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Conserved domains on  [gi|1907122866|ref|XP_036016266|]
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neurexin-1 isoform X16 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
495-644 1.62e-39

Laminin G domain;


:

Pssm-ID: 214598  Cd Length: 132  Bit Score: 143.25  E-value: 1.62e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   495 SISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQR 574
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGG------------DYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907122866   575 DGRSGTISVN-TLRTPYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNYGYVGCIRDLFIDGQ 644
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDL-------KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
916-1044 1.49e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 128.71  E-value: 1.49e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  916 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKIDTKITTQ 995
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRGSDFLALELVDGRLVLRYDLGSGPVSLL-SSGKNLNDGQWHSVRVERNGNTL-TLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907122866  996 ITAGARN--LDLKSDLYIGGVAketYKSLPKLVHAKEGFQGCLASVDLNGR 1044
Cdd:pfam02210   79 GLPPGESllLNLNGPLYLGGLP---PLLLLPALPVSPGFVGCIRDVRINGE 126
LamG smart00282
Laminin G domain;
307-438 2.98e-33

Laminin G domain;


:

Pssm-ID: 214598  Cd Length: 132  Bit Score: 125.14  E-value: 2.98e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   307 EITLSFKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAFEalVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 384
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSGPAR--LTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1907122866   385 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 438
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
30-190 8.57e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058  Cd Length: 151  Bit Score: 115.98  E-value: 8.57e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   30 GLEFPGaeGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFcAEPATLLADTP 108
Cdd:cd00110      1 GVSFSG--SSYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALEL-EDGRLVLRYDLG-SGSLVLSSKTP 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  109 VNDGAWHSVRIRRQFRNTTLYIDRaeAKWVEVKSKRRD--MTVFSGLFVGGLPPELRAAALKLtlasvreREPFKGWIRD 186
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDG--ERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV-------SPGFVGCIRD 147

                   ....
gi 1907122866  187 VRVN 190
Cdd:cd00110    148 LKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
738-859 1.45e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 103.29  E-value: 1.45e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  738 FRSQRAYGILMATTSRDSaDTLRLELDAGRVKLTVNLGKGPETLFA-GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTG 816
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRGS-DFLALELVDGRLVLRYDLGSGPVSLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1907122866  817 QMAGDHtrlEFHNIETGI------ITERRYLSSVPSNFIGHLQSLTFNG 859
Cdd:pfam02210   80 LPPGES---LLLNLNGPLylgglpPLLLLPALPVSPGFVGCIRDVRING 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1148-1296 3.08e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 85.18  E-value: 3.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866 1148 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1227
Cdd:pfam02210    1 FRTTQPNGLLL--YAGGRGSDFLALELVDGRLVLRYDLGSGPVSLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907122866 1228 RYPAGNndnerlaiarqripyrlgrvvdEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNG 1296
Cdd:pfam02210   79 GLPPGE----------------------SLLLNLNGPLYLGGLPPLLLLPALPVSPGFVGCIRDVRING 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
672-705 1.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907122866  672 CLS-NPCKNNGMCRDGWNRYVCDCSgTGYLGRSCE 705
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
4.1m smart00294
putative band 4.1 homologues' binding motif;
1441-1459 2.89e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.89e-05
                            10
                    ....*....|....*....
gi 1907122866  1441 MYKYRNRDEGSYHVDESRN 1459
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1421-1456 6.08e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 426005  Cd Length: 62  Bit Score: 36.55  E-value: 6.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907122866 1421 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 1456
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
495-644 1.62e-39

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 143.25  E-value: 1.62e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   495 SISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQR 574
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGG------------DYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907122866   575 DGRSGTISVN-TLRTPYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNYGYVGCIRDLFIDGQ 644
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDL-------KLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
473-642 9.08e-39

