiGDNYGKKylPE-KPrqysskAKNAQEAheairpsdvfrtpdqlkGLEGDAQRL 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 138 YEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISPGFTEIMPWQS--VPLEES--LPTCQKGDTFTVGEVKML 213
Cdd:PRK07561 379 YELIWKRFVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRddALDDEDrrLPALKVGDALTLEKLDPT 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 214 EKQTSPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLG-IV--LVHGYYkidAELVLP 287
Cdd:PRK07561 459 QHFTKPPARYSEASLVKELEKLGIGrpsTYASI---ISTIQDRGYVRLE-NRRFYPEKMGrIVtdRLEEFF---PRLVDY 531
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 288 TIRSAVEKQLNLIAQGKADYHQVlghtLDIFKRKFHYFVDSIA------GMDELMEVsfsplaatgkPLSR-CGKCHRFM 360
Cdd:PRK07561 532 DFTARMEEELDDIANGEADWKPV----LDDFYKDFSQQLEKAEelreegGMRPNQMV----------ITDRdCPTCGRGM 597
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
14-417 |
5.46e-23 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 103.40 E-value: 5.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 14 VEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLY--------TQGYISYPRTetthypenfdlkgslrq 85
Cdd:PRK06599 245 VDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYegidlgegTVGLITYMRT----------------- 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 86 qanhpywaDSVkQLLAEGINRPRK------GHD-AGDHPPI--TPMKSATEAE------------------LGGDAWRLY 138
Cdd:PRK06599 308 --------DSV-RLSNEALDEARKyitkkyGKEyLPAKPRVykKKSKNAQEAHeairptsinrtpeslkpyLTPDQFKLY 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 139 EYITRHFIATVSHDCKYLQSTISF--RIGPEHFTCMGKTVISPGFTEIMPwQSVPLEES-----LPTCQKGDTFTVGEVk 211
Cdd:PRK06599 379 ELIWKRTVASQMAPAILDQTSVDIasENGKYVFRATGSVILFPGFLKVYG-ESKDDEEEddeklLPPLKEGEKLKLDEL- 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 212 mLEKQ--TSPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLG-IV---LVHGY----- 277
Cdd:PRK06599 457 -LPEQhfTEPPPRYSEASLVKKLEEYGIGrpsTYASI---ISTLQDREYVELE-KKRFIPTDLGrIVndfLVEHFpkyvd 531
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 278 YKIDAELvlptirsavEKQLNLIAQGKADYHQVLGHtldiFKRKFHYFVDSIAGMDELMEVSFSPLAAT-----GKPLS- 351
Cdd:PRK06599 532 YDFTAGL---------EDELDEIAEGKKDWKPVLRE----FWEPFISNLEKVEEDVRTEKVTQEETDETcpkcgGGPLVl 598
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907117376 352 RCGKCHRFmkyiqakpsrLHCSH---CDETYTLPQNG-----TIKLYKELRCPLDDFELVLwSSGSRGK-----SYPLC 417
Cdd:PRK06599 599 KLGKNGKF----------LGCSGypeCKYTKNITRDEdepieEEEIVEEEKCPKCGGPLVL-KKGRYGKflacsGYPEC 666
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
37-376 |
2.52e-20 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 95.50 E-value: 2.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 37 RVASSALGMGPQHAMQIAERLYTQ-GYISYPRTETTHYPENF--DLKGSLRQQANHPYWADSVKQLLAEGINRPRK---- 109
Cdd:PRK08173 298 REANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYlgTVKQTLEMLKESNNYLPHAKQILDKGWVKPNKrifd 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 110 GHDAGDHPPITPM----KSATEAELggdawRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISPGFTEIM 185
Cdd:PRK08173 378 NSKISDHFAIIPTlqapKSLSEPEQ-----KLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVY 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 186 PWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLME----------------KHGIGTDASIPVHINN 249
Cdd:PRK08173 453 GKEAQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddelreamaEKGLGTPATRAAIIEG 532
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 250 ICQRNYVtVESGRRLKPT----NLgIVLVHGyYKIDaELVLPTIRSAVEKQLNLIAQGK----ADYHQVLGHTLDIFKRK 321
Cdd:PRK08173 533 LLGEKYL-VREGRELIPTakafQL-MTLLRG-LGVE-ELTSPELTGEWEYKLSQIERGKlsrdAFMQEIAQMTQQIVKRA 608
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1907117376 322 FHYFVDSIAGmdelmevSFSPLAAtgkPLSRCGkchrfmKYIQAKPSRLHCSHCD 376
Cdd:PRK08173 609 KEYDSDTIPG-------DYATLQT---PCPNCG------GVVKENYRRFACTKCD 647
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
11-364 |
2.94e-18 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 88.67 E-value: 2.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 11 EAWVEATSRKEKaKQRPLALNTVEMLRV-ASSALGMGPQHAMQIAERLY---------TQGYISYPRTETTHYPEnfDLK 80
Cdd:PRK08780 245 TLHVTDVESKER-KRNPAPPFTTSTLQQeASRKLGFTTRRTMQVAQKLYegvdlgdegSVGLITYMRTDSVNLSQ--DAL 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 81 GSLRQQANHPYWADSVKQLLAEGINRPRKGHDAgdHPPITP---MKSATE--AELGGDAWRLYEYITRHFIATVSHDCKY 155
