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Conserved domains on  [gi|1907124497|ref|XP_036016503|]
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zinc finger protein 53 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 53-93 1.25e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907124497  53 LLTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVSV 93
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-627 2.33e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 223 DTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSV--CGKSFTQCTNLKTHQRLHTGEKPYKC-KECGKSFPQLSALKS 299
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 300 HQKIHTGERPYKCKECDKSFAHCSSFRRHQKTHRAEEHCSCPEC-GKVLHQLSHLRSHYRL---HTGEKPYKCNECDRSF 375
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLpanSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 376 TYYASYRRHQKTHSLDKFYKCKECGKSFLE---LSHLKRHYRIHTGEKPYKCEvcdksfTVNSTLKTHLKIHTGEKPFKC 452
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLensSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 453 ReCDKSFTKCSHLRRHQSVHTG-EKPYRCKECDKSFTECSTLRAHQ--KIHTGE--KPYKCRE--CDKSFIQRSNLIIHQ 525
Cdd:COG5048   265 L-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 526 RVHTGERPYICK--ECGKSFTKCST------LQIHQKIHTGEKPYKCM-ECNKSFTQDSHLRTHQRVHTGERP--YICKE 594
Cdd:COG5048   344 LLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1907124497 595 CGKSFTRCSYLRAHQKIHTGEKPYKCKDCDISF 627
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 53-93 1.25e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907124497  53 LLTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVSV 93
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
54-99 1.87e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.87e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907124497   54 LTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVSVEnYCIS 99
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 54-92 6.52e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.29  E-value: 6.52e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907124497  54 LTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVS 92
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-627 2.33e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 223 DTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSV--CGKSFTQCTNLKTHQRLHTGEKPYKC-KECGKSFPQLSALKS 299
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 300 HQKIHTGERPYKCKECDKSFAHCSSFRRHQKTHRAEEHCSCPEC-GKVLHQLSHLRSHYRL---HTGEKPYKCNECDRSF 375
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLpanSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 376 TYYASYRRHQKTHSLDKFYKCKECGKSFLE---LSHLKRHYRIHTGEKPYKCEvcdksfTVNSTLKTHLKIHTGEKPFKC 452
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLensSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 453 ReCDKSFTKCSHLRRHQSVHTG-EKPYRCKECDKSFTECSTLRAHQ--KIHTGE--KPYKCRE--CDKSFIQRSNLIIHQ 525
Cdd:COG5048   265 L-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 526 RVHTGERPYICK--ECGKSFTKCST------LQIHQKIHTGEKPYKCM-ECNKSFTQDSHLRTHQRVHTGERP--YICKE 594
Cdd:COG5048   344 LLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1907124497 595 CGKSFTRCSYLRAHQKIHTGEKPYKCKDCDISF 627
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-432 8.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.62e-05
                          10        20
                  ....*....|....*....|....*
gi 1907124497 408 HLKRHYRIHTGEKPYKCEVCDKSFT 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 532-584 5.13e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 5.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907124497 532 RPYiCKECGKSFTKCSTLQIHQKIHTgekpYKCMECNKSFTQDSHLRTH-QRVH 584
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 53-93 1.25e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907124497  53 LLTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVSV 93
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
54-99 1.87e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.87e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907124497   54 LTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVSVEnYCIS 99
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG-FQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 54-92 6.52e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.29  E-value: 6.52e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907124497  54 LTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVS 92
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-627 2.33e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 223 DTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSV--CGKSFTQCTNLKTHQRLHTGEKPYKC-KECGKSFPQLSALKS 299
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 300 HQKIHTGERPYKCKECDKSFAHCSSFRRHQKTHRAEEHCSCPEC-GKVLHQLSHLRSHYRL---HTGEKPYKCNECDRSF 375
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLpanSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 376 TYYASYRRHQKTHSLDKFYKCKECGKSFLE---LSHLKRHYRIHTGEKPYKCEvcdksfTVNSTLKTHLKIHTGEKPFKC 452
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLensSSSLPLTTNSQLSPKSLLSQ------SPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 453 ReCDKSFTKCSHLRRHQSVHTG-EKPYRCKECDKSFTECSTLRAHQ--KIHTGE--KPYKCRE--CDKSFIQRSNLIIHQ 525
Cdd:COG5048   265 L-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 526 RVHTGERPYICK--ECGKSFTKCST------LQIHQKIHTGEKPYKCM-ECNKSFTQDSHLRTHQRVHTGERP--YICKE 594
Cdd:COG5048   344 LLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1907124497 595 CGKSFTRCSYLRAHQKIHTGEKPYKCKDCDISF 627
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