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 141.79  E-value: 9.08e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  473 PITFETPeSFISLPKWNAKKT-GSISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSG 551
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRTrLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  552 TIKIKAlQKKVNDGEWYHVDFQRDGRSGTISVNTLRT-PYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNY 630
Cdd:cd00110     68 SLVLSS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDL-------KSPGLPVSP 139
                          170
                   ....*....|..
gi 1907122866  631 GYVGCIRDLFID 642
Cdd:cd00110    140 GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
500-644 1.39e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 128.71  E-value: 1.39e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  500 FRTTEPNGLILFSHGkprhqkdakhpqmIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSG 579
Cdd:pfam02210    1 FRTTQPNGLLLYAGG-------------RGSDFLALELVDGRLVLRYDLGSGPVSLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907122866  580 TISVNTLRT-PYTAPGESEILDLDDELYLGGLPenkaglvFPTEVWTALLNYGYVGCIRDLFIDGQ 644
Cdd:pfam02210   68 TLSVDGQTVvSGLPPGESLLLNLNGPLYLGGLP-------PLLLLPALPVSPGFVGCIRDVRINGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
916-1044 1.49e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 128.71  E-value: 1.49e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  916 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKIDTKITTQ 995
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRGSDFLALELVDGRLVLRYDLGSGPVSLL-SSGKNLNDGQWHSVRVERNGNTL-TLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907122866  996 ITAGARN--LDLKSDLYIGGVAketYKSLPKLVHAKEGFQGCLASVDLNGR 1044
Cdd:pfam02210   79 GLPPGESllLNLNGPLYLGGLP---PLLLLPALPVSPGFVGCIRDVRINGE 126
LamG smart00282
Laminin G domain;
307-438 2.98e-33

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 125.14  E-value: 2.98e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   307 EITLSFKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAFEalVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 384
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSGPAR--LTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1907122866   385 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 438
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
284-435 1.27e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 124.07  E-value: 1.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  284 ATFKGSEYfcYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGafEALVEPVNgK 361
Cdd:cd00110      2 VSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT-P 76
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907122866  362 FNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 435
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
312-435 2.94e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 122.16  E-value: 2.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  312 FKTLQRNGLMLHTG-KSADYVNLALKNGAVSLVINLGSGAFEALVEpvNGKFNDNAWHDVKVTRNLRQVTISVDGILTTT 390
Cdd:pfam02210    1 FRTTQPNGLLLYAGgRGSDFLALELVDGRLVLRYDLGSGPVSLLSS--GKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1907122866  391 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 435
Cdd:pfam02210   79 GLPPGESLLLNLNGPLYLGGLPPLLLLPALPVSPGFVGCIRDVRI 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
889-1042 1.84e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 117.90  E-value: 1.84e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  889 PVTFkTKSSYVALATLQA-YTSMHLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIkgSSNKPL 966
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVL--SSKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907122866  967 NDNQWHNVMISRDTSNLhTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAkETYKSLPKLVHakEGFQGCLASVDLN 1042
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-TLSVDGErvVESGSPGGSALLNLDGPLYLGGLP-EDLKSPGLPVS--PGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
911-1044 8.37e-30

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 115.51  E-value: 8.37e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   911 HLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKID 989
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSV-TLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907122866   990 --TKITTQITAGARNLDLKSDLYIGGVaKETYKSLPKLVHakEGFQGCLASVDLNGR 1044
Cdd:smart00282   79 ggNRVSGESPGGLTILNLDGPLYLGGL-PEDLKLPPLPVT--PGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
30-190 8.57e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 115.98  E-value: 8.57e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   30 GLEFPGaeGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFcAEPATLLADTP 108
Cdd:cd00110      1 GVSFSG--SSYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALEL-EDGRLVLRYDLG-SGSLVLSSKTP 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  109 VNDGAWHSVRIRRQFRNTTLYIDRaeAKWVEVKSKRRD--MTVFSGLFVGGLPPELRAAALKLtlasvreREPFKGWIRD 186
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDG--ERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV-------SPGFVGCIRD 147

                   ....
gi 1907122866  187 VRVN 190
Cdd:cd00110    148 LKVN 151
LamG smart00282
Laminin G domain;
53-191 7.86e-29