Cdd:PRK08780 322 AEIRDVIARDYGTASLPDQPNTYKTKSKNAQEA--HEAVRPtsaLRTPAQvaRFLSDDQRRLYELIWKRAVACQMIPATL 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 156 LQSTISFRIGPEH-FTCMGKTVISPGFTEIM-------PWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAE 227
Cdd:PRK08780 400 NTVSVDLAAGSEHvFRATGSTVVVPGFLAVYeegkddkSAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEAS 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 228 LITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLGIVlVHGY----------YKIDAELvlptirsavE 294
Cdd:PRK08780 480 LVKALEEYGIGrpsTYASI---ISTLQFRKYVEME-GRRFRPTDVGRA-VNKFltghftryvdYDFTARL---------E 545
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907117376 295 KQLNLIAQGKADYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLS-RCGkchRFMKYIQ 364
Cdd:PRK08780 546 DDLDAVSRGEKEWIPLMEKFWGPFKELVEEKKDSVDRTEAGQVRELGTDPKSGKPVSvRIG---RFGPMVQ 613
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
14-318 |
3.20e-13 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 72.93 E-value: 3.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 14 VEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLY---------TQGYISYPRTETTHY-PENFD-LKGS 82
Cdd:PRK06319 255 VTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYegvdldsegATGLITYMRTDSVRTdPEALKqVRKY 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 83 LRQQANHPYWADSVKQLLAEginrpRKGHDAgdHPPITPMKSATEAE-----LGGDAWRLYEYITRHFIATVSHDCKY-- 155
Cdd:PRK06319 335 IEGTFGKEFLPSSPNVYTTK-----KMAQDA--HEAIRPTDITLTPEklrskLTEDQYKLYSLIWKRFVASQMIPAIYdt 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 156 LQSTISFRIGPEhFTCMGKTVISPGFT---EIMPWQSVPLEE--SLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELIT 230
Cdd:PRK06319 408 LAIRITTNKGID-LRATGSLLKFKGFLavyEEKRDDEGDEEEniHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVK 486
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 231 LMEKHGIGTDASIPVHINNICQRNYvTVESGRRLKPTNLGIVLVHGYykidaELVLPTI-----RSAVEKQLNLIAQGKA 305
Cdd:PRK06319 487 ELEKSGIGRPSTYATIMNKIQSREY-TLKENQRLRPTELGKIISQFL-----ETNFPRImdigfTALMEDELELIADNKK 560
|
330
....*....|...
gi 1907117376 306 DYHQVLGHTLDIF 318
Cdd:PRK06319 561 PWKLLLQEFWELF 573
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
10-267 |
1.47e-10 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 64.21 E-value: 1.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 10 KEAWVEATSrKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQ-GYISYPRTETTHYPEN--------FDL- 79
Cdd:PRK14724 280 KAATVTEES-KPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDylpvakqtFEMl 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 80 -KGSLRQQANHpywadsVKQLLAEGINRPRK----GHDAGDHPPITPMKSA----TEAElggdaWRLYEYITRHFIATVS 150
Cdd:PRK14724 359 aTSGMRHLAPF------AQQALDGNYVRPSKrifdNSKVSDHFAIIPTTQApsglSEAE-----QKLYDLVVRRFMAVFF 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 151 HDCKYLQST-ISFRIGpEHFTCMGKTVISPGFTEIMPWQSVPLEE---------SLPTCQKGDTFTVGEVKMLEKQTSPP 220
Cdd:PRK14724 428 PSAEYQVTTrISQVVG-HSFKTEGKVLVKPGWLAIYGKEAANEVEdakdgdkgqPLVPVKPGEMVRTEFAEAKGLKTKPP 506
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907117376 221 DYLTEAELITLME----------------KHGIGTDASIPVHINNICQRNYVTVEsGRRLKPT 267
Cdd:PRK14724 507 ARYSEATLLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLRE-GRELIPT 568
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
57-302 |
2.71e-06 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 50.32 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 57 LYTQGYISYPRTETTHYPENF--DLKGSLRQQ---------ANHPYWADSVKQLLAEGINRPRKGHDAGD---------H 116
Cdd:PTZ00407 350 LFQLGHITYPRTDSTRIDESAlpDIYAAVKKEfgkeflyrlEDRTVSAQEGKGSKKTGKKRSTKQKKGADtpvgnvedaH 429
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 117 PPITPMKSATEAE---LGGDAWRLYEYITRHFIAT--VSHDCKYLQSTISFRIGPE---HFTCMGKTVISPGFTE----- 183
Cdd:PTZ00407 430 EAIRPTNIDTTGEslsLSPPTRAVYDLVRRNTLAVfmIPMKTEKIVATVKFTSGSGeklEFELQGKRVVEPGWTRafhkg 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907117376 184 -----------------------IMPWQS-------VPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLME 233
Cdd:PTZ00407 510 dkgttgpaeetdeditaveegapVVPSLSqeefkaiMNLRSQLGSGVQKGFFELRSPQVRENRPVPPLPHSEGTLIEELK 589
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907117376 234 KHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHgyykiDAELVLPTI-----RSAVEKQLNLIAQ 302
Cdd:PTZ00407 590 NNGVGRPSTYPMIVKTLLARGYIAVNPKGRCETTPVGRMLVE-----TAKSTFPSIvdigfTAAFEKKLDRIAK 658
|
|
| |