141-580 3.75e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 3.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 141 NNYRCSKDRDGSVDLLNQDRHKSTHTGEEL--CKSEDCEKSLSLSSNLTENQRL--YAANKLQSQGEYDDDFSSVYSLMQ 216
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPsqCSYSGCDKSFSRPLELSRHLRThhNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 217 QTIYIGDTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSVCGKSFTQCTN-LKTHQRLHTGEKPykckecgKSFPQLS 295
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 296 ALKSHQKIHTGERPYKCKECDKSFAHCSSFRRHQKTHRAEEHCSCPECGKVLHQLSHLRSHYRLHTGEKPYKCNECDRSF 375
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 376 TYYASYRRHQKTHSL-------DKFYKCKECGKSFLELSHLKRHYR--IHTGE--KPYKC--EVCDKSFTVNSTLKTHLK 442
Cdd:COG5048   265 LPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 443 IHTGEKPFKC--RECDKSFTKCSHLRRHQSV--HTGEKPYRCKECDKSFtecstlrahqkihtgekpykcreCDKSFIQR 518
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNS-----------------------CIRNFKRD 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907124497 519 SNLIIHQRVHTGERP--YICKECGKSFTKCSTLQIHQKIHTgEKPYKCMECNKSFTQDSHLRTH 580
Cdd:COG5048   402 SNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
339-642 1.98e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 339 SCPECGKVLHQLSHLRSHYRLHTGEKPYKCN--ECDRSFTYYASYRRHQKTHSLDK-FYKCKECGKSFLELSHLKRHYRI 415
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPsDLNSKSLPLSNSKASSSSLSSSS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 416 HTGEKPYKCEVCDKSFTVNSTLKTHLKIHTGEKPFKCRECDKSFTKCShlrrhQSVHTgEKPYRCKECDKSFTECSTLRA 495
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP-----QSNSL-HPPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 496 HQKIHTGEKPYKCRECDKSFIQRSNLIIHQRVHTGERPYICKECG----KSFTKCSTLQIHQKIHTGEKP--YKCMECNK 569
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSSDSSSSASesPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 570 SFTQDSHLRTHQRVHTGER-PYICKECGKSFTRCSYLRAHQ--KIHTGE--KPYKC--KDCDISFIQISNLRRHQRVHTG 642
Cdd:COG5048   269 SSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 418-498 1.97e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 418 GEKPYKCEV--CDKSFTVNSTLKTHlKIHTgekpfkcrECDKSFTKCSHLRRHQSVHTGEKPYRCKECDKSFTECSTLRA 495
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1907124497 496 HQK 498
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-432 8.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.62e-05
                          10        20
                  ....*....|....*....|....*
gi 1907124497 408 HLKRHYRIHTGEKPYKCEVCDKSFT 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-321 1.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907124497 296 ALKSHQKIHTGERPYKCKECDKSFAH 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 250-302 3.24e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907124497 250 GKKPYKCSV--CGKSFTQCTNLKTHqRLH--------------------TGEKPYKCKECGKSFPQLSALKSHQK 302
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-291 4.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.06e-04
                          10        20
                  ....*....|....*....|....
gi 1907124497 268 NLKTHQRLHTGEKPYKCKECGKSF 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-461 5.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.29e-04
                          10        20
                  ....*....|....*....|....*
gi 1907124497 437 LKTHLKIHTGEKPFKCRECDKSFTK 461
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-517 8.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.90e-04
                          10        20
                  ....*....|....*....|....*
gi 1907124497 493 LRAHQKIHTGEKPYKCRECDKSFIQ 517
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-377 9.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.08e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907124497 352 HLRSHYRLHTGEKPYKCNECDRSFTY 377
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-488 9.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.17e-04
                          10        20
                  ....*....|....*....|....*
gi 1907124497 464 HLRRHQSVHTGEKPYRCKECDKSFT 488
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-265 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124497 240 SLTVHKRIHTGKKPYKCSVCGKSFTQ 265
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 362-442 1.56e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 362 GEKPYKCN--ECDRSFTYYASYRRHQKtHSldkfykckECGKSFLELSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKT 439
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1907124497 440 HLK 442
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
549-573 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*
gi 1907124497 549 LQIHQKIHTGEKPYKCMECNKSFTQ 573
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 532-584 5.13e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 5.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907124497 532 RPYiCKECGKSFTKCSTLQIHQKIHTgekpYKCMECNKSFTQDSHLRTH-QRVH 584
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
604-629 6.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124497 604 YLRAHQKIHTGEKPYKCKDCDISFIQ 629
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 306-391 6.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124497 306 GERPYKCK--ECDKSFAHCSSFrrhqKTHRAEEHCScpecgKVLHQLSHLRSHYRLHTGEKPYKCNECDRSFTYYASYRR 383
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL----KYHMLHGHQN-----QKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*...
gi 1907124497 384 HqKTHSLD 391
Cdd:COG5189   417 H-RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
576-601 8.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124497 576 HLRTHQRVHTGERPYICKECGKSFTR 601
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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