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 112.82  E-value: 7.86e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866    53 EMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDR 132
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907122866   133 AEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTlasvrerEPFKGWIRDVRVNS 191
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-------PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
58-190 3.26e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 104.83  E-value: 3.26e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   58 LKTRSARGLVLYFDDEGfCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW 137
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRG-SDFLALEL-VDGRLVLRYDLGSGPVSLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907122866  138 VEVKSKRRDMTVFSGLFVGGLPPELRaaalkltLASVREREPFKGWIRDVRVN 190
Cdd:pfam02210   79 GLPPGESLLLNLNGPLYLGGLPPLLL-------LPALPVSPGFVGCIRDVRIN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
738-859 1.45e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 103.29  E-value: 1.45e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  738 FRSQRAYGILMATTSRDSaDTLRLELDAGRVKLTVNLGKGPETLFA-GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTG 816
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRGS-DFLALELVDGRLVLRYDLGSGPVSLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1907122866  817 QMAGDHtrlEFHNIETGI------ITERRYLSSVPSNFIGHLQSLTFNG 859
Cdd:pfam02210   80 LPPGES---LLLNLNGPLylgglpPLLLLPALPVSPGFVGCIRDVRING 125
LamG smart00282
Laminin G domain;
733-860 7.28e-25

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 101.26  E-value: 7.28e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   733 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLGKGPETLFAGYN-LNDNEWHTVRVVRRGKSLKLTVDDQ 811
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1907122866   812 QAMTGQMAGDHTRLEFH-NIETG--IITERRYLSSVPSNFIGHLQSLTFNGM 860
Cdd:smart00282   81 NRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
710-858 3.54e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 91.33  E-value: 3.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  710 VLSYDGSMFMKIQLPVVMHTEaEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLGKGPETLFAGYNLND 789
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLND 79
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907122866  790 NEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLefhNIETGI------ITERRYLSSVPSNFIGHLQSLTFN 858
Cdd:cd00110     80 GQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1148-1296 3.08e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 85.18  E-value: 3.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866 1148 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1227
Cdd:pfam02210    1 FRTTQPNGLLL--YAGGRGSDFLALELVDGRLVLRYDLGSGPVSLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907122866 1228 RYPAGNndnerlaiarqripyrlgrvvdEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNG 1296
Cdd:pfam02210   79 GLPPGE----------------------SLLLNLNGPLYLGGLPPLLLLPALPVSPGFVGCIRDVRING 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1117-1236 1.27e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 84.01  E-value: 1.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866 1117 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 1196
Cdd:cd00110      1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907122866 1197 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDN 1236
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSAL 114
LamG smart00282
Laminin G domain;
1143-1296 4.16e-18

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 82.00  E-value: 4.16e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  1143 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 1221
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  1222 SWPVIERYPAGnndnerlaiarqripyrlgrvvdewlldkgrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGL 1292
Cdd:smart00282   80 GNRVSGESPGG--------------------------------LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNL 127

                    ....
gi 1907122866  1293 YYNG 1296
Cdd:smart00282  128 KVNG 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
672-705 1.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907122866  672 CLS-NPCKNNGMCRDGWNRYVCDCSgTGYLGRSCE 705
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
672-699 6.36e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 6.36e-06
                           10        20
                   ....*....|....*....|....*...
gi 1907122866  672 CLSNPCKNNGMCRDGWNRYVCDCSgTGY 699
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGY 27
4.1m smart00294
putative band 4.1 homologues' binding motif;
1441-1459 2.89e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.89e-05
                            10
                    ....*....|....*....
gi 1907122866  1441 MYKYRNRDEGSYHVDESRN 1459
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
EGF_CA smart00179
Calcium-binding EGF-like domain;
672-705 2.91e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.91e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907122866   672 CLS-NPCKNNGMCRDGWNRYVCDCSgTGY-LGRSCE 705
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECP-PGYtDGRNCE 39
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1421-1456 6.08e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 426005  Cd Length: 62  Bit Score: 36.55  E-value: 6.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907122866 1421 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 1456
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
495-644 1.62e-39

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 143.25  E-value: 1.62e-39
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   495 SISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQR 574
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGG------------DYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907122866   575 DGRSGTISVN-TLRTPYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNYGYVGCIRDLFIDGQ 644
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDL-------KLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
473-642 9.08e-39

