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Conserved domains on  [gi|1907124897|ref|XP_036016554|]
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ER membrane associated RNA degradation isoform X15 [Mus musculus]

Protein Classification

endoplasmic reticulum membrane-associated RNA degradation protein( domain architecture ID 10621442)

endoplasmic reticulum membrane-associated RNA degradation protein (ERMARD) is a DUF4209 domain-containing protein that may play a role in neuronal migration during embryonic development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 157-238 1.25e-29

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


:

Pssm-ID: 433574  Cd Length: 89  Bit Score: 111.99  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124897 157 LERALGDVFLLVG-------KECPFLLRDLLASAELAQVFGHAVMDILKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCS 229
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80


                  ....*....
gi 1907124897 230 AMLLLTAGL 238
Cdd:pfam13910  81 FLLLLLASL 89
DUF4209 super family cl16470
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 322-411 9.91e-03

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


The actual alignment was detected with superfamily member pfam13910:

Pssm-ID: 433574  Cd Length: 89  Bit Score: 35.72  E-value: 9.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124897 322 LEAGLRRLFAAVNKcpdrLLTAESTILYTTFDEILAkhmsDGSMNQLpcfLGEPAMEFLWDFLNYQEGPRIRDRISHGEI 401
Cdd:pfam13910   1 LERLLRDLLQLAGG----KSNNKSRDTPRLLRDLLR----SEELKEV---LGEELAFLLRVLFGPPRGLNLRNVVWHGFI 69

                          90
                  ....*....|
gi 1907124897 402 NIREFPEEAA 411
Cdd:pfam13910  70 SPSEFNPSYA 79
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 157-238 1.25e-29

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 111.99  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124897 157 LERALGDVFLLVG-------KECPFLLRDLLASAELAQVFGHAVMDILKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCS 229
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80


                  ....*....
gi 1907124897 230 AMLLLTAGL 238
Cdd:pfam13910  81 FLLLLLASL 89
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 322-411 9.91e-03

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 35.72  E-value: 9.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124897 322 LEAGLRRLFAAVNKcpdrLLTAESTILYTTFDEILAkhmsDGSMNQLpcfLGEPAMEFLWDFLNYQEGPRIRDRISHGEI 401
Cdd:pfam13910   1 LERLLRDLLQLAGG----KSNNKSRDTPRLLRDLLR----SEELKEV---LGEELAFLLRVLFGPPRGLNLRNVVWHGFI 69

                          90
                  ....*....|
gi 1907124897 402 NIREFPEEAA 411
Cdd:pfam13910  70 SPSEFNPSYA 79
 
Name Accession Description Interval E-value
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 157-238 1.25e-29

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 111.99  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124897 157 LERALGDVFLLVG-------KECPFLLRDLLASAELAQVFGHAVMDILKVFIGSPCGLNLRNVLWHGFASPQDIPPKYCS 229
Cdd:pfam13910   1 LERLLRDLLQLAGgksnnksRDTPRLLRDLLRSEELKEVLGEELAFLLRVLFGPPRGLNLRNVVWHGFISPSEFNPSYAS 80


                  ....*....
gi 1907124897 230 AMLLLTAGL 238
Cdd:pfam13910  81 FLLLLLASL 89
DUF4209 pfam13910
Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, ...
 322-411 9.91e-03

Domain of unknown function (DUF4209); This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.


Pssm-ID: 433574  Cd Length: 89  Bit Score: 35.72  E-value: 9.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124897 322 LEAGLRRLFAAVNKcpdrLLTAESTILYTTFDEILAkhmsDGSMNQLpcfLGEPAMEFLWDFLNYQEGPRIRDRISHGEI 401
Cdd:pfam13910   1 LERLLRDLLQLAGG----KSNNKSRDTPRLLRDLLR----SEELKEV---LGEELAFLLRVLFGPPRGLNLRNVVWHGFI 69

                          90
                  ....*....|
gi 1907124897 402 NIREFPEEAA 411
Cdd:pfam13910  70 SPSEFNPSYA 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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