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 141.79  E-value: 9.08e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  473 PITFETPeSFISLPKWNAKKT-GSISFDFRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSG 551
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRTrLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  552 TIKIKAlQKKVNDGEWYHVDFQRDGRSGTISVNTLRT-PYTAPGESEILDLDDELYLGGLPENKaglvfptEVWTALLNY 630
Cdd:cd00110     68 SLVLSS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDL-------KSPGLPVSP 139
                          170
                   ....*....|..
gi 1907122866  631 GYVGCIRDLFID 642
Cdd:cd00110    140 GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
500-644 1.39e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 128.71  E-value: 1.39e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  500 FRTTEPNGLILFSHGkprhqkdakhpqmIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSG 579
Cdd:pfam02210    1 FRTTQPNGLLLYAGG-------------RGSDFLALELVDGRLVLRYDLGSGPVSLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907122866  580 TISVNTLRT-PYTAPGESEILDLDDELYLGGLPenkaglvFPTEVWTALLNYGYVGCIRDLFIDGQ 644
Cdd:pfam02210   68 TLSVDGQTVvSGLPPGESLLLNLNGPLYLGGLP-------PLLLLPALPVSPGFVGCIRDVRINGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
916-1044 1.49e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 128.71  E-value: 1.49e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  916 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKIDTKITTQ 995
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRGSDFLALELVDGRLVLRYDLGSGPVSLL-SSGKNLNDGQWHSVRVERNGNTL-TLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907122866  996 ITAGARN--LDLKSDLYIGGVAketYKSLPKLVHAKEGFQGCLASVDLNGR 1044
Cdd:pfam02210   79 GLPPGESllLNLNGPLYLGGLP---PLLLLPALPVSPGFVGCIRDVRINGE 126
LamG smart00282
Laminin G domain;
307-438 2.98e-33

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 125.14  E-value: 2.98e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   307 EITLSFKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAFEalVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 384
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSGPAR--LTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1907122866   385 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 438
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
284-435 1.27e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 124.07  E-value: 1.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  284 ATFKGSEYfcYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGafEALVEPVNgK 361
Cdd:cd00110      2 VSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT-P 76
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907122866  362 FNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 435
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
312-435 2.94e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 122.16  E-value: 2.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  312 FKTLQRNGLMLHTG-KSADYVNLALKNGAVSLVINLGSGAFEALVEpvNGKFNDNAWHDVKVTRNLRQVTISVDGILTTT 390
Cdd:pfam02210    1 FRTTQPNGLLLYAGgRGSDFLALELVDGRLVLRYDLGSGPVSLLSS--GKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1907122866  391 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 435
Cdd:pfam02210   79 GLPPGESLLLNLNGPLYLGGLPPLLLLPALPVSPGFVGCIRDVRI 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
889-1042 1.84e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 117.90  E-value: 1.84e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  889 PVTFkTKSSYVALATLQA-YTSMHLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIkgSSNKPL 966
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVL--SSKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907122866  967 NDNQWHNVMISRDTSNLhTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAkETYKSLPKLVHakEGFQGCLASVDLN 1042
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-TLSVDGErvVESGSPGGSALLNLDGPLYLGGLP-EDLKSPGLPVS--PGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
911-1044 8.37e-30

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 115.51  E-value: 8.37e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   911 HLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIKgSSNKPLNDNQWHNVMISRDTSNLhTVKID 989
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSV-TLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907122866   990 --TKITTQITAGARNLDLKSDLYIGGVaKETYKSLPKLVHakEGFQGCLASVDLNGR 1044
Cdd:smart00282   79 ggNRVSGESPGGLTILNLDGPLYLGGL-PEDLKLPPLPVT--PGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
30-190 8.57e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 115.98  E-value: 8.57e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   30 GLEFPGaeGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFcAEPATLLADTP 108
Cdd:cd00110      1 GVSFSG--SSYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALEL-EDGRLVLRYDLG-SGSLVLSSKTP 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  109 VNDGAWHSVRIRRQFRNTTLYIDRaeAKWVEVKSKRRD--MTVFSGLFVGGLPPELRAAALKLtlasvreREPFKGWIRD 186
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDG--ERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV-------SPGFVGCIRD 147

                   ....
gi 1907122866  187 VRVN 190
Cdd:cd00110    148 LKVN 151
LamG smart00282
Laminin G domain;
53-191 7.86e-29

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 112.82  E-value: 7.86e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866    53 EMSFQLKTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDR 132
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALEL-RDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907122866   133 AEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTlasvrerEPFKGWIRDVRVNS 191
Cdd:smart00282   80 GNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-------PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
58-190 3.26e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 104.83  E-value: 3.26e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   58 LKTRSARGLVLYFDDEGfCDFLELILtRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW 137
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRG-SDFLALEL-VDGRLVLRYDLGSGPVSLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907122866  138 VEVKSKRRDMTVFSGLFVGGLPPELRaaalkltLASVREREPFKGWIRDVRVN 190
Cdd:pfam02210   79 GLPPGESLLLNLNGPLYLGGLPPLLL-------LPALPVSPGFVGCIRDVRIN 124
Laminin_G_1 pfam00054
Laminin G domain;
500-647 9.10e-26

Laminin G domain;


Pssm-ID: 395008  Cd Length: 131  Bit Score: 103.94  E-value: 9.10e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  500 FRTTEPNGLILFSHGKPRHqkdakhpqmikvDFFAIEMLDGHLYLLLDMGSGTIKIKALQkKVNDGEWYHVDFQRDGRSG 579
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER------------DFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSG 67
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  580 TISVNTLRTP-YTAP-GESEILDLDDELYLGGLPENKAGLvfptevWTALLNYGYVGCIRDLFIDGQSKD 647
Cdd:pfam00054   68 TLSVDGEARPtGESPlGATTDLDVDGPLYVGGLPSLGVKK------RRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
738-859 1.45e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 103.29  E-value: 1.45e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  738 FRSQRAYGILMATTSRDSaDTLRLELDAGRVKLTVNLGKGPETLFA-GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTG 816
Cdd:pfam02210    1 FRTTQPNGLLLYAGGRGS-DFLALELVDGRLVLRYDLGSGPVSLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1907122866  817 QMAGDHtrlEFHNIETGI------ITERRYLSSVPSNFIGHLQSLTFNG 859
Cdd:pfam02210   80 LPPGES---LLLNLNGPLylgglpPLLLLPALPVSPGFVGCIRDVRING 125
LamG smart00282
Laminin G domain;
733-860 7.28e-25

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 101.26  E-value: 7.28e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   733 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLGKGPETLFAGYN-LNDNEWHTVRVVRRGKSLKLTVDDQ 811
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1907122866   812 QAMTGQMAGDHTRLEFH-NIETG--IITERRYLSSVPSNFIGHLQSLTFNGM 860
Cdd:smart00282   81 NRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
710-858 3.54e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 91.33  E-value: 3.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  710 VLSYDGSMFMKIQLPVVMHTEaEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLGKGPETLFAGYNLND 789
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLND 79
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907122866  790 NEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLefhNIETGI------ITERRYLSSVPSNFIGHLQSLTFN 858
Cdd:cd00110     80 GQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_1 pfam00054
Laminin G domain;
916-1044 5.19e-20

Laminin G domain;


Pssm-ID: 395008  Cd Length: 131  Bit Score: 87.37  E-value: 5.19e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  916 FKTTSLDGLILYN-SGDGNDFIVVELVKGYLHYVFDLGNGANLIkgSSNKPLNDNQWHNVMISRDTSNLhTVKID---TK 991
Cdd:pfam00054    1 FRTTEPSGLLLYNgTQTERDFLALELRDGRLEVSYDLGSGAAVV--RSGDKLNDGKWHSVELERNGRSG-TLSVDgeaRP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907122866  992 ITTQITAGARNLDLKSDLYIGGvAKETYKSLPKLVHAKeGFQGCLASVDLNGR 1044
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGG-LPSLGVKKRRLAISP-SFDGCIRDVIVNGK 128
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1148-1296 3.08e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 426661 [Multi-domain]  Cd Length: 126  Bit Score: 85.18  E-value: 3.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866 1148 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1227
Cdd:pfam02210    1 FRTTQPNGLLL--YAGGRGSDFLALELVDGRLVLRYDLGSGPVSLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907122866 1228 RYPAGNndnerlaiarqripyrlgrvvdEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNG 1296
Cdd:pfam02210   79 GLPPGE----------------------SLLLNLNGPLYLGGLPPLLLLPALPVSPGFVGCIRDVRING 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1117-1236 1.27e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058  Cd Length: 151  Bit Score: 84.01  E-value: 1.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866 1117 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 1196
Cdd:cd00110      1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907122866 1197 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDN 1236
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSAL 114
LamG smart00282
Laminin G domain;
1143-1296 4.16e-18

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 82.00  E-value: 4.16e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  1143 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 1221
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  1222 SWPVIERYPAGnndnerlaiarqripyrlgrvvdewlldkgrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGL 1292
Cdd:smart00282   80 GNRVSGESPGG--------------------------------LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNL 127

                    ....
gi 1907122866  1293 YYNG 1296
Cdd:smart00282  128 KVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
312-437 4.90e-18

Laminin G domain;


Pssm-ID: 395008  Cd Length: 131  Bit Score: 81.59  E-value: 4.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  312 FKTLQRNGLMLHTGKSA--DYVNLALKNGAVSLVINLGSGAfeaLVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTT 389
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRLEVSYDLGSGA---AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907122866  390 TGYTQEDYTMLGS-DDFFYVGGSPSTADLP-GSPVSNNFMGCLKEVVYKN 437
Cdd:pfam00054   78 TGESPLGATTDLDvDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
59-195 1.36e-14

Laminin G domain;


Pssm-ID: 395008  Cd Length: 131  Bit Score: 71.96  E-value: 1.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866   59 KTRSARGLVLYFDDEGFCDFLELILtRGGRLQLSFSiFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWV 138
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTERDFLALEL-RDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907122866  139 EVKSKRRDMTVFSG-LFVGGLPPElraAALKLTLASVRerePFKGWIRDVRVNSSQAL 195
Cdd:pfam00054   80 ESPLGATTDLDVDGpLYVGGLPSL---GVKKRRLAISP---SFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
738-862 1.39e-13

Laminin G domain;


Pssm-ID: 395008  Cd Length: 131  Bit Score: 68.88  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  738 FRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLGKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQ 817
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907122866  818 MagDHTRLEFHNIETGI--------ITERRYLSSVPSnFIGHLQSLTFNGMAY 862
Cdd:pfam00054   81 S--PLGATTDLDVDGPLyvgglpslGVKKRRLAISPS-FDGCIRDVIVNGKPL 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
672-705 1.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907122866  672 CLS-NPCKNNGMCRDGWNRYVCDCSgTGYLGRSCE 705
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
1148-1221 2.87e-06

Laminin G domain;


Pssm-ID: 395008  Cd Length: 131  Bit Score: 48.08  E-value: 2.87e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907122866 1148 FSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDiAIEESNAIINDGKYHVVRFTRSGGNATLQVD 1221
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVD 72
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
672-699 6.36e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 6.36e-06
                           10        20
                   ....*....|....*....|....*...
gi 1907122866  672 CLSNPCKNNGMCRDGWNRYVCDCSgTGY 699
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGY 27
4.1m smart00294
putative band 4.1 homologues' binding motif;
1441-1459 2.89e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.89e-05
                            10
                    ....*....|....*....
gi 1907122866  1441 MYKYRNRDEGSYHVDESRN 1459
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
EGF_CA smart00179
Calcium-binding EGF-like domain;
672-705 2.91e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.91e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907122866   672 CLS-NPCKNNGMCRDGWNRYVCDCSgTGY-LGRSCE 705
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECP-PGYtDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
671-705 7.33e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 41.31  E-value: 7.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907122866  671 PC-LSNPCKNNGMCRDGWNRYVCDCSgTGYLG-RSCE 705
Cdd:cd00053      1 ECaASNPCSNGGTCVNTPGSYRCVCP-PGYTGdRSCE 36
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
304-416 3.58e-03

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 433165 [Multi-domain]  Cd Length: 151  Bit Score: 39.67  E-value: 3.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907122866  304 SSDEITLSF----KTLQRNGLMLHTGKSADYVNLAL-KNGAVSLVINLGSGAFEALVepVNGKFNDNAWHDVKVTRNLRQ 378
Cdd:pfam13385   15 PTSDFTVSAwvkpDSLPGWARAIISASGGGGYSLGLdGDGRLRFAVNGGGGGWDTVT--SGASLPLGQWTHVAVTYDGGT 92
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1907122866  379 VTISVDGILTTTGyTQEDYTMLGSDDFFYVGGSPSTAD 416
Cdd:pfam13385   93 LRLYVNGVLVGSS-TLTGGPPTGTGGPLYIGRSPGGDD 129
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1421-1456 6.08e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 426005  Cd Length: 62  Bit Score: 36.55  E-value: 6.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907122866 1421 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 1456
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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